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GENERIC NAME: Salbutamol

BRAND NAME: Ventolin
DRUG CLASS: Sympathomimetic
DRUG MECHANISM: Stimulates beta-2 receptors of bronchioles by increasing levels of cAMP which
relaxes smooth muscles to produce bronchodilation. Also cause CNS stimulation, cardiac stimulation,
increased diuresis, skeletal muscle tremors, and increased gastric acid secretion. Longer acting than
Indications: Relief of bronchospasm in bronchial asthma, chronic bronchitis, emphysema and other
reversible, obstructive pulmonary diseases. Also useful for treating bronchospasm in patients with co-
existing heart disease of hypertension.
Contraindications: Salbutamol is contraindicated in persons with a history of hypersensitivity reaction
(urticaria, angioedema, rash) to salbutamol, or any of its components. Salbutamol is also contraindicated
in patients with pre-existing cardiac tachyarrhythmias (too fast heartbeat, may be regular or irregular).

DOSAGE: Dilute 5 mg/mL solution/2.5 mL 0.9% NaCl for inhalation, other solution do not require
dilution for nebulizer O2 flow or compressed air 6-10 L/min
ADVERSE EFFECTS: Fine skeletal muscle tremor, leg ramps, palpitations, tachycardia, hypertension,
headache, nausea, vomiting, dizziness, hyperactivity, insomnia, hypotension, peripheral vasodilation,
flushing, feeling of tension or nervousness and other emotional upsets. Mouth and throat irritation.
Serious hypokalemia. Bronchospasm, cough, bronchitis. Heartburn, epistaxis, cough, gastrointestinal (GI)
discomfort, unusual taste, dyspepsia and rash.
1. Assess cardio-respiratory function: BP, HR, and rhythm and breath sounds
2. Determine history of previous medication (theophylline), and ability to self-medicate to prevent
3. Monitor for evidence of allergic reactions and paradoxical bronchospasm