{\rtf\ansi\deff0\ansicpg1252

{\fonttbl
{\f0\froman times new roman;}{\f1\fswiss helvetica;}}
{\colortbl\red0\green0\blue0;\red226\green0\blue25;\red21\green40\blue131;}
\jexpand\viewkind1\viewscale100
{\shp{\*\shpinst\shpleft1253\shptop840\shpright11093\shpbottom1560\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2028\shpz1\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 9840}}
{\sp{\sn geoBottom}{\sv 720}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;5;(0,0);(0,720);(9840,720);(9840,0);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;12;16384;45824;1;45824;1;45824;1;45824;1;45824;2457
7;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 2540}}
{\sp{\sn lineColor}{\sv 16777215}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 16777215}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1333\shptop10893\shpright11000\shpbottom10893\shpfhdr0\s
hpwr3\shpwrk0\shpfblwtxt1\shplid2029\shpz2\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 9667}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(9666,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 6350}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1333\shptop3893\shpright11000\shpbottom3893\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2030\shpz3\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 9667}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(9666,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}

{\sp{\sn fFillOK}{\sv 1}}

{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 6350}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1306\shptop12840\shpright5946\shpbottom12840\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2031\shpz4\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 10160}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}\paperw11893\paperh15866\margl666\margr133\marg
t666\margb253
\cols3\colno1\colw2560\colsr-0\colno2\colw6440\colsr-0\colno3\colw2093\pard\li64
0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li640\ri0\sl-293\slmult0 \fs18\cf0\f0\ch
arscalex100 {Anales de la Facultad de Medicina}\par\column\pard\li0\ri0\sl-213\s
lmult0 \fs18\cf0\par\pard\li0\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {E
fecto antioxidante y hepatoprotector del Petroselinum sativum (perejil) en ratas
}\i0 \par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-306\s
lmult0 \fs18\cf0\f0\charscalex100 {ISSN 1025 - 5583}\par\pard\sect\sectd\sbknone
\cols2\colno1\colw9173\colsr-0\colno2\colw1920\pard\li640\ri0\sl-213\slmult0 \fs
18\cf0\f0\charscalex100 {Universidad Nacional Mayor de San Marcos}\par\column\pa
rd\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Pgs. 333 - 343}\par\pard\se
ct\sectd\sbknone\pard\li640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li640\ri0\sl-6
53\slmult0 \fs36\cf0\f0\charscalex100\b {Efecto antioxidante y hepatoprotector d
el}\b0 { }\fs36\cf0\f0\charscalex100\i {Petroselinum}\i0 \par\pard\li640\ri0\sl493\slmult0 \fs36\cf0\f0\charscalex100\i {sativum}\i0 \fs36\cf0\f0\charscalex100
\b { (perejil) en ratas, con intoxicacin heptica}\b0 \par\pard\li640\ri0\sl-493\sl
mult0 \fs36\cf0\f0\charscalex100\b {inducida por paracetamol}\b0 { }\fs22\cf0\f0
\charscalex100\b {*}\b0 \par\pard\li640\ri0\sl-453\slmult0 \fs24\cf0\f0\charscal
ex100\i {Luzmila Troncoso}\i0 { }\fs14\cf0\f0\charscalex100\i {1}\i0 \fs24\cf0\f
0\charscalex100\i {, Emilio Guija}\i0 { }\fs14\cf0\f0\charscalex100\i {2}\i0 \pa
r\pard\sect\sectd\sbknone\cols2\colno1\colw2973\colsr-0\colno2\colw8120\pard\li1
373\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1373\ri0\sl-333\slmult0 \fs18\cf0\f0
\charscalex100\i {Resumen }\i0 \par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0
\par\pard\li0\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Objetivo: Determi
nar el efecto antioxidante y hepatoprotector del perejil (Petroselinum}\i0 \par\
pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {sativum) en ratas c
on intoxicacin heptica inducida por paracetamol. Lugar: Centro}\i0 \par\par
d\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {de Investigacin de Bioq
umica y Nutricin \uc1\u8211X \uc1\u8220XLaboratorio de Bioqumica Clnica y}\i

0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {Nutricional \uc

1\u8220XLeonidas Delgado Butrn\uc1\u8221X \uc1\u8220XEmilio Guija Poma\uc1\u8221X
\uc1\u8211X Universidad Nacional}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0
\f0\charscalex100\i {Mayor de San Marcos. Lima, Per. Diseo: Estudio analtico, trans
versal, prospectivo y}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscal
ex100\i {cuasi-experimental. Material: Ratas albinas Holtzman machos adultas. Mto
dos: Se utiliz}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i
{40 ratas de 2 meses de edad, con pesos entre 280 y 320 g, distribuidas aleatori
amente en}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {cua
tro grupos de 10 animales cada uno. Todos los grupos recibieron la misma dieta y
agua ad}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {libi
tum, adems de los respectivos tratamientos, los cuales fueron administrados por va
oral}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {diariam
ente, durante 5 das: paracetamol (administrado en una dosis de 200 mg/kg de peso}
\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {corporal) par
a inducir la intoxicacin heptica y, al mismo tiempo, un hepatoprotector, ya}\i0 \p
ar\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {fuera farmacolgico (
frmaco hepatoprotector (FHP): Purinor}\i0 \fs10\cf0\f0\charscalex100\i {}\i0 \fs18
\cf0\f0\charscalex100\i {) o natural (perejil); adems,}\i0 \par\pard\li0\ri0\sl-2
53\slmult0 \fs18\cf0\f0\charscalex100\i {un grupo de paracetamol solo y otro de
control. Al trmino del perodo experimental, los}\i0 \par\pard\li0\ri0\sl-253\slmul
t0 \fs18\cf0\f0\charscalex100\i {animales fueron sacrificados. En suero sanguneo
se determin aspartato aminotransferasa}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18
\cf0\f0\charscalex100\i {(AST), alanina aminotransferasa (ALT), gamma gluta
mil transferasa (GGT), grupos}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\
f0\charscalex100\i {sulfhidrilo, protenas totales y albmina srica; y en el homogeni
zado citoslico de hgado,}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charsca
lex100\i {fraccin posmitocondrial, se determin superxido dismutasa, catalasa, gluco
sa-6-fosfato}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {
deshidrogenasa, grupos sulfidrilo, especies reactivas al cido tiobarbitrico (TBARS
) o}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {radicales
libres y protenas. Adems, se realiz el estudio histopatolgico del hgado, para}\i0 \p
ar\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {identificar signos
de necrosis y signos de regeneracin posnecrtica. Principales medidas de}\i0 \par\p
ard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {resultados: Efecto anti
oxidante y hepatoprotector del perejil. Resultados: El perejil mostr}\i0 \par\par
d\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {un mejor efecto hepatopro
tector que el FHP, frente a la accin nociva del paracetamol,}\i0 \par\pard\li0\ri
0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {evaluado por AST, ALT y GGT. La
glucosa-6-fosfato deshidrogenasa (p<0,05, p=0,01,}\i0 \par\pard\li0\ri0\sl-253\s
lmult0 \fs18\cf0\f0\charscalex100\i {prueba Kruskal-Wallis) y las TBARS (p<0,001
, p=0,000, prueba Kruskal-Wallis) permitieron}\i0 \par\pard\li0\ri0\sl-253\slmul
t0 \fs18\cf0\f0\charscalex100\i {mostrar que existi diferencia estadsticamente
significativa entre todos los grupos.}\i0 \par\pard\li0\ri0\sl-253\slmult0
\fs18\cf0\f0\charscalex100\i {Histopatolgicamente, se observ signos de necrosis s
evera con la administracin solo de}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0
\f0\charscalex100\i {paracetamol y en el grupo al que se administr adicionalmente
FHP, no encontrndose}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscale
x100\i {mayores cambios en el grupo tratado adems con perejil. Conclusiones: El p
erejil ejerce}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i
{un mayor efecto antioxidante y hepatoprotector que el FHP.}\i0 \par\pard\sect\s
ectd\sbknone\pard\li1373\ri0\sl-280\slmult0 \*\tx2973\fs18\cf0\f0\charscalex100\
i {Palabras clave }\i0 \tab \fs18\cf0\f0\charscalex100\i {Perejil; medicamentos
hepatoprotectores; acetaminofeno; antioxidantes; toxicidad.}\i0 \par\pard\sect\s
ectd\sbknone\cols2\colno1\colw5680\colsr-0\colno2\colw5413\pard\li640\ri0\sl-213
\slmult0 \fs18\cf0\par\pard\li640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li640\ri
0\sl-386\slmult0 \fs20\cf0\f0\charscalex100\i {Petroselinum sativum}\i0 \fs20\c
f0\f0\charscalex100\b { (perejil) antioxidant and}\b0 \par\pard\li640\ri0\sl240\slmult0 \fs18\cf0\f0\charscalex100\b {hepatoprotective effects in rats with
paracetamol-}\b0 \par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100\b

{induced hepatic intoxication}\b0 \par\pard\li640\ri0\sl-253\slmult0 \fs18\cf0\

f0\charscalex100\i {Abstract}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs16\cf0\f0
\charscalex100\i {Objective: To determine the antioxidant and hepatoprotective}\
i0 \par\pard\li640\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {effect of
parsley (Petroselinum sativum) in rats with}\i0 \par\pard\li640\ri0\sl-280\
slmult0 \fs16\cf0\f0\charscalex100\i {* TrabajodeTesisparaoptarelGradoAcadmicodeD
octorenMedicina.}\i0 \par\pard\li813\ri0\sl-240\slmult0 \fs16\cf0\f0\charscalex1
00\i {FacultaddeMedicina,UNMSM.Lima,Per.}\i0 \par\pard\li640\ri0\sl-240\slmult0 \
fs10\cf0\f0\charscalex100\i {1}\i0 \fs18\cf0\f0\charscalex100\i { CentrodeInvest
igacindeBioqumicayNutricin.Facultadde}\i0 \par\pard\li813\ri0\sl-240\slmult0 \fs16\
cf0\f0\charscalex100\i {Medicina,UniversidadNacionalMayordeSanMarcos.Lima,Per.}\i
0 \par\pard\li640\ri0\sl-240\slmult0 \fs8\cf0\f0\charscalex100\i {2}\i0 \fs14\cf
0\f0\charscalex100\i { ProfesorEmritodelCentrodeInvestigacindeBioqumicayNutricin.}\i
0 \par\pard\li813\ri0\sl-240\slmult0 \fs16\cf0\f0\charscalex100\i {FacultaddeMed
icina,UNMSM.Lima,Per.}\i0 \par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\p
ard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-386\slmult0 \fs18\cf0\f
0\charscalex100\i {paracetamol-induced hepatic intoxication. Setting:}\i0 \pa
r\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {Leonidas Delgado But
ron - Emilio Guija Poma Clinical}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\
f0\charscalex100\i {and Nutritional Biochemistry Laboratory, Biochemistry}\i0 \p
ar\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {and Nutrition Res
earch Center, Universidad Nacional}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18
\cf0\f0\charscalex100\i {Mayor de San Marcos, Lima, Peru. Design: Analytical,}\i
0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {transverse, pr
ospective and quasi-experimental study;}\i0 \par\pard\li0\ri0\sl-253\slmult0
\fs18\cf0\f0\charscalex100\i {only \uc1\u8216Xpost\uc1\u8217X with quasi-cont
rol group design. Biologic}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\
charscalex100\i {materials: Adult male Holtzman albino rats. Methods: We}\i0 \pa
r\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {utilized forty 2 mon
ths-old adult rats weighing 280 to 320}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs1
8\cf0\f0\charscalex100\i {g distributed at random in four groups 10 animals each
.}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {All groups
received the same ad libitum diet and water}\i0 \par\pard\li0\ri0\sl-253\slmult0
\fs18\cf0\f0\charscalex100\i {along with respective treatments administered ora
lly daily}\i0 \par\pard\li1640\ri0\sl-440\slmult0 \*\tx4293\fs18\cf0\f0\charscal
ex100 {An Fac Med Lima 2007; 68(4) }\tab \fs20\cf0\f0\charscalex100 {333}\par\pa
rd\sect\sectd\sbknone\pard\sect\sectd\sbkpage\pgwsxn11893\pghsxn15866\marglsxn66
6\margrsxn133\margtsxn666\margbsxn253\pard\li4226\ri0\sl-213\slmult0 \fs18\cf0\p
ar\pard\li4226\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Luzmila Troncoso
y col.}\i0 \par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\mar
grsxn133\cols2\colno1\colw5280\colsr-0\colno2\colw5813\pard\li240\ri0\sl-213\slm
ult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl
-426\slmult0 \fs18\cf0\f0\charscalex100\i {during 5 days: paracetamol was admini
stered 200 mg/kg}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex1
00\i {pc) to induce hepatic intoxication and concurrently a}\i0 \par\pard
\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {pharmacologic (hepatopro
tective drug (HPD): Purinor}\i0 {\super \fs8\up3\cf0\f0\charscalex100\i {}\i0 }\f
s16\cf0\f0\charscalex100\i {)}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f
0\charscalex100\i {or natural (parsley) hepatoprotector; another group was}\i0 \
par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {treated with par
acetamol only and there was a control}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs
16\cf0\f0\charscalex100\i {group. The animals were sacrificed at the end
of the}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {ex
perimental period. We determined in serum aspartate}\i0 \par\pard\li240\ri0\sl-2
53\slmult0 \fs16\cf0\f0\charscalex100\i {aminotransferase (AST), alanine aminotr
ansferase (ALT),}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex1
00\i {gamma glutamyl transferase (GGT), sulphidril group, total}\i0 \par\pard\li
240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {proteins and serum albumin;
and in liver postmitochondrial}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0
\f0\charscalex100\i {fraction cytosolic homogenates we determined superoxide}\i0

\par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {dismutase, cat

alase, glucose-6-phosphate deydrogenase,}\i0 \par\pard\li240\ri0\sl-253\slmult0
\fs16\cf0\f0\charscalex100\i {sulphidril group, thiobarbituric acid reactive
species}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {(
TBARS) or free radicals and proteins. Besides, histology}\i0 \par\pard\li240\ri0
\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {study of the liver was done to ide
ntify both signs of necrosis}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0
\charscalex100\i {and postnecrotic regeneration. Main outcome measures:}\i0 \par
\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {Parsley\uc1\u8217Xs
antioxidant and hepatoprotective effects. Results:}\i0 \par\pard\li240\ri0\sl-2
53\slmult0 \fs16\cf0\f0\charscalex100\i {Parsley showed a better hepatoprote
ctive effect than}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscal
ex100\i {HPD against paracetamol\uc1\u8217Xs nocive effect, as evaluated}\i0 \
par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {by AST, ALT and
GGT serum levels. Determination of}\i0 \par\pard\li240\ri0\sl-253\slmult0
\fs16\cf0\f0\charscalex100\i {glucose-6-phosphate dehydrogenase (p<0,05, p=0,
01,}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {Kruskal
-Wallis test) and TBARS (p<0,001, p=0,000;}\i0 \par\pard\li240\ri0\sl-253\s
lmult0 \fs18\cf0\f0\charscalex100\i {Kruskal-Wallis test) in liver cytosolic sho
wed the existence}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex
100\i {of statistically significant difference among all groups.}\i0 \par\
pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {On histology we obse
rved signs of severe necrosis after}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16
\cf0\f0\charscalex100\i {administration of paracetamol alone and in the group wi
th}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {addition
al HPD, with no further changes in the group}\i0 \par\pard\li240\ri0\sl253\slmult0 \fs18\cf0\f0\charscalex100\i {treated additionally with parsley. Con
clusions: Parsley}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex
100\i {exerts a greater antioxidant and hepatoprotective effect}\i0 \par\pard\li
240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {than HPD.}\i0 \par\pard\li2
40\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {Key words: Petroselinum;
hepatoprotector drugs;}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\char
scalex100\i {acetaminophen; antioxidants; toxicity.}\i0 \par\pard\li1640\ri0\sl253\slmult0 \fs22\cf0\f0\charscalex100\b {INTRODUCCIN}\b0 \par\pard\li520\ri0\sl240\slmult0 \fs22\cf0\f0\charscalex100 {El paracetamol ha sido utilizado en
diversos}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {estudi
os, habindose mostrado en ratas y ratones}\par\pard\li240\ri0\sl-240\slmult0 \fs2
0\cf0\f0\charscalex100 {que tiene la propiedad de inducir lipoperoxidacin}\par\pa
rd\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {y dao irreversible en el
hepatocito, probablemente}\par\pard\li240\ri0\sl-240\slmult0 \fs22\cf0\f0\charsc
alex100 {causados por radicales libres (}\fs12\cf0\f0\charscalex100 {1}\fs22\cf0
\f0\charscalex100 {).}\par\pard\li520\ri0\sl-280\slmult0 \fs22\cf0\f0\charscalex
100 {Los radicales libres de oxgeno son compues-}\par\pard\li240\ri0\sl-253\slmul
t0 \fs20\cf0\f0\charscalex100 {tos qumicos caracterizados por poseer uno o}
\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {ms electrones de
sapareados. Algunos de ellos}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\
charscalex100 {son extremadamente reactivos, como el radical}\par\pard\li24
0\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {hidroxilo (}\fs10\cf0\f0\charsc
alex100 {\uc1\u8226X}\fs20\cf0\f0\charscalex100 {OH), otros menos reactivos como
el}\par\pard\li240\ri0\sl-306\slmult0 \fs20\cf0\f0\charscalex100 {radical superx
ido (O}{\sub \fs10\cf0\f0\charscalex100 {2}}\fs10\cf0\f0\charscalex100 {.-}\fs20
\cf0\f0\charscalex100 {) y el perxido de hidrge-}\par\pard\li240\ri0\sl-293\slmult
0 \fs20\cf0\f0\charscalex100 {no (H}{\sub \fs10\cf0\f0\charscalex100 {2}}\fs20\c
f0\f0\charscalex100 {O}{\sub \fs10\cf0\f0\charscalex100 {2}}\fs20\cf0\f0\charsca
lex100 {), que por definicin no es considerado un}\par\pard\li240\ri0\sl-240\slmu
lt0 \fs22\cf0\f0\charscalex100 {radical libre de oxgeno, pero es potencialmente}\
par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {capaz de generar fc
ilmente }\fs10\cf0\f0\charscalex100 {\uc1\u8226X}\fs20\cf0\f0\charscalex100 {OH.
Los radicales}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {li
bres pueden formarse intracelularmente en los}\par\pard\li240\ri0\sl-213\slmult0

\fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-413
\slmult0 \*\tx1000\fs20\cf0\f0\charscalex100 {334}\tab \fs18\cf0\f0\charscalex10
0 {An Fac Med Lima 2007; 68(4)}\par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0
\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-426\slmult0 \fs22
\cf0\f0\charscalex100 {peroxisomas, en la cadena transportadora de elec-}\par\pa
rd\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {trones, durante la fagocit
osis, la autooxidacin o}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex1
00 {como consecuencia de la interaccin de metales de}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {transicin, como el hierro o cobre con ascorbato}
\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {o perxido de hidrgeno
(}\fs12\cf0\f0\charscalex100 {2-5}\fs22\cf0\f0\charscalex100 {). Ciertos compue
stos}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {qumicos ingerid
os en la dieta, diversas sustancias}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f
0\charscalex100 {txicas (humo del cigarrillo), radiaciones elec-}\par\pard\l
i0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {tromagnticas, ozono y alguno
s medicamentos}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {(pa
racetamol) pueden ejercer su accin nociva}\par\pard\li0\ri0\sl-253\slmult0 \
fs22\cf0\f0\charscalex100 {en el organismo a travs de la generacin de}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {radicales libres, los
que pueden daar carbohi-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\chars
calex100 {dratos, lpidos, protenas y cidos nucleicos y,}\par\pard\li0\ri0\sl253\slmult0 \fs22\cf0\f0\charscalex100 {como consecuencia de ello, daar seriament
e las}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {membranas cel
ulares (}\fs12\cf0\f0\charscalex100 {2,3,5}\fs22\cf0\f0\charscalex100 {).}\par\p
ard\li293\ri0\sl-413\slmult0 \fs20\cf0\f0\charscalex100 {Cada vez se presenta ms
evidencias que de-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {
muestran la participacin de los radicales libres en}\par\pard\li0\ri0\sl-253\slmu
lt0 \fs22\cf0\f0\charscalex100 {la patognesis de ciertas enfermedades, como cn-}\p
ar\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {cer, artritis reumato
ide, arteriosclerosis, diabetes}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\ch
arscalex100 {mellitus, catarata senil, enfermedad de Alzheimer,}\par\pard\li0\ri
0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {Kwashiorkor y procesos como el de l
a inflamacin}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {y el en
vejecimiento (}\fs12\cf0\f0\charscalex100 {2,3,5-9}\fs22\cf0\f0\charscalex100 {)
.}\par\pard\li293\ri0\sl-413\slmult0 \fs20\cf0\f0\charscalex100 {El organismo di
spone de sistemas de defensa}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\chars
calex100 {antioxidante que actan impidiendo la formacin}\par\pard\li0\ri0\sl-253\s
lmult0 \fs22\cf0\f0\charscalex100 {de radicales libres, bloqueando su propagacin
o}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {interaccionando d
irectamente con ellos. Integran}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\ch
arscalex100 {este sistema la superxido dismutasa, catalasa,}\par\pard\li0\ri
0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {glutation peroxidasa, glutation
reductasa, cido}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {rico
, protenas, glucosa, glutation, grupos sulfi}\fs22\cf0\f0\charscalex100 {-}\par\p
ard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {drilos (-SH), entre otros
. Tambin, es posible que}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex
100 {se ingiera con la dieta sustancias naturales o de}\par\pard\li0\ri0\sl-253\
slmult0 \fs22\cf0\f0\charscalex100 {origen sinttico con capacidad antioxidante, c
omo}\par\pard\li0\ri0\sl-253\slmult0 \*\tx2400\fs22\cf0\f0\charscalex100 {flavon
oides, polifenoles,}\tab \fs22\cf0\f0\charscalex100 {\uc1\u946X}\fs22\cf0\f0\cha
rscalex100 {-caroteno, vitamina E,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0
\charscalex100 {vitamina C, dimetilsulfxido y otros ms (}\fs12\cf0\f0\charscalex10
0 {2,10}\fs22\cf0\f0\charscalex100 {).}\par\pard\li293\ri0\sl-426\slmult0 \fs20\
cf0\f0\charscalex100 {El uso de las plantas medicinales con fines cu}\fs20\cf0\f
0\charscalex100 {-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {
rativos es una prctica que se ha venido utilizando}\par\pard\li0\ri0\sl-253\slmul
t0 \fs22\cf0\f0\charscalex100 {desde tiempo inmemorial. stas tienen la mayora}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de los antioxidantes,
principalmente polifenoles}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\char
scalex100 {y flavonoides, los cuales poseen gran actividad}\par\pard\li0\r

i0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {antioxidante. Se ha estudiado las

propiedades an-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {tii
nflamatorias y antioxidantes del tomillo (}\fs22\cf0\f0\charscalex100\i {Thymi}\
i0 \par\pard\li0\ri0\sl-253\slmult0 \*\tx3613\fs22\cf0\f0\charscalex100\i {herba
}\i0 \fs22\cf0\f0\charscalex100 {) (}\fs12\cf0\f0\charscalex100 {11}\fs22\cf0\f0
\charscalex100 {). Los extractos acuosos de}\tab \fs22\cf0\f0\charscalex100\i {C
optis chi-}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100\i {ne
nsis, Paeonia suffruticosa, Prunilla vulgaris y}\i0 \par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100\i {Senecio scandens }\i0 { }\fs22\cf0\f0\charsc
alex100 {mostraron una alta capacidad}\par\pard\li0\ri0\sl-306\slmult0 \fs22\
cf0\f0\charscalex100 {antioxidante frente a sistemas generadores de}{ }\fs22\cf0
\f0\charscalex100 {O}{\sub \fs12\cf0\f0\charscalex100 {2}}\fs12\cf0\f0\charscale
x100 {.-}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {y}{ }\fs12
\cf0\f0\charscalex100 {\uc1\u8226X}\fs22\cf0\f0\charscalex100 {OH, inhibiendo la
lipoperoxidacin en rin y}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex1
00 {homogenizado de cerebro de ratas (}\fs12\cf0\f0\charscalex100 {12}\fs22\cf0\
f0\charscalex100 {).}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\margls
xn666\margrsxn133\pard\sect\sectd\sbkpage\pgwsxn11893\pghsxn15866\marglsxn666\ma
rgrsxn133\margtsxn666\margbsxn253\pard\li2560\ri0\sl-213\slmult0 \fs18\cf0\par\p
ard\li2560\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Efecto antioxidante
y hepatoprotector del Petroselinum sativum (perejil) en ratas}\i0 \par\pard\sect
\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw
5680\colsr-0\colno2\colw5413\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li
920\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li920\ri0\sl-426\slmult0 \fs22\cf0\f0\
charscalex100 {La ingesta de antioxidantes presente en los ali-}\par\pard\li640\
ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {mentos es un factor protector de
la salud importan-}\par\pard\li640\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100
{te. En estudios anteriores hemos mostrado}{ }\fs22\cf0\f0\charscalex100\i {in
vitro}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {que el
perejil presenta evidente efecto antioxidante}\par\pard\li640\ri0\sl-253\slmult0
\fs22\cf0\f0\charscalex100 {(}\fs12\cf0\f0\charscalex100 {13-16}\fs22\cf0\f0\ch
arscalex100 {), al igual que las fresas y mucho mayor que}\par\pard\li640\ri0\sl
-253\slmult0 \fs20\cf0\f0\charscalex100 {otros alimentos, como naranja, brcoli (}
\fs10\cf0\f0\charscalex100 {17}\fs20\cf0\f0\charscalex100 {), ajos,}\par\pard\li
640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {cebolla, limn (}\fs10\cf0\f0\c
harscalex100 {18,19}\fs20\cf0\f0\charscalex100 {), pimiento (}\fs10\cf0\f0\chars
calex100 {20}\fs20\cf0\f0\charscalex100 {), cebolla china}\par\pard\li640\ri0\sl
-253\slmult0 \fs22\cf0\f0\charscalex100 {(}\fs12\cf0\f0\charscalex100 {21}\fs22\
cf0\f0\charscalex100 {), betarraga (}\fs12\cf0\f0\charscalex100 {22}\fs22\cf0\f0
\charscalex100 {), hojas de coca y ans (}\fs12\cf0\f0\charscalex100 {17}\fs22\cf0
\f0\charscalex100 {) evalua-}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\cha
rscalex100 {dos frente a sistemas ascorbato/Cu(II), generador}\par\pard\li640\ri
0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {de}{ }\fs10\cf0\f0\charscalex100 {\
uc1\u8226X}\fs20\cf0\f0\charscalex100 {OH y phenazina metosulfato (PMS)/nitro bl
ue}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tetrazolio (NB
T)/nicotin adenin dinucletido redu-}\par\pard\li640\ri0\sl-320\slmult0 \*\tx3760\
fs22\cf0\f0\charscalex100 {cido (NADH), generador de}{ }\fs22\cf0\f0\charscalex1
00 {O}{\sub \fs12\cf0\f0\charscalex100 {2}}\fs12\cf0\f0\charscalex100 {.-}\tab \
fs22\cf0\f0\charscalex100 {.}\par\pard\li920\ri0\sl-360\slmult0 \fs22\cf0\f0\cha
rscalex100 {El perejil (}\fs22\cf0\f0\charscalex100\i {Petroselinum sativum}\i0
\fs22\cf0\f0\charscalex100 {) es una umbe-}\par\pard\li640\ri0\sl-253\slmult0 \*
\tx3293\fs20\cf0\f0\charscalex100 {lfera bianual que contiene}\tab \fs20\cf0\f0\c
harscalex100 {apina y flavonoides,}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f
0\charscalex100 {compuestos que le confieren accin diurtica y}\par\pard\li64
0\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {antioxidante; aceite esencial r
ico en apiol y mi-}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100
{risticina, que le otorga propiedades emenagogas}\par\pard\li640\ri0\sl-253\slm
ult0 \fs20\cf0\f0\charscalex100 {(estimula la menstruacin) y vasodilatadoras.
}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {Contiene vitami
nas A, C y E, fsforo, hierro,}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\

f0\charscalex100 {calcio y azufre. Las mujeres embarazadas deben}\par\pard\li640

\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {evitar consumir grandes cantidad
es de perejil, por}\par\pard\li640\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100
{tener cierto efecto oxitcico (contrae el tero), que}\par\pard\li640\ri0\sl-253\s
lmult0 \fs22\cf0\f0\charscalex100 {podra predisponer al aborto (}\fs12\cf0\f0\cha
rscalex100 {23-25}\fs22\cf0\f0\charscalex100 {).}\par\pard\li920\ri0\sl-426\slmu
lt0 \fs22\cf0\f0\charscalex100 {Todos estos aspectos nos conducen a suponer}\par
\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {que los alimentos que
posean poder antioxidante,}\par\pard\li640\ri0\sl-253\slmult0 \fs22\cf0\f0\char
scalex100 {como el perejil (}\fs22\cf0\f0\charscalex100\i {Petroselinum sativum}
\i0 \fs22\cf0\f0\charscalex100 {), debido a}\par\pard\li640\ri0\sl-253\slmult0 \
fs20\cf0\f0\charscalex100 {su composicin qumica, puedan ser utilizados para}\par\p
ard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {prevenir la hepatotoxic
idad generada por algunas}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charsc
alex100 {drogas, como el paracetamol, en cuyo mecanismo}\par\pard\li640\ri0\sl-2
53\slmult0 \fs20\cf0\f0\charscalex100 {patognico intervienen precisamente por un
lado la}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {produccin
de radicales libres y por otro la altera-}\par\pard\li640\ri0\sl-253\slmult0 \fs
22\cf0\f0\charscalex100 {cin del sistema antioxidante a nivel heptico.}\par\pard\l
i920\ri0\sl-440\slmult0 \fs20\cf0\f0\charscalex100 {El objetivo de esta investig
acin fue}{ }\fs20\cf0\f0\charscalex100 {determinar}\par\pard\li640\ri0\sl-240\slm
ult0 \fs20\cf0\f0\charscalex100 {el efecto antioxidante y hepatoprotector del pe
rejil}\par\pard\li640\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {(}\fs22\cf0
\f0\charscalex100\i {Petroselinum sativum}\i0 \fs22\cf0\f0\charscalex100 {) en
ratas con intoxicacin}\par\pard\li640\ri0\sl-240\slmult0 \fs22\cf0\f0\charsca
lex100 {heptica inducida por paracetamol.}\par\pard\li2373\ri0\sl-213\slmult0 \fs
18\cf0\par\pard\li2373\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li2373\ri0\sl-373\s
lmult0 \fs22\cf0\f0\charscalex100\b {MTODOS}\b0 \par\pard\li920\ri0\sl-413\slmult
0 \fs22\cf0\f0\charscalex100 {Se realiz un estudio tipo analtico, transversal,}\pa
r\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {prospectivo y cuas
i-experimental. Se utiliz 40}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\c
harscalex100 {ratas albinas Holtzman machos adultas, de 2 meses}\par\pard\li640\
ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {de edad, cuyos pesos estaban comp
rendidos entre}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {28
0 y 320 g, distribuidas de una manera aleatoria en}\par\pard\li640\ri0\sl-253\sl
mult0 \fs20\cf0\f0\charscalex100 {cuatro grupos de 10 animales cada uno. Se colo
c}\par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmul
t0 \fs18\cf0\par\pard\li0\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {las rat
as en jaulas individuales, en un ambiente}\par\pard\li0\ri0\sl-253\slmult0 \fs22
\cf0\f0\charscalex100 {de temperatura constante, con ciclos alternados}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de 12 h de luz y 12 h d
e oscuridad. Una semana}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex
100 {antes de iniciar propiamente el experimento, las}\par\pard\li0\ri0\sl-253\s
lmult0 \fs22\cf0\f0\charscalex100 {ratas solo recibieron una dieta normocalr
ica,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {normoproteica
y agua}{ }\fs22\cf0\f0\charscalex100\i {ad libitum}\i0 \fs22\cf0\f0\charscalex10
0 {. Posteriormente,}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100
{todos los grupos siguieron recibiendo la misma}\par\pard\li0\ri0\sl-253\
slmult0 \fs22\cf0\f0\charscalex100 {dieta y agua}{ }\fs22\cf0\f0\charscalex100\i
{ad libitum}\i0 \fs22\cf0\f0\charscalex100 {, adems de los respectivos}\par\pard
\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {tratamientos. Se administr lo
s tratamientos por}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {
va oral diariamente, durante 5 das, y estaban}\par\pard\li0\ri0\sl-253\slmu
lt0 \fs22\cf0\f0\charscalex100 {constituidos por paracetamol (administrado en un
a}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {dosis de 200 mg/k
g de peso corporal) para inducir}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\c
harscalex100 {la intoxicacin heptica y, al mismo tiempo, por}\par\pard\li0\ri0\sl253\slmult0 \fs22\cf0\f0\charscalex100 {un hepatoprotector, ya fuera farmacolgico
(FHP)}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {o natural (p
erejil [}\fs22\cf0\f0\charscalex100\i {Petroselinum sativum}\i0 \fs22\cf0\f0\cha

rscalex100 {]).}\par\pard\li280\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {L

os tratamientos administrados a cada grupo}\par\pard\li0\ri0\sl-240\slmult0 \fs2
2\cf0\f0\charscalex100 {fueron los siguientes: grupos control, a) al grupo}\par\
pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {control propiamente dich
o se le administr 1 mL}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex10
0 {de agua destilada; b) el grupo paracetamol (gru-}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {po control de la induccin del dao) recibi solo}\pa
r\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {paracetamol, en una do
sis de 200 mg/kg de peso}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscale
x100 {corporal. Los grupos experimentales: a) frmaco}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {hepatoprotector (FHP) Purinor}\fs12\cf0\f0\char
scalex100 {}\fs22\cf0\f0\charscalex100 {, recibi paraceta-}\par\pard\li0\ri0\sl-24
0\slmult0 \fs22\cf0\f0\charscalex100 {mol y, adems, se le administr una dosis de F
HP}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de 50 mg/kg de p
eso corporal; b) el grupo perejil}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\
charscalex100 {(}\fs22\cf0\f0\charscalex100\i {Petroselinum sativum}\i0 \fs22\c
f0\f0\charscalex100 {) recibi paracetamol y,}\par\pard\li0\ri0\sl-253\slmult0
\fs22\cf0\f0\charscalex100 {adems, extracto acuoso de perejil fresco, en una}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {cantidad de 150 mg/kg d
e peso corporal.}\par\pard\li280\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {
Al trmino del perodo experimental, los anima-}\par\pard\li0\ri0\sl-240\slmult0 \fs
22\cf0\f0\charscalex100 {les, previo ayuno de 14 horas, fueron anestesiados}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {por inhalacin de clorofo
rmo en una campana de}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex10
0 {vidrio. La sangre se extrajo por puncin cardiaca y}\par\pard\li0\ri0\sl-253\sl
mult0 \fs22\cf0\f0\charscalex100 {luego los animales fueron sacrificados por dec
api}\fs22\cf0\f0\charscalex100 {-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\
charscalex100 {tacin. Posteriormente, se separ el hgado, el que}\par\pard\li0\ri0\s
l-253\slmult0 \fs22\cf0\f0\charscalex100 {fue perfundido con una solucin isotnica
de NaCl}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {y se coloc e
n una placa Petri sobre hielo.}\par\pard\li280\ri0\sl-426\slmult0 \fs20\cf0\f0\c
harscalex100 {El extracto de perejil fresco (}\fs20\cf0\f0\charscalex100\i
{Petroselinum}\i0 \par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100\i
{sativum}\i0 \fs22\cf0\f0\charscalex100 {)}{ }\fs22\cf0\f0\charscalex100 {se pre
par licuando las hojas al 25% en}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\ch
arscalex100 {agua bidestilada, luego se filtr a travs de gasa y}\par\pard\li0\ri0\
sl-253\slmult0 \fs22\cf0\f0\charscalex100 {finalmente se centrifug a 2 500 rpm du
rante 30}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {minutos. E
l sobrenadante obtenido fue administra-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\c
f0\f0\charscalex100 {do a los animales de experimentacin, en una dosis}\par\pard\
li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de 150 mg/kg de peso corporal
. Se centrifug la}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {sa
ngre a 1 500 rpm en una centrfuga clnica, du-}\par\pard\li0\ri0\sl-253\slmult0 \fs
22\cf0\f0\charscalex100 {rante 20 minutos, y se separ el suero para realizar}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {diversas determinacione
s. Se pes 5 g de hgado,}\par\pard\li1640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1
640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1640\ri0\sl-213\slmult0 \fs18\cf0\pa
r\pard\li1640\ri0\sl-266\slmult0 \*\tx4293\fs18\cf0\f0\charscalex100 {An Fac Med
Lima 2007; 68(4) }\tab \fs20\cf0\f0\charscalex100 {335}\par\pard\sect\sectd\sbk
none\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\pard\sect\sectd\sbkpage\pgw
sxn11893\pghsxn15866\marglsxn666\margrsxn133\margtsxn666\margbsxn253\pard\li4226
\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li4226\ri0\sl-333\slmult0 \fs18\cf0\f0\ch
arscalex100\i {Luzmila Troncoso y col.}\i0 \par\pard\sect\sectd\sbknone\pgwsxn11
893\pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw5280\colsr-0\colno2\col
w5813\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0
\fs18\cf0\par\pard\li240\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {se prefu
ndi con NaCl 9\uc1\u8240X y se homogeniz con}\par\pard\li240\ri0\sl-240\slmult0 \f
s22\cf0\f0\charscalex100 {una solucin 0,25 M de sacarosa, tampn Tris-HCl}\par\pard
\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {0,2 M pH 7,4, en una relac
in de 1:5, utilizando}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex1

00 {un Potter-Elvehjem provisto de un pistilo de tefln.}\par\pard\li240\ri0\sl-24

