LASIK

From Wikipedia, the free encyclopedia
For the article on the drug used for treatment of hypertension of eye surgery, see Lasix.
LASIK or Lasik (Laser-Assisted in situ Keratomileusis), commonly referred to as laser eye surgery or
laser vision correction, is a type of refractive surgery for the correction of myopia, hypermetropia,
and astigmatism. The LASIK surgery is performed by an ophthalmologist who uses a laser or
microkeratome to reshape the eye's cornea in order to improve visual acuity.[1] For most patients,
LASIK provides a permanent alternative to eyeglasses or contact lenses.[2]
LASIK is most similar to another surgical corrective procedure, photorefractive keratectomy (PRK,
similar to LASEK), and both represent advances over radial keratotomy in the surgical treatment of
refractive errors of vision. For patients with moderate to high myopia or thin corneas which cannot
be treated with LASIK and PRK, the phakic intraocular lens is an alternative.[3][4] As of 2011, over
11 million LASIK procedures have been performed in the United States[5] and as of 2009 over 28
million have been performed worldwide.[6]
Contents
1 History
1.1 Barraquer's early work
1.2 Application of medical laser to refractive surgery
2 Introduction of LASIK
2.1 Patent
3 Implementation in U.S.
4 Further developments
4.1 Experimental techniques
5 Procedures
5.1 Preoperative procedures
5.1.1 Contact lenses
5.1.2 Pre-operative examination and education
5.2 Operative procedure
5.2.1 Flap creation
5.2.2 Laser remodelling
5.2.3 Repositioning of the flap
5.3 Postoperative care
6 Wavefront-guided LASIK
7 Effectiveness
7.1 Patient satisfaction
7.2 Patient dissatisfaction
8 Risks
8.1 Higher-order aberrations
8.2 Dry eyes
8.3 Halos
8.4 Other complications
9 Onset of presbyopia
10 LASIK versus photorefractive keratectomy
11 FDA's position on LASIK
12 See also
13 References
14 External links
History
Barraquer's early work
In the 1950s, the microkeratome and keratomileusis technique were developed in Bogotá,
Colombia, by the Spanish ophthalmologist Jose Barraquer. In his clinic, he would cut thin (one
hundredth of a mm thick) flaps in the cornea to alter its shape. Barraquer also investigated how
much of the cornea had to be left unaltered in order to provide stable long-term results.[7] This work
was followed by that of the Russian scientist, Svyatoslav Fyodorov (1920-2000), who developed the
Radial keratotomy (RK) in the 1970s and designed the first posterior chamber implantable contact
lenses (phakic intraocular lens) in the 1980s.
Application of medical laser to refractive surgery
In 1980, Rangaswamy Srinivasan, at the IBM Research laboratory, discovered that an ultraviolet
excimer laser could etch living tissue, with precision and with no thermal damage to the surrounding
area. He named the phenomenon "ablative photo-decomposition" (APD).[8] Five years later, in 1985,
Steven Trokel at the Edward S. Harkness Eye Institute, Columbia University in New York City,
published his work using the excimer laser in radial keratotomy. He wrote,
"The central corneal flattening obtained by radial diamond knife incisions has been duplicated by
radial laser incisions in 18 enucleated human eyes. The incisions, made by 193 nm far-ultraviolet
light radiation emitted by the excimer laser, produced corneal flattening ranging from 0.12 to 5.35
diopters. Both the depth of the corneal incisions and the degree of central corneal flattening
correlated with the laser energy applied. Histopathology revealed the remarkably smooth edges of
the laser incisions."[9]
Together with his colleagues, Charles Munnerlyn and Terry Clapham, Trokel founded VISX USA
inc.[10] Marguerite B. MacDonald MD performed the first human VISX refractive laser eye surgery
in 1989.[11]
Introduction of LASIK
Patent
A number of patents have been issued for several techniques related to LASIK. For example, Samuel
E. Blum filed a patent application in 1982. Later, on 20 June 1989, Gholam A. Peyman was granted a
US patent for LASIK (US4840175). It was,
"A method and apparatus for modifying the curvature of a live cornea via use of an excimer laser.
The live cornea has a thin layer removed therefrom, leaving an exposed internal surface thereon.
Then, either the surface or thin layer is exposed to the laser beam along a predetermined pattern to
ablate desired portions. The thin layer is then replaced onto the surface. Ablating a central area of
the surface or thin layer makes the cornea less curved, while ablating an annular area spaced from
the center of the surface or layer makes the cornea more curved. The desired predetermined pattern
is formed by use of a variable diaphragm, a rotating orifice of variable size, a movable mirror or a
movable fiber optic cable through which the laser beam is directed towards the exposed internal
surface or removed http://wn.com/LASIK_Concerns thin layer."[12]
The patents related to so-called broad-beam LASIK and PRK technologies were granted to US
companies including Visx and Summit during 1990-1995 based on the fundamental US patent issued
to IBM (1983) which claimed the use of UV laser for the ablation of organic tissues. In 1991, J.T. Lin
was granted a US patent (US5520679) for a new technology using a flying-spot for customized
LASIK that has been used worldwide. The first US patent (in 1993) using an eye-tracking device to
prevent decentration in LASIK procedures was granted to S. Lai.
Implementation in U.S.
The LASIK technique was implemented in the U.S. after its successful application elsewhere. The
Food and Drug Administration (FDA) commenced a trial of the excimer laser in 1989. The first
enterprise to receive FDA approval to use an excimer laser for photo-refractive keratectomy was
Summit Technology (founder and CEO, Dr. David Muller).[13] In 1992, under the direction of the
FDA, Pallikaris introduced LASIK to ten VISX centres. In 1998, the "Kremer Excimer Laser", serial
number KEA 940202, received FDA approval for its singular use for performing LASIK.[14]
Subsequently, Summit Technology was the first company to receive FDA approval to mass
manufacture and distribute excimer lasers. VISX and other companies followed.[14]
The excimer laser that was used for the first LASIK surgeries by I.Pallikaris
Pallikaris suggested a flap of cornea could be raised by microkeratome prior to the performing of
PRK with the excimer laser. The addition of a flap to PRK became known as LASIK.
