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(OSA)



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Chest 2009 Nov 135:1488-95

Chest 2009 Nov 135:1488-95


~ 25%
25
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.

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.
. Sleep Medicine 2007; 8:402-428

Chest 2009 Nov 135:1488-95



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(CVD)


CVD
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2011; 38(4):340-43

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Sleep Medicine 2007; 8:402-28,
Editorial, Chest 2005; 127(1):1-3

2 stress

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;

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1651 .

Lancet 2005; 365:1046


CVD

Chest 2011; 140(2):535

105 .,
66%

CHEST 2013; 143(5):12941301, CHEST 2009 Nov 135; 1488-95

Cardiac Workload in Patients With


Sleep-Disordered Breathing Early
After Acute Myocardial Infarction
AMI SDB ( 10)
24
BP, HR, .
SDB

.
CHEST 2013; 143(5):12941301

&
OSA


ST (SaO2)
K ST
structural
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Editorial, Chest 2005; 127(1):1-3

CHEST 2013; 143(5):12941301, IJKD 2011; 5:215-27

- HR

30% . ..
~ 45% . .


.. CVD
Pimenta E. IJKD 2011; 5:215-27, Sleep Medicine 2007; 8:402-28, Chest 2007; 132:1847-52

42 . :
83% S
( > 10 / )


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SA
,
, ..
CPAP
CHEST 2013; 143(5):12941301, CHEST 2007; 132:1847-1852

10-30% .
OSA
~ 50% CHF
OSA, , / CSR
OSA

Sleep Medicine 2007; 8:402-28

in HF -
.
(SV)
iii. 2

v.
,
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CHEST 2013; 143(5):12941301


, CPAP
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.

remodeling, ,
CMRI
Chest 2012; 141(3):674-81



OSA, 50%

,


CPAP

Sleep Medicine 2007; 8:402-28
Chest 2007; 131:1406-13

Cardiovascular Variability
and OSA
OSA
. heart rate
variability, .


. variability,

MOF
Am Col Cardiology 2008
Aug 19, 52 (8): 686-717

& Sudden
Death
112 Minessota residents,
-
1987-2003
Sudden death; 46%
. OSA 21% .
OSA (p=0.01) (noon-6.00 a.m.)
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1.


2.

3.
S Guidelines 2005


4.
5.

6.
S Guidelines 2005


..
1.682 : 25%
;
.



(Multiple linear
regression)
Thorax 2006 Aug 23


1.387 (Wisconsin); > 15
15% vs 3% < 5
.
(SDB)

AJRCCM 2005 Dec 15; 172(12):1590-5


182 . A
/ / -
> 10 / h, 69/182 . (37%)

- Sat O2 (
),
. (p<0.05)
Koutsovasilis A., ..10 th Meeting of the Mediterranean Group for
the Study of Diabetes; 2007:April 26-29: 145


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2
&

i.
ii. 2
iii.


(, /..)
iv.-
(TNF, L-6..)
J Appl Physiol 2005 Nov;99(5): 1998-2007


J Appl Physiol 2005 Nov;99(5): 1998-2007

CHEST 2014; 146(4):982-9 90



Sleep Heart Health Study; 2.656
,


(ultivariable
linear regresion analysis)
m J Epid 2004; 160(6):521-30, Sleep Medicine 2007; 8:402-28,
Clinics 2006 Jun;61(3): 253-66, Sleep Med Rev 2005; 9(3):211-24


,

,


(Multivariable linear regresion
analysis)
m J Epid 2004; 160(6):521-30
Sleep Medicine 2007; 8:402-28,

CPAP

CPAP


, CPAP

HbA1c

Arch Intern Med 2005; 165(4):447-52
Sleep Breath 2005 Dec;9(4): 176-80

AJRCCM 2007; Jun; 175:1290-7

AJRCCM 2007; Jun; 175:1290-7



C-PAP


C-PAP ?

1651 .

Lancet 2005; 365:1046

1651 .

Lancet 2005; 365:1046

AJRCCM 2006; 173:1300-1308

cho

47 , 2007-10, CMRI
Chest 2012; 141(3):674-81

MRI

47 , 2007-10, CMRI
Chest 2012; 141(3):674-81

Chest 2011; 140(2):535


i. OSA:
ii. OSA:

&
iii. OSA:


Editorial, Chest 2005; 127(1):1-3
Progr Cardiov Dis 2009; 51(5): 434-51

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