0\slmult0 \fs20\cf0\f0\charscalex100 {Luego, se centrifug en una centrfuga refrige
rada}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {Sorvall RC-2
B, a 10 000 g, durante 45 minutos, a}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf
0\f0\charscalex100 {cuyo trmino se descart el precipitado y se reserv}\par\pard\li2
40\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {el sobrenadante. Todo este pro
ceso se realiz a una}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex10
0 {temperatura no mayor de 4C, en la cual tambin}\par\pard\li240\ri0\sl-240\slmult
0 \fs20\cf0\f0\charscalex100 {se mantuvo el sobrenadante que corresponda a la}\pa
r\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {fraccin posmitocondri
al, hasta realizar las deter-}\par\pard\li240\ri0\sl-240\slmult0 \fs22\cf0\f0\ch
arscalex100 {minaciones bioqumicas correspondientes.}\par\pard\li520\ri0\sl-413\s
lmult0 \fs22\cf0\f0\charscalex100 {Para el estudio histopatolgico heptico, se
}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {practic cortes de
0,5 x 1,0 cm de espesor, que}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\ch
arscalex100 {fueron fijados en formol neutro al 10%, los que}\par\pard\li240\ri0
\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {fueron seccionados para inclusin en c
ortes de 2}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {mm de
espesor; posteriormente, se efectu cortes}\par\pard\li240\ri0\sl-253\slmult0 \fs2
0\cf0\f0\charscalex100 {con micrtomo, en un espesor de 3}{ }\fs20\cf0\f0\charscal
ex100 {m}\fs20\cf0\f0\charscalex100 {, para luego}\par\pard\li240\ri0\sl-253\slm
ult0 \fs20\cf0\f0\charscalex100 {ser coloreados con HE (hematoxilina\uc1\u82
11Xeosina) y}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {rev
isados con microscopio ptico, para la identi-}\par\pard\li240\ri0\sl-253\slmult0
\fs20\cf0\f0\charscalex100 {ficacin de signos de necrosis en el parnquima y}\par\p
ard\li240\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {regeneracin posnecrtica.}
\par\pard\li520\ri0\sl-413\slmult0 \fs22\cf0\f0\charscalex100 {Se utiliz los sigu
ientes reactivos: cido 5,5\uc1\u8217Xdi-}\par\pard\li240\ri0\sl-240\slmult0 \fs20
\cf0\f0\charscalex100 {tiobis (2-nitrobenzoico) (DTNB), 2-desoxirribosa,}\par\pa
rd\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {Tris, cido cacodlico, piro
galol y cido tiobarbit-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex
100 {rico, kit para la determinacin de glucosa-6-fosfato}\par\pard\li240\ri0\sl-2
40\slmult0 \fs20\cf0\f0\charscalex100 {deshidrogenasa (}\fs20\cf0\f0\charscalex1
00\i {Sigma Chemical Company}\i0 \fs20\cf0\f0\charscalex100 {); cido}\par\pard\li
240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tricloroactico, fosfato de pot
asio, cido clorh-}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {d
rico, cloruro de sodio, hidrxido de sodio, for-}\par\pard\li240\ri0\sl-253\slmult
0 \fs20\cf0\f0\charscalex100 {maldehdo al 35%, hematoxilina y eosina (}\fs20\cf0\
f0\charscalex100\i {Merck}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\ch
arscalex100\i {Darmstadt}\i0 \fs20\cf0\f0\charscalex100 {); vitamina C (cido ascrb
ico), fosfato}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {dih
idrgeno de potasio, perxido de hidrgeno al}\par\pard\li240\ri0\sl-253\slmult0 \fs20
\cf0\f0\charscalex100 {30% (}\fs20\cf0\f0\charscalex100\i {Riedel-de Han}\i0 \fs2
0\cf0\f0\charscalex100 {); kits para transaminasas 200}\par\pard\li240\ri0\sl-25
3\slmult0 \fs22\cf0\f0\charscalex100 {(AST, ALT),}{ }\fs22\cf0\f0\charscalex100
{g}\fs22\cf0\f0\charscalex100 {-G-test cintica, Proti 2 (protenas}\par\pard\li240\
ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {totales y albmina) (}\fs20\cf0\
f0\charscalex100\i {Wiener lab}\i0 \fs20\cf0\f0\charscalex100 {); paracetamol}
\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {(acetam, gotas)
(Laboratorios COFANA); FHP}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\ch
arscalex100 {(combinacin de sustancias activas como orotato}\par\pard\li240\ri0\s
l-253\slmult0 \fs22\cf0\f0\charscalex100 {de potasio, xantina, adenina, fruc
tosa difosfato}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {d
e magnesio, sorbitol, tiamina clorhidrato, ribo-}\par\pard\li240\ri0\sl-253\slmu
lt0 \fs20\cf0\f0\charscalex100 {flavina-5-fosfato sdico, nicotinamida, pantenol,}
\par\pard\li240\ri0\sl-253\slmult0 \*\tx4400\fs22\cf0\f0\charscalex100 {piridoxi
na clorhidrato, cianocobalamina) -}\tab \fs22\cf0\f0\charscalex100\i {Puri-}\i0
\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100\i {nor}\i0 \fs10\c
f0\f0\charscalex100\i {}\i0 \fs20\cf0\f0\charscalex100 {, suspensin oral (Laborato
rio Farmacutico}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {Pe

ruano \uc1\u8211X Germano S.A.); vitamina A (retinol pal-}\par\pard\li240\ri0\sl

-253\slmult0 \fs22\cf0\f0\charscalex100 {mitato) - }\fs22\cf0\f0\charscalex100\i
{Epiteliol}\i0 \fs12\cf0\f0\charscalex100\i {}\i0 \fs22\cf0\f0\charscalex100 {,
suspensin bebible (Medifarma}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\char
scalex100 {Laboratorios); vitamina E (D-}\fs20\cf0\f0\charscalex100 {\uc1\u945X}
\fs20\cf0\f0\charscalex100 { tocoferil acetato)}\par\pard\li240\ri0\sl-240\slmul
t0 \*\tx413\fs20\cf0\f0\charscalex100 {-}\tab \fs20\cf0\f0\charscalex100\i {Vite
sol E 400}\i0 \fs10\cf0\f0\charscalex100\i {}\i0 \fs20\cf0\f0\charscalex100 {, cps
ula lquida (UNIMED del}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex
100 {Per S.A.). Todas las soluciones fueron preparadas}\par\pard\li240\ri0\sl-253
\slmult0 \fs22\cf0\f0\charscalex100 {con agua bidestilada en vidrio neutro.}\par
\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs18
\cf0\par\pard\li240\ri0\sl-360\slmult0 \*\tx1000\fs20\cf0\f0\charscalex100 {336}
\tab \fs18\cf0\f0\charscalex100 {An Fac Med Lima 2007; 68(4)}\par\column\pard\li
293\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\par
\pard\li293\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {Se realiz las siguient
es determinaciones en suero}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charsc
alex100 {sanguneo de las ratas: aspartato aminotransferasa}\par\pard\li0\ri0\sl-2
53\slmult0 \fs22\cf0\f0\charscalex100 {(AST), segn Reitman S y Frankel F (}\fs12\
cf0\f0\charscalex100 {26}\fs22\cf0\f0\charscalex100 {), alanina}\par\pard\li0\ri
0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {aminotransferasa (ALT), segn Reitman
S y Frankel}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {F (}\f
s12\cf0\f0\charscalex100 {26}\fs22\cf0\f0\charscalex100 {), gamma glutamil trans
ferasa (GGT), segn}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {S
zasz G (}\fs12\cf0\f0\charscalex100 {27}\fs22\cf0\f0\charscalex100 {), grupos
sulfidrilo, por el mtodo de}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\c
harscalex100 {Ellman (}\fs12\cf0\f0\charscalex100 {28}\fs22\cf0\f0\charscalex10
0 {), protenas totales con el mtodo de}\par\pard\li0\ri0\sl-253\slmult0 \fs2
2\cf0\f0\charscalex100 {Biuret (}\fs12\cf0\f0\charscalex100 {29}\fs22\cf0\f0\cha
rscalex100 {), albmina srica con el mtodo de verde}\par\pard\li0\ri0\sl-253\slmult0
\fs22\cf0\f0\charscalex100 {de bromocresol (}\fs12\cf0\f0\charscalex100 {29}\fs
22\cf0\f0\charscalex100 {). En sobrenadante heptico, se}\par\pard\li0\ri0\sl-240\
slmult0 \fs22\cf0\f0\charscalex100 {estudi superxido dismutasa, segn Del Maestro}\p
ar\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {(}\fs12\cf0\f0\charsc
alex100 {30}\fs22\cf0\f0\charscalex100 {), catalasa, segn Aebi (}\fs12\cf0\f0\cha
rscalex100 {31}\fs22\cf0\f0\charscalex100 {), glucosa-6-fosfato des-}\par\pard\l
i0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {hidrogenasa, segn Deutsch J (}\
fs12\cf0\f0\charscalex100 {32}\fs22\cf0\f0\charscalex100 {), grupos sulfidrilo,}
\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {por el mtodo de Ellm
an (}\fs12\cf0\f0\charscalex100 {28}\fs22\cf0\f0\charscalex100 {), determinacin d
e sus-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {tancias reac
tivas al cido tiobarbitrico (TBARS),}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0
\charscalex100 {segn Ney K,Colley K y Pizzo S (}\fs12\cf0\f0\charscalex100 {33}\f
s22\cf0\f0\charscalex100 {), protenas con}\par\pard\li0\ri0\sl-253\slmult0 \fs22\
cf0\f0\charscalex100 {el mtodo de Biuret (}\fs12\cf0\f0\charscalex100 {29}\fs22\c
f0\f0\charscalex100 {).}\par\pard\li293\ri0\sl-413\slmult0 \fs20\cf0\f0\charscal
ex100 {La muestra total fue seleccionada por conve-}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {niencia segn el peso corporal de las ratas y fue
}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {distribuida aleat
oriamente en cuatro grupos de}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\
charscalex100 {10 animales cada uno. Luego de la ejecucin del}\par\pard\li0\ri0\s
l-253\slmult0 \fs22\cf0\f0\charscalex100 {diseo experimental, los datos fueron or
denados}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {y analizado
s, aplicndosele primero la prueba de}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f
0\charscalex100 {normalidad, para seleccionar las pruebas de hip-}\par\pard\li0\r
i0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {tesis estadsticas adecuadas. Al no
tener la muestra}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {un
a distribucin normal, se aplic la prueba Krus-}\par\pard\li0\ri0\sl-253\slmult0 \f
s22\cf0\f0\charscalex100 {kal-Wallis, para comparar medias de ms de dos}\par\pard
\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {grupos, y la prueba Mann-Whi

tney, para comparar}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100

{medias de dos grupos. Se utiliz el valor p<0,05}\par\pard\li0\ri0\sl-240\slmult0
\fs22\cf0\f0\charscalex100 {para la consideracin de diferencia estadsticamente}\p
ar\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {significativa. Para e
l anlisis estadstico, se aplic}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charsc
alex100 {el paquete estadstico SPSS v.12.}\par\pard\li1546\ri0\sl-213\slmult0 \fs
18\cf0\par\pard\li1546\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1546\ri0\sl-320\s
lmult0 \fs22\cf0\f0\charscalex100\b {RESULTADOS}\b0 \par\pard\li293\ri0\sl-426\s
lmult0 \fs20\cf0\f0\charscalex100 {La evaluacin del efecto antioxidante y h
e-}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {patoprotector de
los diferentes tratamientos, tanto}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f
0\charscalex100 {farmacolgico (FHP) como natural o alimento}\par\pard\li0\ri
0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {medicinal (perejil), frente a la in
toxicacin heptica}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {ind
ucida por paracetamol en ratas dio los siguientes}\par\pard\li0\ri0\sl-253\slmul
t0 \fs22\cf0\f0\charscalex100 {resultados:}\par\pard\li293\ri0\sl-440\slmult0 \f
s20\cf0\f0\charscalex100 {El peso de las ratas al iniciar el experimento es-}\pa
r\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {tuvo comprendido entre
280 y 320 g y termin con}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscale
x100 {un peso corporal final entre 320 y 340 g. El peso}\par\pard\li0\ri0\sl-240
\slmult0 \fs22\cf0\f0\charscalex100 {corporal final y el peso absoluto del hgado
no mos}\fs22\cf0\f0\charscalex100 {-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\
f0\charscalex100 {traron diferencia estadsticamente significativa entre}\par\pard
\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {los grupos, al igual que el
peso relativo del hgado}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex1
00 {con respecto al peso corporal final (Tabla 1).}\par\pard\sect\sectd\sbknone\
pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\pard\sect\sectd\sbkpage
{\shp{\*\shpinst\shpleft1306\shptop2186\shpright5946\shpbottom2186\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2032\shpz0\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1306\shptop2693\shpright5946\shpbottom2693\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2033\shpz1\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}

{\sp{\sn fFilled}{\sv 0}}

{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1306\shptop3693\shpright5946\shpbottom3693\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2034\shpz2\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft4066\shptop2440\shpright5946\shpbottom2440\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2036\shpz4\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 1880}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(1893,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1306\shptop10413\shpright5946\shpbottom10413\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2037\shpz5\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}

{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}

{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1306\shptop10933\shpright5946\shpbottom10933\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2038\shpz6\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1306\shptop11973\shpright5946\shpbottom11973\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2039\shpz7\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4640}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft6346\shptop7826\shpright11000\shpbottom7826\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2040\shpz8\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}

{\sp{\sn geoRight}{\sv 4654}}

{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft6346\shptop8573\shpright11000\shpbottom8573\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2041\shpz9\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft6346\shptop9600\shpright11000\shpbottom9600\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2042\shpz10\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn13
3\margtsxn666\margbsxn253\pard\li2560\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li25
60\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Efecto antioxidante y hepato
protector del Petroselinum sativum (perejil) en ratas}\i0 \par\pard\sect\sectd\s

bknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw5680\col
sr-0\colno2\colw5413\pard\li1386\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1386\ri
0\sl-213\slmult0 \fs18\cf0\par\pard\li1386\ri0\sl-413\slmult0 \fs18\cf0\f0\chars
calex100 {Tabla 1. Pesos}\fs10\cf0\f0\charscalex100 {e}\fs18\cf0\f0\charscalex10
0 { de ratas segn tratamiento.}\par\pard\li640\ri0\sl-386\slmult0 \*\tx1840\*\tx3
640\fs18\cf0\f0\charscalex100 {Tratamiento }\tab \fs18\cf0\f0\charscalex100\ul {
Peso corporal}\ul0 \fs10\cf0\f0\charscalex100 {(NS)}\tab \fs18\cf0\f0\charscalex
100 {Peso del hgado}\fs10\cf0\f0\charscalex100 {(NS)}\par\pard\li2413\ri0\sl-253\
slmult0 \*\tx3813\*\tx4640\fs18\cf0\f0\charscalex100 {g }\tab \fs18\cf0\f0\chars
calex100 {g }\tab \fs18\cf0\f0\charscalex100 {% p.c.}\par\pard\li640\ri0\sl-306\
slmult0 \*\tx2053\*\tx3480\*\tx4760\fs18\cf0\f0\charscalex100 {Control}\fs10\cf0
\f0\charscalex100 {a}\tab \fs18\cf0\f0\charscalex100 {339 17,5 }\tab \fs18\cf0\f
0\charscalex100 {13,7 4,1 }\tab \fs18\cf0\f0\charscalex100 {4,0}\par\pard\li640\
ri0\sl-253\slmult0 \*\tx2053\*\tx3480\*\tx4760\fs18\cf0\f0\charscalex100 {Parace
tamol}\fs10\cf0\f0\charscalex100 {b}\tab \fs18\cf0\f0\charscalex100 {329 54,0 }\
tab \fs18\cf0\f0\charscalex100 {11,7 2,0 }\tab \fs18\cf0\f0\charscalex100 {3,6}\
par\pard\li640\ri0\sl-240\slmult0 \*\tx2053\*\tx3480\*\tx4760\fs18\cf0\f0\charsc
alex100 {FHP}\fs10\cf0\f0\charscalex100 {c}\tab \fs18\cf0\f0\charscalex100 {321
50,2 }\tab \fs18\cf0\f0\charscalex100 {11,2 2,1 }\tab \fs18\cf0\f0\charscalex100
{3,5}\par\pard\li640\ri0\sl-253\slmult0 \*\tx2053\*\tx3480\*\tx4760\fs18\cf0\f0
\charscalex100 {Perejil}\fs10\cf0\f0\charscalex100 {d}\tab \fs18\cf0\f0\charscal
ex100 {339 9,5 }\tab \fs18\cf0\f0\charscalex100 {11,9 1,7 }\tab \fs18\cf0\f0\c
harscalex100 {3,5}\par\pard\li640\ri0\sl-280\slmult0 \fs10\cf0\f0\charscalex100\
i {a}\i0 \fs18\cf0\f0\charscalex100\i { Sin tratamiento.}\i0 { }\fs10\cf0\f0\cha
rscalex100\i {b}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: paracetamol}\i0
\par\pard\li640\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {c}\i0 \fs18\cf0
\f0\charscalex100\i { Tratamiento: paracetamol y Purinor (FHP)}\i0 \par\pard\li64
0\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {d}\i0 \fs18\cf0\f0\charscalex
100\i { Tratamiento: paracetamol y Petroselinum sativum (perejil)}\i0 \par\pard\
li640\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {e}\i0 \fs18\cf0\f0\charsc
alex100\i { Media SD ; NS: No significativo; p.c.: peso corporal}\i0 \par\pard\l
i920\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li920\ri0\sl-280\slmult0 \fs22\cf0\f0
\charscalex100 {En este estudio, con relacin a los niveles}\par\pard\li640
\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {sricos del aspartato aminotran
sferasa, no hubo}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100
{diferencia estadsticamente significativa entre todos}\par\pard\li640\ri0\sl-253
\slmult0 \fs22\cf0\f0\charscalex100 {los grupos a un}{ }\fs22\cf0\f0\charscalex1
00\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,05, pero se pudo observar}\par\pard\l
i640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {que la administracin oral de
paracetamol produjo}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex10
0 {mayores niveles (66 U/L) que el grupo control (56}\par\pard\li640\ri0\sl-253\
slmult0 \fs20\cf0\f0\charscalex100 {U/L), presentando los menores niveles el gru
po con}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {perejil (4
5 U/L). En cambio, al comparar el grupo}\par\pard\li640\ri0\sl-253\slmult0 \fs20
\cf0\f0\charscalex100 {de perejil con el grupo de paracetamol, s se ob-}\par\pard
\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {serv una diferencia estadsti
camente significativa}\par\pard\li640\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex
100 {(}\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,10, pr
ueba Mann-Whitney) (Tabla 2). En lo}\par\column\pard\li280\ri0\sl-213\slmult0 \f
s18\cf0\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li280\ri0\sl-426\sl
mult0 \fs22\cf0\f0\charscalex100 {Por otro lado, los niveles sricos de la gamma}\
par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {glutamil transferasa
presentaron diferencia estadstica-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0
\charscalex100 {mente significativa entre todos los grupos, }\fs22\cf0\f0\charsc
alex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,001}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {(}\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0
\f0\charscalex100 {=0,000, prueba Kruskal-Wallis). Tambin, se}\par\pard\li0\r
i0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {pudo observar que al comparar dos
grupos s hubo}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {difere
ncia estadsticamente significativa para la prueba}\par\pard\li0\ri0\sl-240\slmult

0 \fs22\cf0\f0\charscalex100 {de Mann-Whitney, }\fs22\cf0\f0\charscalex100\i {p}

\i0 \fs22\cf0\f0\charscalex100 {<0,05, en el grupo de paraceta-}\par\pard\li0\ri
0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {mol con FHP (}\fs22\cf0\f0\charscal
ex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {=0,038), y }\fs22\cf0\f0\charscalex10
0\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,005 en el caso de}\par\pard\li0\ri0\sl
-253\slmult0 \fs22\cf0\f0\charscalex100 {paracetamol con perejil (}\fs22\cf0\f0\
charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {=0,003) (Tabla 2).}\par\pard\
li280\ri0\sl-413\slmult0 \fs22\cf0\f0\charscalex100 {En relacin con la concentrac
in de las protenas}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {to
tales sricas, no hubo diferencia estadsticamente}\par\pard\li0\ri0\sl-240\slmult0
\fs22\cf0\f0\charscalex100 {significativa a un }\fs22\cf0\f0\charscalex100\i {p}
\i0 \fs22\cf0\f0\charscalex100 {<0,05, mostrando los mayores}\par\pard\li0\ri0\s
l-253\slmult0 \fs22\cf0\f0\charscalex100 {niveles el grupo con tratamiento a bas
e de perejil}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {(4,92
g/dL) y los menores niveles el grupo sin}\par\pard\li0\ri0\sl-253\slmult0 \fs22
\cf0\f0\charscalex100 {tratamiento o control (4,76 g/dL) (Tabla 3). Con}\par\par
d\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {respecto a la concentracin d
e albmina, tampoco}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {h
ubo diferencia estadsticamente significativa a un}\par\pard\li0\ri0\sl-253\slmult
0 \fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,05, pudindos
e observar mayores niveles en el}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\c
harscalex100 {grupo de paracetamol (3,32 g/dL) y menores niveles}\par\pard\li0\r
i0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {en el grupo de perejil (3,10 g/dL)
(Tabla 3).}\par\pard\li120\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li120\ri0\sl-3
20\slmult0 \fs18\cf0\f0\charscalex100 {Tabla 3. Protenas totales, albmina y grupos
sulfidrilos}\fs10\cf0\f0\charscalex100 {e}\fs18\cf0\f0\charscalex100 { en}\par\
pard\li706\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {suero sanguneo de ratas
segn tratamiento.}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn6
66\margrsxn133\cols3\colno1\colw5680\colsr-0\colno2\colw3573\colsr-0\colno3\colw
1840\pard\li640\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {referente a los n
iveles sricos de actividad de la ala-}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf
0\f0\charscalex100 {nina aminotransferasa, tampoco pudimos observar}\par\pard\li
640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {diferencia estadsticamente sig
nificativa entre todos}\par\column\pard\li0\ri0\sl-293\slmult0 \*\tx1320\*\tx238
6\fs18\cf0\f0\charscalex100 {Tratamiento }\tab \fs18\cf0\f0\charscalex100 {Proten
as }\tab \fs18\cf0\f0\charscalex100 {Albmina}\fs10\cf0\f0\charscalex100 {(NS) }\p
ar\pard\li1320\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {totales}\fs10\cf0\
f0\charscalex100 {(NS)}\par\pard\li1493\ri0\sl-240\slmult0 \*\tx2693\fs18\cf0\f0
\charscalex100 {g/dL }\tab \fs18\cf0\f0\charscalex100 {g/dL }\par\column\pard\li
253\ri0\sl-293\slmult0 \fs18\cf0\f0\charscalex100 {Grupos}\par\pard\li0\ri0\sl-2
40\slmult0 \fs18\cf0\f0\charscalex100 {sulfhidrilos}\fs10\cf0\f0\charscalex100 {
(NS)}\par\pard\li373\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {mM}\par\pard
\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols3\colno1
\colw5680\colsr-0\colno2\colw1240\colsr-0\colno3\colw4173\pard\li640\ri0\sl-253\
slmult0 \fs22\cf0\f0\charscalex100 {los grupos, a un}{ }\fs22\cf0\f0\charscalex1
00\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,05; sin embargo, s existi}\par\column\p
ard\li0\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100 {Control}\fs10\cf0\f0\char
scalex100 {a}\par\column\pard\li0\ri0\sl-333\slmult0 \*\tx1200\*\tx2440\fs18\cf0
\f0\charscalex100 {4,76 0,94 }\tab \fs18\cf0\f0\charscalex100 {3,21 0,62 }\tab \
fs18\cf0\f0\charscalex100 {0,58 0,36}\par\pard\sect\sectd\sbknone\pgwsxn11893\pg
hsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw5680\colsr-0\colno2\colw5413\
pard\li640\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {diferencia al comparar
el grupo de perejil (21 U/L)}\par\pard\li640\ri0\sl-240\slmult0 \fs22\cf0\f0\ch
arscalex100 {(}\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {
= 0,03, prueba Mann-Whitney) con respecto al}\par\pard\li640\ri0\sl-240\slmult0
\fs22\cf0\f0\charscalex100 {grupo de paracetamol (24 U/L) (Tabla 2).}\par\pard\l
i1026\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1026\ri0\sl-320\slmult0 \fs18\cf0\
f0\charscalex100 {Tabla 2. Transaminasas}\fs10\cf0\f0\charscalex100 {e}\fs18\cf0
\f0\charscalex100 { en suero sanguneo de ratas}\par\pard\li2280\ri0\sl-240\slmult
0 \fs18\cf0\f0\charscalex100 {segn tratamiento.}\par\pard\li640\ri0\sl-320\slmult

0 \*\tx1866\*\tx3000\*\tx4400\fs18\cf0\f0\charscalex100 {Tratamiento }\tab \fs18

\cf0\f0\charscalex100 {ASTf}\fs10\cf0\f0\charscalex100 {(NS)}\tab \fs18\cf0\f0\c
harscalex100 {ALT}\fs10\cf0\f0\charscalex100 {g}\tab \fs18\cf0\f0\charscalex100
{GGT}\fs10\cf0\f0\charscalex100 {h}\par\pard\li2026\ri0\sl-253\slmult0 \*\tx3053
\*\tx4466\fs18\cf0\f0\charscalex100 {U/L }\tab \fs18\cf0\f0\charscalex100 {U/L }
\tab \fs18\cf0\f0\charscalex100 {U/L}\par\pard\li640\ri0\sl-306\slmult0 \*\tx182
6\*\tx3933\fs18\cf0\f0\charscalex100 {Control}\fs10\cf0\f0\charscalex100 {a}\tab
\fs18\cf0\f0\charscalex100 {56 21,3
23 4,9 }\tab \fs18\cf0\f0\charscalex100
{0,04 0,02}{ }\fs18\cf0\f0\charscalex100 {(I)}\par\pard\li640\ri0\sl-253\slmult
0 \fs18\cf0\f0\charscalex100 {Paracetamol}\fs10\cf0\f0\charscalex100 {b}\fs18\cf
0\f0\charscalex100 { 66 23,6
24 3,1}{ }\fs18\cf0\f0\charscalex100 {(III)}\f
s18\cf0\f0\charscalex100 { 0,07 0,02}{ }\fs12\cf0\f0\charscalex100 {(I,II,III)}
\par\pard\li640\ri0\sl-253\slmult0 \*\tx1826\*\tx3960\fs18\cf0\f0\charscalex100
{FHP}\fs10\cf0\f0\charscalex100 {c}\tab \fs18\cf0\f0\charscalex100 {61 20,4
25 7,6 }\tab \fs18\cf0\f0\charscalex100 {0,06 0,02}{ }\fs18\cf0\f0\charscalex100
{(I,II)}\par\pard\li640\ri0\sl-253\slmult0 \*\tx1826\fs18\cf0\f0\charscalex100
{Perejil}\fs10\cf0\f0\charscalex100 {d}\tab \fs18\cf0\f0\charscalex100 {45 19,4
21 5,3}{ }\fs18\cf0\f0\charscalex100 {(III)}\fs18\cf0\f0\charscalex100 { 0,
05 0,01}{ }\fs18\cf0\f0\charscalex100 {(I,III)}\par\pard\li640\ri0\sl-253\slmult
0 \fs10\cf0\f0\charscalex100\i {a}\i0 \fs18\cf0\f0\charscalex100\i { Sin tratami
ento.}\i0 { }\fs10\cf0\f0\charscalex100\i {b}\i0 \fs18\cf0\f0\charscalex100\i {
Tratamiento: paracetamol}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs10\cf0\f0\cha
rscalex100\i {c}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: paracetamol y Pu
rinor (FHP)}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {
d}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: paracetamol y Petroselinum sat
ivum (perejil)}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100
\i {e}\i0 \fs18\cf0\f0\charscalex100\i { Media SD ; NS: No significativo}\i0 \pa
r\pard\li640\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100\i {* p<0,05 : Test Kr
uskal-Wal is = I (entre todos los grupos), Test}\i0 \par\pard\li640\ri0\sl-253\s
lmult0 \fs16\cf0\f0\charscalex100\i {Mann-Whitney = II (paracetamol/FHP), III (
paracetamol/perejil)}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs10\cf0\f0\charsca
lex100\i {f}\i0 { }\fs18\cf0\f0\charscalex100\i {AST: Aspartato aminotransferasa
}\i0 \par\pard\li640\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {g}\i0 \fs1
8\cf0\f0\charscalex100\i { ALT: Alanina aminotransferasa}\i0 \par\pard\li640\ri0
\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {h}\i0 \fs18\cf0\f0\charscalex100\i
{ GGT:}\i0 { }\fs18\cf0\f0\charscalex100 {g}\fs18\cf0\f0\charscalex100\i {-glut
amil transferasa}\i0 \par\column\pard\li0\ri0\sl-240\slmult0 \*\tx2440\*\tx3680\
fs18\cf0\f0\charscalex100 {Paracetamol}\fs10\cf0\f0\charscalex100 {b}\fs18\cf0\f
0\charscalex100 { 4,77 0,96 }\tab \fs18\cf0\f0\charscalex100 {3,32 0,30 }\tab \
fs18\cf0\f0\charscalex100 {0,67 0,41}\par\pard\li0\ri0\sl-240\slmult0 \*\tx1240\
*\tx2440\*\tx3680\fs18\cf0\f0\charscalex100 {FHP}\fs10\cf0\f0\charscalex100 {c}\
tab \fs16\cf0\f0\charscalex100 {4,90 0,79 }\tab \fs16\cf0\f0\charscalex100 {3,16
0,29 }\tab \fs16\cf0\f0\charscalex100 {0,59 0,33}\par\pard\li0\ri0\sl-240\slmul
t0 \*\tx1240\*\tx2440\*\tx3680\fs18\cf0\f0\charscalex100 {Perejil}\fs10\cf0\f0\c
harscalex100 {d}\tab \fs16\cf0\f0\charscalex100 {4,92 0,43 }\tab \fs16\cf0\f0\ch
arscalex100 {3,10 0,52 }\tab \fs16\cf0\f0\charscalex100 {0,54 0,42}\par\pard\li0
\ri0\sl-293\slmult0 \fs10\cf0\f0\charscalex100\i {a}\i0 \fs18\cf0\f0\charscalex1
00\i { Sin tratamiento. b Tratamiento: paracetamol}\i0 \par\pard\li0\ri0\sl-253\
slmult0 \fs10\cf0\f0\charscalex100\i {c}\i0 \fs18\cf0\f0\charscalex100\i { Trata
miento: paracetamol y Purinor (FHP)}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs10\cf
0\f0\charscalex100\i {d}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: paraceta
mol y Petroselinum sativum (perejil)}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs10\
cf0\f0\charscalex100\i {e}\i0 \fs18\cf0\f0\charscalex100\i { Media SD ; NS: No s
ignificativo}\i0 \par\pard\li280\ri0\sl-400\slmult0 \fs22\cf0\f0\charscalex100 {
Observando los resultados sobre la concentra-}\par\pard\li0\ri0\sl-253\slmult0 \
fs22\cf0\f0\charscalex100 {cin de los grupos sulfidrilos en suero sanguneo}\par\pa
rd\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {y comparando todos los gru
pos al mismo tiempo,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100
{no hubo diferencia estadsticamente significativa}\par\pard\li0\ri0\sl-240\slmul
t0 \fs22\cf0\f0\charscalex100 {a }{ }\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\c

f0\f0\charscalex100 {<0,05, presentando los mayores valores el}\par\pard\li

0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {grupo con tratamiento de parace
tamol (0,67 mM)}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {y l
os menores valores correspondieron al grupo}\par\pard\li0\ri0\sl-240\slmult0 \fs
22\cf0\f0\charscalex100 {con tratamiento de perejil (0,54 mM), seguido del}\par\
pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {grupo control (0,58 mM)
(Tabla 3); mientras que,}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscale
x100 {con respecto a los grupos sulfidrilos del citosol}\par\pard\li0\ri0\sl-253
\slmult0 \fs22\cf0\f0\charscalex100 {heptico, donde tampoco hubo diferencia
esta-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {dsticamente si
gn}\fs22\cf0\f0\charscalex100 {ificativa entre todos los grupos}\par\pard\li0\ri
0\sl-253\slmult0 \*\tx200\fs22\cf0\f0\charscalex100 {a}\tab \fs22\cf0\f0\charsca
lex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,05. Las mayores concentraciones f
ueron}\par\pard\li1640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1640\ri0\sl-213\s
lmult0 \fs18\cf0\par\pard\li1640\ri0\sl-360\slmult0 \*\tx4293\fs18\cf0\f0\charsc
alex100 {An Fac Med Lima 2007; 68(4) }\tab \fs20\cf0\f0\charscalex100 {337}\par\
pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\pard\sec
t\sectd\sbkpage
{\shp{\*\shpinst\shpleft906\shptop2560\shpright5560\shpbottom2560\shpfhdr0\shpwr
3\shpwrk0\shpfblwtxt1\shplid2043\shpz0\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft906\shptop3093\shpright5560\shpbottom3093\shpfhdr0\shpwr
3\shpwrk0\shpfblwtxt1\shplid2044\shpz1\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}

{\shp{\*\shpinst\shpleft906\shptop4106\shpright5560\shpbottom4106\shpfhdr0\shpwr
3\shpwrk0\shpfblwtxt1\shplid2045\shpz2\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft906\shptop10906\shpright5560\shpbottom10906\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2046\shpz3\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft906\shptop11706\shpright5560\shpbottom11706\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2047\shpz4\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}

{\sp{\sn fArrowheadsOK}{\sv 0}}

{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft906\shptop12773\shpright5560\shpbottom12773\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2048\shpz5\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4654}}
{\sp{\sn geoBottom}{\sv 0}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(4653,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}{\shp
{\*\shpinst
\shpleft6026\shptop7133\shpright10506\shpbottom10146
\shpfhdr0\shpwr3\shpwrk0\shpfblwtxt1\shplid2050\shpz6\shpbxpage\shpbypage
\absh15866\absw11893{\sp{\sn shapeType}{\sv 75}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn pibFlags}{\sv 2}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn fEditedWrap}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn pib}{\sv {\pict
\jpegblip
FFD8FFE000104A46494600010100000100010000FFDB004300080606070605080707070909080A0C
140D0C0B0B0C1912130F141D1A1F1E1D1A1C1C20242E2720222C231C1C2837292C30313434341F27
393D38323C2E333432FFDB0043010909090C0B0C180D0D1832211C21323232323232323232323232
3232323232323232323232323232323232323232323232323232323232323232323232323232FFC0
00110800D2013803012200021101031101FFC4001F00000105010101010101000000000000000001
02030405060708090A0BFFC400B5100002010303020403050504040000017D010203000411051221
31410613516107227114328191A1082342B1C11552D1F02433627282090A161718191A2526272829
2A3435363738393A434445464748494A535455565758595A636465666768696A737475767778797A
838485868788898A92939495969798999AA2A3A4A5A6A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6
C7C8C9CAD2D3D4D5D6D7D8D9DAE1E2E3E4E5E6E7E8E9EAF1F2F3F4F5F6F7F8F9FAFFC4001F010003
0101010101010101010000000000000102030405060708090A0BFFC400B511000201020404030407
05040400010277000102031104052131061241510761711322328108144291A1B1C109233352F015
6272D10A162434E125F11718191A262728292A35363738393A434445464748494A53545556575859
5A636465666768696A737475767778797A82838485868788898A92939495969798999AA2A3A4A5A6
A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6C7C8C9CAD2D3D4D5D6D7D8D9DAE2E3E4E5E6E7E8E9EA
F2F3F4F5F6F7F8F9FAFFDA000C03010002110311003F00CE0B21B260A73272D9155AD423C6ED2122
41D07AD6A35BABEC65942B330E40383F8D65DD6E49A50AEACF9E70B5DDCDCD7378B5B22D3EA76E96
D35B4BB5A509F29EF8AC68E1496D16142DF6991F64689D49F5A99B4B7BC9BEDD1CEAAAA989015C6D
FF001AE8BC27690C16B79AF4EA8C96711481CF467FA56351BD5449AAD462D9D66B8BE4F853C8998B
4C23418C6493DEB8BB8BE47B882D9CE2CE35C6FF0046F4E2BAD8F512BE0EFED2B9880B895495C9C9
C9E95E7B32A797E502CBB8EEC0E72714E92D353970C9D9B3A481E158561755943E4A856E48AA4C6C
34E92596580FDA546020CED15C6D83CF1EA31DA2DD12647C264720E7E95D46AD1BDA4AB6773869F3
C480753D81AB9415F43A1497539BD4F4CFB51FED0B78B31BBEDD80F46ADE87C457F73F669EF1409E
C76AA0CE0800F3DBB8AE96FF00498751F0E596B3018AD44501F3540FBED5CFDA5B8B8B6632480CAC
7CDDDEB8ED429B9455C70F6736DA34B5E5990B3DA424C1763CC0F91E9D2B91592E21B92EAC410A55

87A5753617D6DA959DDE912C8CB3B1DD0B81C061DAB9E9E07B5B808C093FC60F6A71D3465C77B199
66B2C7334E6E0A85C95DC339357F734AE25473C9078E82AAC96CEB32867291C7960473D6B7B32AE9
62458E358597EF60026AA6EE694D5B732AF23874C911E33BA70FE6601CE6AF6A1E32F116B2915BC6
E6DA1618DA00F987E5567C2BA5D9DCEB12DCDF486088C7F212720D55D5756B23E2486DA2412C1092
03818A84EDA2472D584272B48BBE10D76FF4AD4D12F2E5DACE77D815B1F7ABD5A6405BD8F22BC82F
6C65D5EEECD6D885995B7AA9381F5AF57B59A4B8B488CABFBC0A1491D0FAD615B64FA9C75E8C69CA
D156452D7F481A8AA5E09FCB6817918CEE1DC56458695A5EAE93C9A4DD472CAA3E649108653ED9AE
B10E463AD733E27B296D2FED351B19D6D577624C0CEEFC0D67077F758539CB62A9D3EE63CC136D59
41CB12DC002B06FAEA7B1BD768A412C4E780074AED759B0B29605D503B17DAAADB49C30AC0B5D36D
E29D241298B73E46E1C015AC65D59D54E575A995797EF1E8775F63016675C7CDC1C77C66B73E1CDC
DA5C7DA9ECE5946C450F1C9CE5BB9E6B3EF2C56EA6B82EA0C8DB9533C05AD6F01E9F2E9DA6DF1911
45EA29DA3B118EBEF4A5A8EBA8B85CEAAD2D4DB899D108691B71F7AA3ADAC30BC2F2CA22795B68CD
79ED9F8CF559BC4B10B9BC1E5331430AA8C8FD2B675DB9D1D74D17570D2B4E92614B6705F3C63B52
B2BDDB39634A498DD7BC2A57541708E23571990A8CEF14FB4BFB7B66F2E38C09A25C26CCE08ABD0C
F6FAA690F732B94B8B65CBC43FBB5407D9C4656DF68565C8623E614F99B474456E9905EE992BE8D2
DE105648642C8AA37104F7E2BB1D1A7BE9FC3D04972A05D94E41E3159BA2493249E76E023076B824
735B577726D817700A638F5A87CD7B1CF5A4DCAC55D49AF22D15D9640EC14EE238C570A88B1C0247
2A4B743D715E831DC45A8DAC89110C1930735C3B412D80114F01088E41206463EB550969665E1DA5
A31964E21BF8EE6718850EE20739A9355F1849ADB9B3B184C70B7FAC25865BF3AAF2DC842F1C3F2C
4E30C4E3814EB4D3920B596F63859635202BF24356DA2D59B38DDA6D85944C6440FB8386014D4D21
7B64982B29507264C8356EC125B87921881336DDDB08C103D6B9C8F45BD5BC9E26DE20605B7FBFA6
2A7995F52AF1BEE5AB2BE2D741CC8C0AFF0011AEDB4059AEDBCE932117F88D72BA1F87E52248AE15
8C05B2A7B9FC6BADC7D9BC3D24114DE4E063CC6EC7F1A529C5E88E5AF357B14350F16D98D54E9EF7
06171939EC7F4A2B8E8F47D3E50764A6FEF1892F21CAED1ED4538CA2959A27D85F5B9A7A4EA2B7FA
19B36897E43BF19C75F7ACEBEB71136603B509F973C9FD6B4A321559A128C8180307771EA0D45711
9BAB19E37611F9720922EE40FAD527A9DD17CAEE47A77879EEE065BBBEFB240BF3167C1C83D715D7
492E87E1EF0F4518DB2588206305B7127AD711AC46F3081B2AC8A071CF4A86DAD4CF10879C313B07
6CD1CAA5AB6675694AA6B73ACF16DF34F1416B1E12D400CC3BE3B57249098A769EDE43B471875AE8
B5267BED2ACEF155249E21E44C8382083D6A34D355EE9EDE2B947FDCEE2338C9F414A2D2490E9B51
8D8C7D3161B0D726BEBF90711FEEB11E406A82C20B8BC5BA17377F69DEFE723E36906A686EE44328
9012D2FC814AE3007E152C68DE684450D1AE1D86EE71DC55DF4B8D455F989654927864B1911A4B52
9F236EC0463DC8AA4966B67A2790D36FBC8A43F30CE3655CBA9602258ADD9E10F8DCA01C81E99A84
3A33456CAB30E39665383EF9A95B15EEA774676A107F67416FAA5A5D34BB8FCCBB70148EB524B7F1
6A37297010219701F9E86B42FEC9D34E9AD57722160CCBC75F5ACD974DB584DBCD6D386200F3179E
0FBD5E8D1A46F7B8DD42D7612814865EE3A558B332DCE9D235DCAAD0AE76654022AF2ED937452A97
5239C1C66B22F76DBDC2245116404640E9517BBB1AC9D95C6CB1497D6CBF6597698D80099C6698D0
E9BA05E4535D3B5D2F59176E0AB5696A3A5C102DBDCC320899B0C501391FAD5C9AD34CD56C2786E2
D8453EDF95CE7E63EB449B460EF2D8A8FADE8D777B0CF6CACA718DBCF15D969BE265934FDCB112A0
90173C915E6567A0BE9E24BA80ACDE59E47A0AEBECA7D3440B75E62A48E30579E2A24A2CC6AC3997
BC76561A9B5CA167B7655CFDE06B23C5F6767AB698932C92477509CC648383EB91D2B2B4BF11A43A
AAD8432BB873805BEEE6BB388CF3C460BAB7568C8F988AC9A7177395C7D9C933986B8986811A5C5C
A99B055E240074F7E959F61A9ADD84D92EFD83693DAB6EF618AD018638C4966B90485CECCFAD79F6
D5D2F597B48C98FE6C851D0D6B4D2968CEA8B56BA3AF9E3172F977DF93F3638CD6CD91925D24F48E
7B63B5589C0917D2B32C9BCC8845B4311EA2A4BC449ADFCB7180B96DB9E87B543DEC29ABE8676B1A
668BA50FEDCB689FCE7936321C9018F7CF4AA7F694D7201A1C90945958347313CA9ADE492DA2D01E
CAE623736B7132A856E0AF6CD606B3A15DE876F732DB44D2592B868E556E40F4EB59CAE9591A5397
493D4D9D39ECFC3A92D85DBFDA6E593048E368F7F5ACFB78DFCD6C1242F1F415069BE1AB8BE0E2E6
45B693699C15F998FB1C5695B0DF6897539558C6432467E6033D6AE9BD3409249B77D4BD6B1796BB
4608634FD5A796F36C71B70064F6A7CB05BD95AA4D1DCB5CCF3381102366D1EB4D58E1B8E5C96763
865071C934FCCC6CAFCC3F4685ED6286E5DD91267DA476FAD4B36A77773733E9B2EC89589313A8DD
B96AB6BD23431C560ADB62418201E9EF54F4DD464B7315DC76A4EEDC881B00B0F5A147A91C977CC5
C86CADD74FFB7DE5A466C94E70B9DC79EB5931EB72DC5CC8F6976E962030F25901541D8F4A875CBD
92DE27B62F361CFCC037CA33D8554D1EF22D394490C5BDDDB6340CBC3AFAE6871958D231D2F221B7
D52FB4CD656F5DB7BECC2671871E86BD12D75286FE2B329122BCCB9607B1C7358A46952476D25D5A
27D925041193946FC2AFD8BE989E7AE9CACE55720B13F20F6CD094ADEF232AAE2D5CB53EB5A4DB39
865BE8D2456C1400E7F4AC3D4241AE4E6C84AF15B1F9811D587AD647F60594727DBA7BC19925276B
29C93EB9ADC9E3834D6844E7CC69572587F0AD3718C5A51338D2D2F2284B6F1ADFA3E9B6A248A05D
AECEDF789EF4557B8D7AC23D54593232D981D533D71DCF5A2B5F6536B634534B46C812F20FB34AA8
810A9013BFD692C674960B9651F2920100751ED55EE6CFCAD4A7B29CEE0A722AC2B436F022C3B309
90BC9CE69BB2D11D5A35A10F88E19604496C24F3A0651C0EA2B3B4F96E52DDA56660ABC8181C1A99

F516483E450DF361B26B7FC3EB15BEA480C02589D7E7466185F7A727CB1B58726E11D4CFB412C36D
34AAC37C9DCF393F4A6DCBA811C8508963C3075F5EF5D4DC69565319ED2D9D7ED5CCC3637DE1E95C
92B7CEF1E0E5588E7B7B566AD264D39295CDC4B86F12E8EDA7ACE90EA2849B67D9CC831D0D70DA25
DDC5BEB93ACD09699331C8A4F00D6DABCB6D3433AAED686412C671D71C115A17F6D6CFE21FEDED3C
34B05DC78B84E811B1C9A4EEB41AF7656E8C8EF90CDA6B0454552F83286C91F854A3ED31F855ACD3
5D885D60A1678C72B9E80FF5A6DA88D62255508E782719CF4A8E3B78022192D58AF3904E79ABBD89
9D3E665482578F48F2A5613BA8DAF2118247AD73525E0B1D40AB3B32C8D82307A577167652DEAC6D
F6791E1CB2B3AF4CF6AE6F50B28D58B4D9CA9E78F7AA8495DA6691D744CD4B322540A1417C67A76A
A77D0332B3C59DDD71D315A1E18C1BE0D303E53424D5FBEB67940996D4E63521CEE0432FAE2A1BE5
91A397D967002D66760F2CCC4B1EA79AE8EDE18A4B59A433B79B120DAAC7EF7AD3E5B54111B858CE
0374F514FB6F2E274B9990B46BF7D31CE3DA9CA57D42D65A1D1E83A39D374FB891A0052E532BC938
38AE7ACD2D6F239ED6E74FCDCABFCA51B008CD759A46A5FD9FA7ABB4BF68B395FE47231B41ED50B5
BA31BAD434D5DD2202C6261F7BE9595F577383DAB4F5391D46DA4B5D5ADD6DEDB644ACADCF53CF22
BD16C3C436F77A91D36683ECF7013E55639DDC571317DAB51433C48F2CEB202606182A7EA6BB68B4
AB36D5535992026F7CB09F7B85F5F6A8A8FA13566A5628585BF9FA9DF411DF379418EE4F2F009FAD
54F11E8D12243751DA2F9B08C1909EA2BAC1C640518272703AD417B6E97560D15C464C647273D054
A9D9DC8854B34723A6C135D37931E3CE752579E0549777E22D1EF165B74372AA016E8548AA567727
4BD4E5923FDE44808898B63EB526BD14B7F73325BC1BEDA48D259A4DF829ED8AD5349EA75EB26416
BE70B5FB15CCC3271317603E5CF6AF400904F60B6B2EC689A11BE363DB15E55AEDB18FC3909B66F9
E49C24ACCDF3041D2AEEA1657FA968B617B71386F2E3F2B11F56F4E94558A714DB2254E537647A05
8693A769DE61B4B7DA255C162C5B8F6E6B1EF34CD3346B196D8452BB5CE724672A2A1D075FB4D3AC
7FB3B52768A5B78FCCCC80E587A56DDDC13EAB616F716338B79244E3CC4CE54FD6B3578AD0C758CA
D2399DCCF636972B234B0480A86618DA476A537A23546C6DD8339F523A524D6F71A4E8634E9E1262
8E72C270C3E627DBA8AA16A1EF26487868F3D18819C9AD92BAB9D29DD32E4F68FA94B23976645C3C
CF8EDE954AF352867BD0638CF96B188E201B3B477352F8D3543A522E93636E210230F2B673BBF135
5AC05BC3A3426393324ABB8A6C3BB1F5A883411BB57E85C5B1B3B98522BE7693CC07318E0A9FAD32
F63B7B3B78D5A4F2EDE32360EA71FCEA586E6DD2C6397C979BCD6DACCC705483CD67789DE4DD0EA2
F105B22BB22447079F7AA77BD876572EDD5A7F68C312E94D98DDB82411CE39EB571352B1D0A58ED6
28CDDDF81B2762DB42D56F0A6B0D75606DEDD3015FE6F51597AD5A47A2EA4D74BBA36918B618E775
29371F74851526D33ADB7D3ACF53B8591190BAFCC73CE07A5737ACCCF71A9DCED66C2C85001D8015
A336A89A359DBA58A15BD9C0925257803D39AA77735B4976AF0AE1EE40773FDD3DE953D352237E6F
23160D18FDADEE656CC63D7B93456CCCA5602038DB907A515D8AA4ADB94E316C89AF62BFD62F2E01
FDD99CAABE32302A3D60B4518DB808A980F9FBC6A3BB8561BE45B06FDC32E5811CE7DC54D24BE6DA
AAB00C149C822A2FADCBA51B591CB453CF713B4586DAA77E40FD2BABB262B12C8D1952482368E954
2C74EB68EEB2CAF9624E056C4B1C5E4168E56568C1DCA78C54CDA6CD65D89AC3EC116A2978CD711C
A926EC7F7877159DACC724978F7168544134C5BE61CAD25A4A92465D812EA490C0E45100B836AF11
C798CDB864F153F0B338AD6E4525879B6E3873CE14F6A8A2936581B61E689FCE2C5BB62B5E35658B
CB7661091C9F7F4AA4C42B17F2D82AE40C7561EB4B999AA937A321909882A9C115BDA168F26A5134
93BB476ED1E227F53DCD66C76DE6125543B60142FC29CFAD7630EA161A6D9C76D753461E38B2CB16
31F8544A4ECAC635A6D69129DA6B7A36921B488E4924F27866500826B07C5967A7585AC3A9A4EE60
B96C10DC804F715CA09648B50B8F2C48B0CB231563F7B19AECF4FB383C49E179F43BAB92D2AB6E88
B100AFE757CAA2EFF792E9CA9253312CE445B012D9C9B88243127381F4AB767E20B68ADE48A781D8
91B7729E48AC68B4BBAF0FA4D677AAD9DFF2CE808461F5F5A8F556F274E8E58C0560D839156A299D
17524A469C721954AC0D9B7553B777514E48A66B59E4DAA625504B8ED58BA26A595689826146DC93
C9AD1BA925B0B81109F36F31CB60F144A09685A7A1BFE18B782F2DE5D326BC64321F3162DB82A7DB
DAA95BF8865F0E789E7D1194CB9FB9237BD66DAEA30E9BABADD4F76AB2464145271B87A55BF1C69A
75A5B5F13E8E1990002658FEF29FA0A954D5ECF6670D74D48EB4CF2DC5A5CCD0DBC6B70A7A63EF54
D67A8CEECBF69B7FB3431FCA77F249AE5FC377B2AB8B9B877629163683F2B1AEB05CC3ADE8771F66
61BDD0AAAB7F0B7606B9DAB3B184E2A2F50D5B557D3D236B5845C363CC70BCE12AA68FA95D6A7732
C3E745F66C090A8E5C03DAB8123C45A6B99EF209D22B73E5C8CC1B6B8CD75165786C92DE6B448956
690465973D3D2B474D25645AA6B96E8D4F135BD8C30DACD70B2476F1316DF173CF606A92DF5AEA96
B71A95BDCF96D2A88A7B66C6E503B8AEA6781668A48E48BCD429B4A3AE41AE0F5AB6B4D1EE615D32
D6489A600306EEDEF59C7964B534A2EED233EE55032A041298C962ADDC7BD6449ACDE4F7713C21ED
42C80841D147BD68EAF7134524D15C45E5DD46984F2FF8CD54F0CE9571E22335C19E38AE0623F2E4
6201F70294AA392B23B9B8C63764DAEACD73AF24D78C27B99902C7E5F73E95E8775AB3F87F42D396
7883DDCA56144DBC66B1DF4FD234FD7B4D87CD6926B652D3CA4E5578F5AE8849A478A6D4B9CCB0C6
E769EEA7D4527CC92386BD48CAD6D8E5353BAB7D535492592716EB10DB70036403EB5A967E1ED1A4
B9804B773CF2712424FCA1B1E9EB54BFE108D4E392F2DA2BCB6FB15D9DCCCC09900F735AFA3F87EE
6D3504BCBFBFFB4B411EC8238F8551EB4F9F4B5C2538F25A2CC9F18E85737CB2DE4CCBE5C602AEC2
7217DEA174D377697646698A4507CD39E0118AED66852EA192DDF1B651B49C579C5E69B2D9DEDC58

