Brand name: Diovan Generic name: Valsartan Indications: treatment of hypertension, heart failure.

Drug classification: cardiovascular agent; angiotensin II-receptor (type AT1) antagonist; antihypertensive Mechanism of action: an angiotensin II-receptor (type AT1) antagonist; blocks the binding of angiotensin II to the AT1 receptors found in many tissues. Angiotensin II is a potent vasoconstrictor and primary vasoactive hormone of the renin-angiotensin-aldosterone system. Dosage: hypertension Adult: PO 80mg qd (max: 320mg qd) Heart failure Adult: PO start with 40mg bid and titrate up to 160mg bid Special precaution: severe renal or hepatic impairment. Safety and efficacy in children <8 y are not established. Pregnancy risk category: C (1st trimester); D (2nd and 3rd trimester) Adverse reaction: Body as a whole: arthralgia. CNS: headache, dizziness. GI: diarrhea, nausea. Respiratory: cough, sinusitis. Metabolic: hyperkalemia

Contraindication: hypersensitivity to valsartan or losartan; pregnancy, lactation. Form: 40 mg, 80 mg, 160 mg capsules Nursing responsibility:  Monitor BP periodically; take trough readings, just prior to the next scheduled dose, when possible. Monitor liver function test, BUN and creatinine, serum potassium, and CBC with differential, periodically.

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