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Name

(+)-CATECHIN

Identifiers
CAS number
PubChem
ChemSpider
UNII
DrugBank
KEGG
ChEBI
ChEMBL
Jmol-3D images
IUPAC Name
InChl
InChl Key
SMILES
Properties
Molecular formula
Molar mass
Density
Appearance

Synonym
NSC 2819
2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)Dexcyanidanol
Teafuran 30E
D-(+)-Catechin
D-CATECHIN
(+)-(2R:3S)-5,7,3',4'-Tetrahydroxyflavan-3-ol
Catechinic acid
(2R,3S)-(+)-Catechin
2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)trans-(+)-3,3',4',5,7-Flavanpentol
(+)-Cianidanol
(+)-Cyanidan-3-ol
(+)-Cyanidanol-3
Catergen
3-Cyanidanol, (+)Cyanidanol
cianidanol
d-Catechin
(+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
Catechin (flavan)
(+)-Cyanidanol
D-Catechol
2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)CATECHIN
Teafuran 30A
Biocatechin
Catechol (flavan)
Catechol
(+)-Catechol
Sunkatol No. 1
Cyanidol

154-23-4
9064
8711
8R1V1STN48
c06562
CHEBI:15600
CHEMBL251445
http://chemapps.stolaf.edu/jmol/jmol.php?model=Oc1ccc%28cc1O%29%5BC%40H%5D3Oc2cc%2
8O%29cc%28O%29c2C%5BC%40%40H%5D3O
(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,1520H,6H2/t13-,15+/m0/s1
PFTAWBLQPZVEMU-DZGCQCFKSA-N

C15H14O6
290.27 g mol−1
Colorless solid

Melting point
Boiling Point
UV-vis (λmax)
Chiral rotation ([α]D)

175 to 177 °C (347 to 351 °F; 448 to 450 K)
N/A
276 nm
+14.0°

Hazards
R-Phrases
S-Phrases
Science Lab MSDS

R36/37/38
S26-S36
9923337

Median Lethal Dose
(+)-catechin : 10,000 mg/kg in rat (RTECS)
10,000 mg/kg in mouse
3,890 mg/kg in rat (other source)

Pharmacology
Routes of Administration
Excretion
Dosing

Oral
Urines
250-1200mg (Chow, H. et al, "Effects of dosing condition on the oral bioavailability of
green tea catechins after single-dose administration of Polyphenon E in healthy
individuals," 2005.)
A daily intake of 3 to 5 cups/day (1,200 mL) of green tea will provide at least 250 mg/day
of catechins. Green tea extract should not be taken on an empty stomach due to the
potential for liver toxicity from excessive levels of epigallocatechin gallate. Cardiovascular
effect: 400 to 716 mg/day of catechins have been used in trials in divided dosages.

Interactions - Moderate

Interactions - Minor
History

Multidose pharmacokinetic studies suggest a daily dosage of 800 mg/day of
epigallocatechin gallate capsules for up to 4 weeks to be safe and well tolerated. Highdose oral green tea extract and catechins were hepatotoxic in rats.
Vitamin K present in green tea may antagonize the anticoagulant effect of warfarin. Green
tea consumption reduces the bioavailability of folic acid and may interfere with the
absorption of iron. Green tea may stop bortezomib (Velcade) from working properly.
Patients taking bortezomib should not drink green tea or consume any green tea
products.
No data
The dried, cured leaves of C. sinensis have been used medicinally for more than 5,000
years. Traditional Chinese medicine has recommended drinking green tea for the
prevention of ill health, and in Asia, this is still regarded as a healthy practice.