CF20263C7959E9B69C520A13E7F75F42C7DAA290469128F26090ECFF006F3DCD675FF85F5A9EDA59
4080DBDC3EE4963624A0FA55E8A39EDD7CE2B1BB47802351F2915D841776D7560B6769B2298C2641
19FE13F4AA6E51B346955F2E88E5FC23058E8BA8A5824EF3CB30CC8C71C1F6A7788B5ED326D41167
B432DCC1288C06E9F5354344F0DEA7A76BF26A5AB1710400B82AC79FD2B0628C6ABE2992F62626D1
58B0F33AB9A9A93539DB7229C39E5735EF2FEEB52D5E59245442B848D470303D6AE5A2AA8F398807
918FAD578ADCC51B348A09DC7703D71554DC3413907EE638CF19AD636D8DB952D11BD1FF0067DADB
4F77756B3DC3232A8453D8F7A2ADD86973DCE872159A246B960CDBC67681D00A29FB4B3392738DF7
31625F3FFD59C48806E18C63352496F13A314B8443FC59391445B5A679A3902965CB6781F8562CD2
C892A91B9501C1C1C735A2573B6316F666F59E9371F6A91C8792155C2C91AF04FB9ACD5984B6F728
5C16230467A558B0D5750B2264B2986C0BFEADF25187D054779762EE65B96B6B7801037F96A40269
EB7D49F794ACC96C1122B10801386DD8C0C354BE76E55CAE2427E518A2DAF622B215087031C0C815
4ECE497CD2EE4B6F6C02C72054DBA9691783BA64BAB18F39603EE8A5454BA9094907943A6E3CE314
F9080AF14C59378200155E38E384F0AD8488B124D66096A517BB956492056054F18273C5695BDFC3
7A65B49B6C4EC9B62971DFD0E6B94BCB8BA85D12311A3CAF90C476AD6D0F3A824EF33466E2DC8DD9
E370F515B4A2946E0ECD8D7B7796E77338257AE0F1C55CB79DEC2FD274C82002DC91B949ED5A2F1C
477490423CB6CED661D6A11109601BD374ABD303200A8B95CCA4AC76377F63F116912D92C8BBA54C
8538DCADEA2BCCA6D2EE7CEFB2DCB289172369EAD5A06EA4D2AE05D5B90265E9CF1F8D74369369BE
288DA0B90F69A8360EE030377A026A52705A6C73A4E93B74388834E8ECCB3CB8DE8CD840793F5ADF
B0F0FA6BF6E821B809308CC87CDE1401DAA1BF844524B6B7F0219626DAE57824763F8D4B6FA9C714
F13448B15AF97E548B19C922897349DCDE4FDD5CA71DE20D325B4D40C9791EE8F1F2B27CC0FD2B6F
C27AADC69D6A9232B496939224463C01EB8AE8B57D3EC6202DD6F239E32BBD43265947A565DDD913
6302A11E4AE4EE8F8E7D2B4F6978A4C851E67766B27D92C2CA7BBB2956E14306F2B39217E82ADE8D
2DAD93CB325C2FD9EF0EF5C9FB8DE86B1AC0C5E1ED164D4EE4C4F7374A5218319DC7E9D69B6290C7
12437303F9B39DCF1AAE5547AD7249EB639EAC6E99DB5DC116AD62F6372CED0CB82769E4FD2B9AD7
6C9744599ACE29DAD8C6180C642B0EFC56FE97B92C4025580E14FA0ACCF1D5D5D5BF868B5B9C29F9
589E98A29DF9AC72C6A7268CB9657973245A3C90DEA335CF32A3B7238ED595791C1FF09D2C93CA65
B47206D27847AE6FC0F771EA32ACD75731C1F62CB004E37568EA3AE79FAFF910592794A44AC4F1B8
0AD5AB368EA8D369DE3B1D86A3E1AD235056B06754BA71B958901F1EA0D7151E957FA07880D9C84B
4463389533F28F526BB492C535F363ABC534D6D888001700D3F53861B2B496E2EA769564051B701D
3F1AC12B6C28D477B3D4F339E7BBB391953CEF32590AF3C861EF5DB780E18ED6DEE3FD2DA6F349D8
07DC1F4AB1A141E1D4B56BC7BB8643202A3CE653B33E959F0E85616522E7C432182225E18ADA4E46
7FBDC734EF2EA6B567192E54768C36641CF1D40A4CE467A7B511864810BB6FE33BC1EB4A7AE4F1E9
48E16AC0A7041F4AE62FF4895A568628FED579724C8D2487E4451DABA5C555BDD46DB4E4DF3B7EF3
69F2D41E5BDA95D954E4E2EE8C5B0D0CFF0065C973712BC1380708E46DC8FE95CD817B789F6D0BE4
BC5956993807DAACEB5AB5D6BDA5DBDDC96D2DBC314E524C1C03E95368E3CAD1EF20BEB49D03BEFB
7DCBF293DC66B4BB93B1DB0BF2B9488F417D462177AD6A974F25A88FCB8E195BFD61F606AB5B4500
9A493647134A776D03016B4AE19AF1819DA328A83CB8D7EEAFE1504D144CAA47DF23E6C74AB8C397
708AB5D956F1C2DB190A978C9C656AA5CDB5B5B69A9A90669E68CEE10C8D953F855DB1815EEBECAF
2EC85CE46F3C66B56EB4A9EEAC4B0B3B7516E368F2CE778F5A99AB6A8551F424F0FF0088A0D6ED55
16236F76073115C01F4F6A29BE1BD1954B5E3B44B38F93CB0790BEF4553696C79F38A52D0E5AC0C2
F7172B1348D0A1C47BBD3D6AD4BA722BCBE7ED20E08C0C826A9C6A6D6DD426719C127A9AD1F37CDB
74DACA5A3FE23D0FA56CF73D38DD24416AB9568DB2B93B770A9EFECAD0408A8FBB3C30F4A71B0B64
91D2E6ECF9E57728888D8BEC692E76CEEAC853007CB8FE2A2FADCB524D98D33342C05BAEC523040F
E2A96EE7398BCBCA2B2741FE7AD5F82D43CF89648B32708A4E0E7DAA76D3257B916D1C124AC70095
190BEF4DCA3D4A738AD591D84C97F7304734BE52AF1248DD001F5AD7BC8B4E96CE66B3F3A595FE55
017395F51562CBC37240A23628D31EF229DA3EB5BB6D64904C270A1650BB4AA70A3E82B07357D0E5
9D657BA3CBB52B2927289E54D198BEE1789B9A934CD325852536F1DC48F29CB39888515EAE76B7DE
446C0EEA0D656B1AD0D2F16905BC7BD9376E230ABF5A15594959212C436F44616AD0FF0067689A55
9A3FEF52162E49C16FA550B212C90092360ADC29DA781F5AE86EBEC1AAD95BB5C069A5BAF914A8E2
2E3AD737BA3B28E4B389C3229C33E7935717746B49B6B4326F6E83CE211B55E2392C3F88D5A467B9
B7FB4452665272194E08AD18A1B3BDB596391109EAAE0724FA5470C09683CA442A3DEADBE88D347B
935CBBEAD1C7793C5BA7857CB94819DC3B1AE6DE096D6F163072C58951D4115D6419B78D1637215F
20863D7D2AB3D95BDC4F1C8D205954E303819F4A953EC11B228306B75DCF9DCCA01359C9AA97CDB9
8D8AA64FCA7A9ADDBC0520F21B6E59B71FA7AE7D2B0278EDE3BB06596256CED054F0D551B35A94BC
8E82D2CE0BAB28F56BE8A5610BF951A11F2FD715AA97423914C76F993072CDDC7A564EA17D32F845
1213BA4B57E473C83D0D3A5815749B6D424B893CF823DEE01C6F3EDED5CED2E639E6AEAECEA34ABE
B49E2F29018DF3F2A1EA6AFDDD845A8E9F3595C0CA48B8E95C5E9F7A9736DFDA91B816A2405DCF06
36EE2BB98655B8812E239049138C82A72054CA2D3BA38A51499E663C0B77A35C4891283148D80E4F
5FC856BE93E1AB4BBD6A44B966963861DA4C6470DE86B67C49713DA6A3A7BABB189DF18CF00D4B36
B1069B13A8B2D97129DEC1131B87AD537292475467250B213C47AAC9E1DD3E06B584793160636F51

E9C77AE5BC4FE24B7F156931DBE9B14F1DD4277382C0263F0AECAF7FB3FC43A1B59BDC411CD72BFB
B5760083DB02B8FD17C05A80BC74BE78EDA053B5CC6DF349F4E2B36DAF50A3C8B596E8E46F6DD25B
5B4DAFF655DB8D8CE012456D7866F6F2C666BAF2FCD51190508CB0AE9B5CF0E5AA45383A3C971144
83CBB85C10A3D4D666896B24DA8242B0A8474C6E5193F8D4B6EF63B79A9CD39245CF0BEB771A9788
AE6C24BA692DAE22DC30FF00EADBD05775D38FEED727E13F0C43A46A377752C122CDBC856FE1C1EF
5D613939ABF53CCAED736819C550D696C12C0DE6A10978E023013EF0CD5E0314D9638E68A4865456
8E45DAD919C52338BB3B9CBE8F6F693DCEA9A19577B59F6CD1F9982509E6A85D5BEA1A695D3EEEF0
BC099DA1DBBD743A5F86E2D3AE96E9AF6E659918ED04F057B035CFF8B62BFB5964926B29658253F2
CABCE3D29A7CBA9D74E4A52B7433755BD96CA389218919D8632D4CD1F557BABCFB1BAC6B306183D5
4D410C892690A6F09C86DAB9EA7F3AB9A743A75B49E6C640E72CD900815D319C65136945AD4B1ADD
D082F9D5A3844D00002E30338EB5A3E0DD63ED4B35BCD26658F95DBF74AD504B2B7D5752B8BB9D8E
D8CE4B13F797D2BAEB5B6D321B78A5B0B648564FBA76006B9DA92BDCC6BC92824CC19351D3EF2EAE
67B39A54C615CAF0334545AAF87A34BD79E2BE8ED239BEF21200CFB5151CF2E84D38D371BB663DE2
3C714722A7CCC3E60C38FC2A95BE239F613D3A21AB371A87970978B33019E189E2B949DEE18ADCC6
C1416DCCD213915E8C20DEE6EE4D1D658DB4B7FA82C125ACA11DB2CE071B7D4D67EA1E65B5A5CA59
3893CA761191DF9E95ABA26ADF62BBB5BB0ECF0BA949533C007BD74EBE1BB6F356485E3587CD12F5
1D2B0768CB513ABC8F53C6F4E9B51BCB99564966F3A35CA839041F415EE7A0432DBE816DE767CF74
05C91CD64EAF7DA05ADC79915B43F69419578D1769FAD594D68C71DB5D49711CB1CD8FDD83F30A89
F34BA1CF51B9A56458D7758B8D2440D15BF9D1BFDE241E7DBEB57BEDD691DB473CB731C7BD33B49F
987EB588D7173E21D5FF00B3D24486D501914A8F98D66F88B446D3628D84EF3AB82033755A4A0AE9
32214EFA33A51AD594B6EEF68C65914EDDA7B560EAF324BA825E3C8B29C6D301195AC7D3BCB54C96
7001F9B6F7148F7816ED64038391823B568A9A4CE9850E577371E6BB11F965638A3D859422E302B9
9990A6CDBC16FD6BA3B39E59A6C4320966D87E4639F97E958378D0B4AC8A5B2BC1CFAD5477B1B52D
25612C018C3C45C105B8CD68B167BB011495C8E1BFFAD58EC1A21BD8838A98DEB46008B793B80029
CAECD251468C848DD861C313F376AC9BABC58A6F2CCA926EE460D69EAC24B4B8F2E545F9D4301EC6
B9F96C096255772B9EA3F8688256D4957E86F476F3DF68AD3145F3A0380D9FBE0F6AE6B59D3A6919
278D4F0394EE2BB0D0E64B6D3A686ED8084E002E7A1A86F6EACEE5D73BA3901C6E518522A14DC5E8
427AD99CF69A6F6289448770C0CEE3D47A574926DB9D2AD6DEF632B6F264453A9C1247F0D5410A4C
4AB3AA1E36E3A135D26976EB0E951D95DC3E6C9E699228B8DC07AFD2949DDF31155A4B531EDAC34E
B2B06B3B781F17278DE46D73ED543C23ACC9A1F88A6D0EF5B6DBC8DF279871B5BD326B67C59A1CFA
B7871534AB8633D8B6E112373F862B8D4D0EEF55D1A396E4B43A944DC3CA082DF89E735516A51BB7
B9CB28F3AB23D3BC51A5CBA9E9062B58FCCBB470D090D803DCFAD645D8966D0E069821BC8D36339E
B9A7787353B993C2AB0EA724AAFB8C42646F9863BD42EA248CA2E644CEDDD9C9CFBD63CAD7BBD8AA
0DAB5CE075717BA76BF05E5CDC322210C1A32700D7AEDADD5FEB7A55A5EDB2C71C6CA1999C12481D
715C0EB9A29BE7851A56481DC46EEDC2A8AD6D1F563A0EA62CC5DBDC69B1C78471C827D8D4499BE2
29A92BA473DFDBBAD497B7B2497F27901D95ADC31C819F435D0786EE351786286D0C16F3C84B933E
41DBF4AE96CA7D0F52965B8B7B040F21C3C8F081935635B89068F732449025DF9456372307F3A24D
B776631A91843D9A435B5CD3A20B14D791CB73D0A4072491ED5712449231244C1908C83F8D79DF86
EC8341FDA47642D648C249641C963EF5D0F8475DB6D421FECB8A370F0EE25987DE35374F64454A2E
2AEB53A5EB4B8A692738F7A50684602EF11A3391C004D78FF88BC69773EB3342D72EB6D1B00A809C
7E35EC042B44E8E70B8EB5E0BAE456507882EE3950C83712A000735329D93B1D7858294EEC1AE27D
724DB1C80A46723666B761D5EDB4CF0CBDA496E92DC16EAE39AE7FC37AAC3A65CCEC5008D8E30719
ADCD1B42FF0084AF509EF44852188FFC04D2553975476D46B9753574D82EFEC70DDB40C96F2F556E
E2BA3BAB8865D2C4F0CD2218BA20E315C66BDA94F130B3174D125B9DAA884806A6D2EF64B881648D
89653828C3AD74AA9ED0E79439926C93C497B71AAE996F0C2C5F073B94F3F8D15A36D6698753246A
4FCC31456918D909463633279D638D4ED192C4140306B17FB323BF66293B2C7BBE647ED5B175079A
8D871BB6F04F5A64366B6F69E639258F503AD6FCCADA1B38A2C476D1451854015235C1DC7B67BD4D
75A8DCDCDFB2C52BC6888136A310B8C7F3A2DE24910153D07DD63C9A4BD4962491FCB072BC9C6306
B3D2E4F2A6D5C88CF6B18CA61991486DE4114EB5896461D3E5E9B6B92DAE92E5F7066FE1FA5745A7
DC08C7CDB815F6AB92B2B22DBD0BDAB5D5D695124D6F23C523AE0156C1ACBB0D4AF2EF5058669679
959724BC84806B42E6192EE205F95E858FF0FD6A1B0B716BBCAA866653862318A49FBB62391377B1
348F2A8F2A356C1700B463A0F6ED52A185ECBCA7910DD0E540F5EE2AF59041A34B6F24400690317D
BC81E9489AA2584522DE5B5BCD1212B098A2C480FAB5436FA15CD6564897C3F03A6AF6ED11CBC40B
91D4B7B1AB9AB695681E43308D242C5B31B607E355F4CD52D2C6EC5C416B22CB2E2325DBA67D2BAE
D4B4E8AEECE40D1466575CC642F56EC2B26DA7739E751C6773CC37B5BCA55E22C19880A3926B63C3
BA7DAEA93079E2BCF351C6D08984FC4D6969DA76A29722F134F48A555C1172BC31FF0067DA997967
ACC5684DBC73DBC99DD208588DDF4A6DB6ED7359D55256449E24D3E55D65B539157EC71A2C4AB9E5
9AB3608200EE240C0019503D7D2B0B5BD56EF46D3525912FBCC793E55BACEC3EFD6B5346D5BFB42D
2D7559ADFF00761B64A10700D69CAD2BDC984EDEEDF52FDC7976CD0FDA563922B88F7347B3E643DA
A9C9F66B7859F24EE1805F9155F51B89EEEE2570F8566C004FF0FA54F611B216F396395553705233

F37A567282691AABA230FB6CBCA91366395E393F8D4B05ECE2E637CE4AAFCAEC7923D2A35B99B50B
9612F95B10600514EB983CB658A3E491919ABB69660D5C75FEA5AA5BEA4B7249B695932A21FB9B7D
4FAD69CB11BAB4D2F50467964B962A531C6E1DEB22E05CC76B1CF113234676BC6C7381ED5D2784EE
67D434B9ACA548E1920977421811C562DF2B33AD6514D233EC35748EF66D327B6D8A092C5C70A696
0860975BFB3C17120500CCC10561F8F34FD411E5B855FB3C8BF334913101F8E68F00DFB6AE937252
F513686EC47BD6BCAB979D19C745737F36F746E6DAED6431CCA4800FDD35C3CA2E20D31219DE5844
736DB62508F347D6BBC6B6DC1236199882BF2F04D5BBFD1E3D6D34FB1BD71108A332461170777A1A
C245C6AA890F862C2FA1B0324B3472DB4843606770AC8F155D5FDE5E43771D85EC68018C47B4F3EF
8AEBDA7B4D0ECE1B79A655230028EA4FD2AEADC0760AAD961F300F9FCEA1A7639BDAAF69CCD1E470
BDFC36B7312C7247E738CC0E082C7B9C56C786648F4437FA9DC5B32460ED1B979FC2BBF96D2D67BA
5BB96DE36B85E8C56A86ABA1DBEA312F96044E0EEC01F2B1FA52B5B5377898CD72F72EDADD437D67
15E40731C9822A71597A359369117F6726E922505D9DBB56A630075E7A1AA7A6A8E192B3D0784077
03D315E1FE27F0CEA773E2AB836D693BAC8DF294435EDE0FCD55EF6536963733DB43E64E10EC5032
49ED438A34A73719268E13C3FF000E34EB2D2BED9ADC0ED703E76524600FCAAAEBBAE5A7F61ADB78
7D0DAC2AF890C6BB4FE9593A9F893C493DB358DF3CB6DD41DF90581A8238EDEC747F2E492513BB00
BE87359C92BD8EE851737CD32A5BAA4F74A978EDE5DC617CD739C1F5AE9BCBFECAB79E3B791249A2
030C470CBEB544456D7AB0406345684F1C7DE1EB5A7141079CDF6AF37C8C6722B5A6BA9ACDD95BA1
774D29736E199406C64514F8E1FB3A2E5D3C823E4643FCE8AEC49339DBEC5489636BB2E464A7CC72
3835664823B82E40DBBC82B8E71ED58D3CC50C8172771EC78C558B6D4061720A71B0807BD271EA8D
2CCBF046C251022468C1490D2D175E62431CC63DD1CDC12F9209A649334EEA14A6FE11723AD4EED7
73986D5DD43439C646116A1E8C5A9893C304971E74B1842B9DA49C06FA536CF4EBBBCBD792CCACA2
350594741EBDABACD034A82E0192F512EB8F91B6831E7DAB7D21B502692C56CC4E89F3088800FD71
44AA6B64653C45B4460BC16B6560B630CD1B5E4A04936F19007A564EA736C99086872A0811A8E3F1
ADA8359D3F55BC963F2025CAA60B1503A7BE6B95B999B737EEF2771E472688174149BD4B96574D70
A8887041E8E78355B5511461CCC0125872BD2A4B3608A25743F2B03802A0D5A2F34168891DF6D5FD
A366ACD8B6605DDBB1404E3A64735A325E5F4F04490DCDCE203C0DFF00366B1B4C792D9373F2C0F0
056B437ABE6FCF1AA799C861DCD12BA7A038C65B9345E20D59B03CEF35A33902407AFE15664F17EA
614218A1DC4F2C01FC873596CBE4DD19155C12381D8D235C446D33B3193F31EC0D472A6F627D841F
43A69F54D2B5DD3847A969CD728B857063DC437B551BFD1B4FF0F78601B086F16DA5977480A6E283
D718AE6ED75292DAF45C428FB1464FA1AD7F0BF8E351D4BC413697AB5B2B47229D80213FCCD3E469
5D6C8E5A9174A49A192E9692E9C354B4BC8E5B4C702418627DAA6B78ADDE1909DDBBCB1B36B77F71
5A53697341A37F6699AC2DE59652D124AD82133D715CEC96163A5EA0CC6EE47942E032BFCA4D4732
D99D30973225FB28826619DBBFD295A4114CB29049518C9A4175E7463E6E475E39A8E6589C05DEC7
27E99ABD5BD4D394A8DABA8B868D55447F75883D3F5A80EAB73A7EAD1DD40D36DB7C1EF875EE2AB1
D0A6FED2327DA0988B6E386ABBAADB896DA2F26670C109901E38153562ACB946A3CC9A91DAF8840D
4E2D3EEF016D5A32ED9E9D3D2B9ED0EDBEC9AB674CF2C317F9C2F4DBF8549A0F8E164B1834EBFB44
9AD80F2FCC51C8FAE4D3E378B45D7167B35C42E70171D41A9836D389C6F9A09C5A3B1BDB586E6174
705081C3AF0C2A9B68E32245BB9F7E386279AD0907DA6027E652E3AD3A10046A588DAA392D58AD16
872F33B9CA5C4901D5D228E392FAE21E642FF311ED5AB04E755996FADE5D9E57FAD8251B5C0A82CF
5886EEFEEE18E3844921290C88BC93EE6B8283C43ADE93E2AF275184464EE8D99A32A187B1CF35B2
8B92D3A1AC96C99EB16F7305E43E75B48B24678F94E706A5AE7742D574D8F16DBA185E5C9010E066
BA2E839F4C8CD64D19CA0E2EC3673B60725D501E0927F4AADA7C7245148AEE64566F91BDAB1FC657
335AD8DA3452449FBCFE3EF4EF0EEAD35DA8B7990B6E1B95D17007D695BDDBA1AA6DC798E8075C77
C67359B7BE20D3EC64F28CC1E4070C108247D6B4247486D679189C2A1E6BCDDEE64D3B48BB912089
DE624EE9572C3D315708730E9439B53A9D62CEC3C45A7EF89A16B841B918B0FD6BCFED346B99EF67
B4B96DE54105B7709E98A4D33C437DA7C824963876C8703838AE92D6E74F4B97BBBB898174C3853C
134E546DB9DB4DCA29D8E7E1816CE431BB9695576800F15BD6963A83226DB8B662CBCC121E71468F
0E8BADDE4CAD1CF1CCA84C65880A7D2B33479A7B0D5A4BCBBC99A172A63753C8A5194559049B9E9D
4D9B882E6D2211496E4443F8906467EB4569A788ADB5431DBB69370A8339445FCB8A2B78BBA314DA
DCE39E618796319191F291496D2ACA09752187A7233EB5A96F6D1CB14AC63453FED63AD54B677B2B
EC841B5FE51F2F15A5F43AAFA16A10F25C438DC54E31B064D682DA5D5F6A115901229DDBA4320C7C
B50E4DAD9AB453F9527258EDFBA2B7FC38975A8D825F5EB3336E2237CE372FBD73CE5A98559B8C6E
5B312E87A4DE9B44691541D91FB9AF3512DC5A49732234D1EEE0A2B10589EA38AF4ED634D9F52D39
ACEDAE0413960EA41E4FB715C1DFE9FAA68EB2DD5F40B1216DBBD9830CFB7A56776D799186E577B9
BF6BA13A7819123F252E1899B7E7A03D89AE7A612C70AC81405231B877FC6B5BC273DD45298AEE37
3657A02C5B9F233EC2AEBDA6357F22D6312410F546E80FD0D6B4DE96348CDD3934CE62C92E9E6211
1F605DCCCC8703D335612459916276C3B0DC4A8E2B745EDD2EB0AAB0C1269B3100B00179F4C532E6
FEDA4BA36F359411C45B6AC8807C9FA55295D96A727AD8CAB3D3CDD335BB4652541B95F3807EB53D
E4F6304AD6EED1ABAE02FCDDFB9AA3A8B5DDBDCC84B3242A708E878715CAEB32B8BC334A1E360B95
079CD6918733DCAB753AE526670AB292FE99E82B6DBC353CD021882EC6C338278FC38AE4FC3D2C77

92C61243B5F03777AF4FD47CEB5D04F96087000E0E0D6536D4924675AA34D289CBB68B65A51FF4CD
5A0450398588DC7E99ABBA5D85AD86B70EA3B2378A55DAACA338FAD731ACC536A178A2588E1C6177
8F9B3F5AD1D3EF2F2D34E5B28DCC8CA7E62F9E054D82509492BB28DFABDD7892FAFEEBCF768E5C43
BB952B4AF6BE65B0931BB7B63E5E48AD13223A4923060EFF0021EA71F851E54915BC91A0DA1BA3B7
1556B335859688CAB50B137F0E549F98F5C5643EA4CBAB767407EE9AD4911A294A498DE73951CD57
8F4A5376662A48272401D2B68DB5B9A3D5685A8AE30830C467E6A6DD6B76B7D77158C703A90305F6
F5A95AD90111AB65C1CE2A2D234F7B6F1045766DD5A15CEEDC3A54FBBADCCE7A2D07CD656914915D
5BC4563036CA87D7D6B6229A3BBB6863961DBE538DB22F522AADCDDC0F777E176ED6FBABD8556B36
98C1B46E25BA67A0AE7E5B48528B942E7A270214C16C6DEF51CB1FDA20316F29B8119ACED1B522D0
476F7470E781CD26ADE24B2D22536AC8CF76C408D369C37E3D0567CAE2EC79CE2D4AD639B8F4F934
4BABB495CCA4B82AF0FF00073DEBA6816CF56125A6A16D1CCE832B23A0DC41F435CDEA3E23D36F35
94B5589E325D44C57A31AE88C437B5E5B169648463CAC6011577BEA74D4BB8A6F7391D53463A45F7
93148D2C4065081B9947BD6E5878A2E8D9A892D7CF65000D839FC6B4A182DEE35C96E62B90657876
B40CB950DF5AE71AF4697E79B9B365B9B53B9A35E8EBEA08AAE6725A909F3AF7B727D7279BC5103C
3671A836D099D948E73E951E8BE21D420D377C90468CF8C26CC1AE6E4D76F62B5BBD4F490A915FFE
E8A06C347EB5A5A42B8D1E0B9795A59DA7F295586723EB5728A564B634847DD69AD0EFECB52B7D53
4E76880690821A2CF27F0AE324B29CC8ACEE8A8A48F29F3C574D25B9D22D62BA58424AA72791939F
A5661BA59E67927500B9EDCE2A5697688A6ACDA473371A3DA97339864C29CE00E055D8ECD3538C5A
1E19D72303A7A53E6B7BBBA764B58E475DD8386C7152CBB344B76B56629793E3F78DD107A5352E75
636E7E5D8CDB2D35F4994DBCB2A7DA54FF0001E00F73506A7AADC5DCB25BAC913C9138DB2275207A
FAD6EEA96F069F3C73B39916E221B8B2F7AE225416F78042C4877C0E082B9AE7D9D8E8A6D4BDE676
16F76BA7DE5B493B3DB1B88CE59F8CE0515837BA76B724C1B50B696745C2C4C064628AD232495999
4A9F3BBA66F6CF31D98A1D8327B007D00EF9AA71DF8B2BA0591BCA66DBB31CFE756543CCBF2A8DED
D013F74D45776E92BC367BCB48E793B7033DB9ADDBB68174CD45F0E3DD69EF35BCBBFCD1F367B669
BAE1BDD1FC08D622F93ED2EDB62D8BC85F4AD258FF00B0343834F460D732E48DC7BD60EAB09BF8ED
C5CB0121E59718C7BD4C2EED27D0C12737696C733E1E9758B6D4239A59246751C36ECE7DB15D53F8
8F5061345AAB47716D37C92C3B40117FB59151DB5985963C29050615CB715723D361BD492DC49BCC
803B9F4A6E7777922DD3A705A163C33A71B769751BF95A582DF8B5278183DF8ACA3AA1BBD667BBFB
3AA98E404BC6FC32F4CE315D49FECFD73C3D25A2CEF05AC24299541E08AC9D1B42D21EDA76B59A49
157F76666C8DDEF509AD599465177722AF8A218AD9BEDD04CCE180F261038527A9AC2D305C5D9916
69583B1CB023A9AE8E7D3E6B0674B895BE63F21232A57B7D28B58112F62851B724C761F97D7BD529
251B1D11692236B789ADE3FDE7968BF2B460679F5ACA7B6B7BA8AE56741232B040B8C63F1ABEFA54
D677F3DB493208437DF522A596CC471867B80D1670A3675FC69A762A32467E8F61169FA8C21A2290
42DE6171DCFA55DD4B52BED42F59CC8CB1FF00045E9F953C9933DB68E4E7BD559DE38E7E7F8D782A
79AA5AB0714DF3326B4D52F2DCC6D249BD22E9C0C81F5EB567C4174F6B6B06A10204494E1988C8AC
CD1B4EB8D46EA4B6563B1C90EC7F857D6B5EFECE3F1111A6D85D241676C8636673905FD79A995B9A
C44ACA44D65A9DB1B44BE8A559D4804ECEC7BD62EA6F05CDEC97115C3183682158F39A8F4CF0ADD6
99A45C5BADFC2F12C999081C81F9D2EA971A4B462CADD1D0F07CC39DCC71FA527157B2D4BA76DD95
123FB55F8993E48C018E4F5AB1797CEB84848593D477A92D61D96ACD1A83B3AD540D1B4534938552
0657DEAEE6C5DB1B5669C4F732F9417041618DC3B8AB9AD6ACB242F2DBBA246A367007CD5C96897B
7BE21D4869240552E407C741EB5D36ADA569F69A95B69E8ED20893329C9C66A269C64948C14A337B
9CCE9B3196EA48C9621F3938AD49EFAE21F0E4F1A0CCD09CEE039C55B92DE1B5C1B750777B55ED33
CA686ED3C8590B47CA1E334EA4AF252EC69B45A313C1EF2DFE9B7535C3CCCB10243007AD6ADA78EA
D34FB5125FC465C12A188E6B22DB51B8B385ADE2905BDACCC55D76E4FF008D6CDEE816777E1D86CE
D2713163BCC8D9047B75A8728CA5AEC653A76567B96E7F0859EB5AB5BEB9A5BAC56863F30AA0EAE3
EA6B3BC37AA6AF71E277B6B89248E191984A5A301411D315B1E05B36B4F0C5CE9CB3AADDAB36D04F
DDFA56AEB10DEC5E129A28807BB44F9881F37D6A249464D23995495B9667391E9D7936A73586C911
9E5DE26EDB7D6BA4D5F4D3A969AB030324CAB80FBB04D63F86BC43E468CD1EA2D218E2388DDA3C31
1EE2BA8F95E34914E51C673F5A252EA88A92927D8F3697C3F6FA737D9A4B578A369372333F43E95B
F7E6DE2D02C934D5D9F679092A4E4E7F1AD9D76CE1BDD32455F2DAE62C38E791F85739B098A49404
589B96DBC807D69AB5F98E884FDA24A45CD1AE21BD221F326B832365837638ACB920759AE6D8EF42
92F1BB838CD3EC8ADB846CBDAC72360BFF00B5ED57F5A9658AE6DE2B98B3298726527871EB54C697
2CEC8A1A449326B9F6690F122952B9E738E2B4749D36579A68755B4C6D73B5D9FDF8ACA8F50F2AF8
CB160C8FD381F2D75BA7CA64D39127BA1733300C78C631434E3A98D64D6A886F35BD26DE55D3B518
CCAEBF7723A715C16AC06A7AA497F0C3B2D63F95541FE21D335AEDE289B51D5AE74DBCD396E2185B
0BF36D61FE35A161AC68F1CC7446D37CBF3C752D9393EF49D39A2E94F923732F50D43C436FA159CD
3EA1B4370B1AC6A703EB8A2B52F2DE2F08DA35C4B6BF69DEDF2166E1067A77A2A39871A892D2252B
799D6C2F120B70D2B8CC3216E87155F47B8D5356912D85BA48D6A373C83001ADCB9B35B98FED665F
B2D9A0059546727D2B22EFC4135FC7368BA1DA476B6E542B480FCC7D7AD68ECD026EDEEA33F55D4A
492FD66B89C24BFC0A067001AB2BAC35EDC437B790A40FFEAF675DC3D7DAA8B5A476572C246DE554

6D2C738A63C5B8EF046067F1FAD5C536FC8E8E58A46BBCC16F3744435BB750474AB3A1DA3DE4F7AC
27689D86D4E302B1ECE29245244A1B60C91BB9A8B508B50D434930596E69E2F9BE5E0B0AAE54F433
9FC2EC74D34937969E18890497339DD238E015AE6752D4EE92F66B5B591A186CFF00745074622B53
E1D9D59F5164D5E0756857F74EE0671E94CD41524D76F9C423C912E4311D5B159CD34F9626745A94
ACD16E1BED46E2C3FD264631B282A0A0057F4AB16B34F06A16B3700671C8CD670D45EEB2ACE431E3
6F6C56836E104522EE05090707EED1668D5A4B6449A1D9AACDAA4DA848AD1CCE576B0E41EC454324
B9D3DB4FDDBA552555C741E959EF3BB31128DEDFED0A64339DFF0074AC64F5EB57CAF7050D45844D
6EE12EE53B941038186FCAB0B529675BEC90D94FB981D6BA86916588A12BF2F71D4D4B63A3C97F30
8D82C49D77B7271E98A6A6A3B95A25765AD12EA25D0EE6571E5398F059792DF8553D23C337934CB2
DCDAF9364A0BEC2E03BFE1D6BA9B1D274EF0FC12B99D49652774878CFD335C5DC5D5EEB1AB8BB8E6
6DD19CAB2E76851DBD2B16FB18294A727CA691D2A2B6D2A4D42DACE4123B90D131E83D6B9C9ACD67
B859D970EC726B6DB589D9E41E76216EC40A749035CC7FBA4DE36E7E5AD53B6ACDE9B696A431C67E
CEA2338DA391EB5937703CE7F749B947DFC76AD0B83E4DA2C73B3459EB9AD0F0769DE50BEB976DF6
A464337D2B394B4B235954518F3177C2F168DA6D80BAB88D619CFF0011CD635D7912DEDDDC413973
2B70C4706A1F14C926A77567180A968873C525BC849F2723CB8FBFAD3517BB31A54F573EE4FB4DB5
B866E4F6EF8A72C8823F310956230C4FA53B709918139E327DAA1B656C970A1D54FCD4CD0AF0C71C
B787CD84EC5191834971A83DADC1416A19C608DAD8CD54BB99EDF52325C38853B91CE455CD4C2DE2
41736C494EA928EF8F6A534D4741E8F46683E752D322D5161974EBA69046ACA7701CF523A56E689A
D491DECBA46A77692CE98314E0604A0FB0AC8F0B6AE6E7CDD3669584854BC41972188E48AA3A64BA
76B3AACB637D66D0DE1959776E206474A504E49DFA1C75631BB4CE97548B49D6356FB0BDEB45731A
61A38D71BC7A66B7E08043E5C48BF2228503DAB830E6CB5A92C6EA444B985948BA5FE25F715D1BCD
7379A99B8D26F619E10A15E30C037EB59B8B5A194E0F4D4E519A5D23C6B7BA8EA5986D3711EA0AFD
2A75315E42E2CE62F6D2B96DE06D0067A55DF1368715FE806F35299ADEE617243124EE04F4C0E2B1
2C85ADA95B532C84ECDFE537191EB554D368DE9F2F2E86CDB69D79ABC705EDC28686C24C242BFF00
2D71EB4FF12C8FF6D823BB118468F3063AA7B1C54B61A82E9D7F671F9ADF659C3663C747A7EA160B
AFD9BCCE9F63BF8242A149CEE506AF77A9936D54B9C6D99946A3B6EA331286C03D6BB38623108674
9801FC43B8AC78B4D6304D7333AA98909D85B934ED17519F51731FD949DA9BD8A9ED4E4EEEC6F369
AB96FEC96A7507924551752F1E69638AC7D52C27B1BC866F94BA4809642735B135E8B5B35BDBA3E5
21380B22F38A5BF02FA1FB5AA87475014A9C669C65677253FB86EA77D27D91C5D62F219F6BC409C0
4A2ACC4AF75A32791011E51DAE99E4515CF38CB999AD39452B58E42E6F6798361CB46C7257B668B5
7964BB5991C2B2B60E2AADD4570995443B3192054C8562B78A40841DC030E6BBDC15AC87A1A22D23
911A6772F26E3BF23807D2B0FC40F3C16602C9B379C122BA2B459E4B13331E19B0ABEA3D6A0B9D1D
754478A5398D79E3A83531B27764B774D1C1D95C4B0DFA04525F7607FB55DE24B7766F2981F6CEC9
F786381E959F65A05B69D7664321765380CE0E16AF480477D1B072C0BE3776229D46A5B0A1E65ED0
6EA74F165A0372F224A87CDDC41C9FE95A1ABDAADDEB5246988B24800753EF5A5069FA76857B1DC4
AC86678F74600C73DEB9C96E27B9D4DEF2E387918E0039C0ED5CD057D4CD36E7CD1D8824B29566C2
47C23E0F3C9AAFA86A1369F02AC409F309073CEDADC95925858BB8562DC9515913C00C6B14C8CE84
643819CD6D1776AE6D7EE51D2F58F3EEE4B7B841210B9DC3B5694134520FB3C6435C48F8455AAD6B
A7C565BEE0425039DAC4E724568584B6FA7DFADD983738230AA3269CADAD84F48E833C551EBBE19B
2496CE159A1913F792EDC98CFD39AD4F00B5DEA5A7C97BA9216707084F048F5AD5875E96F0DCC92D
A98ADA35C94639DD56F48D674ED458DBDB2AC5346BB9A1DA47158CA7EE72DB5EE70C949BBB383F88
16BA96A5A94572502D9A7C8118E33EA714EF0E34B6FE1E9F4E9DCA317DD19F51E95735696DB53D4E
5BB90178972AABD0039F6AA4D7768665891B0CBEB4D42E77D351505A137D9D1B031902AA5D5D5DD8
9692D66311518EC722B4F7AF2982188CE306B0B5749E5F9D227F2475753C1A1DDE8CDA366F537F4F
B8875B86186E424B3A7A7157B5C95E3B78F48D3D7CB765FDE05EC2B94F04E8B750EAEDAA5D975813
8009AEA2EA60DACBDF3710CABE5823B52715196871EB39DBA1CB5D075416FE612D18C54761334D37
92582BE719ABB2D9EEBC9540CE4E54FA8A641A696B862AB8C0CE2B6BAB58ED4EC4D67A9A5C4D3DAE
D08F0E549FEF558D6A1B8B3D16C5ECA32CB3BE1E40781549EDCDB48B20501A1F9FA7DEF6ABA6E26B
BD1225CBB59C84EDC7661DBD6B1E669DD91513FB261F884489044D70BE594043F1935B9E0F4FB569
F2C20875392B95E4714B796AF3E9B691CB1E5CA62427BD58D295B4782778A4F2FC95F9C30CF06ADB
BC2DD4995AC426D445A9A16BAF22789B7A8DBD71567C55E156D5DEDB5BD32510CEC479C80F5C77A7
5CC0C6299126C5D4909F25DBA13ED581E1EBCBED34496978858A124AB30DAD531528A72898CD39B4
75D158D8DC59C898DD70C0219181C938E95E677BA66B7A2EB71DF26E588CA36C8B819E7A57A545AA
2EAB6515DD98115CDA9C4B17A9F5A82FE559EEECED6F8E2220C92230C027D4628A726998BF7B4913
6BDA85BEBDE0F736D2ABDC2ED322118C1EF583AC2E95E2192CE09E5934BD5A380089BEF2C9D3B8E2
AE2F8774DBA63F622CB248C76A9246547AE6B5EC2CB4DF10430C37D66A6EAC7E542AE7A67AF1426A
3A99CD24BDD326DAC750D2ED937CE82F554889CAE41F4C8A9B51D61749974FD3DD3CEBCBA1E65C3B
7181ED5D03451DC6B4963E4A082150E541EA6B9BF18D9F93E20FED5670112DB6A28153BCB534A725
369335D9F4AF10DACB6813C9980D824069C74CBDD162B792D1D9953E56C01CD717A704B89229213E
631FBCAA6BA29356D4746B7555B8DA1B85575CE3DAA9C75B1A4A9B8FC2F42E6B50DC6A1A50BA9ED5