Further developments
Since 1991, there have been further developments such as faster lasers; larger spot areas; bladeless
flap incisions; intraoperative corneal pachymetry; and "wavefront-optimized" and "wavefront-guided"
techniques. However, use of the excimer laser risks damage to the retina and optic nerve. The goal
of refractive surgery is to avoid permanently weakening the cornea with incisions and to deliver less
energy to the surrounding tissues.
Experimental techniques
"plain" LASIK: LASEK, Epi-LASIK,
Sub-Bowman's keratomileusis (thin flap LASIK),
Wavefront-guided PRK,
advanced intraocular lenses.
Femtosecond laser intrastromal vision correction: using all-femtosecond correction, for example,
Femtosecond Lenticule EXtraction, FLIVC, or IntraCOR),
Keraflex: a thermobiochemical solution which has received the CE Mark for refractive
correction.[15] and is in European clinical trials for the correction of myopia and keratoconus.[16]
Technolas FEMTEC laser: for incisionless IntraCOR ablation for presbyopia,[17] with trials ongoing
for myopia and other conditions.[18]
IsoVision : It's a surgical technique that can completely corrects near and distant vision of each eye
(Hypertropia, Myopia, Emmetropia and Astigmatic associated with Presbyopia). Developed since
2008 by the French ophthalmologist Frédéric HEHN.[19]
Procedures
Â
Video of a complete LASIK-treatment
The planning and analysis of corneal reshaping techniques such as LASIK have been standardized by
the American National Standards Institute, an approach based on the Alpins Method of astigmatism
analysis. The FDA website on LASIK states,
"Before undergoing a refractive procedure, you should carefully weigh the risks and benefits based
on your own personal value system, and try to avoid being influenced by friends that have had the
procedure or doctors encouraging you to do so."[20]
The procedure involves creating a thin flap on the eye, folding it to enable remodeling of the tissue
beneath with a laser and repositioning the flap.
Preoperative procedures
Contact lenses
Patients wearing soft contact lenses are instructed to stop wearing them 5 to 21 days before
surgery. One industry body recommends that patients wearing hard contact lenses should stop
wearing them for a minimum of six weeks plus another six weeks for every three years the hard
contacts have been worn.[21] The cornea is avascular because it must be transparent to function
normally. Its cells absorb oxygen from the tear film. Thus, low-oxygen-permeable contact lenses
reduce the cornea's oxygen absorption, sometimes resulting in corneal neovascularization--the
growth of blood vessels into the cornea. This causes a slight lengthening of inflammation duration
and healing time and some pain during surgery, because of greater bleeding. Although some contact
lenses (notably modern RGP and soft silicone hydrogel lenses) are made of materials with greater
oxygen permeability that help reduce the risk of corneal neovascularization, patients considering
LASIK are warned to avoid over-wearing their contact lenses.
Pre-operative examination and education
In the USA, the FDA has approved LASIK for age 18 and over.[22] More importantly the patient's
eye prescription should be stable for at least one year prior to surgery. The patient may be examined
with pupillary dilation and education given prior to the procedure. Before the surgery, the patient's
corneas are examined with a pachymeter to determine their thickness, and with a topographer, or
corneal topography machine,[1] to measure their surface contour. Using low-power lasers, a
topographer creates a topographic map of the cornea. The procedure is contraindicated if the
topographer finds difficulties such as keratoconus[1] The preparatory process also detects
astigmatism and other irregularities in the shape of the cornea. Using this information, the surgeon
calculates the amount and the location of corneal tissue to be removed. The patient is prescribed
and self-administers an antibiotic beforehand to minimize the risk of infection after the procedure
and is sometimes offered a short acting oral sedative medication as a pre-medication. Prior to the
procedure, anaesthetic eye drops are instilled. Factors that may rule out LASIK for some patients
include large pupils, thin corneas and extremely dry eyes.
Operative procedure
Flap creation
A soft corneal suction ring is applied to the eye, holding the eye in place. This step in the procedure
can sometimes cause small blood vessels to burst, resulting in bleeding or subconjunctival
hemorrhage into the white (sclera) of the eye, a harmless side effect that resolves within several
weeks. Increased suction causes a transient dimming of vision in the treated eye. Once the eye is
immobilized, a flap is created by cutting through the corneal epithelium and Bowman's layer. This
process is achieved with a mechanical microkeratome using a metal blade, or a femtosecond laser
that creates a series of tiny closely arranged bubbles within the cornea.[23] A hinge is left at one
end of this flap. The flap is folded back, revealing the stroma, the middle section of the cornea. The
process of lifting and folding back the flap can sometimes be uncomfortable.
Laser remodelling
The second step of the procedure uses an excimer laser (193Â nm) to remodel the corneal stroma.
The laser vaporizes the tissue in a finely controlled manner without damaging the adjacent stroma.
No burning with heat or actual cutting is required to ablate the tissue. The layers of tissue removed
are tens of micrometres thick. Performing the laser ablation in the deeper corneal stroma provides
for more rapid visual recovery and less pain than the earlier technique, photorefractive keratectomy
(PRK). During the second step, the patient's vision becomes blurry, once the flap is lifted. They will
be able to see only white light surrounding the orange light of the laser, which can lead to mild
disorientation. The excimer laser uses an eye tracking system that follows the patient's eye position
up to 4,000 times per second, redirecting laser pulses for precise placement within the treatment
zone. Typical pulses are around 1 millijoule (mJ) of pulse energy in 10 to 20 nanoseconds.[24]
Repositioning of the flap
After the laser has reshaped the stromal layer, the LASIK flap is carefully repositioned over the
treatment area by the surgeon and checked for the presence of air bubbles, debris, and proper fit on
the eye. The flap remains in position by natural adhesion until healing is completed.
