You are on page 1of 1

GI Motility Drugs

Drug/Class Action Use Side Effects Other

- cholinergic -incr. GI motility & tone


-non-obstructive urinary -abdominal discomfort -never administer IM or
-incr. gastric secretions retention IV; rate of absorption fast
by stimulating muscarinic -diarrhea
-GERD
Increase

Bethanechol -hypotension & reflex leads to heart block or


receptors on intestinal severe hypotension
smooth muscle, leads to tachycardia
-lacrimation, miosis -DO NOT administer if
URECHOLINE -incr. detrusor muscle any mechanical
contraction -salivation
-urinary urgency obstruction of GI or
-stimulates micturition urinary tract
-incr. LES pressure

-tardive dsykinesia Interactions:


Metoclopramide - dopamine antagonist -GI reflux -acute dystonic rx Alcohol
-stimulates GI tract -gastroparesis, N/V
GI

-parkinsonial like Tranquilizers


REGLAN without simulating (antiemetic) symptoms Sleep meds
gastric secretions -incr. LES tone & -drowsiness, confusion Narcotics
enhance UGI motility
Caution in hypertensive
patients

-improve gastric emptying


Motility

-appears to stimulate the and


Erythromycin receptor for motilin -incr. propulsion
throughout the GI tract
-gastroparesis
-hypomotility

-xerostomia, -Assess for dry mouth-if


Atropine -blocks muscarinic -IBS -photophobia, mouth is not dry, dose is
receptors and -adjunct tx for peptic ulcer
Decrease

-cycloplegia not enough to suppress


ROBINUL, LEVSIN -inhibits gastric acid -antidote -tachycardia gastric acid secretions
PRO BANTHINE secretion -constipation
-decr. GI motility -acute urinary retention
GI

-relaxes the smooth -tx of hyperactivity or -constipation or diarrhea -Side effects are not as
Antispasmodic muscle of GI tract spasm of the intestine -rash prominent as those of
Motility

Agents -euphoria, dizziness, HA atropine


-drowsiness, nausea
BENTYL -weakness