9F2C43C7DB1557468607D12E7EC71BC6B01CB2C99001EF826A3BFD5F51D474480DAB88E65726445C
10E2B5D34F9BFE105FB382DF6894798D91C9352A2D5EE436E31499876FAB436B14B6D192CB31DCEF
D029F4A2AA4D60CD7309915550AFCC33FC5456CA9A7A9BDA266688CCF24BB893C7735A3A9122FE20
090368E28A2AA3D0A36A055FF843ED9B0376E6E71CD55D3BFE3E13DC7345159F720875BE0DC01C0C
D63C9FF1E767FF005D168A2B587C237B33A2F1D331D434FE4FFAA3DEB2E2004D2600FBB45159FD94
4D1F819A56DCDBCB9FEF8AE9F4E55F25781FEA7D28A293DCA999D7DC8C1E9E674A8B438D0EBF2028
B810138C514525B07D90B803FB13543819F3319AC7F08F3E26909E736CD4515955DCC5FC2CC99091
6571C9FBEDFCEB12C7E6BD8F3CFCC3AD1457643A9D2FE147A740AA67932A3FE3DFD2976AFF00C23F
8C0C6EF4A28AE4EA35B991A9315B32149036F4150B73A5C79E79A28AB8FC4C29F523B6E645FF007A
ACDE80B37CBC7C9DA8A2896E69D8AB00DD770EEE72DCE69FA375917F844CF81D875A28A73F8472E8
69DA8DD19DDCF1DEA8924C1AAE4E7FD1E8A2944E67B31BA99FDCE967FE9D73FCAB3F5BFF008F743D
CCF8268A2A65B171DD1A9E1955FEC191F03713CB63934ED48EFBCB72DF31040E79A28A16E652FE2B
2F4200D6E518E89C7B55CD08017DAA9C720AFF003A28A27F07C8E7A82E8801D6B54620121C609AC6
F19F2D203C811D145547E34187F88E43C124FF006C119E3D2BAF7F9A21BB9F95BAD1456F5373A63D
0CA8C916CA41C7CE6BD1F4FE6C6DF3CFEEBBFD28A2B1A9B19E23A1C4DD28FED19C60604868A28ADE
1B147FFFD9}
}}}}
{\shp{\*\shpinst\shpleft6026\shptop10160\shpright10520\shpbottom13160\shpfhdr0\s
hpwr3\shpwrk0\shpfblwtxt1\shplid2049\shpz7\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4494}}
{\sp{\sn geoBottom}{\sv 3000}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;5;(0,0);(0,3000);(4493,3000);(4493,0);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;12;16384;45824;1;45824;1;45824;1;45824;1;45824;2457
7;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn13
3\margtsxn666\margbsxn253\pard\li4226\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li42
26\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Luzmila Troncoso y col.}\i0
\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\col
s2\colno1\colw5280\colsr-0\colno2\colw5813\pard\li400\ri0\sl-213\slmult0 \fs18\c
f0\par\pard\li400\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li400\ri0\sl-413\slmult0
\fs18\cf0\f0\charscalex100 {Tabla 4. Protenas, grupos sulfidrilos y TBARS}\fs10\
cf0\f0\charscalex100 {e}\fs18\cf0\f0\charscalex100 { en citosol}\par\pard\li933\
ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {heptico, fraccin posmitocondrial, d
e ratas}\par\pard\li1880\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {segn trat
amiento.}\par\pard\li240\ri0\sl-306\slmult0 \fs18\cf0\f0\charscalex100 {Tratamie
nto Protenas}\fs10\cf0\f0\charscalex100 {(NS)}\fs18\cf0\f0\charscalex100 { Grup
os sulfhidrilos}\fs10\cf0\f0\charscalex100 {(NS)}\fs18\cf0\f0\charscalex100 { T
BARS}\fs10\cf0\f0\charscalex100 {f}\par\pard\li1520\ri0\sl-240\slmult0 \*\tx2293
\*\tx3986\fs18\cf0\f0\charscalex100 {g/dL }\tab \fs18\cf0\f0\charscalex100 {(\uc
1\u956XM/mg prot.)x10}\fs10\cf0\f0\charscalex100 {-3}\tab \fs18\cf0\f0\charscale
x100 {\uc1\u956XM/g h.f.}\par\pard\li240\ri0\sl-320\slmult0 \*\tx1120\*\tx2506\f
s18\cf0\f0\charscalex100 {Control}\fs10\cf0\f0\charscalex100 {a}\tab \fs18\cf0\f
0\charscalex100 {
2,34 1,23 }\tab \fs18\cf0\f0\charscalex100 {72,9 27,3
0,036 0,005 }\fs18\cf0\f0\charscalex100 {(I)}\par\pard\li240\ri0\sl-253\slmul
t0 \*\tx2506\fs18\cf0\f0\charscalex100 {Paracetamol}\fs10\cf0\f0\charscalex100 {
b}\fs18\cf0\f0\charscalex100 { 2,22 1,31 }\tab \fs18\cf0\f0\charscalex100 {85,8

 42,8
0,038 0,006 }\fs18\cf0\f0\charscalex100 {(I,I )}\par\pard\li240\ri0\
sl-253\slmult0 \*\tx1120\*\tx2506\fs18\cf0\f0\charscalex100 {FHP}\fs10\cf0\f0\ch
arscalex100 {c}\tab \fs18\cf0\f0\charscalex100 {
2,27 1,28 }\tab \fs18\cf0\
f0\charscalex100 {73,5 30,3
0,040 0,008 }\fs18\cf0\f0\charscalex100 {(I)}\
par\pard\li240\ri0\sl-253\slmult0 \*\tx1120\*\tx2506\fs16\cf0\f0\charscalex100 {
Perejil}\fs8\cf0\f0\charscalex100 {d}\tab \fs16\cf0\f0\charscalex100 {
2,05
0,93 }\tab \fs16\cf0\f0\charscalex100 {70,4 21,2
0,031 0,006 }\fs16\cf0\f
0\charscalex100 {(I,I )}\par\pard\li240\ri0\sl-253\slmult0 \fs10\cf0\f0\charscal
ex100\i {a}\i0 \fs18\cf0\f0\charscalex100\i { Sin tratamiento.}\i0 { }\fs10\cf0\
f0\charscalex100\i {b}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: paracetamo
l}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {c}\i0 \fs
18\cf0\f0\charscalex100\i { Tratamiento: paracetamol y Purinor (FHP)}\i0 \par\par
d\li240\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {d}\i0 \fs18\cf0\f0\char
scalex100\i { Tratamiento: paracetamol y Petroselinum sativum (perejil).}\i0 \pa
r\pard\li240\ri0\sl-253\slmult0 \fs10\cf0\f0\charscalex100\i {e}\i0 \fs18\cf0\f0
\charscalex100\i { Media SD ; NS: No significativo}\i0 \par\pard\li240\ri0\sl-25
3\slmult0 \fs18\cf0\f0\charscalex100\i {* p<0,05: Test Kruskal-Wallis = I (Entre
todos los grupos),}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscal
ex100\i { Test Mann-Whitney = II (Paracetamol/perejil)}\i0 \par\pard\li240\ri0\s
l-253\slmult0 \fs10\cf0\f0\charscalex100\i {f}\i0 \fs18\cf0\f0\charscalex100\i {
TBARS: Especies reactivas al cido tiobarbitrico}\i0 \par\pard\li240\ri0\sl-413\sl
mult0 \fs22\cf0\f0\charscalex100 {encontradas en el grupo de paracetamol [
(85,8}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {M/mg protena)
x 10}\fs10\cf0\f0\charscalex100 {-3}\fs20\cf0\f0\charscalex100 {], y los menore
s valores}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {fueron
para el grupo del perejil [(70,4 M/mg}\par\pard\li240\ri0\sl-253\slmult0 \
fs22\cf0\f0\charscalex100 {protena) x 10}\fs12\cf0\f0\charscalex100 {-3}\fs22\cf0
\f0\charscalex100 {] (Tabla 4).}\par\pard\li520\ri0\sl-413\slmult0 \fs22\cf0\f0\
charscalex100 {La determinacin de las especies reactivas al}\par\pard\li240\ri0\s
l-253\slmult0 \fs20\cf0\f0\charscalex100 {cido tiobarbitrico (TBARS) o radical
es libres}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {del ci
tosol heptico permite en este trabajo mostrar}\par\pard\li240\ri0\sl-253\slmult0
\fs20\cf0\f0\charscalex100 {que existe diferencia estadsticamente significativa}\
par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {a un}{ }\fs20\cf0\
f0\charscalex100\i {p}\i0 \fs20\cf0\f0\charscalex100 {<0,001 entre todos los gru
pos (}\fs20\cf0\f0\charscalex100\i {p}\i0 \fs20\cf0\f0\charscalex100 { = 0,000,}
\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {prueba Kruskal-Wa
llis). Tambin, se pudo obser-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\cha
rscalex100 {var que al comparar dos grupos s hubo diferencia}\par\pard\li240\ri0\
sl-253\slmult0 \fs20\cf0\f0\charscalex100 {estadsticamente significativa para
la prueba de}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {Ma
nn-Whitney, a un}{ }\fs20\cf0\f0\charscalex100\i {p}\i0 \fs20\cf0\f0\charscalex1
00 {<0,01, en el caso de para-}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\c
harscalex100 {cetamol con perejil (}\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf
0\f0\charscalex100 { = 0,008) (Tabla 4).}\par\pard\li493\ri0\sl-213\slmult0 \fs1
8\cf0\par\pard\li493\ri0\sl-346\slmult0 \fs18\cf0\f0\charscalex100 {Tabla 5. G-6
-P deshidrogenasa, superxido dismutasa y}\par\pard\li413\ri0\sl-240\slmult0 \fs18
\cf0\f0\charscalex100 {catalasa}\fs10\cf0\f0\charscalex100 {e}\fs18\cf0\f0\chars
calex100 { en citosol heptico, fraccin posmitocondrial, de}\par\pard\li1680\ri0\sl
-240\slmult0 \fs18\cf0\f0\charscalex100 {ratas segn tratamiento.}\par\pard\li240\
ri0\sl-360\slmult0 \fs18\cf0\f0\charscalex100 {Tratamiento G-6-P DH Superxido d
ismutasa}\fs10\cf0\f0\charscalex100 {(NS)}\fs18\cf0\f0\charscalex100 { Catalasa
}\fs10\cf0\f0\charscalex100 {(NS)}\par\pard\li1360\ri0\sl-253\slmult0 \*\tx2840\
*\tx4133\fs18\cf0\f0\charscalex100 {(\uc1\u956XM/min/ }\tab \fs18\cf0\f0\charsca
lex100 {U/min/ }\tab \fs18\cf0\f0\charscalex100 {\uc1\u956XM/min/}\par\pard\li12
00\ri0\sl-240\slmult0 \*\tx2786\*\tx4146\fs18\cf0\f0\charscalex100 {mg prot.)x10
}\fs10\cf0\f0\charscalex100 {-3}\tab \fs18\cf0\f0\charscalex100 {mg prot. }\tab
\fs18\cf0\f0\charscalex100 {mg prot.}\par\column\pard\li293\ri0\sl-213\slmult0 \
fs18\cf0\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li293\ri0\sl-426\s
lmult0 \fs22\cf0\f0\charscalex100 {As mismo, en los valores correspondientes

a}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {la actividad de

la glucosa-6-fosfato deshidrogenasa}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\
f0\charscalex100 {(G-6-P DH) del citosol heptico, s existe diferencia}\par\pard\li
0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {estadsticamente significativa a
un }{ }\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,05, en
tre}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {todos los grupo
s (}\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex100 {=0,01, prueb
a Kruskal-Wallis).}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {
Tambin, se pudo observar que al comparar dos gru-}\par\pard\li0\ri0\sl-240\slmult
0 \fs22\cf0\f0\charscalex100 {pos s hubo diferencia estadsticamente significativa}
\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {para la prueba de M
ann-Whitney, a un }{ }\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscale
x100 {<0,10,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {entre
paracetamol con perejil (}\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\chars
calex100 {=0,06) (Tabla 5).}\par\pard\li293\ri0\sl-386\slmult0 \fs20\cf0\f0\char
scalex100 {Con respecto a la actividad de la superxido dis-}\par\pard\li0\ri0\sl253\slmult0 \fs22\cf0\f0\charscalex100 {mutasa, no hubo diferencia estadsticament
e signifi}\fs22\cf0\f0\charscalex100 {-}\par\pard\li0\ri0\sl-240\slmult0 \fs22\c
f0\f0\charscalex100 {cativa entre todos los grupos a un }\fs22\cf0\f0\charscalex
100\i {p}\i0 \fs22\cf0\f0\charscalex100 {<0,05, pero, se}\par\pard\li0\ri0\sl-25
3\slmult0 \fs22\cf0\f0\charscalex100 {pudo observar que la administracin oral de
perejil}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {(2,48 U/min
/mg protena) produjo mayores valores,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\
f0\charscalex100 {comparados con el grupo con tratamiento de parace-}\par\pard\l
i0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {tamol (1,73 U/min/mg protena) y
el grupo control}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {(
1,27 U/min/mg protena) (Tabla 5). As mismo, en}\par\pard\li0\ri0\sl-253\slmult0 \f
s22\cf0\f0\charscalex100 {lo referente a la actividad de la catalasa, no hubo}\p
ar\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {diferencia estadsticam
ente significativa entre todos}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\cha
rscalex100 {los grupos a un}{ }\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\
charscalex100 {<0,05, pero, se pudo observar}\par\pard\li0\ri0\sl-253\slmult0 \f
s22\cf0\f0\charscalex100 {que la administracin oral de paracetamol (31,82}\par\pa
rd\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {M/min/mg protena) produjo lo
s mayores valores}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {s
eguido del grupo con FHP (29,93 M/min/mg}\par\pard\li0\ri0\sl-240\slmult0 \fs22\c
f0\f0\charscalex100 {protena), presentando los menores valores el gru-}\par\pard\
li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {po con tratamiento de perejil
(28,46 M/min/mg}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {pro
tena) y el grupo control (28,07 M/min/mg}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf
0\f0\charscalex100 {protena) (Tabla 5).}\par\pard\li293\ri0\sl-386\slmult0 \fs20\
cf0\f0\charscalex100 {Macroscpicamente, se observ una ligera}\par\pard\li0\ri0
\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {palidez superficial en los hgados de
ratas tratadas}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {solo
con paracetamol. Los hgados de los otros}\par\pard\li0\ri0\sl-240\slmult0 \fs22\
cf0\f0\charscalex100 {grupos de ratas permanecieron sin alteraciones.}\par\
pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols3\co
lno1\colw2733\colsr-0\colno2\colw1266\colsr-0\colno3\colw7093\pard\li240\ri0\sl400\slmult0 \*\tx1213\fs18\cf0\f0\charscalex100 {Control}\fs10\cf0\f0\charscalex
100 {a}\tab \fs18\cf0\f0\charscalex100 {
5,2 2,0 }\fs18\cf0\f0\charscalex100
{(I)}\par\pard\li240\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100 {PAracetamol
}\fs8\cf0\f0\charscalex100 {b}\fs16\cf0\f0\charscalex100 {
5,7 2,6 }\fs16\cf
0\f0\charscalex100 {(I)}\par\pard\li240\ri0\sl-253\slmult0 \*\tx1213\fs18\cf0\f0
\charscalex100 {FHP}\fs10\cf0\f0\charscalex100 {c}\tab \fs16\cf0\f0\charscalex10
0 {
7,8 4,7 }\fs16\cf0\f0\charscalex100 {(I)}\par\pard\li240\ri0\sl-253\slmu
lt0 \*\tx1213\fs18\cf0\f0\charscalex100 {Perejil}\fs10\cf0\f0\charscalex100 {d}\
tab \fs16\cf0\f0\charscalex100 {
4,0 1,6 }\fs16\cf0\f0\charscalex100 {(I)}\p
ar\column\pard\li0\ri0\sl-400\slmult0 \fs18\cf0\f0\charscalex100 {1,27 0,6 }\par
\pard\li0\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {1,73 1,0 }\par\pard\li0
\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {1,37 0,6 }\par\pard\li0\ri0\sl-2

40\slmult0 \fs18\cf0\f0\charscalex100 {2,48 1,9 }\par\column\pard\li0\ri0\sl-400

\slmult0 \fs18\cf0\f0\charscalex100 {28,07 16,0}\par\pard\li0\ri0\sl-240\slmult0
\fs18\cf0\f0\charscalex100 {31,82 18,2}\par\pard\li0\ri0\sl-240\slmult0 \fs18\c
f0\f0\charscalex100 {29,93 14,4}\par\pard\li0\ri0\sl-240\slmult0 \fs18\cf0\f0\ch
arscalex100 {28,46 12,4}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\mar
glsxn666\margrsxn133\cols2\colno1\colw5413\colsr-0\colno2\colw5680\pard\li240\ri
0\sl-400\slmult0 \fs10\cf0\f0\charscalex100\i {a}\i0 \fs18\cf0\f0\charscalex100\
i { Sin tratamiento.}\i0 { }\fs10\cf0\f0\charscalex100\i {b}\i0 \fs18\cf0\f0\cha
rscalex100\i { Tratamiento: paracetamol}\i0 \par\pard\li240\ri0\sl-253\slmult0 \
fs10\cf0\f0\charscalex100\i {c}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: p
aracetamol y Purinor (FHP)}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs10\cf0\f0\ch
arscalex100\i {d}\i0 \fs18\cf0\f0\charscalex100\i { Tratamiento: paracetamol y P
etroselinum sativum (perejil)}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs10\cf0\f
0\charscalex100\i {e}\i0 \fs18\cf0\f0\charscalex100\i { Media SD ; NS: No signif
icativo}\i0 \par\pard\li240\ri0\sl-253\slmult0 \fs18\cf0\f0\charscalex100\i {* p
<0,05: Test Kruskal-Wallis = I (Entre todos los grupos)}\i0 \par\pard\li240\ri0\
sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li
240\ri0\sl-293\slmult0 \*\tx1000\fs20\cf0\f0\charscalex100 {338}\tab \fs18\cf0\f
0\charscalex100 {An Fac Med Lima 2007; 68(4)}\par\column\pard\li0\ri0\sl-213\slm
ult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-426
\slmult0 \fs18\cf0\f0\charscalex100 {Figura 1. Hgado de rata sin tratamiento. No
existen signos}\par\pard\li120\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {de
necrosis. Los hepatocitos se encuentran preservados.}\par\pard\li680\ri0\sl-240
\slmult0 \fs18\cf0\f0\charscalex100 {Coloracin: hematoxilina eosina, (40 X).}\par
\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\pard\se
ct\sectd\sbkpage{\shp
{\*\shpinst
\shpleft1360\shptop-853\shpright5880\shpbottom2146
\shpfhdr0\shpwr3\shpwrk0\shpfblwtxt1\shplid2094\shpz0\shpbxpage\shpbypage
\absh15866\absw11893{\sp{\sn shapeType}{\sv 75}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn pibFlags}{\sv 2}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn fEditedWrap}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn pib}{\sv {\pict
\jpegblip
FFD8FFE000104A46494600010100000100010000FFDB004300080606070605080707070909080A0C
140D0C0B0B0C1912130F141D1A1F1E1D1A1C1C20242E2720222C231C1C2837292C30313434341F27
393D38323C2E333432FFDB0043010909090C0B0C180D0D1832211C21323232323232323232323232
3232323232323232323232323232323232323232323232323232323232323232323232323232FFC0
00110800D2013A03012200021101031101FFC4001F00000105010101010101000000000000000001
02030405060708090A0BFFC400B5100002010303020403050504040000017D010203000411051221
31410613516107227114328191A1082342B1C11552D1F02433627282090A161718191A2526272829
2A3435363738393A434445464748494A535455565758595A636465666768696A737475767778797A
838485868788898A92939495969798999AA2A3A4A5A6A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6
C7C8C9CAD2D3D4D5D6D7D8D9DAE1E2E3E4E5E6E7E8E9EAF1F2F3F4F5F6F7F8F9FAFFC4001F010003
0101010101010101010000000000000102030405060708090A0BFFC400B511000201020404030407
05040400010277000102031104052131061241510761711322328108144291A1B1C109233352F015
6272D10A162434E125F11718191A262728292A35363738393A434445464748494A53545556575859
5A636465666768696A737475767778797A82838485868788898A92939495969798999AA2A3A4A5A6
A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6C7C8C9CAD2D3D4D5D6D7D8D9DAE2E3E4E5E6E7E8E9EA
F2F3F4F5F6F7F8F9FAFFDA000C03010002110311003F0065942D6BAE992FF4E473140CCD123EDF27
B0606AC86FED1F0E936D1811C4DE5C211C300739393EF547C4B0DDFF006387B097CF86ED8C335E2B
1EA3F876F61EF51F852FEEED27BEB59A358A3F215CA326DF9C7A7AD6F1A2F97539675B9A49A7A90A
5CAE48B98B3B328C0373F8D6D2E9F6B388A381CC90C9106922C9C9C7A1AA70DCA43348668220D27D
EDE7D2AD59DF5ABB2BC518B79E373860D9CA62B9D46299D35A53946E9166EEEA199A784D9C914B34
5E579E5F2580E9F2FA563EA106A9069EF7363A97908AA776E8C3871E9CF4ADBBC964BA940965134C
8EBB11400594FBF4AE5F50D4751125DC373262DD65E23E02B027A5675E4E3176270EB9AC49E1EF10
CFF6AB0D3642905ABBED790F5C9ED5D9F88B517B196446B342235DB6AA5BA8C72D9AF325302B3B47

1B3C6F200B1A839CE7AE7A8AF46B1FB46A3A04D6DADDBB472589F96573F7D47B8F6A5826F95AB118
C51552324CE39A76BB9A396CCA41207FB927273D9AA5325DD95D3AF980497583249EE3B8A8AFD967
916F22882963B02FB67B56AC7729F679595551F01195D7381DC8AA97667A29AB2691976B1433DB5D
5EDD44D7C911CA202554313824E3B56B473FD8EC62D46CAD8B451CC209A00E76827B83DF15434999
74AD59663148D660950E8728C0FA83D7F1A9EEEFEDB51FB359E9F03B242E59A5E63CFB815D09C790
E0A919BABB68691984B77F669217649B70F20B7120F5FA8AA9717AAD345A7C10C97D041B516490EC
31F3E9ED514DAC4763A8A34E82548982AC89F2EDCF53F5AE834568AEEEA68D637689D77A5CF467F6
3E82B3A493DC75F9A0AF6218B4D060BA89A710CD83B372E71EE2ABE97A6D95A49343777325D5C140
88D226C48FB8240EB5AFA85D6956BA97DA45DA65517F740162A7B1F7A68F104650497118B88B2024
FB3186EE08C715A3847539D54AAD791CA2DE336A57569AA02CF13845B88C6402381F28AB52437DA7
0996280309E23126C6FE33D0E7EB59D731DAD9EA37B8BC92E15E51B9E288A6C27F871EBEF5AF6569
736E8B6B17DF405A08DDC0DFBBB827D2B86151F335247A1292493898DA879C237825044B6CA04A0E
3233CD312DA496795D6E1D1E6838C0C6E61C003EB56A59A2D42E234BF516B7F2111191583090FA11
EBEF54924BBB5963B4995C0B5DE14F7F63EF5B42517B335D5C517F46D5E6B7B1934FD483DD5849F2
344EF868C7F781F6ABFA9235D78674E6004F756B72D6D2CE3AEC39DA71D3A639AA7A5016F6EF72D1
10246C393D97AD5AD2B5178259204B602CDD184A84E4853D0FAFE55AFB46D38B39A5497373C56C67
BB4BA55EDA4D05B83776A1B60DE30CA460AB7BD4E34DB5834D171068A34F8A5DCB713BDD6F767EBB
00E95149A5DB5A3C4125124570C766E3CC8724F27B115A303489E11BE70EBB5EF63452BC989B1CB7
BD14EA4ACE22AD08C9A998F1B4BA8471010C8268D3680AB80ABDB9F6AB92B3CF349E5956740A083F
75980E453623776F6D2C2672927987721E4BA9A6DB36C882C6AAA8C77E49C92DD38AE77ABD4EB4AD
B090584C52E6580C6EE804A63538D8FDFEB5B76D7FF6811DABE609651C9246318E9ED93595A7EA2F
6322CAF6E91C59CB36DE4E3AF153EBB6A45F4D299559D955D625036C887A306EDF4AD12B474D8C2A
4B9AA72CBE45132C105D477E6067FDE1531A39187E9C1AD31309EC63D3AF4B996E55A48094FBA3FB
A4FAFBD57296B737F6B0EF10A22A931893703EB53CF0BC78BB8D583412168F7F3B931C003B544744
C73B3B231ED634B19EE48731CA9B040D9C85078391DEB43545B64D37E5793373B59A400812607A76
AAE9A95F472E679639A293A31880213A1FA55B1746F6479A288C516C113A83B8E0F4719E9569E964
5352E64D9480D36E5DE7B82E44676175CE578E0FBD3F49D2EE2CE39D6C2E1C19233292D0863B01CF
524D442CD60B7556FF005826DAA85F2193D73D055CD3EED6297F7938B67563145E5A92547F167D69
D29D9DAE4D78F346E8CD6B5885D2BCD721E4B960E0904963FD2BA8FECFD36C04B12DF4AB3C6A3E75
C9553E954F545B6BB92C63561191202D850091EB55EE63417D24E01368EA510138F308EA7F1A5CD3
57D0C1BE7495EC437F6B34E1EEBCC1C305DEABC05EC6B39E326668629CB2EEDA140DC4E0E735A275
286E6F97C99418C6DB7FB294C0C7A934E792CF4FBAC08BC9D4210515D1C91927AE3A74A4E09EA6B1
AB28A5168C6309337DA181085B283FBC7A67DAAF7F6BB7FCFAA7FDF02B72DEE34D5B74922B778E46
6088B22EE0F9EA7356FECEBFF4043FF7FA9FB2B697337889276E42BD8A5C596B56B1697119D04A63
B8567EA9FDE20D5BF13450A9669D45C4AD28F20920607FF5AA1865BAD2EE0EEBE8D43108D108B716
1EB9EB504BABC53DEA5ACB64B70ECEA0066DB8E7B576A9AB58F39C25CDCC919B71A75AF94B2DD4BB
4B233614E79EC0FA553F2556DDE58A5699D14103A122AFEB1049A67886F12D55210E81515B0C1D8F
619E959F6134934E18C063911489027471EFE95CB385B53D2A5579A3B9621981691248638C79588C
127233DEAC5A2DB5CD98B992D05DBC7F2B44C703CC1DEAC59416E9771CF2A09DA089D95738193EA7
35980DEAC865F2C448D96200CA81E84D24DAB0DA52F8741F178B2E7ED3E58962B3B958F736D83383
E95D668572BAD786A48B529E375949DAEA3195F71D6B8EB7874FB9D5E29EEE468EF233C79684065F
535D2D8DC45A7692D3948A275CBA296C9C2F735D6A71B687057A4D689146EBC311DCC32A699740C9
692ED789C1DCA07A66B9EBF86EE4BC996394808B863D093EC2B56CB52BCBDF18AEABA748E219110C
E171B1BD460D74BE22B1FB56A2CCBA7A4E5E0C9CC98298F4F5AE76A3595E06F4EBCF0F2519BBA387
B29E5905AC97259228DFE65071B80ED57DB50B6BBB9F3A6B7DAF2B3206DD8D8BEBD2A7BDB089563B
3B5997748A27247603B5549F4F6B983CF865408A0076C727D7E95838B4EC77C650A8B9CBD6CB6DF6
09A0BBB5F3163C2039F99CF66AB4257B79A69EDBE5F930B19FBDB4D655FDCA5A85FB246CB3145219
8EE0B9AD0456D55A59B71116040D311819C67E5AA5B68653875E867817115D998398E453B176AFDD
CF7153DACAB1D9C422FDD4ECC4CCDCB7998E41C74A9AE2C96448A178D9761FDDCA3B8EE08A2D6E25
512A4AC122671B78CFB62A114DA71D10CB29AC755957CF26C7500DE5B4A91EE49FD091D0559F1269
B7B796D14B19CC567280B205194E3D075AC986568CDCC6BB319C636F1C1AB9637F2072F6D3FD9C86
1232E32A7D01AD172CAF16655694A2F9E2655D59DEDFCAB3CF119D9ADC6582EDDCD9EA16B42C6D45
D690D7D752ACB73A73B47730C4C72A9D9B70FBD8AD9D53C4B26996A62BA991F50625E275E4C4A4F0
091C115C95ADFF008A3C34DFD9E0C09E712D31910310879C7E3594214E9D46A3ADC14AAD482BE963
78CC2F2D0A1255382507191DB1C77AC396E26F395C488589D9B147239E95BB38B2BB9D0D9C0CBE52
E671B801171EFD7F0ACFFECE4BE5DF6056692DD8B4EBF7491DBFC8A2A6AF43A68D927CC8B1E6450F
912DCAAEF2E7742391BB1D78E94E8A6974DF08DC888A3C93EA0AB0FC990A36FE46B17EC0F1585C5C
489F676CB32C9F7B7003A1F4ADDF07DD6E11DADC8592DAF515DA1C86DBC63767D69D094F9DA7B331
AFCAA378F410B37DA53CD43186455C2AE5CE07526A8EA1E56EB6692316F1FCC07944923D0E6AE6A1
68D67732A7998B84240041F9D73F29FCAA3B251359CF04AF1A98E30648B19C01E94E5177B335A538

F2A9A29D834D25EDB4F1317110D9890850F9FC2BA1D210EA0F2685ABE98B042A0FD8A48CEE2BDC8C
8AC38E68CA4D1DC3A79276B0918FCA87D001CD6AD96BB2C1A65CDB6906299F6EE86161B4AB77396E
A0D6946518AB3D8C31719CBE14519747165AB4368C665B80BFE8AAA9FEBB6F525BB66ABCB73F61D4
6392E62646964D85339E076AE87C3FE26BAF10DB5D5AEA022B6D6AD5B30C6C300291FDEE879AADE2
0B595F4D6B898813C2E54E06707AE411D69D4A568DE2CC68D792A8A150C0B9D4A63334684B41F70A
A004E33E9D69F6933E972ABEDF2A6902A8B571C153DC9ED5068B1482E6F9AD0096FDE0D96448E431
E4939AD037227F0C34DAA4AF3DFC722C51CEA3E691BB8E3B0AA8D08F25EFA9B54AD28D4E5B685DB2
B7B4B89246607693B5A1E9C75AAB12B9B60E6218883626738E33C6053A396332A3D94CD349210244
D983D390334E58879AF708258943986343F307EE4D73A77691A59ABBB8B9937BFDA1048AF119236C
8CA91DFF00FAD5932F9F7AAF86678633B634E9D7BD74373034905AC676A5C6CDF22ED0093DB03350
24096366F777F8292710A1F90C83B11E94E716D914E4AD77B999069EED7E8532432A9C9381B81CF2
296EAE1D352BCB89200F6F2380B2119098EA315711C295B85B15521849BE2909154DED0C76D3461C
B48493BB38073E94A57514D1B45A73BB191DC3DDCE23B68DE7400F9685B00B0E4E3E94FF00ECCF15
7FCF583FF1DFF1AAFA5422432A4D28B792F2D2586D5DCE177F4E3D2AA7FC2AFF00137FCF2B7FFC0A
FF00EBD75428A714D1C988AEE9CF9516B50BCBE89A2D4E3708D710AA962A33C53EF424EDE6BDAFD9
D2C914A4C8F9321F61595AE197C8B485A35F32DCEC48D4E7E84D56B596E5EE9ECAE61F358C81832F
0723B0ACA4ECEC8D60B997A1D069DA84DAB69D77776F248B751E5A48A58811B874218F7ACFD1352B
85D416C2FA163797248670D851BBA822B4ECB4B1A841225A4F241FB92AC8E3EF38EB53E9B35B5A4B
1DCB8C5B263ED042EE25C7A1AD6734E3639E30E56EC416F6DE4EBB71657801C40C63456E08EE38AA
13EA8FE54505A095159CF9716FC9702B4ACD6D6E35C377A78695599CA12761542B8239AAA621697A
2D2E665B65922DD048002622BDF3594757637E651D6C457773F6889AF2F19B6AEC0B26EE304700FD
2ACE9D7B288E5175701379062774DC241E9F8D57B9D4AC6E5650D0A8BB030B31C94723AB15E83E82
9B6F7131D0916ED774AB237921460B2F60455548A83D0BA72F691B4D1D1593209A6FB3DBAF9C533E
503C447D7DEBA74BFB6B4B0FB4DC4EB772A1CC683E561ED5C0D848F62D1BA82CC086762704FA0FC2
B72386CD642618CC172F205626424C84FF0008CF4AAA52E55647262287BC9935D5BDC3E8D3496FE4
B5D4CA5FCA400328FEE827DAB94D24196768E397F76E37794AB9CF1DEB55A396CE496399089E190B
10DCB7E07B8AB76DBD5279FECF88A45F902808D9FE958D44E52E63A28DA9C2CCE6845A8EAFA9C165
6E0A5C4877138C8441D4D6CEAFA5432411431F8855CED2CAB2A10491EC2B2752D42E6CF4E9628A6F
2DA7511BC89D5573D41C55DB5D41745B6F26CEE6D99204DE2F9CE4CB91CA2A91D7EB5D145C1C48C4
7B5E75CBB176C3ED3AE43613A5C470AA011CA5DC06254FF5AB9245776974AB3445DA5624600C023A
73587A4C314F6F76F720143134AAE57F88FB5416E5E0B658AF6491A199B3BCB1CA0F602B06D27A1B
72366B4F0F9B2CDE6464A2CBF317F97E53C9AA335D88D4C56C8A2C412A71F79B8E39EB56D27DB1C0
649D8D84DFBA9DDD3279E067BD43AA69E2DE19034CAF2E48450323A706A5F745C1A4ED223D16FF00
4E8600751859E26021C2A92C83AF6FE756AF9AC35B997C8B3B989D7F76B72EE4F9E17B6DFE1ACA96
29608C31BB0B9882A3797826A6892682385ED2EA4912221914700C9DC53BB5A214A945CB9931242B
224972FB7CA8FE558F92383C827D69A86C74F8643716CD3C8CA4446394AF96DDB38EA3EB5A5792FD
9EEE5492D847E60DC90939F99B939358F2FF00A4DDED8A20CD2213228C1247B7BD62D3BE87445F34
7537748F115C2E9D1010A4B194613C61B7923DFD3F0A9A27B8960B2BDD2D20D3ECADA4CC90E325DB
A9EBCD607872D6E2DE5B8B80FB95C1C40876B3A8EBC9EFED5627BB5BCD32FDE0F3238030DA5CF461
D6BA53925E6714E8C6536E2759AA5FC97B7467827DEAF6CB2AA320053771D7AE2B0ADD64B643A82D
B168BCDD9E70E8C47622A1D2BC4563796C74CBBBE115D26DC5CF964EF455E17818EB56B51692C48D
225BA2F68AC2E92464DBE6B119C0F4A9A8A4AF262A3EEFB8CCEBA41797576CE48F972015CE09ED8A
AF24B3DC5D25B940C9101955182D83DAA6179959615B6C5D1C6263C679E722A1374B04368F0890CE
1986E61CFD2B915D33BD5EC69CD7D6D776EB6D7BFE93114D859548DB93C0C8E78AD28AF6DA3D3574
CFB42CCA32AAA09529ED9F5AE525BC8CC50A42B2A80E5F96072475A9FF00B4ED3ECE6490AAB5BB83
809D5CFF001671827DBA575464DA392AD086EF425BBD26D9233F6E86558D1F0B731CF92A0F43C7A5
35B4EBAB89D6D1DA47441E644EC768C74C85EE7EB56156348A29D1B7BCEA7728CE383E9EF5622B83
2228790828C225629D07A509BD90ED6F790D8ECBEC2E1A0BA1773BAED4891304377E4D4A2DE5516F
64CE4CA3E77DAD81020EA09FE226A4BD716D310238DC919C29C37E154CBC717996F66CFE74A9FBC5
DA7E4F4C9350EE9E83579ABB64D6BFD8BABF8B258F558E7490A85B084B1DB263A0DC3D7DE99AE4CF
6B347A7C88D0CFD76A7CC107719F41573C3160D63726F750D4629022822DA24C36EEC01AA1AF5FC4
35A0EC6590312D2C61B05463A66AE4A4A9C53DFA9852D6BE9B1761B99A2955ADA3FDD9521D940618
1D69248643F6786E324EEDEC146307B0FCB9ACA8AE0A5D453DA4C2DFCD8C8604E4E33C569DA34FBA
5999FCC878DF823E620E41E991C528EAAC6D38B8BB999736115F5BB87B970C9968408F86FA556F32
6FFA7DFF00BE87F856DDC40E2F1EE91D7ECEE7747B173DBA7B549E437FCF45FF00C7AAA2E51564C2
528BDCE240BAB7995C80A036D2EFD4D5FD3963B7BA0D966B84C9478FE6193EB5B3A9F8726B388ADD
48970C08DDE49C88F3F5AC9B5B76B7BF778A758A34192F20EA29D48352152AB09C342D1D41A5B560
D282CB2648718DA1BAE6AF942D15B594988E3951C33C2D95231C7E359F15ABDEC173232B5C073826
15E3F1AD9D0748796C27711BA2C40E15FBD52A7296E6356BD382D1989398EDB4DFB38B3BC7DCAB0B
4A8B92A376326B67C4DA4347E54F6AAB3C12DB2C014B670475E9DEB4A464F312EB5B96D2CECA38BE

685E4C4B31EC154F5ACE87C4365ACC06DADACB52B3452440CEB819F534E4A304D37B9CEAACE72524
B447353A048CC0F6EC42B8F2D01DC10FAD6E5B5A470D849B24692E5A6C8994630BD40E7A1A66A10D
D0B7499040CCA71E682374833D0FBD5BBFB88F4F963B55657B898290879038FE7593DCED9CAE972E
E578E6923B20E7647B9D8B31C927F1F5A905DCE74EBA88C4A04AEB2C6C7EF264FEB58D335EBDD398
E39D91C37C8C70030EDF5AD1D3B5386692492EEDEED3F742084C1183871DF9ED4479B9ACC2A43DDE
65A91EB378FE75A59CB334B711B908BB7E6C11DEB42DD659EC8489107053CA9771E2339FBD5A3AE7
86A1F109B0D422BC4B7BD5454942BFDE23E9DEB15ECE4D3ACE5885CDD4B023FCC33CE7D0D538494A
C66AB539C177463C8F71B55642A6256312374EFD4D5BB98B4C4B41732046911547EEB9566AD2D521
87FB3EC6630CBF6A939F2C28202F5C9151FD9ECE47541064326EDB1AF1EFF2FF005ACDC795D8EA8D
78CE299268C11216937AB428BF300793F4F6ACABD779668402AA6295A45523057DAAF3DAAE964066
5667F997C87E36FA1155AE996FAE62FDEA2C92EDDEEFC01EE294D974D272E62482E6309341179720
98B1DADF7547F8D2ADBDB1B71F60F3449B8B1493E625BD07B543169FE5C682DDD0C803BB2E46319E
B53DA3C5A74823B8976CD3444E02E4A73C73DA9477D453518EAB72262C5FECF1C44A3632CC0E73DF
1F4AB76F7B2A086DFC98E4577CC6C060123FAD1A7D9EAB2EAA81EE6CE2B761236D90F2DC7F0D6945
A6DA456FE6FDA4EF401D54B8C06AB51BA31A95A11F7598ED79279F2B5C32C85E43B97771CF1C7A56
4EA2BF65BF8A68AC0A35B7CAFBF8C7A1AE92F7469A6D19675B740FE69DE6319073C8ACE820B9B9D5
162B91E684994CE01C92A78E3D69384934694AAD392BA0B39FED36F7B77709712F9729DAB14631B9
BBAFAFBD4F77A7CED2AE9D6B6ECE87929C6ECB0EFED5A69A63477AF02E238A090F90A1F0198F4CF1
52EBD3B5B3EC85D0DDA14133C27AC9DC67FA574B92B5D9C5ED5FB4F73A9CA6A5A118347FDDBAB44C
DB58FF000A9F41E95B1E1FD4E6D56C7FB16E9A29E68103D9E782EBD0AB9F5AA7E75DC9FBE8645788
CC62288DBC13EACBD87BD411A3DACC63922482E508918C07923D41F7A94E56F79686B2519AE54F52
6BAD3676D696031CE8B149B9E674390073CFB550FB43EA52AE637059D9FCE45FDDE33D7DABAE36C3
5C974FB980849CDA992EA3DDB7207A8AA175A45C0574495614DDB4C39DA1907F773D7DEB3952B6A9
154B137F764F5392920325CDB59B0F3229DC06950FCC173D41AE9D753BCB5D4EEF4A92D618B448D5
8EE31102489470E1FA67355E6D1DBCC258AC459C0899480594FF0077D699045A8DDE9D77A74B7D6D
2DADBCEAAE90AB1982FA027A29F4ABA334A3CAF464E2939B4D3D0BBE1CD05E42976259BECE637950
27232725403DF8C565C570AEC277122ED720A6300FBFD6BA0592FADA0B8BFB695228FCB36F6F00FB
9B8F70A3A102A8A58C92E9F69710EDD914787E48C1CE7E6A8A8AEEE8BA52E54DCB543C5C14B74892
565281544928E1831E71F4A6871A699D16F1CA9C64BA6430FAD3A7B10B1299648E3953F780119073
D1571DEAA5FEA22E62114D6D8F2CF25170001DB159B6D1B43DED23B0AD7E6F5A2408A046A77AAF5C
FAD5192D5AED96E558B1231F8FAFD2AD6FB758A19A2571BFE76CE0633C6DFAD116A30C532186D982
9E319CF1D295EEED72D45457BA848D2EB742EF032A88F01D06718F5AD833AADAC69E6EF7990CC42A
9E63E807BB55669750BB5C44512077EB1939524E3E6FEB51DDC93433FD8E04CC56DFBA0E33BDBB97
FA66B48FBBA9CF34E724AE2EE9ECAEC48A5A3270BBF1BB6A8A5FED89FF00E828BFF7D0FF000AA0F3
4922347E77F091C3723EB4BF646FFA67FF007C54D9B3754A36D4EB356D1CEAD7705EC9711D9452C8
AF3234BB7CCFF1AA77DA7FDBFC416D656E6CA48D6432CBE5B64851D01F4CD739A1F88210D1683AEC
7717568587977879287DCFA5743756E741B6BCB48E0B682DEED4F957A5FE77047AD7A0A5192E63E7
9D3AB0972773AA55D3AD266D3618A38CCCA1F2000BF9D56D5515AD920B590C6FDC467A8FC2BCDEE2
DC5D5A8B65BF93CB8C8604CA403F8D741A05DCD63AAC72EA2E8B6905B84B708F9323E7BE6B086279
A5CAD1A54C14A30E643FC41E0F9FC4960FB2559AF6D4AEC4638C81F8706B234475B516B6B3B3B5C6
F911A3DF9DBE80D7756BAF69ABA8DD8B854D3EE950305B8655593D31CD70B6DA6DEDBF8923D49AF2
C255BE919FCA89CE1188E95862E30E68B4F53A308E7CAE32D859ADFF00D2D8411394DECCE84E703D
452DEDBC3A9797721A486EEC5439247FAC5F6F7ABE970EB308D564FB66E2BF27DD00D2CCBB619BEC
21EE244C2C90DCAFCFEB918ED4968EE7637CD64F7322F3569EEF518E29E0952368C80C3E5C123EF9
AB7E1EB66B8836E240CBB9FCD95B3190BD49AAD72D6A96C2FAF6195DA405762F5CE718C7A56F5C5A
5CE97E1FB3B48A2DF2DDA892EA40B831A1E8A95718B9FBCFA0AA558C57227AB1D61ACDCDDDDA5B42
88517FE5BC709C16FAD5CB4D7750F36ED0DAD8A451F07CE88962C7819AE46C511AE44D6373749701
8AAA16C0C7B8EC6B4AE2386D7507BA5BC7B896465F35647CAEF03B528D56BA913C342F646FCD7F65
AAC60EA9A54B35D5BE437F66E329EE4139C556D0F4712D94AD6B725ED54B18AF4B7EF91B3CC6C3D3
DAA2B2B59A69E6983CE4CC5333C4C463279C9C738F7ABD6FA4DC2DA5EB437F6B24525DE6348E6CB1
DBC640FEF56D1F7A5CCCE39A74D5A2CC8D62CAE8EAA16658D6358C6D60A72CA7BFB5615A69F3CB7B
783CA0DE5C7E626FC95033D315DADF21BF0EF70F309D3E52235C00074C9EF9AE7AFB47D46E2C66BF
B48278D21C34815594C8A3FBA2B09E1EEDCA274E1F15CB1B48834E65B76066020006C1BD7AFA0355
EE75072024D6B0B7011A68E33CE39E4FA555BB692E348496486E77190EE7618E7B0FAD5767696ED9
6D6491447B77865C26FEEB50E0D2D743D1A6E32D4DEF0B96B8BBF2EE44724962CF2DBE0E439F4AE8
E7BCD1E19E17BAB79CCD738468E35000723A60FF002AE66C92D34FD72DE71E7EF784C8A131807B8A
BDA8DBBEAB7D6BA844C61668C48F13B7C871FC7EC6B54E5C89A3CEC4C20EAEBD4EAD23B6B68E57B4
3345E5FCCE27C636FB565DF8B236525CB5AB799E606865880591B8F515913EA17AF035BC685DE46C
869813B87B5561AEEA8CAAEF042F167CA65F29B6FE1E956EBC5E8CCA3829DB99136B56EB16896DE7
9BA591EE43B90DF31CFD2B2EE2F963D17E78DB62BB3A9084C8CE7B939F4EF5B535DAEA0F228499C4