Postoperative care
Patients are usually given a course of antibiotic and anti-inflammatory eye drops. These are
continued in the weeks following surgery. Patients are told to rest and are given dark eyeglasses to
protect their eyes from bright lights and occasionally protective goggles to prevent rubbing of the
eyes when asleep and to reduce dry eyes. They also are required to moisturize the eyes with
preservative-free tears and follow directions for prescription drops. Occasionally after the procedure
a bandage contact lens is placed to aid the healing, and typically removed after 3-4 days. Patients
should be adequately informed by their surgeons of the importance of proper post-operative care to
minimize the risk of complications.[25]
Wavefront-guided LASIK
Wavefront-guided LASIK[26] is a variation of LASIK surgery in which, rather than applying a simple
correction of only long/short-sightedness and astigmatism (only lower order aberrations as in
traditional LASIK), an ophthalmologist applies a spatially varying correction, guiding the computer-
controlled excimer laser with measurements from a wavefront sensor. The goal is to achieve a more
optically perfect eye, though the final result still depends on the physician's success at predicting
changes that occur during healing and other factors that may have to do with the
regularity/irregularity of the cornea and the axis of any residual astigmatism. Another important
factor is whether the excimer laser can correctly register eye position in 3 dimensions, and to track
the eye in all the possible directions of eye movement. If a wavefront guided treatment is performed
with less than perfect registration and tracking, pre-existing aberrations can be worsened. In older
patients, scattering from microscopic particles (cataract or incipient cataract) may play a role that
outweighs any benefit from wavefront correction. Therefore, patients expecting so-called "super
vision" from such procedures may be disappointed.[27][28][29][30]
One method of planning and analyzing the results of LASIK surgery (as well as cataract/IOL, corneal,
and other refractive surgical procedures) uses vector analysis, and in the case of LASIK, may be
combined with a wavefront-guided approach.[27][28][29][30] Many people undergoing LASIK have
preexisting astigmatism, which may be regular or irregular, and is caused by some combination of
external (corneal surface) and internal (posterior corneal surface, human lens, fluids, retina, and
eye-brain interface) optical properties. In some patients, the external optics may have the greater
influence, and in other patients, the internal optics may predominate. Importantly, the axes and
magnitudes of external and internal astigmatism do not necessarily coincide, but it is the
combination of the two that by definition determines the overall optics of the eye.
When treating a patient with preexisting astigmatism, most wavefront-guided LASIK lasers are
designed to treat regular astigmatism as determined externally by corneal topography. In patients
who have an element of internally induced astigmatism, therefore, the wavefront-guided astigmatism
correction may leave regular astigmatism behind (a cross-cylinder effect). If the patient has
preexisting irregular astigmatism, wavefront-guided approaches may leave both regular and
irregular astigmatism behind. This can result in less-than-optimal visual acuity compared with a
wavefront-guided approach combined with vector planning, as shown in a 2008 study.[31] Thus,
vector planning offers a better alignment between corneal astigmatism and laser treatment, and
leaves less regular astigmatism behind on the cornea, which is advantageous whether irregular
astigmatism coexists or not.
The "leftover" astigmatism after a purely surface-guided laser correction can be calculated
beforehand, and is called ocular residual astigmatism (ORA). ORA is a calculation of astigmatism due
to the noncorneal surface (internal) optics. The purely refraction-based approach represented by
wavefront analysis actually conflicts with corneal surgical experience developed over many
years.[30]
The pathway to "super vision" thus may require a more customized approach to corneal astigmatism
than is usually attempted, and any remaining astigmatism ought to be regular (as opposed to
irregular), which are both fundamental principles of vector planning overlooked by a purely
wavefront-guided treatment plan.[30] This was confirmed by the 2008 study mentioned above, which
found a greater reduction in corneal astigmatism and better visual outcomes under mesopic
conditions using wavefront technology combined with vector analysis than using wavefront
technology alone, and also found equivalent higher-order aberrations (see below).[31] Vector
planning also proved advantageous in patients with keratoconus.[32] Additional discussion of
wavefront-guided LASIK can be found here.
No good data can be found that compare the percentage of LASIK procedures that employ wavefront
guidance versus the percentage that do not, nor the percentage of refractive surgeons who have a
preference one way or the other. Wavefront technology continues to be positioned as an "advance"
in LASIK with putative advantages;[33][34][35][36] however, it is clear that not all LASIK
procedures are performed with wavefront guidance.[37]
Still, surgeons claim patients are generally more satisfied with this technique than with previous
methods, particularly regarding lowered incidence of "halos," the visual artifact caused by spherical
aberration induced in the eye by earlier methods. A meta-analysis of eight trials showed a lower
incidence of these higher order aberrations in patients who had wavefront-guided LASIK compared
to non-wavefront-guided LASIK.[38] Based on their experience, the United States Air Force has
described WFG-Lasik as giving "superior vision results".[39]
Effectiveness
In 2006, the British National Health Service's National Institute for Health and Clinical Excellence
(NICE) considered evidence of the effectiveness of laser surgery and issued guidance stating
"current evidence suggests that photorefractive (laser) surgery for the correction of refractive errors
is safe and efficacious for use in appropriately selected patients."[40]
Patient satisfaction
Surveys of LASIK find rates of patient satisfaction between 92 and 98 percent.[41][42][43] In March
2008, The American Society of Cataract and Refractive Surgery published a patient satisfaction
meta-analysis of over 3,000 peer-reviewed articles from international clinical journals. Data from the
prior 10 years revealed a 95.4 percent patient satisfaction rate among LASIK patients.[44]
Patient dissatisfaction
Some patients with perceived poor outcomes from LASIK surgical procedures report a significantly
reduced quality of life because of vision problems or physical pain associated with the surgery. A
small percentage of patients may need to have another surgery because their condition is over-
corrected or under-corrected. Some patients need to wear contact lenses or glasses even after
treatment.[45] Patients who have suffered LASIK complications have created websites and
discussion forums where prospective and past patients can discuss the surgery.
