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TISSUE REPAIR

• REGENERATION:
– REPLACEMENT OF
DESTROYED TISSUE
WITH SAME TISSUE
TYPE

• FIBROSIS:
– ACCUMULATION OF
FIBROUS CT
– CREATION OF SCAR
TISSUE
TISSUE REPAIR
• 1: INFLAMMATION/
BLEEDING
– CAPILLARIES DILATE AND
BECOME PERMEABLE
• WHITE BLOOD CELLS
• CLOTTING PROTEINS

• 2: CLOT FORMATION
– STOPS BLEEDING
– HOLDS EDGES OF
WOUND TOGETHER
– SCAB = EXPOSED CLOT
TISSUE REPAIR
• 3: ORGANIZATION
– GRANULATION TISSUE
• NEW CAPILLARY
GROWTH
• FIBROBLAST
PROLIFERATION
• NEW COLLAGEN FIBERS

• 4: REGENERATION:
– EPITHELIAL TISSUE
• DIFFERENT TISSUES HAVE
DIFFERENT ABILITIES TO
REGENERATE

– VERY GOOD
• EPITHELIAL; BONE
– VERY BAD
• CARDIAC MUSCLE, NERVE TISSUE
SCARS AND ADHESIONS
• SCAR TISSUE:
– FIBROUS MASS MADE MOSTLY OF COLLAGEN
FIBERS
– STRONG
– INFLEXIBLE
– IMPEDES NORMAL FUNCTIONING OF THE
TISSUE IT IS REPLACING
• ADHESION:
– NEWLY FORMING SCAR TISSUE CONNECTING
ADJACENT ORGANS
– RESTRICTS NORMAL MOVEMENTS