7845440372F1C9193CE2B2E486636D1C334A92E093E5AFCA44607F10FEF7B5733BFB4725B1DB4636
8F2BDC7697AD4123B69D696AD6A860669AEA28773C8CDE9EA077AAD7524D6D7D6515AC71CF35BDB2
C6D3236E2F9EE6A9D8A9DEAD6B2CA1C8C041E84F207715A0F045E6DC0863648A34FDDEC6FDE9C74A
E99D5BC6C11A0A1539BA1BFE10803BEA978B34C59E230B211C96273C1ED59B75A83FDBBCE4D8B284
D8A2750503F7EFD0D58D2EE1B49F0C5A7D9E10EB79A83B07FE268C2FDE359979FE93E69DA1636265
D853E61CF1C54D76E29246787873D594996DEF481245F655BABB880936C592B18EE57B8AC68EE664
BE32C32AC321914C8F2705C0E3923AD5C89DECED22B8B76FDF9665925CF6C71D3B5535B8FED0B636
B35AC4015237A47F393D7AD72CD3E64D6E8ED8D38D9A3ADF124BA62E82977A718A59D8ED1B589DB2
8FA7B573134DA9CDA759ADDDAADB379A4E14E05C71D319EA3BD74FE1FD3EDADF4C88DE9915AC6E0D
CB6F8F3E7230C0FA9159DACE9773ABB436F0C41628CC971179BF2B65BB0F7ADE709CA5EA79F4E71A
778F443525BFB75B2B8BE80DB90C414484AE107720F7ACA0B235C175752EAC4BA33F0E0FA0AEC134
76B5B2B7D3AEEEAE256F244A669E5F98647426B9E9F4A5B09A46924858C7CB60FCD8F51ED55529B8
9BE1B1319B7DCCA94CED6AEB6F17C8AF92C071C5431CD23DDC73B811955398D46302AEC2B2091813
2796E49006467DFE952FD8EDA3293B6F5DF905247009FA66B2715B9D9CFCACD1F0E15FB44204876A
4E2431920F98BDC63B9AD5D6B49BDB3927BAB789EE61326E66B7199117A60AFA565E906C4EA0B3FC
B68F6AE9E6176F93613D88FE2AC5F11DBEBC9E257D5AC6E6EE78EF25255AC6562303A2E01C1F7AED
87238A4CF26AA9FB7BA7634A5D3A386D9E56F2D4E7CC52180F301ED4DFB63FFCF8DBFE6D52DFC625
733DCA1492245665DDF2F239017B1AA9FDA16BFF003F573FA560DD99D94DB71BB32ECEE1A678E316
41B68F2DE151F3EDF5AE875022E3E1E697F6BF34B25E796A64392ABC8009FCAB985D39AEF5295E0D
456DF6A31505B12391D81AD0F0D5DA5EDB4FA1DF094C378736EC4FFAA9C723E80D6D084A37B9C752
719DA51E857BCBC57BD48E2461128D9803AD4D141AA5ECF1C96F665A0C9547930071CF1EB58F2A5D
BA4D1DC46EAD03952A9C60835B8EB75E23D011EDEE45B25AC819009B6AA7B63D4D674A9A6ED23A31
156518271D99244C9ACEAF14F71224B730FC92C320E47A1515D4B785EC934969E7BCB8F38C9E6C72
8902043E840AE36E9CDAEB76D7B6EB1CF3A05594C58C93EF8ADDB8D4ADED349D5EF22BC59A36B7D9
25BCC4B14958E071E94469C79D9CD5DCF962D6C57B758975226692E1523F9F72B60B9EE067822AFA
49A3CEFE48B9952698B306931B947A31FE55CC583DCCDE1DD30DC492BCAAAE42BB630B9EA4FA559F
F429A232A3B876C2C664017737A1F5AC5A6B63B392E936CE96CEEFC3F1C90C4B05D5DCDBC26D9A20
142FF7862B575C5B6F22DAD05C6F78B77CCCD8DA0F4DD5C6436B399D238A6F30C87E66886768F6F6
AD7D7B592E91DB25A45955092CADF79B1F4FEB5B2AD683B9C953097AA9C595458A24F6CF1B6D93CD
DB310092413D4F157FC4BE1C8F44B582F34E8EE2E0EFD8F1BA9650A7F88E0564D84BE6DC491CF349
1C0C8D83BF0015AD1FEDDD56D14C71DE09A77013CBBC27615ED8C56509D371D56E6D521554D599A1
A5DF4167E179A1D41E685537AB3952A81587047E3D2B1FC2E2D62B78165B08E53688D2F9F0EE6CFF
00B4727AD6CB6B70DCDA981ECDDE390082585A2CAEF1D0A8EF53E99A35F5843700AC5B9C10B1A360
B03EA3B56FCAE56E5396738C13E65AB302DF5FD4E34292DBC375A6190EE720ABA83DB35B5A14B3D9
5DC92DCCD8870ED995C95C1FBA066A8DF5AC5673C96F6FE5DB46D1F9C6390ED573E8A2B2E4BFD47E
C867B68E478D86D31C838033D00F5159464E9C9DD9A7B35563EEE86E5E4B6FAAA43232B20F33CC91
090B19E7A9AC336162F7F6B1B87B0B7790B991BA3313D33E95336A2F2CF6F2C2D00DB08468A44C02
7D08F5A4B9FB54EF35B216316E0FB0AF181D4AFB5129A65D384A93B12DA431B6A52D8868DFEC0E58
3A918994F400D37ECCD676B069CDBA454573311D48DD903E82996DA66A5099E6B72A25DE1C447F77
9C7619ABEFB9654BD97895583B47B81001EA0FAD4A6F96C5CADCC9DCCE985CC1A9A5A899192284CC
B228CED5C671556D2EAE26B5DF0B165126E723927FE0348E2484614382F2128FCFCCBFDDFA556B86
8ECDE293E789668FCD0A9C3839E87B560E2D9D8ADB234A2DC92472147065937C6C06DE73C8CFF853
63BAB587528DEE16F63983B2B8650C0E3A104F5AAD713DCC5716FB49BA8060A47B89DA0F38CF6359
D7324F7EEEB3C4F1E4E4300708A0F154A4C3D9735EE7477BA75D2593DD59AC0F6D72364134648752
7B30ECD50BC5749149A788F65D5CC6A2353110EEE3B063D38A85E4BA9341827B1BD68B6CC86E6DB7
6031ECCA3D6B77493359A69336A2DBAFFCD218DC49CC6A780771AEBA704DDEC7055A928271B953C4
1A841A3C765A4C527FA44100B72DB0044E3E66CD72B7055E349A691D2448821547E719EA3D735B1E
32D3E29B519A38AE21984AE632AAC329CE707D0D656E73125B246762B0C1906F3191D837A567295D
BE63A70F1F71346846C258952DE23324D1FEF23753B81E9EBC0A9DDDAD953C9821F295B0415CB1E2
9ACF028DF6D04FE63AF5070ABDBF2A7D8C2D2DE0850492C5F799D7B63A9C9AC96BA1B36926C95A5B
AB3D075594CF3B7976AB12B96FBA4B8E013DFAD4BE1D76BF8435CF972ADAB8904C5F21147F7BD2B4
ACA3B55D2EE66B9BB69D1D5E1366C43E0755723D7DC5665AC86C74E920B74B657601A65C60103B91
DC56AEF092773CFBBAAA4A28EA52FED352B92E1EE0492AEED8546197DB3DAB2B53D3E296D98CE3CC
95158A98141254740D9ACA82796378E77F22409C87889E3DBE956ECE647995F2ACD70EC8AAF29C17
EC2B5E753D0CD61DD27CC8C0D9761647DFE415031131C90B52EF79EC6D90796C412D89F96209EC6B
535148AE96679A54867E1263F771B7B0F7ACCB9BAB27D3AEE4862916E6411C215BEE22F7C77CD60E
37972DCEF8D5E68735872CD613CA27558D62F2FCB9010482CBCFCC071556CA6FB110915D5D5BDBF9
85E2913A07EFC7A1A9FC4175FD93A669CBA7DA47258DC0F326FDDFDE3D31C556B88426B6E96C2316
B0C68446CDB980DBC9C0AD270F67AC4CA8D4551B5246DDD87BFB09AF92425237DB320E4C808FBCA3
FC6B13CAB3FEECDFA56B692F125C5FC62E145B792CF1C8BD371E808AA7F60F6FFC71AA5A6ECD09D4

F64F95991A641A6DBBCD79A8055C950851B2CBEBC37AD5BF0B5B5A4BE24B6BA29750C226DF10C039
2A3807EB57EFFC2F342BBE0D977239188D3EF2FD6ACE950247A8C2C658EDA3B6F99FCC9D72CC4630
00ADDCA4B439E31A76724655C5BDCDE5FDDDC23102E276678DD71B493D3DA89745B486DD64594489
BF3E5C2FF331F7C56CDB6F6B9F2EE08092CC5BE73832E7A11EA2B3521B39243E5437692094EF1010
7663A9AC65F15CDE9BBAE57B10D9C701BA9480901C82889D463FBDEB4E4B68FED1A95BDEB4045DAA
E4927E5756C81F8D68A59DB69AA2FCDE42C2162465725C13D31EB53982D9E78F5182DA5BB84A6E28
10168DFBEE5EB8ACECEFCC5CA717A5B430E2B980447ED3E5B45080E163C9241FE13ED5A32C56D3FD
86C0DB5CCF1B65C35BC5F77773907D2B9EB8B577945C425628B7B23FF06F3DC56FBDE5E2D95AC96F
1DB5B941F2CB14846DC0C11EFF004ADE9CD453B915E9C9B4E02F8764417F25A799218159D639718D
87D18D45756B25B42B1B265518976424923FDACD34E973D829BE8EF14452306DDBB976C752288AEA
E2EE28C5CC472D960CA7AFA673DAB09DA499D34D352E620F2D1E319201E46D63E869F713197F7B24
88AC146EC9FBB8E98F6F5A9FEC6F2161F672CDBB0DB549C1F5CD6B59E836F1ED3AC6C16824FF0096
58C9F4058F41F4ACA9D093762EB6269D3577B99BE19D7AFEE7C4D0C2E8BF6658DB6318FA10321BF1
AE9E2BFB2B7D544E5E57DB9672A0B1DC78C1ACD736362B21B3B25B733923ED807F0FA67B5504B810
09245959CA37471FEB07A8C75AED72E45689E4BA4ABCB9AD62BEAF35D5DCCF7124F14C4CADB223CB
4633DAA1B59CC90CD12FCE5D7732ABE0A9079C52030B5E6E04E776F057DBB7AD4170618B50DF6493
838258487904F51EF5C926D6A7AD4E094790BD6DF636BA4977A08C9D80CA39DFE87B66ACC96ABA7C
E926A374CF741F36F0237CC07A9F406B26D6295ACEE2768E5204A8ECC41DA9C70DF5AD9D4E059754
647522ECDB46EF248BD091C7D07A8ABBB71B984ADCF6B942D6DDEEE4779754760FB9D2295B7151D4
93E9ED4ED475B58F4C06C61185502496E000A4FD28B3B389495792479A50DB4C2FCFFF00AAB32EE5
861B436ED6EA619581556E1D083839A516CAF66A52D8BDA0F885351B88F4FBFB4B700A1F2DFEEFCE
3D0FBD6A6BBA34D084945AB490B7CE17765F3E98C62B9BD260B0B197ED0FE6B856F936E3F77CF7F6
AED86A126A035292F1C058E1511496BC976F415D1EECD58E7AF1952A9CF0D8E4276BB8161451B4C6
0FC823E4FE5DEAC471B948C4E85632C0307520313C8E4D6BEA360B642DBC9799AE2FA12D12B0194C
7F7BD2B32E66D4151A19B7CB0C642B646E51CF6AE671E56D1D90AAAA24D684F6B1C1348B6D2A8F39
F1B8A8C08829E3F0356A7BF6BBD4184B033C713AB2F9BC2B1EC31DEA4D3EE774B6C258A35211971B
7E623B6ECF5ACF9ADA568A6BB5983B005822E772FA30155CD28DB94C1C633935234B5FFECEBF952E
60B311CD7030AA309BA50792FED5846DEEDE258E0B59523046E0463711D71ED5D02C646856F34C90
5C18AE034258F2463387CFEB5913C3737F646F6E2EA20824E02CBC2E7DBDFB51537BB1E1E4E31B2D
916034CF6CAF730C4C91E095800CA83FCE9D74AD018C4570B1DACE0E5D73B78FE1CF63EB51D8476D
0DD0449A469B6B451C6AA5891DF2074F6AA736B26E635B4B158BEC5112367DE727382C7EB472B51B
D84A5CD37145FB9BB8208ED6048630B22EE6310C386F4CFF0077DAB3E1B85BDB97695C2CE480BB46
06DF7CD17714E2591EE2557758F18518C71FCEA4D2DADE692D63F2241228D8AEF83C11DFD6B35AB5
73A631508B696A5D6664B31E7F928A9B99044BB7033819F5AAB6C1DE5681B62DC2B19118B11C819E
31D3DAACDDDC2CD035B309256465CB84CA903B1A5D3ED1406BD5C2B87D8AAE703D3F3AD62FDED0C6
5FC37CC64D9F8A26F14DDBC37763043364CB6CF6EA7692BD44993514D6E6FA7FB2CA5F820A0B7FBC
EC7DABA49744D27C3FA94D756DA7BF9AE9BA3DEF988487A8C0E6A84B7F7703B4AD0E989B8ED57B64
D854FA83555A51524D333C33938B4904D6BAA402DD2CA54BB821077232E7606E8A71FC5519DB1167
DAD1CD20F9D40DAE7B1E0F38A9AD8C4D7AE65578A36F9C35B4BF7D8776A4BDB98649FCF4589C0017
65C8FDE11EAB8A89D4E656B9508B8CB61960A92D9DC347005E92953C17DBCE3DEB7BFE12D5FF00A0
42FF00DF9358E9A844916E86D7C92177933B6E0AF9E83D2B53FE134FFA8741FF007C0FF1AEAA52A7
18DAE726229D49CEE909AAC52269EB7366A1639F6C91CC25C393FDDE2B97B5920B6BC12BDA2B95DE
1D634C95C9AE9B552E74D82DFF0076B243C84FBA194FA0AE6EDD1249648A1CAB818DE14F5F43EF58
D57766B8349D37CC5D87510358D3669629BC882E06D1B064678C7D29DA9E9ED61AEDDA4D756EB133
12D3799B0F96DCF4EED54A4BF4785EDA431236E20B2FDE5F435B535BC1E29F0F4B6D3A81A8D8C5BD
6E5D3293283C67DE943DF4E2554FDDCB9BA18721B7B6DA4BC52D9952F189A6E71EA45496D7AD65A8
1B9811D8CA0055E42927B9F5159EF6B6372F0595EADEAACA0E5954647A0FA54B710ADB58C76104B2
CF7B14989096F9554F41C53F67EEDDB2B9937CA741AEE9FB63F392DD4E4832471E4AAB119C8E3BD6
7AE9971079B1A4919298942CA72AACDD856C585CC96D0A59C825C7920C81F2D83DAAAF88AFA5B7D3
ADA4B30E6E672035CA8DCAD8F4352F95C79850A9522D416C45651B476FFE97340CA8FB3646FBB19E
F8A74F0C762B32892220A7CAC4E77FB0AAE6685ADE09E27CB1013E7501B70FBD9C510C91DCDCADB3
404AAB160CFC9CFF002ACEF7D8D541DEECD0863B982C5DE296606E63DC3072579E722B524B8B3BD8
974ABEDB05B2ED304F0B7CC48FEFE7826B0D6CAEEDA39248DA705C7F1F385FAD557B86BDBB65771B
E2E0E40083FF00AF5BC6738EC613A0A6EF734A4B8B72D12DA07758F217CE39DE09EB8152DDA4125D
C82E11123684245E5AED68FF003E9596079F3C7E5A146946429C6001DC0EC2B56CB46B8BF52D25D2
9DF948FCD7196C7A67A9A84E5295AC0E31A714EE672476C96C8B67B98C0C76C8E3EF7FBCD542E2DA
39AE62B9336D95DBE651FC241FE5562F1E7B16303279508C8951F866C7B76CD457978975A7C332C6
91824A858F9217D4914A76D8DA0DD934F422D42D2E27D3A545BA9CC2B2E1D619392A39278EB835A7
04F717BE161A9DC40C6491C599765C1913A2C9F5F5AC0B7BF96DED0B1B878E30F85448FAE78624FA
5757A7EA9259A3C5732ADF69F1A8290A81F229EFF5A70B24E3239EB7336A5131628E7B09F646EFE7

63E69235DE067A0CF6A7496A264796EADDA59BCC5DC3680A07BFA1AD192159755F334C778B7818DC
D84604719C75C52CF19FB43BC4629E2DBB65F2CEE0CDEA7F2AC9C6DA9D10ABE4539E15B0D3999A14
42F26D550B9CF7FC68B2B7BAB78DBCE499108054F40013D6AE9BA827B26F33CDCC6728429C0FA135
99A8406D4C2619A4B852A1D9CBE719ED9F51DE9DD2D4A8372F764589E378B52B6D62EA69EEAD844D
E5BA12CA8A3823EA6AA7DB6199479D24CBB3E631AB654807772696CF5092F34E6D1E693C984334CB
3C606D420F46FF0064D4B369CD69324ED2248D70B908A7E52077C62A141F37345E828DA2ED3DC9ED
75A9A78E4B8FB0C0B1C8C1567552BB07B9FF000A5DEB7F7A97B0DCC115D2911C76EB20CB6071F553
5911DF8B4BB54BEB699FCE3BADE08E4D88ADD07C9DC1AD7D5ADA0B59D752B2D3238502A068C2EDCC
878C71FA8AE954ECB991CF29DA7CB6DCBDA8B4EF631452C7046182C92C2B9FBC7EF7E1586F0FEE53
62A209146E89D791839CD5FF003A6B996EAD5AE6D639FF00D726092B8C72B9F4A851A3FECC8AFAD0
5C8BC8A5292C6CA08901FBB83E9ED58C9734AE6D4EF08B8B28358EB73E931CDA65CC10A223CB34F0
5CED91F1DB03A1157BC41E5DB49A3EA114507D9E7B7411EC1B5A46C1DF93F5C55792D6E62BB32476
B0C0663F3C6CBFC67D40ED4D302DD14B87F337DA03B6203F73EFB54FEB5D5ED62E36660A84D54E66
C8585D1D3FCFB67599A52DE687F9B007A7BD2408D7C52507C884050B20E00C75A837B5C5BB3DBC7E
58E570885724FF001015D1E88AF269F6764EC258BED1E63023AAC6A5B19F738AC7962E7A1D92A928
536D995E21D6ADF45B86CC12CF3CEA24863518455EFE61FAD5DD3EE2EEF7C336734D2C30A4DF2A98
F8F9B3C7FF00AEB37544835AB746D4E068EE04ACD880846009C8193D7E95A164166D2EDACA20B127
940C0EF938653939A5294168B7314A6E3796C5F492E545C58DCBF9C922B3337DF911B1F787B5673F
D924B2590E639E350CA5871267D2A19EF279163B93E62CA720CB08DBBFD88F4AD3D4374DA62DD491
AC771120568997E509FDE03D6B3D64AE6CA3C8D35D4A7A7DB876790B1023F998A75E7A8FF0AA5696
C6F65BA6B5BBF29ADD0CB335D705141E84D36DD92F6211C3388248FE790E70A703F3A5B011E99797
0FA8452C969A842D03C8007033DC8EF5B515152BB2310E5C8F95EA68A41A5C961F69D3AFA3BB6821
F32E23949757627E65FF000AABFDB3A1FF00CF8C9FF7CD32C66D3B45D127B4B590DDDF5D90CC2118
5555E878AC3DB2FF00CFC7FE395BD4B736873508D4699D3DF094DA3B5E48B2DC2484AB2B1247B1CF
4ACBB4B812C30C913C82E94E1C2B707DF15A5AE4EF64DE64D1C5219C83BA3E63607A64FAD73F25AD
C59DE096DD46170EAF1A9C107A8CF7AE79DF736C338B8D997A5B400B5C84FBFF002B965C107D6B4B
C1DAAA595D49677EADB25C2869385C7A73DEA6B5326A700281826087128C6180ED8ED561B45B5B1D
065D52EE337B749868EDA23D1CF76F6A29D3BBE623115E2E0E9BDC75C69725A78866B796256B0C19
8CA7058719014D73C9651B4B3CD0BB224A4B36D3B9D8E78E7BD75916BD2DB69B6335E35B5C0B8431
F93226ED8DE86A0B8B68F51923F21EDECDED5D43DA63CA493FDD3DEAE7692B232A35251779222F3A
3BCD3A396079A1608125C9F9891DCFB54B613ADA472C5322DC40CC3CB47E4239F4F6A89AE2492F2E
6D5ECD2352E090502B617AE3B63DE9F7B6F78B796AC1ADBC99B0DB872368FEB59DADA9A6FA16A2D1
C41632DAFD9E079A57F312463F74FA7D6B26DEC5B742B2168E452ED2053F7883D056FE99AA7F675C
411F9914B62E0BB4B29F997E9EF53C5A14033A84574E46F6908760463D7DAB451535A1CEAB4A9B6A
7B1842FAF898D66C246F90A9DB6F6FC6A83451DA25C2C91DADE0958485637C98F1D8FBD497823B6B
89440D72109326D0437D00F4150C4F15E5A1FDDC30BC8851B6B6C0C4F4C9F5AC54E51677FB3528A6
B6653B9BD12EA514F6805B15505C2B648156FC601DF4A8350B52E0DAC9E61311206C6E372FA60F5A
583457B5F925857F7C563593B11DF15A7A82A595CC9696C7CC816D80066198DB3F7866B6A73E5973
7431C446324A2B7452BA99758D0AD3539D897B8B50647C6EC146DA7F3AC13304B698DB4CFE5CE443
1951855CD74922E749FB3C315B410DBC66483CB9090E1B9271E9C564DCE9EEF6926C49220D2A8751
D8F51B6A6A4939DD22A845C6972B296982F62D61EDAF6DC94BB616EA98CA67A923DAAD5B345FDB12
C71ACDB549C154C6EE70722AE8B3992C2296EAEE22B092ED95FBACC318159DA695D32F12591DC6E4
68C20CEF6C9FBC33455945A490B0F19272933A0D35218E131C9E6BCE8F850C46D51EAA6A2805B584
F2797F68291311246D16D597DC9F4A247923BAFDDC6B2610A9DBC855F7F7A8F509A436D240D74F22
ED531624CE4FA1F5AC657B686897BD7BEE4535BCD24175BEE6416D14464053A1F402AA417ACF6D74
AC6268DA3564901E7731036E7D7AF4A6C9E6DCB9895E558E51B4E49C02055D884B2E9B636F1DBDB1
9E204CAA623E5823F8D70396C7AD552A775A9A559F2E8645CC64DC4B6D6FFBB64011950E40239C71
D6BA4D3E76BEB47F3D5218E38FCA323820AF3D45664F148ED2DC44B047234DB8A838DA31FC5EF567
4E697ED721F3D45B3A94C3900161E9EB4A3EECB40A9FBC87A11CD6DF63B8314F1477691CD1BC5270
CCA3A9193D29DAAB5DEA461893759D8A306C3B8DECFF008704568AA417DA73CB14B1C72C0DCAC8B9
DEC3DBD05519A0816D5D9B76D2AAEB0EE1B801D587A0AD25295ACCE68463CCA4F722B38859DD5D07
452654D9F381C93DD455AD2752D3AD6C6E60B80C970F380B1B90BB5BFBC33DAABDCCB15F99EFA089
2244894279E7E60071818EF562CD46A29B6E2C927956456F3A5401547AFA9FA56514F9958D6B59C3
9985C589B895D85CB49A864022618F93D723F4ACDBE92417A9266E12DD5F6AA3A8E5BB81F5ADED73
56B887577B4BC54B7B58630D6F224197B95E8096FC7A0F4A875479119EDE656795115DB72E028C67
767D6ADC6377E4451AB2764FA95E4D39BCB86E90AB6E24B08F90B81C002A74D4E6B329F65583110D
CEBBB1827A8ACB17C923C96C54886E18142AC4320039FCE99711C76AC1AD82BC127399397C8EA081
4B9B9754747B272D246DDDC9E1EBE92C6EAE2DEEDEE091E6C76ACBCE3A161EB4D8FC3274DB89ED92
69DADE3FF485926521769EC5BA002B161B958E3797CB584C8BB99C0E53D39EB5D36A72DCF8ABE1D5
D5BE92F2A5D42E14A34993328EA0639C1AE88724D376D4E2AEA745A49E863C90C70858DEF1248A5F

9D6285B7373D0E3B0AB2B35B42A8A63BB9DD0EE6C9DCCC7DC7A5737E0C4D565D5BCBBA8DE4322ECC
15C3A9ED8C8AB57D7E8B7AD99D84C64314BB06028E871EF59CA2E36F33A17BFA762C4D76E59583DB
146909610DB80CA0F63ED535F056B0B77370A248D8822100F1E98E99A2DAEAD7ED9369115A5CBC2C
E2213040198EDCE093FA566DDD83C1749669248B13C627D91E43447FDA3553A6D2BA6654EA734B95
E86827D9E69238195D23BA8CEC9A250A573D33F8D55FEC3BDFEF5C7FDF228433A6D9E25370F1460C
48325171FDE1DB9AE93FB5F50FFA07DB7FDF66A22D5B53593945E8CE06D3C41A93F9656D91AD8FEE
CAB4595527D8F7AD1D1239DE0768AE4CAD04A0ADBCE725D4F5DB49169F6F2D95C4304D0DCC7049BF
CEE436FF004E6ADD968F3CC2D9208DE18DBF78B38E7EA33DAAEA412B729853B59DF437F4AB9B2B58
0CED34F6FE6963E548A3087A63D6B1F5BD45A54FB305D91B1C892DD8EE71EF52DBC534B6CF205F39
9AE7CC5DE707038EFEB49AD5A5A9B78EF6DCC9B14E42B2EDE7D2A5CA56B21429C154BC8C49AE63B3
B2B68A5549023330F2E4F9F93C135D1E8525B5D6A0165995A2921C2973921BD79AE6644D97C2E191
7CD5508D0919C28E7269612B1EA28ED2F91E60C2851D33D0D43B2D51D72829C5A3B6D6239E0F0B3C
6EFE6CAD7223DEDCB041FC39EB8AC68A596305E70523DDB910039231C6067A5760D11D5BC231DBC0
CA661282C59724E3A571B744606E97CC9082ADC63611FC23357885A267260E49DE2F72286469B4B4
924312BCB29F2C39E4A8EA7DAB7744D522898DBCD721E1957E40EC0E3D88AE4BECC9318D6399DB28
0ED0B9D87D2AE59E9B7399A602354B73BE4738E3D80EF59F359A68EBA946338B4CEBF55B016F702F
443BC4643058B8DEA474F7AC7BE5B596258AEA7B25E4911DBA7CC3D335B70DCADF6873A234A45BAA
CA5B77CC41E3A7A571D24124FA94A2D9565565DE81880CD9E0649AD2A2E6B389CB86BB6D49EC6A69
837614A5EBA17E0C8B803FDDCD5AB890082E8BA095EDD8B6E0091BB3C0ACDB64D51E7884F2CAD8DC
59412FB1876EB5A2B0CA2D0A3CD1BAC9CBABFCA587AD4A52D8D2A28A77B95A716CB756B720B423CB
50E76FEEF38E40F6A95AE6396030DFAB986324EE8570C7D0E6A0D66C9ED85A5CEF06C00195328208
C77AAD213FD910CE11E281EE36B291B8A0C63AF7ACAD24EC8D1462E3726B9B2B536A6D45EB609DFF
00BDE807A1ACDB7B68410F3493DC5C094456D182199D7D57FC6B461B6FED4992C4B08AE2470913B2
E49E3A91562F3C4BA0782DDD6D2CA6D5B56402312CC85151BBFCC4103F0ADA10D39A4F431A959C7F
7715766C8D135081ACD8DA3B4382B2041C953DF245106936D6D713698F702EA678DE4863D80BA7B0
AE4AD755F12C178B717BADCEB05C82FE4F99B873D979E952E97AFD8D95DA491349733891D9E59090
549E8A0FA514F1309CACA3A231961EAA8DF98EC6DB44963487206F74DCE1D00D87DEAC2DAC5696B7
F70B736EB68881D662DC21C7CDF4AE78788F50BCBA479FCB8E20AC5D54609F6AAD36AEDE63DB4843
DA4A80CB16DC07CFB56D29C55D58C6342AB77653B7B88E4D46EF518DD5F4B232DB32CD271D476AB9
032DAC62F6D638E54319688CFB58463BF03F8BEB5535646D3CF956B3F976CE99F2D576AAA1E73C7F
2AA0903C76C92C6ACCBB4ED2928FDE738FBB8AE64A4D591E9DA364E4CD68EEA49251E6BDB8677060
997E40C0F5DD8AD03242D63761ECA28AF648DA24C8CE7078007604573D14092585EACEA491B55768
E6323A023DEB7A49E25D42EE498860F146C8B8E41DB8E0D116D2D48A9057D0C9B98C98442E915B79
51AB9588E03BD334969C9782ED921329223676EA7EBE956AF256B6BAB49A4B7611344A0EEF9B07BE
6B8ED723B8B4F114D3C8A63493E78555B31EDF6ED453BC99AF2DE3CACF42BBD306A77165315679E0
8C5B4AA0FCB185395907D735CFDDDF36A5E21BD94B4BB27C04524E7E5F51EF5BDA55CC1A9411EA0A
1E1924B505543F1215F5ACD9ADEEAE7548EE8D8F95239E63F300FBBF4F5ABAB169FBBF339A87BB26
9F4282341E62C8CC9BDBF807F07B1A7AC70CA8EAF32E43615B7639C77CD56624CCC5E2006E207186
18F4A446F2C3AC60038C10CBDFD4D70BA8E2DA91EBA85D5D0DDBCBBA396407051CF5C7AD32CF5E9B
4D321B2DB10C0E5F3BB3EA08A81667925657C30395DC38FA55792DB7BF965A45763B55003D29C6A3
4ED12A54A325791B36FACDFC9A8DBEA3F682B2AB82141FE2EDF856CCBA259EB9ABDCBAAADBC57517
DA18639561CB01E95492D3ECCD05B2AAA314DC19D72C474CD6858B2B6997F71C894036EC81B06490
FA1EDC735D94F9AD691E6D7714EF4CCCB617D61756492878D159991870EE4742D9A85669BCC7BA7B
90D2B2B677F707B5693E9EE58CA2F9E4B83197582652C460E3EF52CBA6C89690DECB0471451A069A
4660C3938200EE69DE52D1B2632A7177EA3B4D8BC8B7B584AECB84DD24A0202AC99C8C9AB3E768DF
F3F175FF007F0536F74DBB8DA79EDA060B21578D94EE0D1E3A63D2A8FD9BFE99C5FF007EC539426F
6464DC24EFCC67DCE970595CCF0895A53184F9B81E7391CAFF00F5EB52CDA5FEC75B5DCB6F0C9290
10E5B7FD3BD6B7882D541B8D4126133C8F98E255C631D57D2B99BC945AC96B3437534880AB3A1882
F96DDC0A75172BD09A53F6D049EE6902B39FB40426D518AC923BED2A71C617A9E6ADF9724F0CDBD9
AE336ECB193C2EEFC2B8E935686EEE249268FCA685848D71231381D80503935AB35CDC69E6322E0B
584BFBF553F2B0047A75A20A56E668AA904AC93D4CE9ED6EA1B74BA58FEF02933C873D7DBAD4770C
2E6E6392520ED4558CE7B0EA0E2B79441A808A375C451A978E756C10DD40614CB5B1B8B716C64B41
BE2666950383953E9CD64E1B389B42AD95A5B9BFE19D4E38CDC35C17FB24DB4EFCE0C4471D076AA3
E25B2F26EAE6E6147DB959236209055BDAA16F22E2167B362825FBCAE0E476C66B596EEE6E2D4EE9
63616F1058C9391907BFFF005EB452BC6D2391C5C2A7B4875316DAE2D16DED8DBDA47E73026E6652
428F6C7AD1756F0CB15948881AC492C5402A48079CB558B3D47ED13B349711EC5CEE3E58556FA0C5
3AF0493DAE5D4DEC4492EFB84613B85C77AC3468EB575224D22DA337726786B946450AE728ABC81E
95857397B7694C6647954293D0263A0A7DEEA1AB69FA8E9FACD9296D322C6F8D4AE547439EE462B5
35682CEDB52B7BE484BE9B76BF685F2E4200CF518AE8B3E4BA3153B5571975332DE7912EEDA6B376
B768A22B2A28CEECF5393D6B6A68DCC093B5B9798A9C6E7E00239068B592DB52BB8E2DAC1030F2E3

61F7B9F51536AF3421DACE20A8D183BD7A823A67359E8D730E6EF35148E7E4FB3B43B2CD02E4F3C1
EA073B6A9E99A8D922C0DA8C734F6C923A2C20958C1EBC9C726B53C95B8FF4C89FC8318548E3C746
EF5420BABA82DE6B2B88E4B9B49AE77A4514E11A16EE4647CD9A541A5266F5E0DD3B44D86B6B8D2A
F34DBAB1FB3CA2EE7059D58155CE7039E95C8788E191FC4772B62DE63DC5CE06F1D1C9C6CFFEBD6B
DD62E2592E574BF223B6D8B141E774C1EBEE6B6A2B48359D501B768E3B8876CC195771DDE98E95A4
9F3CD5B639629D18F33DCE6FC4E21D2AD2DF475632DCD9B80F20E0236394FA54DA25BC569A7CBA85
C5C2FDB010ECAC061509E0E3A1AD6F1DE81F6DD4AE354B397705D82E62111E5C753EFF0085637DAE
E80905BCA5AD02A7C8500DB8E40C919A752D4D69D4E9C34BDAC51379CF108BCF666477F31580FBDC
F4AD00421736C23E1B7677E7007F0F3590F7325C4888B2148D1B801376055A37AD7523A811CCEAA4
05DB804FAD73A91D52A6EE4DAB476CDA24D1CACE0C87CCD839239E003566DD92E8E931D95D2D85E4
326C9126019CA9E473D39A8A351369F05BB86DB3868C0037149473FAD655BD9DA319512D9D16775C
90C40E3A9EBC62B6A75792FA1C95282A8AC9EC6B5917B8D5358B8B3DB1EE8A57F2DBE6F9B7601C9E
B562656861F3A13868D06D03E6FBBEB44579696D6BB6CEDC2DBBDC603024801781C9E7E6A40D6F3D
CC6A92EEDE6491F20AE31FC3513698E2A48A726A11D84C6E51257565398CBF4C9F4EF57752D2ADEF
22166F684D94132C80ABF386E5883E9EDD2B260B995AF7F7D682E7CB42D1812636A83DE96FBC6179
E1EBAB6686649AC9A0065B378C0F94B7203E33574559D8589524AF14685FECD2FC3F67F63BA8A001
DE2851725C21EA33552D956D7ECB29B9482459564C33172507BD69EAD020B082E6CA72F677710962
180491DF03B563ADC4496E864265DB302EA06DC2E3A5151BE7B8F0F152A77362E74A378CD7F6652E
6C6524AC911C156EC0A9C1158DB95655597249F9588F51D722AEE91A9C362B3496F76B6EEFBB8233
E663A0C5683C29AFC0D736500FED089497D8BB7CF8CF0594138C8F4EB5954A6AA2B2D1950AB2A2ED
2F84E5882EDB550BEF6E140E41AD4D1B4E92EAF82BBEC94FCE4673B00EA69B6BA7CBF6B65915A145
3F248FC1FAE2B66DAEEC6D125B8C3A330F2F76FCE78E78A9A50F629C9EE6F88AEE71E5813DCCD616
B2476B1CA125036AB3062CEC79EBDBF0AC4D42FE3B8234F168166B67CC6622480C7EF1C74AA0E246
9E4B99243200C590A753F41502DCA1B7B6BBB968CC73DC956B38DB6B6D1D4EEADA11757767338469
24DEACD0B1B89DAED10DD6D62DE5E557A0F5E949258CBAA5F18A3960B8B985CA4259FCB47F523D4D
496D98EFAD645BFD969A95BCB2464A8262C1C006B5ACEDE0B9B4B0DB3A8D461120B25914FEFBD49E
C3F1AB5492972CBA1352B47979D236B496B844369A85C24B2ADB958CAA81B00F6154B30FFCF23FF7
D561C573A9E9AB7104B6E6355564765404F3E94DFB1FFD309FFEFEFF00F5EB5949E963CE741CB54C
B897B058B436F212B13210581DFE593D4D665DA2BC73CF6CC368C189704E5BBE41A86D7ED3ADDCF9
3A7C51C33247B99B78C9C75E0D36C75392CEF255B9454B811148C918DFEF8E959A8B6AFD0EBF769B
B2DCCC5BB783576F22E025DCC0049241C063FC20118CFB9AB57D7767737B77742EE49262AB6BB644
24A37B638ABF79A7CF70F1C327CB33E2569180C818FCAABDADBC969389C5CA09246C01E4E4313C83
47372AB1B2519BE7EA3B4F72A9716F30CAAA81B40FBEE7BD6A1D523369196B768CAC642CA1F966FE
E565DC4B32C70ADC04322BB333A7038FA552B016B776B7F7178FE4D8C12A3395CEE393D001EBEF59
C22E4F950EAA84573C8E96F7528E3B38EC52DF63471290DBB712DD483559659B4E7265D82CAEA308
F10FE207AB67B62B3EFE1B196D63D5F4233A7CED1C91CA71F778CF35A969A8DADC5CC92CC81963B6
EEB904FA1A9A90941EAC9A738CA1748896D7CA91B78322C6BBE073D1973EBEB5124D71258DC26769
2FE6B165182318C56A2DEC32C46111A98E518F2892BB4FA0AA130934E68A53349B9C37EECE080076
E2A1A56B9B424E5BEE456AF7103C57C912C16C8312BB1DC17BE40AE860D497598BFB36E2D3091212
B246C0650FA2E38AC1D32F6E6F9DA49A4C89237F90A0265F45F6FC2AB5F5FDF24D1EA1BC5ADD4322
ADBAA263F77D38CF5C7BD75422944E6AE9CE76B6A6CDB69F2437503DA5CC9200DF2C9E510CCA786C
FA532EF4F96CE19EDA326790911BE4E08FCEB535AF126A0A34A96CF507489F2647DAABDBA1E38ABB
3C714EC2EA78CB43756C927DAD641B55C1E8454C7926EC8C155AB06A5339092CA4B401A7E6DCB856
0AA4ED3EB4F9A5996D9AED50C60388810A3E739E0F3D2A3F139D67C3F2C12F9AD25A5D7EF031008C
8E80F7153F85B574D76EAE74BD4544CD31F3235E982BCF6C7E42A5D1F7F96C753C45E1CEB514627B
9925B93E5DC9914C68AB9C281D49AB05A0B5923F22D4C924926F137998DDED5A16F1C9AC6B68B1C4
B680424C83209DA475C7B7A532436365609E7BB996573B661C011FA8514E29455FA18CEB736962C6
A1672FDA0A4F7F9FB528F2213FC3CFCC7777FC6B1356D326FB0C5733322CB13B42E8C3FD605E878A
D6B09AD35979279D4456D129B780B7DD2DEA075154EEAF4C133D88C8F98ED95CFDECF5C0ABA96B58
9C3CA7CDA1CC2DB2CD379688D06E5E14B1393DCFE356A058E49A1577F2C11E59C0C126AF4AC6E12E
9A7432B2EDDB2671B00FA5361D3AF18406D518DD2E3CB500312A7BF3C7E75C8A377A1EBBAAB97537
B48B2B868C59171F3912021032C58E873505DF862E4DEE03A79920C8018E064FDEFF00EB559D2E4B
9D04182EAD446D26048FBC3607A900F1F856FDFEBDE1FD220433EA9696E6700C6092C589F40338AE
D82835EF1E155AD5A151F23386D4D05995B296D9952D5CB6C66C89081D78ACC9F331546B44FDE478
122E7BF435D9EBDA38B8D616E23F9EDE65C3151D4819E3EB5C748B24C7C83BADC6FF0028C6092107
515CF520D3B9E8E1B1119C527B99D2DBC47555BA7DE4942B708091B481C75EB9AD7FECEB4D4AD59B
588DA76550329F2B2FA1E31525A07669E4C96114A23909C37E3CD6C5BE9D6F19F3AF2572AF1F001C
07F51C5541BDDBB057A8B62BCDA7489A5D9DBC68E2E2DE010A0071BD09C835CFDEE9EDFDA10A891B
C824062EBCE7B835D20D534C6B9B71A9B0D345BF314AA0C8AD181C03E86A5BA8B4CD6B4CBBBBD16F
12EED7CC12DC3AA6D7B738EBB4F257E956D293E6BEA7352AD2A4F964B4EE72F710C8229268EDD142