In 1999, "Surgical Eyes" was founded in New York city as a resource for patients with complications
of LASIK and other refractive surgeries by RK patient Ron Link. "Surgical Eyes" has since been
superseded by the "Vision Surgery Rehab Network" (VSRN).[46][47][48][49][50]
Risks
On October 10, 2006, WebMD reported that statistical analysis revealed that the infection risk for
contact lens wearers is greater than the infection risk from LASIK.[51] Daily contact lens wearers
have a 1-in-100 chance of developing a serious, contact lens-related eye infection in 30 years of use,
and a 1-in-2,000 chance of suffering significant vision loss as a result of infection. The researchers
calculated the risk of significant vision loss consequence of LASIK surgery to be closer to 1-in-10,000
cases.
Morris Waxler, a former FDA official who was involved in the approval of LASIK, has subsequently
criticized its widespread use. In 2010, Waxler made media appearances and claimed that the
procedure had a failure rate greater than 50%. The FDA responded that Waxler's information was
"filled with false statements, incorrect citations" and "mischaracterization of results".[52]
Higher-order aberrations
The term "higher-order aberrations" are visual problems that require special testing for diagnosis
and are not corrected with normal spectacles (eyeglasses). These aberrations include 'starbursts',
'ghosting', 'halos' and others.[53] Some patients describe these symptoms post-operatively and
associate them with the LASIK technique including the formation of the flap and the tissue
ablation.[54] The advancement of the LASIK technology has reduced the risk of clinically significant
visual impairment after surgery. There is a correlation between pupil size and aberrations.[55] This
correlation may be the result of irregularity in the corneal tissue between the untouched part of the
cornea and the reshaped part. Daytime post-LASIK vision is optimal, since the pupil size is smaller
than the LASIK flap. However, at night, the pupil may dilate such that light passes through the edge
of the LASIK flap which gives rise to aberrations. LASIK and PRK may induce spherical aberration if
the laser under corrects as it moves outward from the centre of the treatment zone, especially when
major corrections are made. Others propose that higher order aberrations are present
preoperatively.[56] They can be measured in micrometers (µm) whereas the smallest laser beam
size approved by the FDA is about 1000 times larger, at 0.65Â mm. In situ keratomileusis effected at
a later age increases the incidence of corneal higher-order wavefront aberrations.[57][58] These
factors demonstrate the importance of careful patient selection for LASIK treatment.
A subconjunctival hemorrhage is a common and minor post-LASIK complication.
Dry eyes
Some people experience dry eyes following surgery.[59] Although it is usually temporary it can
develop into dry eye syndrome.[60]
Underlying conditions with dry eye such as Sjögren's syndrome are considered contraindications to
Lasik.[61]
Treatments include artificial tears, prescription tears and punctal occlusion. Punctal occlusion is
accomplished by placing a collagen plug in the tear duct, which normally drains fluid from the eye.
Some patients complain of ongoing dry eye symptoms despite such treatments and dry eye
symptoms may be permanent.[62]
Halos
Halos and starbursts occur around bright lights at night[63][64][65] At night, the pupil may dilate to
be larger than the flap leading to the edge of the flap or stromal changes causing visual distortion of
light that does not occur during the day when the pupil is smaller. The eyes can be examined for
large pupils pre-operatively and the risk of this symptom assessed.
Complications due to LASIK have been classified as those that occur due to preoperative,
intraoperative, early postoperative, or late postoperative sources:[66] According to the UK National
Health Service complications occur in fewer than 5% of cases.[59]
Other complications
flap complications - The incidence of flap complications is about 0.244%.[67] Flap complications
(such as displaced flaps or folds in the flaps that necessitate repositioning, diffuse lamellar keratitis,
and epithelial ingrowth) are common in lamellar corneal surgeries[68] but rarely lead to permanent
loss of visual acuity. The incidence of these microkeratome-related complications decreases with
increased physician experience.[69]
"slipped flap"Â - is a corneal flap that detaches from the rest of the cornea. The chances of this are
greatest immediately after surgery, so patients typically are advised to go home and sleep to let the
flap adhere and heal. Patients are usually given sleep goggles or eye shields to wear for several
nights to prevent them from dislodging the flap in their sleep. A short operation time may decrease
the chance of this complication, as there is less time for the flap to dry. .
"Flap interface particles"Â - are a finding whose clinical significance is undetermined.[70] Particles
of various sizes and reflectivity are clinically visible in about 38.7% of eyes examined via slit lamp
biomicroscopy and in 100% of eyes examined by confocal microscopy.[70]
Diffuse lamellar keratitis (or DLK)Â - an inflammatory process that involves an accumulation of white
blood cells at the interface between the LASIK corneal flap and the underlying stroma. It is known
colloquially as "sands of Sahara syndrome" because on slit lamp exam, the inflammatory infiltrate
appears similar to waves of sand. The USAeyes organisation reports an incidence of 2.3% after
LASIK.[71][72] It is most commonly treated with steroid eye drops. Sometimes it is necessary for the
eye surgeon to lift the flap and manually remove the accumulated cells. DLK has not been reported
with photorefractive keratectomy due to the absence of flap creation.
Infection - the incidence of infection responsive to treatment has been estimated at 0.4%.[72]
Ectasia - post-LASIK corneal ectasia[73] is a condition where the cornea starts to bulge forwards at
a variable time after LASIK, causing irregular astigmatism. The condition is similar to keratoconus.
