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EFFECCTS OF MANOPAUSAL STATUS AND

DISEASE ACTIVITY ON BIOCHEMICAL


MARKERS OF BONE METABOLISM IN FEMALE
PATIENTS WITH RHEUMATOID ARTHRITIS
A. Elhewala, A.Abou-Elsoaud,T.Afifi, Y.Abo Elmagd, and M. Elgaweesh.

Rheumatology & Rehabilitation and Biochemistry Departments, Faculty of Medicine,


Zagazig University

Abstract:

Rheumatoid arthritis is associated with both localized generalized osteoporosis.


Periarticular osteopenia is one of the diagnostic criteria for RA. Generalized osteopenia is also a
well documented feature of the disease. Bone mineral density (BMD) and biochemical markers
of bone metabolism have been used to assess bone metabolism in patients with RA.

The study comprised 60 females RA patients classified according to the


menopausal state into:

1- Group I: 30pre-menopausal RA.

2- Group II: 30 postmenopausal RA.

3- Control Group: 30 healthy females.

In this study the effects of menopause and disease activity on bone metabolism in RA
were studied by using the biochemical markers of bone metabolism. We measured serum
osteocalcin and bone specific alkaline phosphatase as a marker of bone formation and total
urinary pyridinoline and deoxypyridinoline as marker of bone resorption.

Correlation between bone markers, DEXA and disease activity was studied and
statistically evaluated.