4A40CB8041C7156AD56696E95EDA411CC30C4023E56F63559EC6FA50A65916DD1B858E500B15EC73
5624D3A58ED52E08F30821020ED9E84D6534F9AE8EE8CA3CB66F73A6B58DF5BD1D65BA246A1604C7
21E3956E55B8EB58BA8E997164EFE7C9188860EF1CEE279E29F14B77A3E8B75F628CB6A4F12B6430
C000FDDDB4BE18F1245E35B5974CBC58EDF5584130C8AB92C31823D2B7943DA46EB73CF5527466ED
B19EAD1CD19B8B721D9188661FF2CD3B7D6A0096F1CA566B03A844E7CE813714D9263183EDF8D596
89A38DC5D48762B795E98C1C355DB7F262B1F2A5CC5636EFB9E7DBB8C8BD80EFD6B1A3783D4ECACD
4E052B986EE6BF88BDAA27930AC11451A019CF35D6786F4E955CDB5E821AD1C14C91CA3751F9D733
71AA32973A5C6CAAC03990F5EBDB3D2934FD4324C8C5A49482189E83FC6AE15AD26DA31AB4253A49
47A1D078A61BEB39ACB5396189AC239312B44D90CB9E0F1C9A5FED4D0BFBFF00F8EB7F8553B5B8BC
D2D6EAFEEAE5E65B303CA7886D0327EEEDE873EF9AABFF000B13FEA1C7FEFE1FF0A6EBBFE5672468
4ED64CE2CD95F20FB3A4045E4C1C82927CCE0F439ED5A9AAA4D3E8D6706A11092FAD1FCB6B81C865
3D07D6AC8D2FECD2C73472B20B88D47CAA7F763B8CD511A73450B1919B7AB1C67BFA1A14D4133A9D
3F693523A3B379356D1FFB37ED01A58CAB2B37C8083D573ED447A6DC0632C2A5E3538201DDB40FF0
AA2879DC24F2E16C7CC177671D71566D08B1B7D492DA3951AE997C821B3853C9CD651A8AF69152A5
285DC48D6DA489E449630AEC72232465C77FA56558C874F9F50B09CBA69778CB9C00C783EB5BF35C
C96CB1AF911CB1A02B2249D73D7F95422D62D5D921CADBDB672AE4600EFF005A6A5CAEE876E78DA6
538B6DBE98349D2C33CF34AE630546E31F7624FF00FAE9F0ACBE624113140C3262F2FA6DEE4D5CB0
B0FB18492E27649A366645DBD0E3827EB4C9B549A2B695E3DCCDE618E7D8A016DDD71E9F853A93E6
7A8A9C547489A1A549106958CCB7122212C0290393D40A62C70C30DCCF35AEE313068C8938707BD4
1A13C9A5C5F636976FDAE5F2621B326253CE7DC9F7A23B76795B4E9A660012A8FCE01CF7F6A9BDD5
8391A936D998825B5BFB6B99ADCF97E619ADD50E0AE7B9F5FA1A97509EDEF36DD4B1B147DDBF7C87
71F4C0EDF862B4A5D263290805D2ECC6C0AF2436DF4E78CD575B2961B813343E6468159837B0E98A
4E534AD7D0DE2E9C9F3F5274B10BA4BD9DEC2DCB89EDE51C95CF055B9AC3D1F41FB3EB297177295B
786491D8B392AE147CA00CFAD6B5B4D6725C411FC8BF6C252566CE15B3C0E6AE41A33DEDE4B125CF
93E5160F6EC996523BF5E41ED4E9CE56D0CA4E37E591143E20FB235CEA325C916F32295571C16CF4
0A4714EB59A0935AB9BCB786D927B40D2C4EB11E38EA01C66B3A1B4D38CDA843ABDAFDA2ED2458E0
B7F3B691819CEE1D2B575B8AEF54B41A8EA76E2C0C1C5B2A4C1D6640B81C8F5F7AEA8537CB74F538
E5387B4E5B682C9756371ABAEB3776223B83FEB6E51D8865230DC76AD9BB9B419EF2C6550ED1DB2E
D450AD809DB35C95A453B47244841915046883F84E32473DEAD4D14B25B42EB179B2792A27F9806C
E6B99549474369E1A2DA699A5773ADB25FC11C690C4F3F9990A480A47DECFF004AC5FB51B7B49CC3
721F79E408F700BEA33CD4B7572B3B3ECB769E3F295658DDB033F5EA2A5B682D268A093F7F04BB48
4931BD5703A30A87294DDD1A53A6A9AD518D02DC34AE9F349139C641C023B9AD4B766B8D36486DE3
F2ED106D575932D337D7B0AD05B98E07758A5279DCECA9CE7A631497302C9A3A6D902CBF331751C9
C1E38A56B2766692A9CCD268E6E2B88AD820B7B758E7597870DCB81D49AB5AD685E1FD4EF03C4E23
9C43E6BDC796763BE3386154CCBF65CAEDCCAD951B8F287D68596EE531AC771B9181076E0703D6A6
2DA46F5285F5476116BD2DA7856CD35BB29644881324D0C9F3C2A0FCB26D1F787B550BEBD8EDDC6A
56138BFB5B80260593CBDE4F033E9F9549A6CDF6BB49F4B5937A2DB35CC3211F70A9E50FD6B3AC2F
AC96CCDA5EE63B799405811B38E73D6BB2734E279B4E8F24DDC27BBB60E26DA1D194314C1F91BD05
58692DE6B1805A7CD216255771F95876E7B5324B0FF42D96778B2A26480CB838EE39ACA549600260
1E0B847C118CF07D05725DAD19DCA109EAB72C6E659A4B1BB891E1322894B0CF268F0F5AE9DA16BA
DAB4371E55A167B59A2C7542386FCEAB24EC3CC25C8663B583727EB4F8ADDEDD5982B2950131819E
BDFD69D29494B991556929A699B5335A5B69D3FDB2D85C246A1609E33B59B3D0E7AF4ACE6D5E04B5
8E38ADCC7290422EF2CC307BE6A5BA93CFD3E4B549E57938745913A0C5645F69D716DA5FDB213E6B
B32A0206DC7AD6977396E610A51843DEDC4D3AE235D494DAF9AA431662B16F3FED0EBCD36E2CE2B5
D62CBC45A35D244FE6A96DAA7923A8C1E9F4AEAED2C34C96E2DF52B3D35956104CD179A4E640B923
1D8565491ACFAADC2F11437317DAB23EE82474000C8AEA70F656699CDEDFDBB716B636FC471432B2
DD58AACB0CE7CC90F0307E87D6B197CB987910AAA2E4EE8B927D735A3772DB45A7DA34918864895A
DE4574DC492BC35538629C5F436F04DBA770A9FEAB1818E7F1AE79DB9EC8DF0F16A9EA3258A38BED
0CCA7CA650A541FB8476A961D2F12805923DAE2465C763DBEB53CE6CADAE5E080C8652816565E87E
945C34134CB716ADE648708E19767D293692294A4F4D8BD03C16FF00DA70C4CE561804ECC4723DB1
DEB27FB6D7FE7CD3F3FF00EB55DD05E4BBD53508267479EE20923640B8C00B918358BF606FEEC1FF
007F1AB6516D2699CB51C69CAD227909FEC894F7172E07D2A0939B272793EF45158CF635A1F12165
E24B151F77C93C76EF5674FE74D627922E00CFB628A2B956E764F62F5D7DFCFAC4C7FF001DACCB35
06DC6403FBD1FCA8A2BAFAA3187C0CD1D3C96BCB904923CDE87E9556E005F0ECCC061BEDCBC8EB45
151F688A7F118DA63B79F1B6E391239073DF15D8DD0FF438BDECC13F5CF5A28A17C65561F80D3465
8024C29927E955AE58FF006B28C9C1B6C9FCA8A2AEA6E8CA898BE28551AEC2A146DF32238C7B8ADF
F1112BE2B89D490C665048EB8DA28A29D0FE0BF566353F8A8A76AA1BC4FA9060083139208FA54BAF
806D670402166B70A0F619ED4515BD1FE19956FE2921551AA5A100025D89E3BECACAB5E755881E86
319F7E68A2B91EE8F49EC8B973C5DDD8EC5A3C8F5A9E227FB3ADF9EAD2E7DF8A28ACE1D42A7C28C6
8389CE38CC24FE38A4B1270E73C827F9D1455542A2625D9255D8925B2793F4AB561FEB0FFD713451

49EC8ED8EC6DF86891A56B272722D383F8AD65C9F2918E312F18A28ABA9F0AF439297F1646BE9DC7
88AFD7B0B6240ACCF13332EA49B491FB85E868A2A7A111F8D936928AD02165049887247BD6DEA033
E1D9D8F243A609ED45154FE145D4F88CAB6667B89CB3162107539ED54F5EFF00915ECBDD1CD1455C
BA7A99FDB43FC224AE8DAF30386C3723AFDCAD9D086EF1C4FBB9FDCA8E7FDDA28AE8C66C79F43F8B
225D6B982F09E4ED1FFA0D675A81E43B6064439CFBE3AD14571AE87A74BF84C9D40FED9B718E0C4B
9AB3E2103ED2BC0EA28A2ADEC0BA15F4938F11E938FE20FBBDFF0076DD6BA8F221FF009E49FF007C
8A28AEDA7FC347978DFE21FFD9}
}}}}
{\shp{\*\shpinst\shpleft1373\shptop2146\shpright5866\shpbottom5146\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2051\shpz1\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4493}}
{\sp{\sn geoBottom}{\sv 3000}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;5;(0,0);(0,3000);(4493,3000);(4493,0);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;12;16384;45824;1;45824;1;45824;1;45824;1;45824;2457
7;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1866\shptop2093\shpright2546\shpbottom3093\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2052\shpz2\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 680}}
{\sp{\sn geoBottom}{\sv 1000}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(680,1000);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2466\shptop3026\shpright2573\shpbottom3146\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2053\shpz3\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 120}}
{\sp{\sn shapePath}{\sv 4}}

{\sp{\sn pVerticies}{\sv 8;8;(0,66);(93,120);(93,93);(93,66);(93,40);(80,26);(80

,0);(0,66);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft5160\shptop2066\shpright5466\shpbottom3666\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2054\shpz4\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 306}}
{\sp{\sn geoBottom}{\sv 1600}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,1600);(306,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft5106\shptop3626\shpright5213\shpbottom3746\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2055\shpz5\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 120}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(0,0);(40,120);(53,93);(66,80);(80,66);(93,40);(106
,26);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft5306\shptop2066\shpright5466\shpbottom3986\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2056\shpz6\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}

{\sp{\sn geoRight}{\sv 160}}

{\sp{\sn geoBottom}{\sv 1920}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,1920);(160,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft5253\shptop3973\shpright5360\shpbottom4080\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2057\shpz7\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(0,0);(53,106);(66,93);(80,66);(80,53);(93,26);(106
,13);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2186\shptop4773\shpright2320\shpbottom5240\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2058\shpz8\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 134}}
{\sp{\sn geoBottom}{\sv 467}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,466);(133,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft3120\shptop4160\shpright4386\shpbottom5253\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2059\shpz8\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}

{\sp{\sn fFlipH}{\sv 0}}

{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 1266}}
{\sp{\sn geoBottom}{\sv 1093}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(1266,1093);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2266\shptop4706\shpright2360\shpbottom4813\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2060\shpz9\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 94}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(106,106);(80,0);(66,13);(53,40);(26,53);(13,66);(0
,80);(106,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft4373\shptop4906\shpright5053\shpbottom5240\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2061\shpz10\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 680}}
{\sp{\sn geoBottom}{\sv 334}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,346);(666,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}

{\shp{\*\shpinst\shpleft5000\shptop4853\shpright5120\shpbottom4960\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2062\shpz11\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 120}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(120,13);(0,0);(13,26);(13,40);(26,66);(40,80);(53,
106);(120,13);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft3080\shptop4120\shpright3186\shpbottom4240\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2063\shpz12\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 106}}
{\sp{\sn geoBottom}{\sv 120}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(0,0);(26,120);(40,106);(66,80);(80,66);(93,53);(10
6,26);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}{\shp
{\*\shpinst
\shpleft1373\shptop6053\shpright5866\shpbottom9066
\shpfhdr0\shpwr3\shpwrk0\shpfblwtxt1\shplid2095\shpz13\shpbxpage\shpbypage
\absh15866\absw11893{\sp{\sn shapeType}{\sv 75}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn pibFlags}{\sv 2}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn fEditedWrap}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn pib}{\sv {\pict
\jpegblip
FFD8FFE000104A46494600010100000100010000FFDB004300080606070605080707070909080A0C
140D0C0B0B0C1912130F141D1A1F1E1D1A1C1C20242E2720222C231C1C2837292C30313434341F27
393D38323C2E333432FFDB0043010909090C0B0C180D0D1832211C21323232323232323232323232
3232323232323232323232323232323232323232323232323232323232323232323232323232FFC0
00110800D2013903012200021101031101FFC4001F00000105010101010101000000000000000001
02030405060708090A0BFFC400B5100002010303020403050504040000017D010203000411051221
31410613516107227114328191A1082342B1C11552D1F02433627282090A161718191A2526272829

2A3435363738393A434445464748494A535455565758595A636465666768696A737475767778797A
838485868788898A92939495969798999AA2A3A4A5A6A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6
C7C8C9CAD2D3D4D5D6D7D8D9DAE1E2E3E4E5E6E7E8E9EAF1F2F3F4F5F6F7F8F9FAFFC4001F010003
0101010101010101010000000000000102030405060708090A0BFFC400B511000201020404030407
05040400010277000102031104052131061241510761711322328108144291A1B1C109233352F015
6272D10A162434E125F11718191A262728292A35363738393A434445464748494A53545556575859
5A636465666768696A737475767778797A82838485868788898A92939495969798999AA2A3A4A5A6
A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6C7C8C9CAD2D3D4D5D6D7D8D9DAE2E3E4E5E6E7E8E9EA
F2F3F4F5F6F7F8F9FAFFDA000C03010002110311003F00D6D7EE747BFB36B8D4E58A0860903F9DE5
36E2B9E9815563D461B98E0B8B58F115DBB1B6E4F41D01F4A9F55B0B7D465FECFBAB4552EE1642AC
5847DC74AAE3407834BF2219E2668D8AC4A80FDE1F535ACDE8CE3A2A375CCCA0750B88ADDEDE775F
34CE09DBC945EE335A10C36175FBCDC628836C741963EC6A947657096B23DDE9CE8C010CE18023F0
EF41D424D2EE6147F325B7950300C00DD8EFED5826F791DD2B3D2057BC89C6A4B6D3CE0C6A4790DD
368F538AB5F6C48DEF64B5FDE2DC009BF6F25FF1E9559112EE41796C3CD44761E5B7079EF9F6AB3A
65AA24171BE501A3E1CB1FB849E0D46A9DD16DC796CF7349849F608ECE12509F9896F9829F5A86E5
7ED6D159C37A5E2DDB5D7C9E4B77C66A2B999AE207FF00479229A2DB9984A312E3D17B52DE0F22DA
E75319330819ADC249952D8EBEDF8D57C4ECBA9CFF000EAC9E5F0FE951EFB796EE1B7BB03091B4A0
107B719AAD65A65E2F9B6F332476E7264561B8AF1D411FD2B8844B39273035A99CB2ACD34CC79071
CF35D5F856575D1B5384DC7936B15C02B3757452BD3DEB49421F12D2C17A918D9BBDCD486D164D71
66442B3E164255CAEFC7F101D391D8D69DC585A9D4E49609B65C2AB797110783D73D6B9F8664B8BA
7064F3559D667971B4E00C640EDF85559757D39F5896C25B9945C927C85C12CC3A8C9ACD4E2A2EC3
95197327D0EAADD92F239EFCB379853C999369DAAC78DD58F3A5EC539C80BB08420807CD07F953AC
96D9D42485E749172B1F9BB3383DFE86B49DEC2DE38AED9E57943639073001EA3BD3E5F696BB25CB
D8B765B90EA7732BE9DF65F2DA46493CADD82A5E31C802A8C5A5AD94573710DF2C4AF8223724ED3D
C57462381F5297FD24CE648FCCDE470A08E302B2EF6D869F65E6B468D752CA238158E429C725B9E4
D692A7CD2BB33A55B4E548E76E9966781C1689E05382577890D471DCCB1DB496B6B78217B9752EF2
2E4707F4FC2A9CFAE5FCD7E05B5C3B3C6DCA90A15B9E7B56CDF595AC8CB3DA96FB308C4A46EE037A
67AD6128723523D28B4D72B34EC81B0D365B19D1AF6E7CC56126FDA361EB81577518A4B785A2BC8D
DAD58868D09C3A63A1CF7ACCFB5DB41651BFD9C5E4EA4F9533B10727B6DF4A92279EE7CA75625E25
2C627704E7D335A3A8A4B4383D938CF999931CD27DBE0BD5569CC6C76BB39001F5DB56D0DECACAD7
48EC51891B88E73FD2B42CF4C6BB9A5CC00DCB465C2B8DBB8E7D7A0A3515BB530C4D69F658140CB2
480EEF6CF5AC129456A74BAD172E556310AACA6689B72AB36F1E5827728ED9ED8AD5B6D4ADADEC66
4388E16500303939E9CD4778CB189B4E1B9C29C4C4701FD30DDAAB197EC969121CA29CED21437E79
AB578A6CB769AB334975BB9B6B079CDFB08D388A1540039FCB9A4FB45CCF32CB6D1C4A58194C581B
B38F988CD6325D21B79ADB3BFE51E5BB0C0128F4ABB6B3ACD35BABC823B98A208CC395DFDCD28D56
F4E8673A0A2EE5AD2FECF2461D2560DE4956C2FF00AEE78C1EDF8567CB7737DA844ECF0EECA300A3
243574296E925F5B5AEFF3617B47F2B68DA3CD5E4D625B2CEBB1A729F6E73B11D8642E7D47B56938
5AC9332A555393B93DB8FB7BC96D3DBC90C480468EA321877A96E74BB6B4D3423470C644B9124B29
2187738CFE94977ACDEE9565B614505A5113BA80CA3D5875AA1E2F564BCD365F2D6DACD2069071BB
74A71D4FD3268846366293973AECCB969A969ED78BE5DD2DC5CB0688C21B1F291D6B56169A48D848
8BBE2C100119DB8E95E7B0B8BC644C07BA67023E36B32FD4576DA6DCB471C6CB17957316E8B7E7E5
2C3815AA4A3B935E17575B966E7546D36D6D2D5185DCD32B98A59576ECC9E063DA8B39EDA11731EA
77B15C3DB5B979CA8DA360E7B7148D7A2DAD9567812611E5A553C18C93D41F7F6A59F45326917E21
B7FB50D41011229DBB13FBA39AA52F79CAFA1CDF6396DA9CAEA3E33B09E44B63A6C42DB6931AB3B6
E71EE71C57470DBDBF88F4886FED1FECF1C3198DD643B9948EA3DF15C25E6817D71AC1411CAFB516
3658F185F6CF4AF41D06C65D1A34B19E0DD1287B8FB433F018F45C55C52941B91555AA6D726E63EA
9708F2F9BE78B954508A5E32A54FA8AAB65A63EA376CC9018A293FD74A64DDF2E3D29D7D73717893
35EAB4204BB448BC2AFA7D6B2ECF56D46198CB148158008378C86038E95C5EECA49B3D1A6A6A9FBB
B9B5A74B0C564C936D7680B155DDF7707A8A5FED98FF00E78B7FDFAFFEB551952EBFD22FA4758AEF
782CEA037CBE98A83FB56F7FE822DFF7E7FF00AD53293BEA898D05257B9DA5A6A10FDB656834D648
C4665797760BB63A62B06F7571AAC968BF646B68F3E6291D55FD08EB5A4D7BAC19237B3DD6FBDBCC
9231B59718EF9E9589E2AF1DCDA6DE259D8D8C316A057CC377210C157D42E39AE96FDA4796F63823
0709A6A371FA9CE9A9689A8DC4EAF135A3A2ABED2410C7935109DAF74FF2A78E3B90AA025C2FCA24
8FA118ECC2B23C3DF113539B52FB3EBB711DF58CD22C52831226DC9EBF28ABDA95AF97ADEA460FDD
DB452F0B9E31DB159D48A8A56D8E9A7772719AB3DD1D15BC22CA164B401E164DA232A0127D79A8EF
B469D4CB24B1936F3C6AEDD3A8FA54D61762E4C8D38091A45E4471BF473DDB22B492CC3E84D6D7D8
8110799BF7708A3A64D6D04A6AC8E59B9D39EAF530ECFCC171BA08331489B4271853DE99A8DDC96F
31B3B58A3F2661B64882E7771CE09E9F8556834EB5B87BAB8D0B524D426886F78946C60BEA3279A8
A7BFB98CDBD9DF5B9923760C849C30CFF0F15CCD7246DB33B6094E7CCB53362D1E28ADDA1B8D564B
4888DED6D0C4242C3B0DD572E350D1B758E8762B359D9D9A7DA2E9E48D897278C1F5FC2A54883CE0

C28502C9B546DE8076CF7A92F23B9BD6F39E1650FC95FEF6DEDF4A1D49F2D8B74973A9264696CBA9
CE92048DA2607CB743B5B18E322A928D356EE1BB86D19EF973179D23F20FDDE474FD2AFDC5B30B74
D4AD14BAB4677C4ADF71874E7AD6778681D4D65B7B980A4C30C8518B6F3EB9A5C8E4EC91A39C12BC
9FC8DBB3B3B14D1EEEEFC409F65B4870A265F98EECF4007539ACDB6F11E993DE1B58AEEE2DC48E04
324D095DDE9C9E99A7F8B750F320B0B4650F1594DBA50B91BDB6E377D0572F31BA9209BED61AE527
F9610241C93F748EF5D2A11B25139D7336E750EF60BE874CD544CF18318936E3B9038FCAA7D474BF
36F2E6599C0B3901911B3F7D8F46E3BD675CDB5ED85959581118BA7850094AF32B0EA9EC6B42D6D4
5CDB79570CAD0DBAEF697A796C0F2BEE2A1377691125149545D4E5DB486B9B890C2AA26E55F7FCB8
1EA3D6B4E5B25B7B4B4F39D92D447841B7EF38EB9F6AAB3432DCDCBC11DD896688EE5206383D073D
6A0D6A2BBB4B982D642ECC132589C8C9ED8AC6A4F995E477D349B4932EDCDDEF984C8A5961B727CA
CE1467AF3DEA1D3AE9E480C51BC68B1B09154AE4B0F4A8E0BB8CC86568C5C1F2483D8A3765A9ED61
7B3BC8EEEE82C8AD1EF64C6DC67B52D9DE3B14F96CE0D6A6A7DBD9A5324667810BF36D236E130C76
35A90DE8FB344D3445532523673958F3EBEBF8D739697319D61E56B79248B7811C6EDB8A71D8D5C6
782E2E119F75A0F39818B25FCC6F5AA552EBBB392A5149A560BFD3D8C1711DB5CBCE37075D83FD67
B7E15466B4D6269A3B5FB024D345B1100C63D726AE5A03A7A3C1BC48A8C5E39581527270411ED528
D4353D255AE2D6432A348239E2917E5E3B03DA95A3A5CA8CE76B44E6E6896DB51B986554BA785D95
E28DB6A2B7A835BDE108E392E92CA7806E31EF5476CE3157248749D627711422CAE96369A678FE75
3FECE0F5A228B4DB2B28E7CCAC56456372F90CFE8AA076AE88B8257473D49CE4B91A7734352710E4
D9868AEFCDF323738223C70473EB505FCC978B1EA0F17FA4C3308DB1F28287EF1E2B3B50365A8DE2
3EC36F09621C8DDC91CD4C97D3A58C8EB6BE544EED20566CEE0070477A8552F7E6D88FABB8A4D6E6
6FDA9E39FCCB68844846CDAC7771EBCD6E457097966B61A9430DF5A0432E1E4DA5476E7B5645B347
33B37965A34427613819F5A516B3DB1B6B48E70AB32979136E0C83B0C9FE9510E683BA3AEAA84ECA
5A0F8E4D3E1BE81344D261B7BFDBB48126F651E809E2A7585D9FCCD80452B15F277724E7AFB5568A
CE0B7927926997819CA9E43FA0ABD8D92C42E0AAC92459017079FC2AB57ACB7339462BDD816A4922
B8B5164156378F286DD9B89777239EC6B2161BF8134F8A49591E36784441B383DB24543033BDFF00
9C2E5D4CC006223207B002AD12F181279521851F6BAB1E55BB1F7CD447DEBBBEA350700B5D566D29
CE9F15CB2981CBC926CDC266C7DDF6AE8EC6F6FAF74D9649E352D22928CB8CAFB6DEB5C1EAB7CF66
9E6C5E6CB2CDF7C281C7A1A93C1DAD472F88638FECB2ACEC0B212FC9F5E2B7A4E6DB8C8CEB518387
3A2D6B515CDC79F1DC5F2CAD028290E0E14FAE7A7159F068DA8C1A7FF6D34A8F1A8DA8A46D26BADD
562B4B382E248F32B4D213344460C6A7B0ACDB8B6FB759247691342A1498A17391263DCF4AC6CA32
6BA954EB374D72EC52D3E45B88A649D8F9F91B885C9383D38E956FCB4FF9E72FE5589A66A8DA7CF2
8923748D976C82320367DCD69FFC24963FDCBBFF00BFC2B78C924554A736EF1D8B8925D5B4920BBB
64595C068E556CA9C7F0EDAC7F1169161E2AB35D6EDA66B6972B6CC92290A4FB7A5743205BE85DB2
232A4B07519045645DE8D7A4C26C8446D3CC0EB1C526CF31B1DC1AA7169371D8F35568B925276673
BE14F04CB3EA064B93025ADB5D0598B49F3B639C015BB245BB5AB9592602359F90BCE73D0536EB4E
BCFB48596D5ADB629799C10CD213D09ED5A5A15A5E26CB6548DE04F9DE593197F4E7AD6329732B34
772695EA290E8A6B5F0FDCC53DC21B9DCDF715F3B33DCD667C47D6E6FB643A144D88980924723EF6
E1C023DABA15D0CC5AEDBBBC85631FBD68235CE48E40CF7AABAEE8B65AB9BF9B55D597763CD842C0
7744BE8718CF4AD292718BBE8613A909544DEA79C5C4234B6F31AE07DAA2C08BCB4C023A9E7A1AF4
7B8BBB5FB2595BDCD935EDFE11D977796518FDD19AC6B0F0969B6F3DBB5F5FCB71046BF688A1106C
120F4CE6AFDEC96B3EA92DFC5224F0194384407E56C7033ED5351A51BC4D5494E766B4406DE19F4F
9D54975B762F3424F2A49EC6AB24223B98AEA282478EDB2F86972BF434E8DEF6086EEDB4F8479D39
DF339C676FA0078E6A0874DD5B65F4EB712585AC5189651956590562FDE9A48EBD6306EE4A247D2F
508660E91B4CFBB644A481EDCD74722C1343F6CD16FC5BCF2291242F955753D704F435C0085C58F9
825697CD2A55B04F5AE96D2409E7DB03F69B74448D94AE36FA923AF5AD39B91F9331AB4D4D2927AA
33AFE1BCB3B586DCC29345BB0A93104C44FF000E6AE69F0BD84777712E976E970CCA45C46A018877
005694FA47916E88E7CB8E46E2391BA8F407A8AA5259456230F72A559BA039C2FBD4A528EB7D0AE7
8548D9A2B4113BDD2DCB3BCB1C2C5C79A7D7DF35A715E24565729F673710CC0A3AACA0143D7229B1
69A97904B756ED1BA4ADB0B1041520761EF4B6562F75123FD90DB44921DB12B6770C77352F9E9EC3
94E9CF47D0AD7F3B10F2D9A17B8650CA5A3DAD195FE75A90DA1D76D6278E348352F2D646BA93E60D
D9B0B55652F1AC76F10DB7C1B799D70C91AE7A63B9A8A49236B93F3986F606CB4E1372C807518EC6
945A5EEC88716D2712786D34CD2EC16691A599669FE4DF160B73D7FF00D755BC4C264D4F29230796
3468A274070BD326B46C2F3499A5892E2E1EDCCEC5A38A61F2CBF46E82A5FECE96D75282736133DD
804FDA01DC8476181C0154E9C9C6C969E4446AF2CEF2DCC2D3A478ADA49A4DD23BCC04618602B772
71572CD44B791CD23A09E357F2C630189EFD38A4BE5922D89E50120CBCB1AB64264F5CF7FA56AB5B
B4768059DD88A49621B9CC79FC81A231E55A9A4EB5DE9D4E72293CA60608CBDC8521FCC3CE29D10B
A48C5C44E278EEB20B349B777FC04D36CEC1D2F834932942C41949C73E9C56E2D9C7ACEA56B0C2B1
B471C080B87C8C0EA7EB4A2AEB4DCD2752317A6C612D9DD2CC8E912C6E926410DCB01E99EB56751B
D9AE228E14412A459652E006418E9572736EDA8CB3EA324BF61798416D36C0122C741FFD7AC7BDBF
69B50960BC759E238026808C003B10294D38AB215397B5926C6471AA4704A66691263892300F03D7

3FE15D047A9DB7FA3CE6DD5542111CE65C8651DB6F6AA9A5446EAC19C5BACDE54847D983ED6438E0
826A7F0FA2B5AA8BF8216906FF00B3C51B0025C73B4FA1AD6309AD17533AD5612776B54392D1AEA5
96EAD9375B4D1E642CFC7EBD3F0AB179BEC34F8AE2EA5890237EE06376DE3AE6B335195F559E2670
60B789405B46C85539E72C3EF55A17F1DAE8F28D4A58BECE488ED623D587F7BD87D6ADC7962CC1C9
CDA16D3FD2AC2E59046F364BCDC838503AAFBD67595B3BDFDB4D6002C6650C2461F7867D0F4A54D3
5743920BA8E62F113B8951C0FF001A8B50B8B28F4C364FE75C5EE433654C451FDB1596ED499D11D1
351D4E8358D1527BB69A09444A9289198838381DA9972B62638ED95E469E770FE7942557D3BFAD68
E90D2268B69BE5632DB216960EAC491C2B1F5AE5C79A3C42D3DF4AFE549FBE481719DA3F847A7E35
A4E3183D3A9CD45CAA68DEC735E20D1EE2145BFB70CF2424A5C8507B1EB573C2B7B6F0AADCC58F32
13BB6C8D8207A57690EA31885CBD9F9AB364950DB4A0FEB58BAAF84ACFC431CA7C3DAA42F7509FDE
420004FB75AA8C5AF7A3A9A3C45D72555646F1D62C6FF4D975192DD631091B9D1B39FF00808E4D53
9B477711DD7DAE59AD49F34A00178EC3D6BCE64D1357D1E7759CC96B2EFF00BBB49CFE238AEFBC37
1EA17BA1DE45AA89F1132BC73C8B83B7D302AADCFADB5316A14D5E9CAE8C4BD9259AEE5B9B8B28D9
6225822E00233C67D6AAFF006C5B7FD0221FFBF95B17D6B019E69A4577FDDA948F7601E78CD65796
3FE81D1FFDF55CE9CA3A5CF520E328A6744752B5B59C5A0D92C4A300E4719F5AA7756DE55E6EB879
260EDBD4AF2991D00AC8690CE586C8D1A3FBA3A1E7D735A9757D003730E6449022854520056C76AD
235B993B9E63C1A84972EA4AD6FE71219F0157CCDC5B1FF0134C96FA19C28485624853CB38239F71
EB59DE44F2008CD3891D09C6EE3F1A92CF4F1169D756F792845655922F30ED7CF7FC2B253948EB74
A315AEA7496DF6E608209D4AC51E42A365C0C77F7A8F53915905CDCD93046882968867F3F7AC98B5
295441A8BC2238641E48784EDC60773DCFD6B5E47692DB6DDC4DBB6070AE368604F515AC25169A38
E509C2499956176B244D7D65E74D71146D029908D91E7D00E4FE354D8CF119E5658494E24120E483
E80569259C42E13EC513C5BE505368E7F1ABDAA69D16A1A11B47B88E0BB79B1B9982BB907B7AD45F
9B48F437538D3D5F53CA66D375B975B923B2999ED666CA296E767A7D6BA0852DCA5D69AB24CD6B22
08CB20F9867D7B574D6367169379FE956524AE1B6097A04154F53D2EC7EDB3B69B14C42A990C0000
C71D7A564A2ED76F53A63352938EE8D0D1ECFCBD1A082D19638A18CF972C83EFB039AA9A4C1776FE
209CA4D10FB41FDFCA5B7704E703DFD29BA5DDBDED9BE9D09F2E6425A30E7B9EDC53DEEDAC2CA3B5
58120D4645324972D1E188CE01C7AD6975269B7B19284A3782EA4BAB5E4F7528D32F465E39B3BA54
DBF21F7CD5D9F4C597492D0478B6405031FBCE7D41EF582B652BCD3B5FDCC93C8ABB95CB64C8BEA4
D69E95AB8D3D6E24490CB680AAB5BCBDC9FEEFA1A4BDEBA9750A90704BD9BD50B677CB67697F609E
6C642C7B1E53F75FDEA6F1AEAD2D8E8D630465E47B88B73496E783EB835575D1678FB7DB2CD296EE
3A8F4120F5F7ADBFB2596B3A6C50CB2155B7D92A9B723CD43DC1ED8AD29BB7BAF632A89594D2D7A9
CA68FF006A9B55D38E9EC4201FBDB43FCCD6ECED67750496AE45B4A9233B37F7DCF635B3A2D8E9FA
7CB777D6F289667F94AAB29603D300551D4A391A17BABBB582DEEA575F2F232AC33D79EF4ABC63CB
CCB5269D772A966AC72F75A4BB68D73617D751CFE500F1B4470109FAD1A2F822F74E4696F2F9BECF
3C27FD1A076DC41E879E054B1DCDD5C5DDD5B4E914E62986DDA38E3B1AEB676920F0F5D4314B2196
155243805B1E8B534669C19789BA693672B67697DE1F585ACE413478F313CD192A43720E2BAAB9BC
8AF104925A8FB7C60000B6D8CE7DEB95BEBCD52E2D349821B60C86665679811B93A9CD6C5BDF5D9B
776BCB0897CB90222C230C533CB60F51554EA2D53D89AF4DCA2A5D435AD3249DA169A26B6914EE46
D9888FB351E1B82C6DAE2177768A40EE89192065BFC3D2AC3EAD70903B46D0DE42D2E6413E4AB460
F45FF6AA86AD650C71ADAAF946DA6226B5B867C31CF2109EC4553514F9D13194DC7D94BA98DE30D5
3ED3AC5BE9934125BDBDB2963038C6F627EFFB8AC9D16E1AD7C450DCDB41134724822F2C2F0EA7A9
1F4AE8B58886A9A55B5F6A79835281FEC90C88389908FE2CF7ACED2678740824BA502EEFFEEA8986
23814FA0FEF53954827AB3A29424A9B8A5AA3A7D37CFB77D422B97896695B6A1B6E7615E0139EC69
DFD9E8EB0EA062862B881B74914B26DF38FF00780F5AC092E2EF4B985CC8FBE79DBEE118639E791E
9548C92DF4BFE9477C8A4B218D8672072326A1E2124935A91F539393927A1D9EA17BFDAF6CB6807E
E18E7E6C2329F63E9591AD69598D0412439DE1506E19C77E3D2B32549156D5A492788B2617278041
E723BD5EBD26CA54DCB16E6C859B6E495F622B295A6B5348D1F6725CACB1347E65AC7A7C17415E24
DD70ADF2F963F8467DEA0B9864B1BD92785DA32DB03339CFCDDC835A8C6DE6D3A1608B1793109679
A4E1E455E3271DAB2EC352B3D452EB4E92656943B35BA4CB8F314FA7BFA55B8EB6B99C67777EDB8C
97C413C1793BDA4ACCAF20C33721C8E327154B52091DFCB71748C6E258FE7309E32DD3AD492E92B1
06934FB7B995CC8A85668F88D875C815A1ADB5BD8ED8268A493EDE8A627B641B436791CF3F854A4E
4BDEE8743952A724E266C51FD8EE1228A40E248F3207392011D0D61FF65C9A66BA7C9465FB3C80A4
A9C1391C11EA2B61910DE3B42EB14ABB51A394FCC71D7F1AB5A89B992EDBE688B2C5BC01C6D3EDED
550938ABA2E71529599B5FF098EA915ECB11B559CAECCAC8BB415F55AD4975B8E3D3C5D5BAC7BAED
8A344464C78EA4D7276523BE9D9B850F22B84F35F38E3B0AD2B411A99219DC99A40422E370CFA93E
9554EAB4DC64CE2AD868B578F42CDF69CA3EC6624991EE9033B05DC9F2F200FAD33FB267FF00A69F
F7E8D6F699A80F2A49E775640CA82353B8C67A715A1FDA76BFDE6FFBE6B674B99DE2610AF3A6B959
E3D25F9F366B599A013B90EA1C7CDB075C9F5A8BED115E27DA2ED2611E70BE5FDF2BD8D45A934524
71A98ADE3641B06064B67B93D6A4B868EC255884BE6C4141608338E3B5724B4563D2A6DBD4D34915
CAFD98B5C371B496E17EB579E2F22F333BBDC29428CCE7704FA66B9EB6805A2492D934922E036FE7

0A0F63EF5D9C418E9B69723C868A4555958F5049EB8A29DA7EA4D7BC2DD8CAB38F6C288524862576
2E261F20E383835674D8EE354569A4324914098DC25C86E7B67A52DDDAEA3A9DEDC9490F93130182
D81205E322A69F4291EC6FE0B79EDEDE0B884155498E43FF00855429B53F230AB522E365B95754B4
BAB3BA8137C911701D18C980C3DBD6A4B8986ADA9E992DC1C35BC814796BD5BBD5FD1EEA6D234C36
77D07F68496E0BC6B8F30AFD09E76D5E8F57D26DE15B992D67B777FDEC891A6E28D428C54AF1958C
E73A8E3671B9A9AC2466DCC93C0F2C41833A20258915E79AD36A3A9DE8974D50A44BBB1699DE07A3
115D8D8789EDD9AE609A0D420DA0E259D3823F0AAEF359F866445D3A65692E183DD3CC72CAA7EEF1
C75ABACA152CEFA2270F29D276E5D4E62C2EAE3CA9D069826B888963282DBA3523F880ACBB87B8BA
95AEEE598EE3E5891F2428EDCD761AA5EDCCF7729D3523B66650AFE5A8527DDBDAB3AC74CBDB5BA9
2468F7C770851A29BEEB0F551DAB374D3B47A1DD0ADA39B5663AD6EE5D16F52DDE3B768638FE696E
064367A734FD76EA0D40182DECA3594A2CDB6140371F5CD579ADA05BE8EE1C310EA22FB1B383B71E
C7BD25F4504129B38937A0FDFF00CE712AFF00B391DA8BA51E42142F514CA01DED6E638D9CA6F50C
CAE70A7D88F4AE91996E2D898BCE8DD9F01A3C22F1D791DAB3E2B7B48151AF976CFF0067F3E38F6E
501ECAC4FAD2E973B59DC42269DA15915E690CDCC6808E800A56E57CA54DF3AE65D08ECA1FB22CE9
1CAB19DE4B1493E6CFAEE1D6B6E4786FADA2174F751A5BB82BE7212D20F507A57173F8E6C7ED2B1D
8E82C6358CA92CC3E6F7DB5ABA46B772F3C3F64BD4114A83F773B6F847AF1DAB55CB0D198CE1526B
9A2AC6C5C69CB2472BA95512CBE649288F8033D38A9350BEBBB5B392DA30B211B4C2C509DE3DCD3E
7D4EE4C32C33462068C066DA3F76C0F4208ED50FF6AC70D8C84F9B2C0002B801F1C7403A8A534B5E
531839B49CD5C9E5BD30E8F10536C8A6539328C9DDB7242D513AD46E26F2635F29E11186EAE18765
A6DBBC5AF58A7D9ED82C3082544D16D6E7AB020F359CD68F6373349610BC9B485F9C64053FC4B50D
BBDD3D0DE9283BA7A325135CDBDBC9692CB122C6FBD62719720F526A5BBB6D2FC416296935CB5A48
EE0448AE0AEFF5F6AAF2F8735755935531933A80AA4A96DE3B8393CD4D77A5EA4A2D6E23B0488B00
ADE5291861DF1DA9A7516B6D0A9BA6F4BEA73AD36BBE14B936570A9A858391932E645523A10DFC26
BA7D26D6C356B3B836EA5DB67992B4BCAC4DE9B853BC452A1B6584A9304DB45C088FCE5F1D7E94DF
0FDB41A1DA5CC09348D677389247924C6C603807D69DD4A7E826E5EC6EB76413419BA8EF2E258B7C
F26C8F7FCE770ED492D8DCDAA25FADAC6B31BAD91AA4794618FBC055930D9CB25BBC8C864672F13A
B8640C7A8CFAD59897C883C891A7CC72294EB9DF9FBC0FF7715128EAD97ED5D9126911C170AD2EAC
CC658FF771A32ED186EFCF43F4AA9AAB58CF79F618AD6E4B43F2296FBA3E9EB5A377771C16935AEA
7E5BDD4499B729C3BFA6F07F9D51B592F5A4B767920F31DB7A338C30503A83E94D54B5A2B5467CAE
4DCC4B69E5B79843742DD248A3291EE076C887A87AC996CA2B3D6AD22B786E32CCA515D32C80FA30
EA07AD5F307F684AECB3A64B10039E5B1D4FD2A7B7BA731DB79971BA597EE6FC9288BD71F5A4BDF6
9C96CCA6B9758EED6A6AC3242922456B24F242E7E74917967F5AA970D2AAC50EFB7495DF11A4EB86
52BDFD8FBD646BD73790259DED9CAD15BCA19803C6C23B1356AC27D4BC45A3C578E2D05DA4C73E58
DACC07639AD2A4398C61EED9BD8A3A7CBFBEB8BCD4368452445B939660718F7A9ED1D6F243BE3756
4639031F32E2A1BD7BCB048DAFED6542EECBB66185727B8F5AB90C4B0C32DCD9CF14A2250A515B24
13D01ACA327B47A1DD2716B98B57F8BCB782DD82084B060D1100AB0FD29B7B7AB1B3B5B46619D942
280392BFE35953482D4806E15C3B8778A453F2B63B55F8DD6650D2C736D7C84D8BF38C8EBCD689F3
2BB32F66A1E83E2261B4124CDE51760A89170C5BD7E94BE74BFF003D2EBFEFBA8E38664DB1246D75
2AFCC72A7620F4CF5CD4BE5DEFFD0393FEFA6AB4E7D1994B92E72C61B269A4134C15CB6220840DA3
FDACD5F922B46B08254849DDC3327623DEB9F174E75B0AC206623EE31CD6BEE9629238B6CA1D9484
48CFC833DC8ACE334DB562ACD24EE472346675FB248D187E1B9F90D6D5D4A5BC31A8AC31EFF2E48B
CADBC3E33CF1ED552FEDAC74D86D2DEFA393ED863DD218480833D063AD69D86A33CFA8369B09B064
4B5CE4677071FED77A236849A22ACDD582696C79F083505BE8DBFB5669206CBAED99B7A63B15ADDB
5D6C2DF5BAC933A8E09B797866F6E7D6AFDDDD398663F6553871FBD118DCADF5F4ACFD5AD214B57B
DD4E32B7646C8F3C15F73EFE950D4A4924F63AA0A1ADD6E7573431DB9B89ADECAE56E5981540C4BE
08E41F6155B4AD39A674370F2932168DC3F1C75CE2B2B4D69DA337134F994C41C3094F9817D7AF34
B1EB172B3AC6B33485BFD5AEE27EBBBEBDAAA72B34DA33549D9C62CEB4E98235F2E79A66881CEE91
95B3FF00D6ACAD7EDA32B1CED3433E783240B9208E99F6AD7826845B69FF006AD3259A77059C44B9
455F5A8F56F0B5BA8924B76312BFCD1C478E7EB5B4D45C2F1470D1A9255573B2AE9176CF637B7622
8D8DBB2F9B2CA78917DBB57297DAE4F15F3DE8BDB96B70FB668D0E7CB07FBBE86B6B45992DAD66B3
99E575B906196D88DBB71DD7E959F71A0479586E25B85B6638691E3DAA71F74B1C5429A54F53AD45
2AB265DB6B431DF4AB15DDB5C1C2CAAF2365883DB3FDE15B6DA0D8CB6D70E920B9923E5F6382C3D8
D633B36973DB486DD3CF9014E06546780D8ADBD324B9D30BCBE543B2663BFCA1F34BEC7DE8A56EA8
CF13CF6F7599FABC726A6D1B2C2C3CEE064E14851803EB59D0D9C72C17F6523A0BA963F28096420A
7AE07F5AE9AEF5258588580C9651A83E5B27CCA4D51B7B8F36F5EF84363F30F2EDE7763BB6E390DE
F4E54573F345EA4D3AF350E592D0F2D7D035146D91585E025B08D1C0CCACA3D0E2B4B4C93ECF1A5A
B1588062CD206C673EBED5E9316A37563079305CADC7533389B7845F441DAB826F0F5A9BB9AF57CE
CCADB551E4EA7BE054D669DAC75D0AB395F9968741A5809A9F9135E89ED5610D398DF72E3D1456D0
D4AC84A90456F1812676E506F434CB0D374BFB45BC96A83CCDB864750148EE38EF5792C234D40F97
6F6AC92027718FE74F7CFA5094D2D19CB52A41CACCCFB79A0482E25B6951A2E0C8A130FB6B2AFA3B