If this occurs, the patient may need rigid gas permeable contact lenses, Intrastromal corneal ring
segments,[74]corneal collagen cross-linking with Riboflavin,[75] or a corneal transplant. A
significant risk factor is forme fruste keratoconus, a genetic condition that predisposes the cornea to
thinning after surgery. Although this condition is screened for in the preoperative examination, it is
possible for the condition to appear later in life (the mid-40s). When cross-linking is performed only
after the cornea becomes distorted, vision remains blurry even though the disease is stabilised. As a
result, combining corneal collagen cross-linking with LASIK ('LASIK Xtra') aims to strengthen the
cornea at the point of surgery and may be useful in cases where a very thin cornea is expected after
the LASIK procedure. This would include cases of high spectacle power and patients with thin
corneas before surgery. Definitive evidence that the procedure can reduce the risk of corneal ectasia
will only become available a number of years later as corneal ectasia, if it happens, usually occurs in
the late post-operative period. Some study show that combining LASIK with cross-linking adds
refractive stability to hyperopic treatments and may also do the same for very high myopic
treatments.[76][77]
subconjunctival hemorrhage - A report shows the incidence of subconjunctival hemorrhage has
been estimated at 10.5%.[72]
Corneal scarring - or permanent problems with cornea's shape making it impossible to wear
contact lenses.[45]
epithelial ingrowth - the incidence of epithelial ingrowth has been estimated at 0.1%.[72]
traumatic flap dislocations - Cases of late traumatic flap dislocations have been reported up to
seven years after LASIK.[78]
Glaucoma - After LASIK, measurements of intraocular pressure (used to diagnose and treat
glaucoma) can be more difficult. The changes also affect the calculations used to select the correct
intraocular lens implant for cataract surgery. This is known as "refractive surprise." Preoperative,
operative and postoperative measurements can assist.
Retinal detachment: the incidence of retinal detachment has been estimated at 0.36 percent.[79]
Choroidal neovascularization: the incidence of choroidal neovascularization has been estimated at
0.33 percent.[79]
Uveitis: the incidence of uveitis has been estimated at 0.18 percent.[80]
for climbers - Although the cornea usually is thinner after LASIK, because of the removal of part of
the stroma, refractive surgeons strive to maintain the maximum thickness to avoid structurally
weakening the cornea. Decreased atmospheric pressure at higher altitudes has not been
demonstrated as extremely dangerous to the eyes of LASIK patients. However, some mountain
climbers have experienced a myopic shift at extreme altitudes.[81][82]
corneal keratocytes - There is a report of decreases in numbers of corneal keratocytes (fibroblasts)
after LASIK.[83]
Late postoperative complications - A large body of evidence on the chances of long-term
complications is not yet established and may be changing due to advances in operator experience,
instruments and techniques.[84][85][86]
Onset of presbyopia
Myopic (nearsighted) people who are close to the age (mid- to late-forties) when they will require
either reading glasses or bifocal eyeglasses may find that they still require reading glasses despite
having undergone refractive LASIK surgery. Myopic people generally require reading glasses or
bifocal eyeglasses at a later age than people who are emmetropic (those who see without
eyeglasses), but this benefit may be lost if they undergo LASIK. This is not a complication but an
expected result of the physical laws of optics. Although there is currently no method to completely
eradicate the need for reading glasses in this group, it may be minimized by performing a variation
of the LASIK procedure called "slight monovision." In this procedure, which is performed exactly like
distance-vision-correction LASIK, the dominant eye is set for distance vision, while the non-dominant
eye is set to the prescription of the patient's reading glasses. This allows the patient to achieve a
similar effect as wearing bifocals. The majority of patients tolerate this procedure very well and do
not notice any shift between near and distance viewing, although a small portion of the population
has trouble adjusting to the monovision effect. This can be tested for several days prior to surgery by
wearing contact lenses that mimic the monovision effect. Recently, a variation of the laser ablation
pattern called PresbyLASIK, has been developed to reduce or eliminate dependence on reading
glasses while retaining distance vision.
LASIK versus photorefractive keratectomy
There have been a number of studies comparing Lasik to photorefractive keratectomy, or PRK. Lasik
is associated with decreased inflammation and quicker recovery, but at the cost of decreased
expression of nerve growth factor (NGF) at the surgical bed.[87] PRK, on the other hand, has longer
recovery time with more postoperative discomfort and irritation, but rates of lasik eye surgery cost
reading pa ocular dryness are less,[88][89][90] as only the epithelium is denuded in this approach.
Lasik, on the other hand, involves creation of a corneal flap.[91] The medical literature is not
uniform, however, regarding their comparative effects on ocular dryness,[92] although the majority
of research supports PRK as causing less reduction in the tear film. Surgical technique has improved
with time, and a more recent study has shown no difference in ocular dryness in Lasik or PRK at 12
months, as compared to pre-operative baseline, although interval assessments at months 1, 3 and 6
did show dryness in both groups.[93] Quantitative changes occurring at the eye surface are more
pronounced with Lasik, but more irritation, pain and eyelid sticking are felt with PRK, which could
be related to increased denervation with Lasik.[87][94] A Systematic review compared LASIK and
PRK and concluded that LASIK may probably have faster recovery time and lower pain in
comparison to PRK, however results may be similar in both beyond a period of one year.[95]
FDA's position on LASIK
Since October 2009, the FDA has had LASIK under a Quality of Life Collaboration Project (LQLCP).
LQLCP is a government partnership among the FDA, the Department of Defense, and the National
Eye Institute. This project examines patient-reported outcomes (PROs) following LASIK.[96] This
investigation was supposed to be concluded in 2012; however, no conclusions have been reached
yet.[97]
On December 6, 2011, FDA posted a video on FDA's YouTube channel and FDA's LASIK web site to
help explain the risks of LASIK and other important information to potential patients. The video
includes images of what certain visual symptoms may look like to patients experiencing them.[97]
See also
Samuel E. Blum
Automated lamellar keratoplasty
Femtosecond laser intrastromal vision correction
Refractive error
Wavefront
References
^ a b c Finn, Peter (20 December 2012). "Medical Mystery: Preparation for surgery revealed cause
of deteriorating eyesight". The Washington Post.
^ Maguire, Stephen. "Laser Eye Surgery". The Irish Times.
^ Lovisolo, CF; Reinstein, DZ (Nov-Dec 2005). "Phakic intraocular lenses.". Survey of ophthalmology
50 (6): 549-87. doi:10.1016/j.survophthal.2005.08.011. PMIDÂ 16263370.
^ Sanders, Donald R.; John A. (May 2003). "Comparison of Implantable Contact Lens and Laser
Assisted In Situ Keratomileusis for Moderate to High Myopia". Cornea 22 (4): 324-331.
doi:10.1097/00003226-200305000-00009. PMIDÂ 12792475. Retrieved June 22, 2012.
