XII.

Drug Study Mechanism of Action Indication Contraindication Adverse Reactions ♣ Nausea Nursing Responsibilities C – Antibacterial Nursing Implication

Generic Name: Ciprofloxacin Brand name: Quinosyn Classification: Antibacterial

Dosage: 500mg Frequency: BID Route: Per Orem

Source: ◙ Nursing 2007 Drug Handbook 27th Edition, Lippincot Williams & Wilkins

Inhibition of topoisomerase (DNA gyrase) enzymes, which inhibits relaxation of supercoiled DNA and promotes breakage of double stranded DNA.

 Ciprofloxacin is Ciprofloxacin is contraindicated in used to treat persons with a infections of the history of skin, lungs, airways, bones, and hypersensitivity to ciprofloxacin, any joints caused by member of the susceptible quinolone class of bacteria. antimicrobial agents, Ciprofloxacin is also frequently used or any of the product components. to treat urinary infections caused by bacteria such as  Coadministration E. coli. of ciprofloxacin with Ciprofloxacin is effective in treating other drugs primarily infectious diarrheas metabolized by CYP1A2 results in caused by E. coli, increased plasma Campylobacter concentrations of jejuni, and Shigella these drugs and bacteria. could lead to clinically significant adverse events of the coadministered drug.  Contraindicated for the treatment of certain sexually

◙ Instruct patient not to take ciprofloxacin with dairy ♣ Vomiting products such as milk or H – Prevention or treatment of yogurt, or with calcium♣ Stomach pain infection; signs and symptoms fortified juice. He may eat ♣ Heartburn of infection like fever an pain or drink dairy products or are reduced. calcium-fortified juice with ♣ Diarrhea a regular meal, but do not ♣ Feeling an use them alone when taking urgent need E – Twice a day exactly at 6 am ciprofloxacin. They could to urinate and 12 noon; Make sure to make the medication less drink plenty of water or other effective. ♣ Headache fluids everyday while taking ♣ Hives Ciprofloxacine; Do not take or ◙Tell patient that Ciprofloxacin can cause eat a lot of caffeine products ♣ Difficulty side effects that may impair such as coffee, tea, energy breathing or his thinking or reactions. drinks, cola or chocolate swallowing Tell patient to be careful if within 6 hours before or 2 he plans to drive or do hours after you take ♣ Hoarseness anything that requires him ciprofloxacin. or throat to be awake and alert. tightness ◙Instruct patient to take ♣ Rapid, C - Instruct client to report any ciprofloxacin with a full irregular, or adverse reaction to the glass of water (8 ounces). pounding physician or nurse. Tell patient heartbeat ◙ Instruct patient to avoid that antacids and mineral supplements may decrease the taking antacids, vitamin or ♣ Fainting mineral supplements, absorption of Ciprofloxacin ♣ Fever sucralfate (Carafate), or which makes it less effective when taken at the same time. didanosine (Videx) powder ♣ Joint or or chewable tablets within 6

transmitted diseases by some experts due to bacterial resistance.  Concomitant administration with tizanidine is contraindicated.

muscle pain ♣ Unusual bruising or bleeding ♣ Extreme tiredness ♣ Lack of energy of appetite ♣ Seizures ♣ Dizziness ♣ Confusion ♣ Nervousness ♣ Restlessness ♣ Anxiety ♣ Difficulty falling asleep or staying asleep ♣ Pain in the upper right part of the stomach ♣ Yellowing of the skin or eyes ♣ Dark urine K - Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

hours before or 2 hours after you take ciprofloxacin. These other medicines can make ciprofloxacin much less effective when taken at the same time. ◙Inform patient that Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take an oral steroid medication, or if you have had a kidney, heart, or lung transplant. ◙Instruct patient to stop taking ciprofloxacin and call the doctor at once if he has sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Also instruct patient to rest his joint until he receive medical care or instructions.

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