AFB2CF74970B3403180AE77A83DB1566E3CAB5B9BBB6B69970D846DCBC053D4EEAA4229104AA650D
1E4658BE43E3E953B9AD38257944D3F0FDE5EC052D8DD2B3F5114AE4851E9F5A5D625BC1712C8C1B
681FBB7190AFEE6A94174D15C192C2DE39BCB5077B8C96A57D42E7569BC99D6611467E544E993DCE
7B53A92538A8A26145C6A39B2D4B28924B291A22B21B51B4941B58E7AFBFE34F80A20861B958DE07
20C9E71CE7279F947B524D6C25D62432316B68A010C5146C09675F41FCEA19AF66305BEE884770DC
4CCCBB420070AA3BE687EEAB8692B4505CA5BA5CB471C464D319B6B6C5F9813D0A9F5A97ECF7B1A1
B296E1E5587E6B776C9DC076FAFB559B7B9B677699644B736F28FDD373BDBB1C7A1A860FB4249BDE
F2532B31385E554B7714E366ACC1DD3BAE866EA569E75C10E0C9E680E93B93E6050395E69EADA8DF
2207998C48762E546E03B0151EABA8DCDE148752B632C16F37135810251FECF3C1A9F4DB58E35925
8AE2752C0882299F0F83EA3B1A874D29371D8D54DF2FBCB51D348B691C7396846D4D881719CF7CD5
6645B8863BB7992290A92533B4AAF7DBEB55750D3E14B78DC7DA5AE39DEB8F973E83BD5CB1BA8C18
0DEA3958D372071823D4568B55A8DA515CD12CA6A16C2C36916F3206C24330DEA07726AA6A0269ED
9ADE2960B6669467C9CC6A0FD6A6885BC96AC52DE28DE5C91B8127F2A736986711CB393F6690797B
F81F3E7AD55E56B233B534EEF42B5ADA6A2B613E9FAC5DB5DC3260C4AEFBDE3C746463D2ADE9B6EB
6693C9F698D9E54D85D71B1CFBE075AB5AB696DA744A924F6F1AB26D33CF284663E8BEB502412A59
C76B05F69ED6D73FBDDC8D958D875C91D29352BDDAD8CF9A2D68F7122B857692211AB48CD8F3387C
3760335B5690A5CEA92ACAB2A82AB1B485B68271CEDAE62DA1587516FDE46B6A7979666C0CFAAD74
70DA5D5D3A5C19DA75C0FDC33EDC8EC71574EF257B5C588E58E97B124E97D6B3C504104B1C0F288E
23183975EE58F4ABBF64BFFEE4DFF7D8ACB4BC96D6FDADA692E62468CFEEE690FCA4F4201ED4BB87
FCFECDF98A15551D2D731E49BD4E363D309BEB796E2D1489CE15ED940205592F125D181E39D8F999
0CA70C71D07B8A7B6FB4B8115A3CB8003ABE73F5C7B55C58E6B993CF310372A81A3684128E075C7A
3564B55CB13A26F95A72D8C8D66E2EDD1CDE40A2F24C1876A64EDE986F4A9F439E2D3758B3436320
12AE242E9C86EF8356F54BA8EFFECEC633E72A8C4D160990FF00748F514DBCF0DDD288259EEA5645
01A38E33F364FF00789E82AED1B364AD945F5249600FAA5D5B5845731DBCD832890E4A0FE95567BA
8F5188C139445C98A0F3177F98C3F88D68D9DC1D39E4B648AE1D9918C92FDE1D3A6475AC599926B2
89D94AB4722B12BC165EE40AC9546968744217767D0B4B1C161A4C658C42F6793CBF30AF0807F0D4
73ECBC9A3786D1A2923205C301FA8AB2F6B0DF5E794D32DB46503969DB70E7D0FAD7430E9091DC22
B4A52DD861590FEF1D40EBEF5518CEA6AC89568D1BF72845AABFD92F1E5370A658FCA8043C0451DD
BD0D73F6FA9EA2F7ED64D75782067C66E66391E98CD68DEDBDE5B4CB7D1067818B2E1B2564C9EFEF
4F81B4FB0F2A0B9D2F176ADBD6E2E40908FF00781ED4466A378CC4E3CDEFC15EE549C348EC8A92DA
CD1CC17CE94E414C755357663A9DFD9A94B9F3E2E6390C8E48057DBDFB5364DDA9DBB9BC8E528CDB
90C29B5500FEE934FB29EFF43FB43C71BB99946D574DCBC7A8F5A851BFC5B1ACE5A5D6E8C6B9D582
FD9FEDA4BC8D925C732205EE6B646BF15E5BC91E98E76E11D1A453B99875DDE82AA7883C2D14BB75
5827681AE6105831C81EA071D6A0810D9C11D9C11466248C92EDF2B49C7AD68E0E01070AC93EBD8D
3935637B2CA195926237218FA31F435D069FA380B6B717607CF876855780D8AE63CDB789A1923894
2C88BB99470ADC700D77B6B319EDD19777DD0B93CE6AE95A4F5672632F04B915919175E12D3AE4CA
D14B3C52B9C8D8C147D2B8990FD94496570C43AC8DB449F2BA3FA8FF0066BBAD5B5792CD18411319
5481BE553E59FA62B26F469FE23696CF50823B1D4A26568A738C48319E49E79A559464FDDD19385A
9522BDED5185A378856D6204C4D34F1C6C5D10F04678233FAD6BC1E24B8BCD62D0D840EAACA04A26
5E71E805734D0C36FA9CB6FCB606119D786FC456869530B7D5E0B89A375117CA594E0FCDF77AFBD6
0A4F44D9E854A1077925D0EADF4E826D2649E18E0FB4C52166207CADECDE958B14776B205F222DAF
21609167E4E319E7B55A82F5DF30B810C664679C13CCA3FAD4575ABC1693164B7BBBA6DDB11ADD3F
769ECEDFCEB66E2D7333861CF0BC7726B1D222B55FDF2E66662863CF63DEA79AC918CF259400C680
0C0E19A9916A935DDBC7E525BB1D85DF07E7500E36FD6A7D189F3A5BE8A4896DD494952593EEFD07
F2CD52E57EE99CA53D64CAC259A288010DAC6FB7A4792E0FD7B1AACD7E676555B7B792E464B79D93
BF6FAD3B5BF1869B69746D6DF4EFB61DE0B4FC2AE7AF07AD2E95069BE218A6BAB067B72A192E6191
C799083CE41149C64F54EE8A838AD64AD72AC16D05CCBF6992D2666DE19D609018C7E1D40FAD125E
CD6B7F23BA0236608850958FD0E6A2826B97B729146D11132C71CB1A9DD2F19C39EF522099C26A10
4931619826894654107A91594E574B9743A611B6B2D519367A1DF4334B3CD3DECB14BFBC3BD4A85E
7B56BDEDA4B1AA42F2379B17EF44A4E4B03CE0B75A5BA8E79EC5ADA79981833BB739C60F39AC0B5F
B48BF86D9A6B832CB305468D880C98E41CD5725A2CA5272D2FB16AE84D2A9F32E1481228286421D5
AB5ECADDD6DA68A5F2EE64972B0E5B3B33D77135976735BC77199C1989C8C13B8A9CF535B5A75C58
5979B6AA858CED92ACC0AA9FF67BD14DA6B716239A2B445636735B6959923792E11B77CE7236F4E0
F5EB4DD32F26BDD72DD045855601A161B8103B815D0456CF73024D6C96CCDB0868D8F0403D07BD65
A96B4BF8EE34CB511DD331244EA415F51C76F7AD651B494AFA1CD0ADCE9C5AD4E5755D46EAE757BD
D42EECCDE6E99A3883A978E25538000E8A4FBD5EB044B6D7F45FECF8E455BD6C4F6253183DC91E95
7751B39E0B817967746096E1B3241B498643EA14F5A5B18A2D28DD6A9399DB5564689094DA91678F
97B835AC670576C951972A51441A9594316A3A9F9B33B46F31F2A28BE60BEC01E2B76DAE671A6C37
458C6B1A602C9FEB1F6FA56142523576495CC846F6FDE676FF008B56B58DB477B7988609AE210815
F79F997D718AE5837B2DD9D35A31E54A7D0CA9757B9D7751966124236A05DCE84371D293CABDFF00

9FC8ABA49AC2C52EE49120983A2848D4A00BD3A9351796FF00F3C61FCA87171255585B4D0E665177
130B99AEC0882058CA383BD7DAAC685AADCC57AB0C2CB8670B106E1437FF005EB9FB1B26FED43665
7CD8E21993CA6C843D87B1ADBB07B6B7782568DC4A8F851C6DE7B9A525CB3D363694554A566AECE8
F53B38B72DED92082E24C8604031A9F5F6AC76599ED512FA4B9043938EBB87F5AD7B6D52DA4B4BBD
36790159B2B1CCAB88D571D49FAD64E99637F6967736B75BA62E8CB1BB3E4027BAB13D2B59A53F79
1C3465282E4648B2CA8EC6C032C3220475C838FA11DEAB058A0BD01627976C254C25777CDEE076AB
FA6587D8ED6DA7B89E0B79D00516EEF90C7D481587AAEA92EB1A9DF3E9B72BA659DA9DAC62F92598
F739F4F4A88C14958E8F6AD4EC9685C82F24459ADAE63F2BCE60F1AC716463D39E6B66DAEE38215B
89C5D41205F9447FC3F83572BA24F2DFEA31E9934A4A491196DAE1CFCE7D8B575CEF6A62B38DEE4B
0E22696E0FCCC7DB352A3385F52AAB849A56258AEE4BEB68E1B92CC8C0988226DE9EA3A565CD0E99
14F2CAF2B1674FF58C039CFA6714EBA43A6DE2C50CA1C2C4CE77BEEC127B63A552B77696058269C4
693AEE5675E98EB83552A97D1934A925EF27644D03DBACD14135E5C3D994CB1590051DC63B7E1568
DCDACF6B2B9BC9C49BCB46243FBC38F6ACC36ED3DDC6D9C5B85DCD085EBB78F940AE8A0D3639BFD3
AD8892D8024344E18E3D08EC6A75969BA2E728C757B9C858DEEBDA66AED6D3092EAD26C13131DEA0
1F6FE135BFACD94621DECCAE84810C71F39047423B1AB175A24D1450DD5B42D2978D8B91F29F6CD6
242BA9945220DD03234A7CD04952383F303572768DA4851E59CD4E0C6CE9716B670DB9441B9B7146
FBC01F4A9AEEFEEAD6C265B7B99E38948DC866C480FAA8F4AB575045A858994DC885A4895944CD87
420F7EF8AC2D46EDE68FC9B588B471A85333AE5CE3D0F615CD27C899D11B546935B118D7AE1AEE2B
89AEAF64F25838469308C7D08AD5B2B8BAD7B55FB45F5B40240FF795081B3DBFC6B9EB8D34C62377
7574DB9650C0B03D8115BBA6C0FE5300F7116D0B13049319CFA5654D49BF78AAB1A497BA4BAB5AC5
F6D6300291C032558E5BFF00D5550E9374443388E59A098E0857CF3D719F5AB5796B159C4C88CF32
48EADBCB73B7BD6BE936C6C1E69EFE68459C482587328DACDDB8AEA8D34E566632ABC94EEB528C7A
6DD69BA54BA95C5D1B393A442E24C654F5001EA6B3E296EA24B796299B683B0042763B67AB8EE4D7
3D79A84BAE3BEAF7F2DC5C5E072CB6C49F2E219E8A0F4FAD747E17BA3FE976927CBA72C2677F3C67
ECCC7D0FF2AD25493D53D888CE4A2E525AB346C659A0BE31C90430A4CD991146083DF19AD6D3534F
6D7EEA18A2DD6B30CE5D7019876F722B928A479238D0B4F3DCBFCC9C6490075F5E6B5B56BB92EEE6
CC5B4EE88F046C1623B083DCF151ED1463CDD89AB45CA56EE70FE2AB1974AD7A7B40D200D2B4819B
3CE791B7DBD6BA9F8736F3FDBB50D40239B13682390819DEE0F41EBEF5B56B7371AC5BF977FA658D
F22E63F3AE22DC63C772C7B7AD487548E2F0F793A48B28A33C33DB9DA9BF3D57D8FAD6F1A908C5CD
75309FB494552B6C5BD4AEA1FB35ACB651AAC517EF1D31823B6703BD614B37D9EF7ED36F70236BAD
B2FEEDB014E7A30AB16D2449732ADA040C40F31A51B919BAE3FDDCD65ABCB701FCD5B6CF998568D3
E6CE7A1F6AE794F5BB67451A565CA8B9732FF68C86195A444933F311B64624FF000FA8AA125DC6F7
50858983A0551203CAB038CFF8D68CA21BC0EF2DB3C73DB8089E47208CFF0000F5A8A7D30C524802
5D448EC5C3DC8DA5500CB64FA9A5CB3E9B1709D38BB4B7338DB6CBA26131158C9699E33B867EA3B5
5A8B4E97EDAAE6E630C406DF0CBF2AE4671D2B42CA037D0C76562B1A4380C48FBDB7BEE22B46E7C3
CD3D8FFA2B38607E68A51B4EEF6C76A6A9DD73456813C4A8FBAD9930D95FE97A8A23CAF28994CDBE
395B68F607D6ACDCEA090A4724F6FE748C705D24DAC07D3D7F4AB1BEF23B89239212D060165653B5
140E4E7B560C72C6DAA486CBCCB88D57CDDF2F409E83D714E3269A4B42153553565A4F12686D3049
4DF2B00423CAC9294FA8EA2B6469BE6DB2DCDB94BBB2964126D818925BFDA1FCEB9597C3FA75ECEF
3C13ED95BA654727EB5A5A7C3E258EDD6D2DF6242926E12C048208F5FF0066AE12E6972DAE655692
8C6F0760D417C8613B45189CB15912DC6154763F5AD9B7B84D1BC3F713C32ABCF81F330FBB9EDEE6
A3D4EF62FB66F48983746124606481C9FF000ACA43F6FB49A30E66B56FF5914BF29CFAAFD2A39D42
6D772945D4A4AE72F2EB97AFA8157965903303BD58EE3F99ABBFDA93FF00CF4BEFFBED6AECBE1DB3
1A942D1DC0783CAE648632E7E9E991567FB174AFF9F8D47FEFC0AEA528C74B8F9E3FCA6569D144F0
4B0C4BB5E56057925C9F72298B6724D3DC6D908310F2C293C927BD325964B05B79E125195B1C31E4
8A56D4E3BFBFBABA6B79104ABE5B84E003EA0D71369AB4DEA74F334EF0D8D2B491DECEEB6B2A18B6
A00E38C0E0E6ACD862EA67B4B8954AB11B55988519EEBED5CE2DC34D14A199A5837655617CB8F76A
BFA549B9E58A07C3A7CC1A77C85C0E82B48C5F2AB333A8AE9B362EEDA59F4EBD997E6B95976118C3
B4638CAE6B9CD5FC377BA60090A3DC5BDE2F98044BBE48D87F0903B574976E3CA86F199FCD285648
37FCA41E8CB50E992D9AD83893CF7BA693FE7A65801FD284D4276B6E651E670BA650F0F68F73A63A
EAFA83C76C6CA3220B4B97DAEFBBAF1DBDABA29EE6D67D39EDE76959D9F7C2E304A83EB54AE96FAE
A048C69F23ACC422BCA3927B63355ECA3B9B0BDB944FB34930FDD1080C840EF81D88A2A36DA56B21
C211E5726EECB8D0A5CD941F6486459D0BEF59872D83F99ACD9A5B96B4B78E4100081FCB5C1CE3D2
BA4F29ADE40AB73109436EF359B00FB1F4359FA92012497314B23EF90842FD233DC1FAF6A2704A2C
746ADE5CAD1474F94C5731490F9BE77D95DD54F638F43DABA2F0FA4126910412B98A694B3148DB1B
8762C2B96D3ADEE0EAD15EFDA37200C8559BE751E847A55C36ED25ADDEA0D7105BC96EE13F72CDBF
00FCA73D39A887345269175E0A774D97FC6FAE49636DFD93179D04822F399D7E50EA38C29AE1F4DD
437DBC724B3CE37821ADD24381CF65AEEEE2EACBC41A4452EAA624BE8D8C511853717E39C8349A7F
836D2C9DB53BA952450A1E38C00067D0D755E33D6FA1CB097B18F2C96A65E5F4F7FB35FC16E60C02
5CE7CE03D076ACED52C1AD2491636658E46DCBB170A54F23FF00AF5A77B7371A9EB1FBF4899D4EE2

2D54B2118E9CF7A9B59BB8B4F786692E241F688519227404360630AA7F5AE4B45C6527B1D5ED1C5C
74D59CCDB2DC4536D9A0F3243207DD0C7CB7E7FC35B764D1CB24A9865795D9898FA2E3A1AD65BC4D
4B4A69D6030CAA422048F938FE951C16E9690C73CE7609A4116E8E3CB28F7F4AD214D74319D6BDDC
9599761B589A48AD5ADA46771E62C822FDDAA91D09358F3D94FA7C8D15F88E784306619F7E8B535D
6B9A968D73B00992DE398000C658491E3AE4F4AB77B7F6DAE696B71347E54B13FCAC500561ED44A7
092D3722946AC1FBDAA673EBA1C37FA9C89A4C9359339F30C57C9F263FD865EDF5ADD7D36CF45F0F
DD5B059E59E79144B7328056423A018ED5412DEF16E0BCDE6DBC5B76F99CF27D01AB3F6B02C85A35
93190383B99B017D38ED4FDAC9C5A7A1A4A8FBC9A77B7433375C5D6A6B700283115CBC2987555EDC
74A9962927B8589212AC1C8466521C21A49A675799A4310720967B61B54E7D7B9ABBA7DB3CEC9344
F379C90EE67924C86F603B565049BE5BEC7455768DCB9F60BA368DBAE2575E1BECD130507EA3B8FA
D374DD2EDB52B91134135BC714788B90AAC7E9DE9EB726778669ED64576428161E18806B4350B7FB
6DA4B6DE6B5A4919125AB197CB3D3A035B4795BBDB638A5292567BB39BD46FB4ED3EFE6B2B592468
223B5A44032CE3A8F714C7B269E092EE0BB89A4C16D901F994FD3D6B2351F0FDFC57537DA77210BB
A39A25251F3DD4E393562CE1974EB3B471E61BBB87202A121D1075671EA69544A2AED1D34F65666A
CB26A8863B985A3E63123321DA5507523DFD6ADC5713DF5B5CDE49742E23C2068A6CB81F507D4524
6651691C1200F248D8B7565F976F46563DB35A44DB259A0863105B15C2A46B81C7504F734461A735
CE5A927CD6B09E1E5B582EE46B68DA2F306D3128383EF5B36BA82DC6F60AD02A36CFDEFCA735CCDA
DE5C5BDCDBB4B2C6B0C6C11474241F5A966D425BB6F2EF3F72D1C9CC81488CF38EBEB4FDB38C5215
4C3B94AE687882E3CDD358DB4F3394FBC901F91C9ECD5C95B59C9F6471200933C4402DF2A2A83DEB
40DAC93DC896D352F25A362CD0097689109C1C7A9A44B210D8DD44FBDC81956DDB89F6352AF2939D
8DE9A8D2872DCCDBD92DD6DF65B6EC0209318EFDFF000AB3617E21BB30C29751991543094FCC4E39
C7B7B53AC6D26B0BC9AE1EDD8C32C677201DBB62B4ECECD6E248E470C25441246CFC657DFDFDE942
1DF72AA545B5AE86DC25C3DAC86FA3778C23301B46E07B283D73F5AC195269CAB2232C430ACD2038
1F956DDD4B3F90ED3C32A484ED6995700AF66CFAD53B49E5964BA86D9C676A9513F438EA78A6DC5C
ACFA0A973462EC523E7C572D14524BF638F187538DCD8E08C76352EF93FE7E66FF00BEEAC916A525
FB6E1270A3315A8C054FC6AAEDD1BFB9A8FF00DF4943F62F56C3DA545A2473FACADBCD753B588944
390A859BEFFBA8F4AA29E7989219BCD58509DEA07047BFA9AD43A05DC7049712C6BB73B5097002FA
62B61F4B912D61B293115D905C0948C49C7AF6A89A94A4DC91A5294230514EE63A25B0804D641E2C
E15D49191F5AD5F0E68C2E2ECB0B88D327E55273B8FB7AD5782C3F77139091CE5822443E6F30FA93
D2B70DCCD68FE57F655BA3E411309C2EC39E42802AE8ABEADEC1889B51E58135CC6B15C5C2F970CB
15B8D878CEDF7F6AA3671456B732DDCF1E244DBE5448E0CB203D78FEED57B9BD168CD752B186399B
CB930DB83FB9FF00EBD1637913EB50346F14893911924E19077E6AA734D9CB4E138A7D8E9ED6E86A
DA98B1B9B768440BE74446768C7A9CD50B8F115947E29855A111C0AC5649618B877C7DE2DDC569AD
EB4B16A00405582ED899541DCA3FDAAF35D5E3B98351CBDC5CA5B3CFF2AA72076C119E95AA4D4772
68A8CE6EE76F73359982092D54DCA5D4CFF3821B9FF68567DCB42B1BD92DC93319301720818F5A8B
49BB3A7681751BA4335C4D70D0DB9C61D41FE223B556D1B4B8E379E4B9BB8E078CEDCB0DD9EE7358
54F8B951D5460945C9F4376C6D265B3B9589ECF9F9BCC8B05978E84D43686E134EBA79D415917C95
3081B70790C4543710B4D347169F17D9C4B2AF9A14E17EB5B76B750C65B798AD9B705F29CEE52071
CFD6AA9A4F46675E4E3EF2D59CD4F1FD9120299741D644E083DEB5966B44F0EB5BDCC9744201B5E1
1832679EF57278B493929B2DA5F33E6890EE439EFC565DF5D4D6AB1C0EF1B195BCA2D28CEDC7A567
ECD52BD99A46A7B7B26AC55B58C4D708D6A64B55452D286940CAF4CE477A5335BDF37D9962F3A050
5604BB50C073FC27F86A28ADA79D6E1620A85212724801867D7D69E2D3EC9670EE7F39A401997FD5
851F5AC62EA5EEB446F2847AEA751A36A36D3BBD8DBDAC9BEDE2C3E0038207AD673EAAFA66F0F6F1
0898E241D5D581FCAABE9FA994BF861602D9A498191914E5C1EC71D692E9AC5677490A4BB262BF3A
E3CDF5238FE75B557371567A9C6A8C6351A92D0CCB7B917F7EC679E6D933EC7491FF007617B3006A
1BCD300792D2DE77611B662571B14A8F4C75ACED55628B5001B889A40F18233C7D6AEDA96B8B5406
6DED1C852342C7761BD2B354F471EA77AD2D25B17ECEF8AC2B6E6EBCCB779C178E47DC40EB95CF6A
B105BCB2DDDD5DBA9B7628E50A67E7E703AD655BE932420309C33C48C8F0B60119E7AD6ADA497531
52B2A98BC9F264DC7EEF7CF34D4656D489F2AD60259A2DDCD1687771BF925709244A3CC8BBE49EE2
A3D4BC4B77659834836A2D2DD8C4249C7EF2661C1C9ADF89E2D2EDE4BCB78E1967917CB9640C3745
9E847B7D2BCE75FD1AEECD55A525449865C31D9F51EE6B7845A8DB7672271A952EF4474DA3DF5C49
6DB82CC642F87C8DC63F7FF76B47519E4D4A0B75BA31836B1BB9F272483FED7B564436571A3E8DFD
A9713C9E64F1AC71A2927CC6FC3A0FAD6AD8BB5D43F698762975607B6E24743515217BC0D1F2BFDE
762B476977AAF87DFCBBAB80F6970AE6391C81B31FC3EB5259402185A7BE86612C672A1F8494E380
58F3576CAE67B4F3648A3591E450AE8781111E9545A69F509258AF2E199CF29095CAE3DBB7159B6A
29596B6125395D27A0F925BCD596D2795122898EF93CBE234DBDBAF5ADA8022DBDBC71B178E78414
8A43C2B1EE2B988DA32E1526570E85044AA46377F17A56C1D4AD1A481588F3A10888A0646475ADE8
CAD1D7766388A72BA4B62499F3712C170B0C6E1371CA850807031EF54A1D3A7B9964324932246AD3
260FCA4FFB40F1497623BED452478C9F39CB1DBD38E00CD45AFEA57315D369B66D2C90C1B4C89B88
C64671EE2A6DCCDB65479A2925D4AB1BC979728E18F9688103AF1B1BD09E957ADB56D40ED8E53045

1C63FE59A60B2FA907AD62695A9C96F1DE1360E20B852C6377CA87078DBC74AD086E16E6F2DE2951
554A16478D795E7F5A86ACF913D4E89479D5DA37A59656D36358D996566668FCD42094159768914D
AA4D26A17522038061933BF691D87F76ACC905C86303312F1743B89E08A82D9652D1E583DCCA7CA2
4A6FE3B02DD715B5EF239211E583F3346F96DA6B17B3B67324236B862D90C17B67B1ACE30C52188D
B40F1DC06DA173C633F3669D1C50DAC825B6B9480AB62784292871EDD2AE8B908CA8AEB182E5A497
67CDB7B01EB9A395B92726253508B486CDA642638E49D999E760BB940FD73DA8FEC0B2FF009E8BFA
56C3CB67710CBC09CDA8F3B67F4AA3FDB96FFF0040F5FD2AE5C8BA1846AD45BB396D62F00F0FE99F
6BD3C3960CCFB65C0C0E14FE35942F2DF56D4DAD8DABC21005505F701C74E7AD6E6BB65FDBBA5A0B
585A178311CB16EC803AF07BE2B1EC6D5AFAE537339B5B4914BCA4618FD2A26A3386E76517CA9E9A
9A12C6964608A49B615809545538049E39AD7D02D52EA482F4BC4B6F6819591F27716EFCD635FCB2
EAD3CB0A319A2DE136B003601CF156F46B88350BE991AE27DA225C6E8721D94D654D4549729556FE
CAF2DCB9E28D09A6950D85BFCB28E51300061DF9AE7E4D29AC1A194152D19533C2C00DB9F7FF000A
EC2EF534D3249A26B92D3C8018A2099C7AFD3F1AC0BEBEF36D9628AFD27F31BF792343B76B0E42D6
D5143595B539E854AAED0BE86A69DAD5D9B45548165DAE4148F01553FAD5C8B41D3F53BDB3D54DA4
6836E5BE638247238AE72DED966BC8AEACE54631B2BB6D52083DC62BA3835690EB6BBA49CD872100
8FA9FA52A536B56F42AB534B4812CFE1FB279AF2E1A112CD230DC15B6607A0E78FC2B9BD516C5236
86C2085613232B3173971DB04D686A5731DF6A492231F2A01BA5F31766E3DB8AE375ED25355BCB47
FB53886390B247B71BD73D71DAB2AB524DBE537C3D376BC9DFC8DE8A4B2B39AE11C333ED4F291075
E3A1A9ACAE6DC4D24970B10F3BE59232701474EA3BD43616F36A375752FCF1B4250F0808C0EB516A
37B6ADAA7F695AD96DB25608EBD0B9FEF56705392E6366A2E5C869A69AD325EA1B347000FB3A79B8
2E01F4AC9B9C5ACD1446EC3E7963E59FDCFA75ADED36191A05D4C798B991977A8CE23C75A917C3F0
DDCAF726457253076F249F5233C56B2A7295ADB99C2BC6127CCF4302EAF2E2189AC9B63287DE932F
024EF8F6FA50DE6CB180A88B2A0612165CF99C718A96F34E4B082E206B620CAAB2460CB90E3E83A5
58D31202B1A344B1421370919B710DDC62B271D5A7B9D2AA47979922ADA99AEED842D2B452A0DEF2
B2E723E9D78A66A30A41AC911CA6588A8757917683C56AD9C56063D4AF23B9CBC0A51A131939C8ED
58D2482EE2B85D49B176225113227CBB7B7038A97751572613529B6B6326E5EE64F2D2E51578202E
4700FD2AE68925BDA44A97B6CE616395756F9948351C16C9333A13E70600AFF09C77AB1F606B7D4C
2C086DC20E4AB6FDC7F1CD28A9295CE8AB25CBC8743AD6DB7F3A5955950322021776E3FC278F5AA4
8C6609FE8E4B04D8E84E77B13C1F6AB9A46A936F93EDD1B2D94AA543633E591FC5D39A96E2749ECA
2934BB995A75244EE90ED0CBEBC8AE8F66DFBC79DED543DC96E652DCA59413C4F6C91976F9DE36DC
50AF1B40A823D62FF4E88369D74FB1CEF78C80C0B7D181A73DAEC8FC8F231247F3C8A1F93EBC8A8C
5B2B58FDA11191D188D8DC923D8D64E3CD2B5CEC8C69B8FBDA93D85CCCCAD66F3030CAE24F2E4E7E
6F507B7D3A56FE9FF234C97E91C30B8C2239DCCA7F0AE721D560B39E1B0B99BC80C415DD839CF6CE
38ADAD4A75B448AE4B24724054CABB7775EE6B783508F31C788A6E52E45A2659BCB8B4822876B4E2
3947EEF07193EA6B0A7BA179731032B2029CA9E39CF63E957EC74A975395AE2FEED1915B11B6D203
0FEEE074FAD469A5CEF3B48B1221B09F243F643FFA154C94E569742697B3A578B7AA20BDB44856E2
E113636D5CC68FB8553B78AFDDA27882B451E4C83215893D6A4D434F4B5479575146B7B9CC91FEE8
E4B2F3B7DAA969E21B8BCB413444C129F31D8920AE3E9D6B2E66E4933AE1671E635EC23824B868E2
BF51132B7C8E18312790307A7E1552FE496D9922BA88FDA0314186EB1FAE7BD32DEFA2B469049143
24524A7C92E4E7DAB5A6B48AF2D2DE2B58F73E7E5E48F9FA919ED5AA8BB5CC1CA319EBB19696F15C
C22EE3B5705485D8D3751EBED534B657315EC0249511A33E601BC36D53F4EB53C577736933C57899
2C36B211C6DEE7DE9AD1BCD2A192D42C903615E33B7098E3EB50D6A9F5356DD9AE868BBDA3EA315D
1B874F371BD9412A31D2997522C5A99B88CC52894170C8307078C015CEF87753B9D6A4BBB29D0308
4F98B8520A8CE31EF5D1496892DD5AA16CA87FBEDD7D86DAE8927A5CE5E58ADDEC446C14D9C7E45C
FCC5C8443F78B76069E92B23FF00C4D6DE3475003B17FB87B703A54CDAE5BDB6AEB0411477389024
926DC0DC4E38FA5657886013EA4C2E1A3765044AD19C0721B8A94A32F8022A4DDA66AF87F51B55BB
9219EE3323029BCA60107D6BA3D963FF003DE0FCEBCC7448BECBA83CEEEBE4F38E785F4CD749FDA1
65FDE87FCFE15AC15A369115E8A94AF1209A1D42368545B285DE4908F9C03ED54C5A156984F334A3
218AA82BC67A7D6A78C5D5A6A3B03096D554BABEEC1CD69D919E408D25BA84662A5776491EB59AA7
193B326A579415D7539E9ADEDA2BC430BF936CAFB8CC7A9EDD3DAAF6951DF5B6B114B676D8815CA8
05C15743FC42AD5E346CAD692A1126F01587A679E9542E2D1F4FBC7769DD5E218DB08C9514A71E5D
52B853A92AB1E593B5CD697C392A6A31DD69CA1ADE725DCB7556F4E4D67A4F742592C4E9D6E57CF0
CD3C9CECF538AAE2EB556B98D06A53B91F32FEEF007B6286648C3B0B9691E45226B7542003DDB3D3
147B694F44AC5C68FB3F8A571B1865BE22064796360C5E24396E73D2B7355D2CEA722AF952C1244A
67E1F19CF5C552B7DD69AA5BDC5B49958554B38392E1872066B4EEF55824BDFB4DBC6ECE994761C8
098F7A88CA318B8B1D4E673525B2399D474269F4F98C5792BE405F9D0B321F7CD4C96F70B1DB8B5B
7496480AC6CCC065A4ABF73ABDE59580BBB58228E0BA04994904F071C2D64D99F383DFC81594480B
B9936990FA81593924F9123AE95DAE696C6E5ADA5DCF2DD6CBD56B8543BA15181CF6CF4AE15C0FB5
BC65A465850F98587423A576BA65C3E9F1B2CF0C96D13B124BBEF3221F414DBAB8B75B50F1693118
4865F9DDB7B8F7C74ADE152108FBC64B9B9DD95CE4AE35DBF6D0AD74991DA1B677776DBF7A61D00C

8FBA3E9599631DC6997BE7D9B9B478F2C4F2770F439AEC67B4D375EB51600A69D2C63CC82466DC32
7AA9F6AA51784B57457B6B99E086098A92D9DCD37FB284F4AD21CB35CC99139C61752566CDCBDBE9
B51B5D2F534B132DC5DDBA844CE360EFF5C9E79AA1F64965D492192236D88D9589F9B77A67D2B5BF
E25F637A15AEA3B78A24DBE5231768B03E5E9D6AA4D7BE65D3BDAC13C5114DD2DC3B0632FAFCBFC2
2B9E6A2E5CCD95465251E548B5A52FD8F58DD6EE25804419D95BA1F523B8AAD76B70904937DA576D
CA932944FBA41E83D2A7D3033012D9151311B0B479CB8F4E69973A6CB1453C5F6466124A5CC28E48
3C75DDFD2A953F77440EA25535673D0B337992A45B5D3003678C7718A92D3503657332ED5926E301
BE5DD9AE89ED2D63D1ED05C48F1CDB8952A32D183DB1DEB1E6B29AD35CBC9E1732C2C83CBCE3E66E
E0E7A7344A0D3D0E88D78D44E2D1AD75ABDE695A788F4E8955DD95BCD2448153BE0537FE120F10DE
6A367F66702D8E7CC8846A0483BF2471F85536548EC34FFDD62E206F3258C13F32B1C60D42B34171
225BBB940AF9C313C01DAA6A37CC9DCCE142167A1798CEC6E6286311283BA3431824AF71934B70E9
0C76FF00667CC626C48645E9C73FAD5BD3619AE1237B7BB959C875F347DD23B2E0D25BD94D7B22C3
2B12621872001B48EE69B849BD3A91ED14747D0E425D39A4F14DA584D2EEF3251971CE476E6BADBD
68EE6E27B78808D27944649392E3A7E1524126DD48DC0404C48189E4018EF4DD42716B20BFB2903D
BDF210372E363771EC6AA71B477D88955E79AF43A5B0B27B1B44B696449658D8E580E003D07BD3A4
96DBED4F038FDEB2F231CED15CAE9779712EDB0D3AEE186499FE457539651D464F434EBD721A44B7
BC12EA0836B6C7CFEEF3C8E78CD5BACF95492397EAFF00BC6A4CD661A4DE3CB6D653A19CAB14B723
866C63A9AE4A0D29A78CC5712797F668CF0072A3BF4ED578ADC46FBE2749675612A6D39D84751EFF
008D5A90ADC5D492831C66EED7894AE363E7A1F6278E6A55EA6EB53A23274344F4324E80E9670449
6A5E7621E2641C32F6E73806B7C46B6F6925B3CAAF74019A7817868FFC7F0AA7A7C3776C4596D7B7
DC773207057F3ED54EEAE5FED49F68B771308B6C72A30575427BFAD13ACB96D2560F65394D34EE10
DF4D7912A155448398988C36CEE33D735B4B6F058DBA4B784CBF685C4718EA148EFE959B07977613
65A93260849D8FCEE33E9D2BA0D6DFCA816468E26C205284F319C6055534A31E66F533C44EF53916
872B1C1A7F87E767B7B9984570E0F3C951DD6AC5834B71F2ADC068226DCB36CC9719FCEB3EED6213
C8B209188186D9D59C771525A5F7D92799A1B9F21B00C5181BC67D335177395DEC757228C34D5962
5B7F2A692EE3CAC8920751FDCC7723BD64EA173F698A6BE7851EDFCD01151CAE7B9EBCD75B0EB2CF
750DA4F64373A79735C0605A327A10BDC560CFA447BA68FED7F6B111C49060A03DB229F2A8ABC49A
751B95A6559E48AEFC99E1823855FE6681589E83827D693CEFFA778FF5AD1B48921B686F238C2C81
B106D0482474EBDAAF7F6AEB1FDC4FFBE169421296ACD255229D91C45D4B797B3C06FE42923A9DAE
AA0027F0ADFD275ABA3636E2594C6CABB4483F88E71822A8C9A75A34329766B80A376101010FB1AD
1BB7B6D2EF519A2131013CA0E0955079C9FC6AA2BADCC2B72C92858DEB1D30C7AD5CC25245046F12
8E40EF8A8359B27D36253033223C844D20C1676C71F4AA961AFEA3797124AF009214524342FB147B
9CFF002AAA88D13816F6EF26584AAEF212ADEBD69F3C651F74C69D09C6779325B02D751ACFB16365
52371971B88AB2BAC5B594A524063291317B641E66FCF62DD29B67A74AFA7CF717F148B6524A5818
D4022A6B882CE6D1D12C6DCDAABC60091CE59B9F4CD44A52847535B4272D8C45F36C2D34E17B1305
490B3AAB72A09E39EF8AD5B188681A5DE5CFDA4482693F72265DBB81AC8482795A645259A1F9638A
5230E07DE1ED8A96F2ECEAD1A5B5B0930550A8739DAF9E9CD6709DD5EC744E8DECAFA0C92F6EEF99
2C5EC56E56DC192331E17393CFFF00AA96578AEADA4B44B357681C32177DA41F4AD5B3B34D2AD9DA
E0B35CE3323370011DC62A1B5B6B6B8D6A4B98D50613ED13348DC337A0CD5CE316EE9EA4C24927A6
9D06D8DE5EB5C26982E629E223E712A0F9703A0355D45BDBBC77525A15338650EB31D847D3D7EB52
D83585EDC4939956D2E154CA90B8CAE7A75ABD0CD3C39B6B4994D909158A795907775209159C1FCC
A9BE5F231AF16248119F4C785DDB08CC770AD1B6D4A7B6B41645407C1C65830853D47A9F6EB57BC4
F1C316AF6F15C59BCD6A9080184854127A818A82C6DE1482759991ECD7374B1BE711A0EA73D49FAD
38C2D55A4294D4A8A94910B592185E5B79E394E770971824639045676A513C566AF3C0DF38291959
381FE3F8D6C7F64C3AB6A515DA2B4627E11938CA91DFD2A0974E5D3D61B774F324F32454F418E86B
371BEB62E35546D1652B1D4A5858DB35D3C7E52FCAC532307BE2BAA4B8B7B916E6395BED100C6029
0241DEB8ABC95A6B78DAE2E08915C830A800B01D3FC9AD3B4BB95EDE38B0E92152D08CF2BF535AD2
9F22B364E270CAA2525B9A3A95AC926A42F16611E213B40E800E41C572769A842B7890A462E92EC6
DBA91F8DB8FE202BBAD2992F234C4D1AC9B4A3452807E6F407DEBCF27816FB547B9B128933BB6209
1B60041C6413C1AD2A249A699961A4ECE125B1B11CF7D0C2AD0BC972F3B90802EDF947A835B5A669
285ADA48A145EAB22BBE76B7A9CF5AA76D6972B2286B813BADA32CADD36E4718F7FA5468F713E9FF
00650D1908CA51C7CA578EFDEB3BA8BB58D67CD25EEBB1D7E9BA5C71797F2A70CCCCAA30726A19C4
1A75C35FB3925D192450738E7AE2B2ED4DC592ACDA8B989630773E3258FA60573FFDA12CBA833B2A
A06461E5962700D695ABFB3B687252C34AAB6DB343C67E66A1E18920D32396694CE8F2B2FCA718E5
6B1FC2EDA8C1A55CC7A94728B6C01862093EFC5743FDA46DEDED2160B3C45FCC320F9718C641F5A9
B5A4B596ED45A86412A90E8C48183DF342AAA6B6D4B8C1C3DD7B5F731E556B2BB6FB3D8A02843995
E43DBB81561EF124D93B14059F23F764641E4E7D6A83696F24110B98F055CA4936FCED1D00F7ADBB
6D345B48D0C88278E250CB313B5557D7AF359461295D743A6A4A1149BDCAB637E6D9BED36F086640
C482428FC4D7436DE512AB309662F1862E3EEC9919C63B5732562B4BC4FB2B47240CDB4ECC1DCBF9
56BE9D7725B5CC9147BC5B1C0781882533FC6A7AFE15B50924B959C58AA7CF69C471D3609E195518