^ Lindfield, Dan; Poole, Tom. "Nd:YAG Treatment of Epithelial Ingrowth". Cataract and Refractive
Surgery Today. Retrieved 12 September 2013.
^ "A Look at LASIK Past, Present and Future". EyeNet Magazine. Retrieved 12 September 2013.
^ Troutman RC, Swinger C (1978). "Refractive keratoplasty: keratophakia and keratomileusis".
Trans Am Ophthalmol Soc. 76: 329-39.
^ "Prize for the Industrial Application of Physics Winner - American Institute of Physics". Aip.org.
Retrieved 2011-12-10.
^ Cotliar AM, Schubert HD, Mandel ER, Trokel SL (Feb 1985). "Excimer laser radial keratotomy".
Ophthalmology 92 (2): 206-8. doi:10.1016/s0161-6420(85)34052-6.
^ [1] VISX USA Technology (Last accessed 4th June, 2012)
^ McDonald M.B., Kaufman H.E., Frantz J.M., Shofner S, Salmeron B, Klyce S.D. (1989). "Excimer
laser ablation - human eye". Arch Ophthalmol 107 (5): 641-642.
^ [2] Patents at Google.com (last accessed 4th June, 2012)
^ "FDA-Approved Lasers for PRK and Other Refractive Surgeries". Fda.gov. Retrieved 2011-12-10.
^ a b "List of FDA-Approved Lasers for LASIK". Fda.gov. Retrieved 2011-12-10.
^ [3]
^ "CRSTodayEurope.com > May 2010 > Industry interview: Aiming to change the face of refractive
surgery--again". Bmctoday.net. 2010-04-16. Retrieved 2011-12-10.
^ [4] IntraCOR for presbyopia.
^ [5] IntraCOR for myopia
^ Advanced Isovision: Predictable PresbyLASIK > Femtosecond Laser: Techniques and Technology.
JP Medical Ltd. 2012.
^ "US FDA/CDRH: LASIK - What are the risks and how can I find the right doctor for me?". Fda.gov.
2008-11-11. Retrieved 2011-12-10.
^ "Lasik and Contacts". Usaeyes.org. 2010-04-12. Retrieved 2011-12-10.
^ "Age Issues For Lasik, All-Laser Lasik, PRK, LASEK, Epi-Lasik, CK, P-IOL, RLE, etc". Usaeyes.org.
2010-04-12. Retrieved 2011-12-10.
^ "All-Laser Lasik - iLasik - IntraLasik". Usaeyes.org. 2010-04-12. Retrieved 2011-12-10.
^ "Patent: ultraviolet solid state laser". Freepatentsonline.com. Retrieved 2011-12-10.
^ Dimitri T. Azar , Damien Gatinel (2007). Refractive surgery (2nd ed. ed.). Philadelphia: Mosby
Elsevier. ISBNÂ 9780323035996.
^ "IROC . Institut für Refraktive und Ophthalmo-Chirurgie". Iroc.ch. 2005-04-15. Retrieved 2011-
12-10.
^ a b Walsh MJ. Is the future of refractive surgery based on corneal topography or wavefront?
"Ocular Surgery News". August 1, 2000, page 26.
^ a b Walsh MJ. Wavefront is showing signs of success, but can it do it alone? Ocular Surgery News.
September 1, 2000, page 41.
^ a b EW Dialogue: the future of wavefront refraction as a diagnostic tool. "EyeWorld". May 2000,
pages 64 and 65.
^ a b c d Alpins, NA (2002). "Wavefront technology: A new advance that fails to answer old
questions on corneal vs. Refractive astigmatism correction". Journal of refractive surgery 18 (6):
737-9. PMIDÂ 12458868.
^ a b Alpins, N; Stamatelatos, G (2008). "Clinical outcomes of laser in situ keratomileusis using
combined topography and refractive wavefront treatments for myopic astigmatism". Journal of
cataract and refractive surgery 34 (8): 1250-9. doi:10.1016/j.jcrs.2008.03.028. PMIDÂ 18655973.
^ Alpins, N; Stamatelatos, G (2007). "Customized photoastigmatic refractive keratectomy using
combined topographic and refractive data for myopia and astigmatism in eyes with forme fruste and
mild keratoconus". Journal of cataract and refractive surgery 33 (4): 591-602.
doi:10.1016/j.jcrs.2006.12.014. PMIDÂ 17397730.
^ American Academy of Ophthalmology. "Refractive Laser Surgery: An In-Depth Look at LASIK and
Brief Overview of PRK, Epi-LASIK, and LASEK: A Science Writer's Guide". Accessed January 29,
2012.
^ Abbott Medical Optics website. "WaveScan WaveFront System". Accessed August 15, 2012.
^ Emory Healthcare website. "Wavefront technology". Accessed August 15, 2012.
^ Croes K. AllAboutVision website. "Custom LASIK or wavefront LASIK: individualized vision
correction". Accessed August 15, 2012.
^ Liz Segre. "Cost of LASIK eye surgery and other corrective procedures". allaboutvision.com.
Retrieved 2012-08-15.
^ Fares, Usama (2011). "Efficacy, predictability, and safety of wavefront-guided refractive laser
treatment: Metaanalysis". Journal of Cataract & Refractive Surgery 37 (8): 1465-1475.
doi:10.1016/j.jcrs.2011.02.029. PMIDÂ 21782089.
^ Sue Campbell. "Air Force aims for 'weapons-grade' vision". Af.mil. Archived from the original on
2012-07-28. Retrieved 2011-12-10.
^ "Photorefractive (laser) surgery for the correction of refractive errors" (pdf). National Health
Service. March 2006.
^ Saragoussi D, Saragoussi JJ (September 2004). "["Lasik, PRK and quality of vision: a study of
prognostic factors and a satisfaction survey"]". J Fr Ophtalmol (in French) 27 (7): 755-64.
doi:10.1016/S0181-5512(04)96210-9. PMIDÂ 15499272.
