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Stability of Drugs and Dosage Forms

Stability of Drugs and Dosage Forms

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Published by lu_nguyen

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Published by: lu_nguyen on Jan 16, 2010
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11/17/2013

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Formostparenteralproducts,thedrugcomesintocontactwithwaterand,eveninsolid
dosage forms, moisture is often present, albeit in low amounts. Accordingly, hydrolysis is
one of the most common reactions seen with pharmaceuticals. Many researchers have
reported extensively on the hydrolysis of drug substances. In the 1950s, elegant studies,
especially considering the lack of high-throughput analytical techniques, concerning the
hydrolysisofprocaine,9,10

aspirin,11,12

chloramphenicol,13-15

atropine,16-18

andmethyl-

phenidate19

werereported.Hydrolysisisoftenthemaindegradationpathwayfordrug
substances having ester and amide functional groups within their structure.

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