^ Bailey MD, Mitchell GL, Dhaliwal DK, Boxer Wachler BS, Zadnik K (July 2003). "Patient
satisfaction and visual symptoms after laser in situ keratomileusis". Ophthalmology 110 (7): 1371-8.
doi:10.1016/S0161-6420(03)00455-X. PMIDÂ 12867394.
^ McGhee CN, Craig JP, Sachdev N, Weed KH, Brown AD (April 2000). "Functional, psychological,
and satisfaction outcomes of laser in situ keratomileusis for high myopia". J Cataract Refract Surg 26
(4): 497-509. doi:10.1016/S0886-3350(00)00312-6. PMIDÂ 10771222.
^ "Study On Post-Lasik Quality Of Life" http://www.medicalnewstoday.com/articles/103194.php
^ a b "LASIK Eye Surgery". The New York Times - Health Guide. Retrieved 10 September 2013.
^ [6] "New site details downsides of laser eye surgery"
^ "Better eyesight for most, but a few are seeing red.". Nj.com. Retrieved 2011-12-10.
^ "World and nation: Seeing LASIK's risks clearly". Sptimes.com. 2000-10-01. Retrieved 2011-12-10.
^ "Feature: Shuttered Sight, Shattered Lives". FWWeekly. Retrieved 2011-12-10.
^ http://www.visionsurgeryrehab.org
^ "LASIK Surgery: Safer Than Contacts?". Webmd.com. 2006-10-10. Retrieved 2011-12-10.
^ Rodemich, Karen (2010). "Former FDA official warns of LASIK risks: the man who OK'd LASIK
now warns of an "epidemic" of eye problems". Review of Optometry 147 (10): 4.
^ Pop M, Payette Y (January 2004). "Risk factors for night vision complaints after LASIK for myopia".
Ophthalmology 111 (1): 3-10. doi:10.1016/j.ophtha.2003.09.022. PMIDÂ 14711706.
^ Sankara Nethralaya; Basuthkar, Subams; Joseph, Roy (Jul-Aug 2010). "Ocular aberrations after
wavefront optimized LASIK for myopia". Indian Journal of Ophthalmology 58 (4): 307-312.
doi:10.4103/0301-4738.64139. PMCÂ 2907032. PMIDÂ 20534921.
^ [7] "LASIK halo and starburst; pupil size importance". USAEyes
^ "Individual Risk Factors of Halos, Loss of Contrast Sensitivity, Glare and Starbursts after LASIK."
operationauge.com
^ Yamane N, Miyata K, Samejima T, et al. (November 2004). "Ocular higher-order aberrations and
contrast sensitivity after conventional laser in situ keratomileusis". Invest. Ophthalmol. Vis. Sci. 45
(11): 3986-90. doi:10.1167/iovs.04-0629. PMIDÂ 15505046.
^ Oshika T, Miyata K, Tokunaga T, et al. (June 2002). "Higher order wavefront aberrations of cornea
and magnitude of refractive correction in laser in situ keratomileusis". Ophthalmology 109 (6): 1154-
8. doi:10.1016/S0161-6420(02)01028-X. PMIDÂ 12045059.
^ a b "Laser eye surgery". NHS Choices. 5 March 2012. Retrieved 26 October 2013.
^ "LASIK - What are the risks and how can I find the right doctor for me?". Food and Drug
Administration. 12 September 2011. Retrieved 26 October 2013.
^ Simpson, RG; Simpson, M; Christiansen, JN; Edmonds, SM; Behunin, N (2012). "Laser in situ
keratomileusis in patients with collagen vascular disease: A review of the literature". Clinical
ophthalmology (Auckland, N.Z.) 6: 1827-37. doi:10.2147/OPTH.S36690. PMCÂ 3497460.
PMIDÂ 23152662.
^ "LASIK". Fda.gov. 2008-11-11. Retrieved 2011-12-10.
^ "Night vision halo after Lasik and similar laser assisted refractive surgery.". USAEyes
^ "Night vision starburst after Lasik and similar laser assisted refractive surgery.". USAEyes
^ "Pupil and Lasik Night Vision Halo - Starburst". Usaeyes.org. 2010-04-16. Retrieved 2011-12-10.
^ Majmudar, PA. "LASIK Complications." Focal Points: Clinical Modules for Ophthalmologists.
American Academy of Ophthalmology. September, 2004.
^ Carrillo C, Chayet AS, Dougherty PJ, et al. (2005). "Incidence of complications during flap creation
in LASIK using the NIDEK MK-2000 microkeratome in 26,600 cases". J Refract Surg 21 (5 Suppl):
S655-7. PMIDÂ 16212299.
^ "Eye Surgery Education Council". Lasikinstitute.org. Retrieved 2011-12-10.
^ Tham VM, Maloney RK (May 2000). "Microkeratome complications of laser in situ keratomileusis".
Ophthalmology 107 (5): 920-4. doi:10.1016/S0161-6420(00)00004-X. PMIDÂ 10811084.
^ a b Vesaluoma M, Pérez-Santonja J, Petroll WM, Linna T, Alió J, Tervo T (1 February 2000).
"Corneal stromal changes induced by myopic LASIK". Invest. Ophthalmol. Vis. Sci. 41 (2): 369-76.
PMIDÂ 10670464.
^ "Diffuse Lamellar Keratitis - DLK and Lasik, All-Laser Lasik, Sands of Sahara". Usaeyes.org. 2010-
04-12. Retrieved 2011-12-10.
^ a b c d Sun L, Liu G, Ren Y, et al. (2005). "Efficacy and safety of LASIK in 10,052 eyes of 5081
myopic Chinese patients". J Refract Surg 21 (5 Suppl): S633-5. PMIDÂ 16212294.
^ "Ectasia After LASIK". American Academy of Ophthalmology.
^ "Intacs for Mild Nearsighted Vision Correction and Keratoconus". Usaeyes.org. 2006-04-08.
Retrieved 2011-12-10.
^ "C3-R Corneal Collagen Crosslinking with Riboflavin". Usaeyes.org. 2010-04-12. Retrieved 2011-
12-10.
^ http://www.revophth.com/content/c/46548/
^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775081
^ Cheng AC, Rao SK, Leung GY, Young AL, Lam DS (May 2006). "Late traumatic flap dislocations
after LASIK". J Refract Surg 22 (5): 500-4. PMIDÂ 16722490.
^ a b Ruiz-Moreno JM, Alió JL (2003). "Incidence of retinal disease following refractive surgery in
9,239 eyes". J Refract Surg 19 (5): 534-47. PMIDÂ 14518742.
^ Suarez E, Torres F, Vieira JC, Ramirez E, Arevalo JF (October 2002). "Anterior uveitis after laser
in situ keratomileusis". J Cataract Refract Surg 28 (10): 1793-8. doi:10.1016/S0886-3350(02)0136-
-0. PMIDÂ 12388030.
^ Boes DA, Omura AK, Hennessy MJ (December 2001). "Effect of high-altitude exposure on myopic
laser in situ keratomileusis". J Cataract Refract Surg 27 (12): 1937-41. doi:10.1016/S0886-
3350(01)01074-4. PMIDÂ 11738908.
^ Dimmig JW, Tabin G (2003). "The ascent of Mount Everest following laser in situ keratomileusis". J
Refract Surg 19 (1): 48-51. PMIDÂ 12553606.
^ Erie JC, McLaren JW, Hodge DO, Bourne WM (2005). "Long term corneal keratocyte deficits after
photorefractive keratectomy and laser in situ keratomileusis". Trans Am Ophthalmol Soc 103: 56-66;
discussion 67-8. PMCÂ 1447559. PMIDÂ 17057788.
^ Hammer T, Heynemann M, Naumann I, Duncker GI (March 2006). "Correction and induction of
high-order aberrations after standard and wavefront-guided LASIK and their influence on the
postoperative contrast sensitivity". Klin Monatsbl Augenheilkd (in German) 223 (3): 217-24.
doi:10.1055/s-2005-858864. PMIDÂ 16552654.
^ Alió JL, Montés-Mico R (February 2006). "Wavefront-guided versus standard LASIK
enhancement for residual refractive errors". Ophthalmology 113 (2): 191-7.
doi:10.1016/j.ophtha.2005.10.004. PMIDÂ 16378639.
^ Caster AI, Hoff JL, Ruiz R (2005). "Conventional vs wavefront-guided LASIK using the
LADARVision4000 excimer laser". J Refract Surg 21 (6): S786-91. PMIDÂ 16329381.
^ a b Lee, K.; Lee, H.; Kim, S.; Lee, E.; Kim, E. K. (2005). "Nerve Growth Factor Concentration and
Implications in Photorefractive Keratectomy vs Laser in Situ Keratomileusis". American Journal of
Ophthalmology 139 (6): 965-971. doi:10.1016/j.ajo.2004.12.051. PMIDÂ 15953424.
^ Sridhar, M. S.; Rao, S. K.; Vajpayee, R. B.; Aasuri, M. K.; Hannush, S.; Sinha, R. (2002).
"Complications of laser-in-situ-keratomileusis". Indian journal of ophthalmology 50 (4): 265-282.
PMIDÂ 12532491.
^ Lee, J. B.; Ryu, C. H.; Kim, J.; Kim, E. K.; Kim, H. B. (2000). "Comparison of tear secretion and tear
film instability after photorefractive keratectomy and laser in situ keratomileusis". Journal of
cataract and refractive surgery 26 (9): 1326-1331. doi:10.1016/S0886-3350(00)00566-6.
PMIDÂ 11020617.
^ Mrukwa-Kominek, E.; Stala, P.; Gierek-Ciaciura, S.; Lange, E. (2006). "Assessment of tears
secretion after refractive surgery". Klinika oczna 108 (1-3): 73-77. PMIDÂ 16883946.
^ Alió, J. L.; Pérez-Santonja, J. J.; Tervo, T.; Tabbara, K. F.; Vesaluoma, M.; Smith, R. J.; Maddox,
B.; Maloney, R. K. (2000). "Postoperative inflammation, microbial complications, and wound healing
following laser in situ keratomileusis". Journal of refractive surgery (Thorofare, N.J. : 1995) 16 (5):
523-538. PMIDÂ 11019867.
^ Pisella, P. J.; Godon, C.; Auzerie, O.; Baudouin, C. (2002). "Influence of corneal refractive surgery
on the lacrymal film". Journal francais d'ophtalmologie 25 (4): 416-422. PMIDÂ 12011749.
^ Murakami, Y.; Manche, E. E. (2012). "Prospective, Randomized Comparison of Self-reported
Postoperative Dry Eye and Visual Fluctuation in LASIK and Photorefractive Keratectomy".
Ophthalmology 119 (11): 2220-2224. doi:10.1016/j.ophtha.2012.06.013. PMIDÂ 22892151.
^ Hovanesian, J. A.; Shah, S. S.; Maloney, R. K. (2001). "Symptoms of dry eye and recurrent erosion
syndrome after refractive surgery". Journal of cataract and refractive surgery 27 (4): 577-584.
doi:10.1016/S0886-3350(00)00835-X. PMIDÂ 11311627.
^ Shortt, AJ; Allan, BD; Evans, JR (Jan 31, 2013). "Laser-assisted in-situ keratomileusis (LASIK)
versus photorefractive keratectomy (PRK) for myopia.". Cochrane database of systematic reviews
(Online) 1: CD005135. PMIDÂ 23440799.
^ "LASIK Quality of Life Collaboration Project". U.S Food and Drug Administration. Retrieved 7
September 2013.
^ a b "Latest on FDA's LASIK Program". U.S Food and Drug Administration. Retrieved 7 September
2013.
External links
What is LASIK? -- Food and Drug Administration
Laser Eye Surgery -- United States National Library of Medicine
Retrieved from "http://en.wikipedia.org/w/index.php?title=LASIK&oldid=614836234"
http://en.wikipedia.org/wiki/LASIK

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