46846E08549C0F73585752696130D788640400C4902303B56FDD23C960F6B69791133308CCBB704A
7F4AC2B7F0A4735C4CB797798CFDD1E59E99AD270E6D8546B5BE291D36858B78ED301A78A6FBB70A
C3080F6E3AD721696B716DAE5EE9B14E996B864865F52391915B56BE17B4D2A095C5F4E11F1F2ED2
031FFEB5506BC56B8F3ED1A399E394E666006E3D8E4D4556AE937B0E841B729475B9575C9C4FF656
12EE9220629E503193DC8159763A7CD693097329896412ACDF7720F4C56CDCC306A325C35B2B4B7B
10DCF06EC1463D4E3B8FA5325D3EE1043737A9B2DD76C633F3038F6ACDCAA5BF53BA1C89257F91A1
60B35D6A41918894305201C6703A93D0D2D9EB0F75B5DD230E7782DE5E0121BD475A7E9F796D0DCC
51EC645B5667DB9C861D8E6AB4B6221D5A598C4A913B8921456392ADC920F4A69B4A3CAFD4E69C6F
27CCBD075F4D75048277B9797CB71891D38727A803B62A3FEDFB8F55FD3FC2A9EA7677179733456E
B3A4436B4790482DDEB3FF00B0758FF9EB3FFDF9A508735DB3A1351491BAA4AEB640E0145C81DF8A
9B5203CD9381F7C0A28AD69FC2CE5A9FC5819D6E49D11864E0C8723D6B6E1276BAF658F81E9C5145
674CB9FC4CB5A51264D4A327E416D90BD87E15CC5A003569147408B81E9CD1452A9FC344E1BE365A
D7405B890A8C132C7923DFAD36F95478AF4F500005232463DE8A2A61F1A3B3FE5DFC8DCF1A716969
8E32C73EF58F80749071CF9883F0A28A2B7DB32A3FC28FA956E55458DE100021801C7BD76FA02AB5
A6D600AF1C114515786F8A2678CFE1B21F12F31DAE7B5C103DBE5AE7AC49096CA0FCAD6F7208EC68
A285FC74671FE0220D358FDA6C864E095C8FF80D68DE3168B73124AEEC13DA8A2B0A7F13F566F3F8
D1CADC00D25D330C9DA3935A7A79274EBA624E405C1F4A28A70F899E94FE035703EC4CD81906220F
A7358D3AAFF695EA6D1B45D1C0C71F7A8A2A6A6D1F53CFA5BCCE82FD5574EB72A003F6C032076C74
ACDBFF00F91A6E17B6578FC28A2B7ABBA153EA398EF37BBB9C5C1C67B573E003AF4208CFCD45142F
891B61FE067A108221E179B112710C847CA3AF1597E1F777F873ACB333315DE14939C73DA8A294FF
008DF79C73FE1BF53174F25934D5249529920F434FBE27EC3A70C9E6E6453EE3D28A2ADFC00FE235
634545B0DAA17FD19CF031FC55268803DB5916018932649E68A294FF008887FF002ECBEA07DA1C60
60CAB9F7A9B01BC5B72AC0151047807A0E68A2BB3A23CD8FF1193EA8A3EC1D07DE92B819634F374A
F917E687278EA7345152FE391D787F806C1FF250EC8F7DE8B9F6F4AEAF59E0DE81D16E4ED1E94515
9D3FF778973FE323223451A5CB8503F7A83A76ADFB38E36F0DC04A292180191D051454D3F8A474D6
FB2729A33B963966E2F1C0E6BA9DEDFDE3F9D1456688ABB9FFD9}
}}}}
{\shp{\*\shpinst\shpleft1373\shptop9066\shpright5866\shpbottom12066\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2064\shpz14\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4493}}
{\sp{\sn geoBottom}{\sv 3000}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;5;(0,0);(0,3000);(4493,3000);(4493,0);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;12;16384;45824;1;45824;1;45824;1;45824;1;45824;2457
7;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2053\shptop9066\shpright2080\shpbottom10733\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2065\shpz15\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 27}}
{\sp{\sn geoBottom}{\sv 1667}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,1666);(13,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}

{\sp{\sn fFillOK}{\sv 1}}

{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2000\shptop10680\shpright2120\shpbottom10773\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2066\shpz16\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 120}}
{\sp{\sn geoBottom}{\sv 93}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(53,93);(120,0);(93,0);(66,0);(53,0);(26,0);(0,0);(
53,93);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft3866\shptop8986\shpright4253\shpbottom10666\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2067\shpz17\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 387}}
{\sp{\sn geoBottom}{\sv 1680}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,1680);(386,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft3826\shptop10600\shpright3933\shpbottom10706\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2068\shpz18\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 106}}

{\sp{\sn shapePath}{\sv 4}}

{\sp{\sn pVerticies}{\sv 8;8;(26,106);(106,13);(93,13);(66,13);(40,13);(26,0);(0
,0);(26,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft4013\shptop8986\shpright4253\shpbottom10986\shpfhdr0\shp
wr3\shpwrk0\shpfblwtxt1\shplid2069\shpz19\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 240}}
{\sp{\sn geoBottom}{\sv 2000}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,2000);(240,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft3960\shptop10933\shpright4080\shpbottom11040\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2070\shpz20\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 120}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(26,106);(106,13);(93,13);(66,13);(40,0);(26,0);(0,
0);(26,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2346\shptop11773\shpright2746\shpbottom12146\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2071\shpz21\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}

{\sp{\sn rotation}{\sv 0}}

{\sp{\sn geoRight}{\sv 400}}
{\sp{\sn geoBottom}{\sv 373}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,360);(400,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft4053\shptop11960\shpright4226\shpbottom12160\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2072\shpz21\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 173}}
{\sp{\sn geoBottom}{\sv 200}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(173,200);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2666\shptop11733\shpright2773\shpbottom11840\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2073\shpz22\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(106,0);(0,40);(13,53);(40,66);(53,80);(80,93);(93,
106);(106,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft4040\shptop11946\shpright4133\shpbottom12066\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2074\shpz23\shpbxpage\shpbypage

{\sp{\sn shapeType}{\sv 0}}

{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 93}}
{\sp{\sn geoBottom}{\sv 120}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(0,0);(26,120);(40,106);(53,93);(66,66);(80,53);(10
6,40);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft1693\shptop9080\shpright2066\shpbottom9346\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2075\shpz24\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 373}}
{\sp{\sn geoBottom}{\sv 266}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,266);(373,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2080\shptop9080\shpright2773\shpbottom9333\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2076\shpz24\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 693}}
{\sp{\sn geoBottom}{\sv 253}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(693,253);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}

{\sp{\sn fLayoutInCell}{\sv 1}}}}

{\shp{\*\shpinst\shpleft1626\shptop9306\shpright1733\shpbottom9400\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2077\shpz25\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 94}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(0,106);(106,80);(93,66);(80,53);(53,26);(40,13);(2
6,0);(0,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft2733\shptop9280\shpright2826\shpbottom9373\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2078\shpz26\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 93}}
{\sp{\sn geoBottom}{\sv 93}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(106,106);(66,0);(53,13);(40,40);(26,53);(13,80);(0
,93);(106,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}{\shp
{\*\shpinst
\shpleft6360\shptop6040\shpright10853\shpbottom9053
\shpfhdr0\shpwr3\shpwrk0\shpfblwtxt1\shplid2096\shpz27\shpbxpage\shpbypage
\absh15866\absw11893{\sp{\sn shapeType}{\sv 75}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn pibFlags}{\sv 2}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn fEditedWrap}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn pib}{\sv {\pict
\jpegblip
FFD8FFE000104A46494600010100000100010000FFDB004300080606070605080707070909080A0C
140D0C0B0B0C1912130F141D1A1F1E1D1A1C1C20242E2720222C231C1C2837292C30313434341F27
393D38323C2E333432FFDB0043010909090C0B0C180D0D1832211C21323232323232323232323232
3232323232323232323232323232323232323232323232323232323232323232323232323232FFC0
00110800D2013903012200021101031101FFC4001F00000105010101010101000000000000000001
02030405060708090A0BFFC400B5100002010303020403050504040000017D010203000411051221

31410613516107227114328191A1082342B1C11552D1F02433627282090A161718191A2526272829
2A3435363738393A434445464748494A535455565758595A636465666768696A737475767778797A
838485868788898A92939495969798999AA2A3A4A5A6A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6
C7C8C9CAD2D3D4D5D6D7D8D9DAE1E2E3E4E5E6E7E8E9EAF1F2F3F4F5F6F7F8F9FAFFC4001F010003
0101010101010101010000000000000102030405060708090A0BFFC400B511000201020404030407
05040400010277000102031104052131061241510761711322328108144291A1B1C109233352F015
6272D10A162434E125F11718191A262728292A35363738393A434445464748494A53545556575859
5A636465666768696A737475767778797A82838485868788898A92939495969798999AA2A3A4A5A6
A7A8A9AAB2B3B4B5B6B7B8B9BAC2C3C4C5C6C7C8C9CAD2D3D4D5D6D7D8D9DAE2E3E4E5E6E7E8E9EA
F2F3F4F5F6F7F8F9FAFFDA000C03010002110311003F00D385CC90B31E71D87AD546976C52CFE5ED
8010B938E4771EC69B033DBCD202C563CF2BE83D6B36FE71FBC5019632C067A8EBD2ADCF4D451A5E
F3B05C5FDAEE01E58E273C0046EC1FAD68DBC2F751442291C9EA64723007E14962B697A26B4F27C8
938D84E1FF001FC6A9585DC10EA0514F9684EDDA10F0C3AE727FFAD552A6D2B91ED39EF182D518DA
B780F5037531B7BB1F659DCBF9263C91CE38E6B7747B1FECEB68EDAD849B635C311D71DF27B75AE8
6DAEE7B895201386B72D9C60640EFCF5ACAD42DEFA4D56E61918BAB82CA4285DA3B29F5ACE74D5D3
B950AD297BB3B22A9BB8D2574752E81428C31F95476A7E93AD0D3A57597135BC9C3A9EB8EDC7AD52
9AD6581248EE2365907239E08F4C8A91D2C27B359F7A4602F2BCE7E9C73451BCDE9D0D2AC69D92B5
EE75A2DAC2E10FD95A27475230EC46DCFD686B374408648D11470B807AFE35C6DB4E628C0F30AC84
642819C8FAD23DECAEFBA59B6AA60919C7EB571AD0BBD3633582A9BA969E64F7E820B92B25C04833
C1D99C0F5F5A6DCF922DCB5B0538E8D9386CF5EB52DA436D75A97953CCA64651E53329033E86A0BF
D23FB3EFC98F6AF9B9FDDAB6ED8071D7356ACE3CC91B29255141BD8D7D0F7451B4ED8D98C36391EB
5BA2DD2F74B785D83B0CBC61BAA7E23AD73FA4D998ECE7769739E541E01EC456D68B892DAE5724E1
01603B71DAB5A4928A47938D95EB3B1CC6A77452748B6EDB741BDF033C9E0134C430B4A378279DDB
8771C62AFC76AD75AFC5087C433C644F851CE3953EDF85497BA6B69D34AEAA000BD09182077AE0C6
C6CF996A7761EAC5C140CED476C37ECB8DB6DB495CF39A82CD61BABC0ABB9471919247BD4F731BDD
5AA4E769488ED73BC2941FC3907D706AAE9CD11D5BFB106585EDA1324AA73E5A6D3C93D8F4E05733
8F3CD72F537E651A6DF62D5FDE456B22A4819215642E42EEDABDCE075FA5694B6CF7FA74C637691E
0DB10B8DA732A372B81EA2AD03E1EB158ED6DB64CCA02A163B954FAF3D49AB33EA77967672C71BAF
98C0F947815B461CB78D47A1CF3AAE56705A98D05A268F7A9116CEDC1689C8DCBFD6AD6A8AFAD39B
9B29FCC529E5BA14D8CA146335CD5C58C8DA9C9A84AC2391CA8DF8DF9C7383CF1F8575760F77A4D8
1BC963F9A4CA45F30DB8F4CFD6B3838B4E0B489A558B569DFDE3357535B397ECB6C43451C6A9E636
4F96DFD7EB55E38A2BBBD861BBCB4523FCE002703DC8A6E9EF6E756D86360ECA5B3D361CE026D3C1
CFAD6DB5EDBE80ED1DBAC735FCA9E647CF4E719E7F974A5152AA95DDA254A4A9ECB56658F0CCB931
D95B89A39958BA0981560DC655BF0AD1D5E0B8B3D0ADB4EF914DAF11EC23253B024FA1E2AAC5ADCF
6D045E59C707647B5711A82C339C64EEE4FB629C6F0EA4EAB7700DF1A2869C9C610F6DBC7E7C9AD7
DC8A6A2F5667FBD9494A6B44505B0D4278527B668E3B4490B5C331077263EEE3A83F4A934DD4750B
1B3CAC10ED42D1A4492FCE0E4F27238C66AF58F9FA6E9925DC322891E468F26304487A0209F4FD6B
9FB9B9918FC8D99257259C9E41F7CF5AC538D24A4B766D6755B8BD8DAB5BCBCB68E148B7CD306C19
A520F5F453DABB193CBD5B479114AE2688ABE3F85BFF00D75C269DE73DA99E6C2C3172663D139C74
EA7F0AED7459AD5AC4FD8E50F1872D9DA4100FAE6BB30B294AF7D99C38D84636B743908ADA3D4AF5
1A470BB9BCA6F5E0631531B4B686F610B26F64CED3C8C0C60D4FAADB2E97AB5BBA81B2EE721149E4
1C678FC6A9DECEB6D2EE98EE182198738ADEAC62E3CD6D4AC2D69CA4A0F623963119CAEE11AA9513
13C3763906A5B59110B0386E4FD09C75AC6D435058A682343B8BB951F3E38F4C63D48E6AB8B92146
F3B25518DB9E3AF358A924D33D3749B8D8ECE0BB99C79500F2DCF27BD46F6FA84233FEB0A92C198F
6F434787A58594B37DEDCA59B3D05748D100BE6C87605F9998F4E3926BA9C1CA3A33C5A951D39B56
38D97C42EC7CA9951871F2B2E7DBAE2AF4C96B2592BC2561233947EFE9D6B97935A966D51A1B351F
67693BF39507279A65D4DB278F31B98F23824E1C77C573C534AD3773BFD838D9C742F4B8BB2E210C
0C630C0D56FB24BFF3D47E5FFD6A1B5154BA5B95917782404C741DB3EB56BFE12197D63FCBFF00AD
4548D9D9336839DB63AA5FEC7BBC04BA42D8E1B6E00155E6F0C452DB992D9D240C06E757CE7DB19F
E95C53413450F911CC0C454AE14723F3A34DB3FB0DEC73C57A639860E5636058FA6338A729539475
473CB0B569FC333A17B1B9D3CA040AAEB90188E40FCF9ACD168A919DD234929C8662B83F415D15DA
4B79696D726226E40093329C96E476E3DEA95DE952C4F0940CD13FCA70A085F7CE69B9B92E54B426
84927793D4CFB466B6933E630539DA723EB5B10F8984090C57012424ED41B3249C7527B551B9B18D
03E59838E4E531953C6EFC7D2A890233B599821E83B7159B72833A1D2A75F568DBB8D5B4EB856558
590E483DF9FC4564CCB03C9E6A32367B11826A85CCAC4C4D1B7FA3BA0006D2AC093CB64FF5A411A9
742AD264F0506727D3934734AA45CB6348D08D2D15C9D1A568252D001226EDB12CA18903A723A669
8CEC8B29991CC9B4E101001F6C54ED6AD3C5E547852C3E75C8191E84D4D268B31B5185611630C143
74F638AC92D2C8DFDB417C4CACF67706CD275B6251F929D07AF5AAF65771C3F34708C375F981DB56
6F16FA0B25B5D80C20923691F2FA75AA3676B3DBA0465DC1876E39ADFDD8C572B229DE77723A2D4A
E6DAD6C268BE611C7B4894260963DF1E9CD6AE9F7F141A21D40A848E4212465CFCA7A67F1AE6B5DB

666D2ADE098B3CB2A2BC64718E7A135D068F234361F62B989A36921242B1E370EB915D4A4AE8F12B
D3508735F56CA5A3DF897C4F2416E177C726C60DFC4B8EA2BA1F10C6CD6E3CB4DF807E5E0138FAD7
110DB9D27C6DFDABF6851667E4690AF46F4C735DB5D6B1A6AA59C3AB3C56D35C8DD1C618C836B1F9
4EE1D01A8A907523288EA2E471947B199A8787A1BBF0E5E30B755BF7F2DCCAA4F210E47CBD3A311C
55BD190A594B7F259C70BEDC2CA0E0B8C6318FF1ADBBA922D3D15AEE55822DDB14B743F4AA7ABFD9
E28637B884C84337960363395E73ED59BA2D59DF64671ACE5EEDB7670F7F1BE8FB2E9200C8CE1865
F2189356752BA92FFECC96E3ECCE27421E4024C467EF715306172ABF6F6499E3198DC45B428CF4D8
BD78F5AC6BA5B97669518905F6EF0723AF61DABCE9FEE65A1EB420AA249E8D16A76BB798DA436926
31FBB9130C920DDF7B35D9D9E9AD2F8620B4936C53AC648E8423673F8D79FC3A96A7A3C76D7B6D09
68988430AB8F9977761D3BF5C66B57FE131D61E449A26458769021705B07BF3C555195285DC9E8CC
EBD1AD3B28AD8875BD365826B39AEE7960991642A9BB24FCDC74F7C9AC7D57C5B65A5F96B3E9C64B
A921F2D6732ED2ABD0718E6B62F6E6E7C4B249792C2B612450148E391B3BB03EF81E99CF15C55D78
0B5ED5EC2DF56B49BFB4E0B940CCCA543291C63920D5469DA6EDAA29545C894DEA7476CF632E9925
DDB4ED7515C862DD886E8571F5AD779B4C31D86D96527CB5C449D159460E49E78F6AC2B3F2F46D23
4ED2AE74D59E44DE5E7170362927AE071C7B9AD0BBD385BCBA4DCDB4881655327978C8049C633EB5
8BF72FA5D1A2B4AD7D0EE2D6DEDAEBC386D4C6AF1A1608049861FED0AE4E4B3BA875686C040CFE5A
92D219972A0F4CA9E33F4ADBD3F48D41AE15E79B618E442623C65792DFD2B37589356B7B91FDA314
5248C76978F68C73F29E3D056F52D2829495AC72D2BC66D45EE36EAC8DB23594B1328CA9F95896E9
C018FAFE9563C1E19757B889666C22319060A863F747FF00AAA7D3B55CC9F65B65577D8AAD26DE50
FF00173F4CFD2A7F0FDEB8BF7866BB245DA96484A71953EB4A9457B48B4C55A53E49268C7F8876D7
37E34BB8D3833C967238750304138C71DFBD5AB5637B042D3911DD303E6C608215876E2B735E49C6
857F269E317A22DD111D7AF35E7BE1B79FFB1C8990C33894BA9638CAE7BD7A91D1B527B9C90B4E9A
B3D9926B76B1B3A343746332294B94C644A99040F6E9DB1556CAE1269E79D42BB1503E61C21279C0
3D7EB5B97D0BC31C5B4972633B860027B71ED5817AE22991C85200C65810A17D335CEDC633B48F5A
945CE8E9B9AA1AE74D75855943BA6F048E9EDD6AE0BFD66EA330394F28923CC0465B23046DED5416
57B877966C798C1771006147A55D8E4FB342ECAC76838C03DCFAD65564FA3D3A150A4947DF4AE56B
7B0834F46015909EF9DC589F6ED52456B6FA9302265F2D4EDC905B9EA40E78ACE90CCF26EB99962B
361D011D7D38E6A10C604786D4E199331E7919CF3F5F5AA54E495D83B4DD93D4EAE0D1F4E8A404B8
247418E9F5C9E6AD7D8ECBFD9FFBE6B9AB691CAA92F920632CB567CE7FF9EE3FEF8A69C3B18BC2D4
6F59952F24F36E0F97015461C90DC8CD505B6F2A245376F2306DCB2C990C48FE956277C92A4C6C41
0D9E3A0A964945DC91B6C076B73F522B2505CB77A58EDE671B2B682DCCF70638D5E460EA7EF0270D
5A3A5EB179650B090A48BD958E707BD549956620484E091819E87F0A578602AAE090CBD4F5E71441
C9B527A3329C69CA3CAD1349ADA5E38899E312120811F201F738A8CC05E3232C10F4C1E45473B285
3D4000125573FCAB42D65115BACA06770C8CA8E954FDF766C9D29AF7119F168D7970E312348BB42E
4A7CDF8E2AFDB7856E1A439C670300753FAD45717F2BAA3473948CB738209FE54F1AA5EBDA8DB33C
8AC4E7E6C003B9FF00EB52508C776CC652C44B5563A2B5B35D2ADCC8F0BEEE3397078FC2A2975F91
58B8314699C0639CFE55CB8D46F2F23DD1A92A7FBEF8F3076C7A7F3A403ED4A1C0501860333F23DA
B653515A23286194DB751DD9AD75ACCDA81687E40B19032300FF00F5EB32E1DA0919718619C0C7F4
A69B5665525491DF000C7A535EDC34091AC4FBB3D8F3EFC54396B767653A7082B45E86DE8B7E6F51
2CEE5546CE858039C74ADD92633AC71FCC3CE243E31E9D39E9F85731A7699702FA305586E2082DF2
F6F415AF74ED12CE2EA4DB24522C88CC33BD718E38ED5D34A575A9E463631553DC3275AB3FB7C771
A7C5208DB6925B1901BB66B2757D1E44B5B3D28CA1AE42476E1CB019EF903FBA33D73DAB123F13CF
ADDFDF69D733C489344C88590105B39C640EA7D6B6B4796FA0D1A7B2B880C98730AABB2E5632A776
0F5EF9183596256964CE9A309422AE49E23BDBEBCBB86DE6B91722DB0B0440AE0BF4F9B1CD767E25
B2BEBE8AC638E0CB88F326DEC7182335C85C59E9DA3B19A3296DA97971F908C493245EA7030A4FBE
4D4B61E22BFD3608E492F4CC6721BECD39C18E327038233CF6C9AE7A7565FF002F1BD4274F69525B
0EBBB8934C11C16D6F37DA82EE52CB8DB9E07B114585F5B5C788A7B3D46066915154A63612CDD5B3
DABB2D6F491A9D8BA46ABF6954CC0C4FDD3D76E73DEB8CB4B73A7C734973BE4BF44313C72E17613C
F2DDFF000ACF10A4A6AFF09A51A8AAC1F735AEB43B73E2D58BCD760CA1E30F90233EC4718FAD675C
F872C9A39351D3A593524F34C4CE5701187E854FB0A580DF4BE1CBC8B4CF3D15CAE448D807030CAB
BBA0A93C2B2DF5923C70C0112575657C82D200BF3291DB06A952A75375BFE02E6AB05CC9EC432C77
F627465974F8F135BFD8EE670FB86C2795C76AEA0B69FE1AD252D34E8C42AB9291AE4E01E49E7356
752557D244B3CC620A433388F711E9C5729733ADE4C87ED196724248D9039F6AB9D49514E2BE4735
287B7777F333F45B517573742FA0492D162759E42FCED6FBA360E4E7D4735B17DE26D1344DB6AB60
D3C16A062432145420741C1CE2B99B0B492DA769C63FB489DEF2479C2FA119E83B62A5B78617D5A3
17F6D21882B65149DBCFF78FBF38AE68548C5592D7A9DB528733E693D0EFB46F12DB6B3A7C57B1A2
A23B152413C60FBD63EBB1C96F72F7131F3EC673811B3000FD3B8C63D7BD496F6B61672DBE970AAC
71B203E48046C1DC13D49E3F5AA9AAB3C530B35B8FB440C37AC381C60E39C73D05756266DD3BB396
8C12A9EE1474C9FECFAB24175308E192D99A0DA465DDB209E3D054CB0DCE9B7EB716F14925CC215B
E5505B6F5CE2B2AE35077063564531AE15579281BF0AE9BC1F68FF00629A6908CAC9E4C7747018A8

E769FF001EB5C94BDFB423BA3AB11682727ADCDE8A67920824914ABBA067047233DAB99D58B5AF89
E355428B7118547C654F72066BAC9632BC104639EBCD6078B2D8CDA1A5D2644B6928391FC2AC79AF
65E89791E361DA752CFA9977F6734F3B132931AA908EE0648FA76AC33B4B9460AB918CE739ADD496
796D6E1A05056DA2DF24AC7B1E071D49CF15434CB8670935DD9343064952CC093F875ACAA53849A6
7AF82AD38A7096C8A4A8D12B0EAAE79E719ABD71E4C9A73C28C11DC67763B8AE62E34F7FB537CC5A
2663807BE6AD5B2AC36A17CCDF9E41618FAD72D5A4A5669EC7A7CAB9752195D4DAA5B2C0DE72CA58
B76638F7ED562D6DA5768F7DC29648F852B8DBCE4D578959A432198B167DFCFBD5D8AD9CCF1246AB
2BC87E6566DB8E39049AD6153DA3B1CF351A6AE8D4B3F2400E25E73820E4FE3F4ABFBA3FF9F88BFE
F9354658ED07FA379622B880338F2F20360E76FBF154FED0DFF3C65FCC56AE9B5D0E555F9B5D4D37
D1A555458E09A49093C95E39FC3A522DA0B2954320193FC6464F6C81E95786AB709195134AB20600
6F240E3AF3EF542EAE85C432653987E43B5396F4C67AF5E7E9585A0FE12612AD7B4B62C4BA796C3E
36EEF9BE5E33F4CFA77AAE9A53BCEA1FE601B70C1273DAA3D2653035CC066BC91146F49A76DDB998
7CC307A63DAB6575A58A3DE6D229245FE22A420A7683DD84A75A1A2572086C6485D911026E5D9924
D47241240DB24C3161C77040EDF85687FC24B0AAFCD6D02336003D8B7A7D6A94F78DA8C9F3484483
D3853F4A5250B68C9A72AB27EF2B15B4FB6B7BB7B97775377F36C8C9C11E87D855116D07992C5033
0429BB0EA3E535665D3652EB326E427EF3A7CA5971D09AB5A7698436F920E3F8F72EE247A0CF7FAF
1429AE5E48AD4B7EE4DCDCB432E196F6EA116A6D0EE2A7E7236AE47A1F5AE82D3C3337D922DE5A36
DB85F3085DDF418E957C5F5A5A1022822070704805C1FE558F77A8CA6733995C91D097E40F61DAAA
D74B9D99467524DFB35643EE2DD2D1D965753B7A8DD9A81350B7619578D4F652BDFF003AA5379D7D
328462481B89278A468A38156DDB6B49EBD8FBD38EBB6C74F2A56527765B9EF65B6D32FAF2C8092E
5B20220CC8A0E32547B735CDDA789F57D5352B5B19619E6B34C2C984DAE40F526B4E21225F0316F0
09DBF271C56E45A6B8921B889D23B98B3BD546D257F2E7DEB584E528D8E6C4D3A54536F767253784
96C7C40F7C88DF6269C3A46C32E17D2B5F5DBBB9BC974F2F1B44909DC836FCC4374CE3D315BB78BF
6EBDB2B52CC0EF2C78E9C74A66A57D15C69E918B716E1D31B8637820FF007AB2C52F75ABD828D572
E493573831717114577776D2DD35CB33451EE43C638E0E7B0ABBA0C71DE4FB3539B6DB46A9E7EDCF
98D86F9719FE1A5BB9AD1E4FB3DADBDD288084798F059B1F36303F5A955F4C8EC9E492DAE81784AF
9A6501B1D8AF182BF5AF3936E566F43BE6AF4FDD5A9EA3A758C3A5DBB416E5BC8323488CDCF5F7EF
5CA6B7677ADA00B8BF8C35CD899EE46177060795C7A11E9E9553C2BE22B7B8BEB5B417973732BA10
55A50561E091C7A0DBC9AB7E29D664865F216713594A9B5A181B988E7AB807241E95E939C254EE78
F0A752156C8F197F1A6BF76B3C6D72D279C40DA07DDFF747BD7A60D722B116D1CF14CB34F6D134AD
1A105770E76D62DAE99A35A6A11EA96D68230C3708A4C1018AFCC31E99E456CDC6A5FDB2A968FB63
9E588431331D816407A13E8474F7AE4F6FD23B9E8BA4EFAECCE8A6F134B7D3DDD82456AB6BB4AC72
5C12B901720EEE958DA24374258AFEEA785821FBD1AEE4FBB81C9C7D0FBD3DF48FB35B20898A22C2
A650EC0EDE73F30C7AF15567BDBD36CB616EF047A7C71BB3E78954EEC839E86A2551CE579BD48853
515686CCE9ACB4ED2E5D3D6DA1B8313B4818ABB67CD39E84FF008561EAB15B689A9DFCB1F9A90EE8
F7BB93B405EF9FC6B4F4AB3B2BBB13A925C1DB000ECACF83191CE4FA0FA57052EABA878EB58BDD36
186186C15195A68D18B797BB20E72464FD29B8DE9F35AC447DD9B57BA3A7F0FDB5B5EF8965D6F45D
45AE567004D0AB7CA8DC72475C1C56CDF787D20D4CCFE43CB2ED3185C8DE01E49C0E703D71915CE7
827C323C356D36AF1EA8924934122ED5936E074F986324E7A5496973269977019AE676740519A67D
CC99FBC1BEB5AD59C1C1293DC508CDCDB8BD8ED7474B1B2D2924B68201718660AD8663CE393DEB98
BFD52699FC98E53651FF00AD30280ACE4F048A647A85ADBEA259418DDE51E5AC4DC32E39001E41AA
D7F671A7896C60B6BB3219E23224AE7763764904F6C54A9AD394AA745397BFA9DB68CF24DA347E69
0CD17070D923D89F5AB32DB7DB2D65B4E009576FCDF9D73BE0C965FED0BC82400662DD2206C8523A
1FC6BAD8D70EB5E8AD627995A3ECEAE879E7876F557FB4ACA58AE19AD20685A148F25A3073BBEA2A
2D5E73BA0B8830F13C3B23973F79475CFA30EF58BA6EB1A83F8D752D456092389A6749BCB5E14138
C62A7D49FCA86451F6682112F40318CFA7D6B3A93B40F52950BD58CA2F72096F76AE09248E991D05
6649742E509F9F2D9E3D295E27946D0C029190C0FDEA596D8456B9F2D5B006481D6B8B9DB5B9EADA
CECC4B21E50664DCACC49DAFD715BF2C312DBACAB9CB00C075073D00AE51755F2E4DB3158D54E327
A67D0D68DBDD804052024DF3039240C7F769D3D25722B41336E49E496F7CF9447B950AE064EE078C
0039A4FF0047FF009E127FDF96FF001A5B6682E25884D1C3BC28C12BE9C67FCF15A3E5D97ADAFE62
BA79E6727B38F6338C57114B672AC8E9203892266C6E03FD9F4F5ABE6D2E2499A4DD36D601719F97
EA2AD5B41082AEE7CCDCDB19DC6E201F4ADA8D60F282AEE570B8676E981D4FD6A5C39E574CE5957F
6492B1CA17914BEE88C6AAA49C3F26AA892460CAB24936E3FEA83E4AF6E457572E9F6E4874B98654
393B03FCE7F4E958D369E6D5D9A29044A41CE180C8FCA9461CADF31AC6B29FC2558903DB2C8E8A50
721CF3CE7F1ABD690B4B2A85C640FBC4F038E99F5F4A867BBB74B74552367DC191B803DBF1AAF25D
CF931C44AA0E465B193FCB8ACA54D2775D4D5734D58EA92FA2B485F322990A8FDD920A8F7F5AA379
E235310548516323198C707F1CD72F792B080B7466C2EEDBD73FAD5F912C069FFB9DE64F2D1C3641
C9EE2B6A7394D351E873BC2C29B4E7AB63AE6F0C8832E155CE428E4FD2A08ADA72DF2C6D28FEF2A1
3FAD4D6FA6C6D70184842918231D3E95D10B98ECA00B1184923A38EFE831DEB38A72D6E6F3ACA92E
58A306CE796C26691A1251C01CAE40E6ABDF3FDAAF1AE234D91637631820F7FC2A5D675692795628

A08C2BE09DA369C938E9D85571E743B5BCCDD206F954A96CFD7DAAB9ECB956A5460EFED64ACC974D
BBF32E4B08644810705FAE07535BD6D736F2C82EA1DBB76FCBCE303B8233D6B3E699EE2C04851A09
4A310044028C8C723BFE1597A2E99AB412C32DC1262562CFB90806BA293B2DCE0C428D4D5E8CE9AC
2443E28964219D04396F6F5C5645EC3E668AD768CBE45B5D18B6337CE4360AF3D3380735A7E1E2B7
71DCDC12C1BE756FF67FFAD5896D2CED35D59C9119638E53B9640400070A7D33CD73E2A51FB5D474
62D3D37450B9789D22B96883A2E37853B1981E0FE151DEC6D7979358D99FF4485D4A92DE637923A2
27BD4D7A61984B3A45345042859D582E769380071EBC51A1493DBDBB5B7911456F39695E69148703
A7CA7B609EDE95E6A497BB73D27B732DCDA8ACE0B7D1AEEF52C52C66454FF4978C45FBA63CAE7B1E
6B898A73A95CDE4C81C4EF962CF205DA9D300FA7B56EAC97B0E9F74B25C892268F69865667D99CE1
FF00302B26CB4C6BD995705411F338CED6C9EC7BD6B26DC524998D28B8CA5291ABA7E87334D6F682
E1A541134A2E2D8EF21021C6EE38A350B51A74514B22A945DAC5F6E446D8FE2F6CF4AEA7C3DA4449
65A8F967F7AFFB912AF5DA0640ACAD3B43BD7D4AE61D42C6E16D1D563936AFCAFC641C9EC289515C
B176D5911C4DE524DE886EA1A9CB3D8C13C32616E220B260EE50F8E55BB7F9E697498EDEED65B799
1657642ACA08200E3AFEB59D6FAA787F54D60695A75A6A324A198FD96E4A8850AE73800F19ADFBBB
B8348D3F4CBBB4D3E38ED1DB64D6F6AC0C9230FBCB9EE7F1AB952973DE42F691E5E58233D56417C8
B64C2CEDBCA2D30BA611E57BE463E6E9D3AF35B165A6685A7DAFFC498169A55DF23636B90793CE3A
7A0A87C4B1DDCF69A64D3A5A7D9227215E75265F34F2083D318AA9A2B2DD5CCD3CF232205017E600
020FCB9E78F6AD3DD8BF64B5B99AE69A752F6B0CB5DD3D9DCD9B0921162CD70C36152D1B7A67B8F7
E2B3F51912769AEAD62DADCB85FEF00B83F5E953F8BF5CD4F4AB0B8BBD3EC7CB775F2667F2F3853D
49ACCF004579ACC4B7D713C36B0DA4A119A7CE1C91C8C7D3F0A8A9464D72A36A5351BCDE8662DD5D
4BB2792DD249C72A6452E8BC6320E7AE3A54DA85DDE5FC43EC6C609AD210C4C4D92E09C02BCE7EA2
AEEBBA5FF655E44AAEFE4BF2D331F95B9FE00383FCEAB2DBD8CB6325BD8DDC876B133973B1C9EC17
1FC35CCD4A0ECCEE5C934A48D3F057C4086C24874ED42DA2489FE596E36FEF09CF049CF41DEBD59C
E1C1520A91B908EE3D6BE788BFB16281A4963BD4BF0E504AA54C6DCFE7F5AF72F0C5E6A9AAF87D2E
B5482DE2950858FC93F7931C122BD5C3D5E756678F9861F95F3AEA6678CADA3B3F0F5C6A76D02279
2C5E611A6DF333D0B63D0F35C4DF3DA6AFA7D8B48D8B901E62BC0073EC7AD7ADCB6B15DDB4D6D711
ABC13214915864579CDC786D34FD612C018E6B3953CA8AE339F298FAE3A56D25A592DC8C1548A779
7430B46D366960955943C51313B867E5E3A9F6ADA7B4313055552CB820638618E957FF00B321D060
92324CFC8C48920F9BD723B83DA9D6BA88B8980F9042A393804D734A9451E87D62536E51D8C94D3A
D674F2DEDE3396E03A8393FE7A53A1F0C02CCF16536E484F43E98C706B5E786DA4C18080E0E0799D
07BD55B5D5245BB58A65DCAA70B229219C67A8CF5ABA697DA46139CE6B9A2556D34C2EF118A44720
A961C6067A669BFD9A7FE7A4FF00F7F0FF008D74B342654F3F79963600A80D938F7AADE5AFFCF23F
91A9938A766C98D795B539DD2A39F23CD965D9BC32E0F1C739FA569BEB1111E502C5153079F7E87D
AB36F2E1BCBCECC28EA63C600EF550DC46CEBB3612EB9F4007A9A4DB8EA74FB2555DE48D21A8EF39
8954919DA42E71F8D51BEBC964825225955CAFEEC03819079CFA559B5B204ED0A01240E46067F1AE
822F08C7752896EE57DEC398E2E576D649D493F74539D1A4F539FB1BAB7BEF0FC963140D2DC75424
6E3B89FC6B4ED3C2B7DF66CC920C95FBA589AE861B6D2F460B16E891870540191DF9F7AA92F88A69
AF0C11298A33CABB2EDCE3AF35D4E3CC97B4D0E18D69A6FD8EC637FC2277E5C929049F78FCC5891E
FD2A05F0FAE9EFF35C2348D8E07DD51FD3F5AD2BBD63555BA8C2DCBAC595638EA40E7F2AA6F7EB71
34B1A8C37246E5C0CFB563C90837CACEC84EBCADCFB11CACD6912331254FF10F6FF1A8EDAE227B85
595C92E303BE2AB5DBB9289206116E52771EFDB1EDED5774AD3D9FF7A7682A73F30C1FC2949B6D24
6CF9631BC9EA2B582FCA923B82C9C6DEA6A6B3B48E3DB34ECE406185450588AD094EF61E6A9F9464
32F6F6E6ABC9A8C56EEB15BF2F827208000F735A4524EECE69549CD5A2666ADE22B85F32DB4EB5B9
96E59BE4D8BF7141F6E95D4431C9368E64906D99E2CBBB9C88C918AE5C6A623130B684B5C1055594
7CEDE9D3BD7590A4D1F878A6A7E6A388D59FCB6E776781EF5D31926F438711174ECDA397F065E5C4
9A9DDD922A15460CEA73B88E878AECC68564B33C8A0E1BA800735E73AD5A6A7A378A86AD1911CE08
91D514AAF1EA3D0D7A168BAF5AEB47789D96E7CA591A30D88973D81F5ACDC212D265E21C9FEF61B3
33F58F0B58CB6CCC86E2147C24C236006C0739E9EB5CDC918D36FE5D2A3792E14EE45584F2C08C82
B9E87DBA57A0DFDCFD9AC2695023B7DD55CE431F41EB5E61AE585D798753843BA3CA11C1E429E830
3D6B9ABD18423CD146B82A93A978366BD85827DA5B45D565B0DB041F6859AD986F963E3F7673D48C
1AC7B9BED334B963934486EEF216184538611961CE5474C573BA4EA434EF144093B0FB3CEC372038
DB93818F4EB5DBC5A799B5CBA7D2CC4C934696921846DD8CA79618F6EF5839732B451B4A0E9C9F3B
B9D6786AE0DFE8515C1B77B6762DBD5D768E3AB0F6AD2B88BED10045900246E5218723D7E9587E25
748749874C8AF5E16254338E5B674F51D6B1EC639A28675BAD56C7CAB007E78E521C21E14367B726
BAE75145723573CF8D173BCD33462F087872FB504BCFDCC9791B1676B46DBE667D71D7F0ACCF15E8
F0D84CF736F15B8D3EDE2DAD6E920DE1C9E4A0FEF7AD7596375A75969BA797BAB7459625589C11CF
A91EC0F5AE1EFB4DBBD1E77B5D5654459D5A48EED94B46CD9F9416ED9A9AD08FB3B25AB37C3CA4E7
ABD88964F36E5EDEF6EA44B491505B48791D728D9CFD41151691677BA96A2E34992606297E676C88
C11FDF1D00E69F6BA95DD94905D369D35E5A49132C7034664859B391B300E0F35E91A7BB4FA74171
2D98B39A740F2C1B36ED6F7C573D1A0E7AB96C6F5F11EC938A471FAAE9177670C0B7B7CD72CE0ACB

BA3DC92313B8004F61DEA3B078ED74A9E0934D4FB2A0F3516C490E67FEEB13805315BFE2DBD8B4FD
3E0926F95F0C627907C808EC6B8EBC9759D4CC56BF65668A631F9B244A0C5E9B94F61EF5A4E4E9D4
B2151BD5A7EF16D6F92FBC2B15AC90059D23791A075E0007EF2E73C5715A85FDA58CC23B19260B95
752000C5BB8FA57AADBE8F676506A3689A9C33CE62F282654B451B7A1AF26D4ACAD567BC8249A34B
981885333641E71D8565886DB4E48EBC24A2EF14C5D666B6BBD62DEFEC2CCB2AC0249E331908AC3A
E40E2BD2FE1ADC412595C2CD7C05FCC3CC169BBE555FF647A579C235C5EF82DD4DDC1149012CA626
20CAB9C60FA8ABBE018B50B8D7A1D5016FB159B6C9E7662067FBA3DAAB0D2E5A960C645CA935D8F6
E08C7CD551F36C381EF5E67A44FB6D759D3B568A78A6964DD1227CAC0E4E48CF6AF4F675132B67E4
23A8AE25FC3BE7DF7D9EF24533FDA0BC3267E72B9247CDE95E936D6C7894A51BB5239BD3F5B6D52F
9C5CECB682084C21369185E8339FE2A7584515C5C32994A0191F2E003CD54B2496EEFF0053265B05
96240EA09F94F6C123BD17226592231C71B89E3DD8B73B88C7FBB58D56F46CF5B0D14A2D459D098F
64223F94B8EA49EDDB159D2582C913CB0CA1AE6170C03C9C1EE42FF4E94D8E7DF016E405EE7823DA
B42DAFF4FF002A51769B25888CF97C1743CE08EE6B28B8CB62AAA9415D156DB559E30704AB7242B0
23F3152FF6EDE7F7EDFF002354E465D49E731C0F0A01BA2503EF7D4555FB05D7FCF06FFBE294A4D3
D4C9518CB56AC4A6CEE589B754C895873B7B56B69BE1455712DCB048BEF7CC40CF3D0D476F790A3C
71C6A84600DF9DC491D7F9D432F8827795908F31E351BD446C762E7AF5E2ABDD96921D475ACD4343
B1834EB1B5DB9589997E6FDE609FA9ACFD4F5462CAB6734B1A2920B21505FD307B0AE5EF75196E25
3789249B82E7626413D80E7D6A04B7D4EEEC679A5BC95255750B14638663C91CF6C735AA95BDD823
9A18569F3D566B25C34AFF0068BAC6FE8AA067F1E7BD46D7852E642B1ED8D8F43D2B2B4C79A58D65
91D8975DFB1BD4771ED55754BDB80A130B946E5882013FD6B9E73EFB9E853A116EC8D29EEC4F3B09
7118E4139191F85465D2771B769524EC2060FE7EB591A56977B7B70815A41B72C4B9240FAFBD7496
FA8E936322470DBBCB72A06EF32100202393529B9EA8D6A38D2F756ACB25638220D7050B3101481B
BE61D7191C9F7ADFD2819ED81FF964532BE60C311EFE95CF586AD26BB72F612DAAB22366368E2DA5
08EA07A56F6A7A90D3ED7C88230AD8C336472DED5BC3953D3A1E6575394943A99BA81926BA31C608
C7F9E6B9EBD5813CD3F688565521A44771F28FF3EF54350F105E5BCAF8858990E09C1214FF009E94
A16D27D02E277BBDD3CB085FB2330C120F5C1E7F0A9569C8EF509508A6CBFE1598DE78811E1CAC6A
41C13D483D715EA5346B3A18A450C84E483D7D6B91F05D969B059C5E527FA5282198F3F37A035D80
3F3018AD2826AECF2730A8A756C61EA1A7BCB731BF94938F344651816DCBEF51D869911D6EFE58A3
8A38ADE45458E303691DF8A926BC65927796696D62762A7CD7DBB17FBDEDEC2B99B9F8B1A369D7C2
0B4D3E6B88940579D900DF8EFD7AFD6B7714CC29AA9CAD2D8EEEF2D52EADA486450A08251B1F71BB
11E95CFC9E1596EA09126D4F63EC223112E222C7A123D6AB5878D6D3CBB8D4D619A6D296232C8C47
CD130E361ED5A96BE26827B0B0BDB8856D52ED4BED66E42F6239F4A8A9CBB4874FDA53D523C9ED7C
13E2187C5100B8D3A69E1FB4006E7CB2C9B41E4E6BD574CF075AD86AC97EBA85F34E246720481637
CF6DBF8D4B71E2CD12CEDADA57BA9658EE73E5AC4338C1EA7D052693E294D635796C6CF4FB8FB322
64DCB2FCA3EA7359C68538BB9AD4C455A8ACD18BE20BE49DE57D56DA4B08A12D1C0EB1ED76ED9E7A
D7330D93C96C8F20372278C054B4259645EFE61C7DE15DB78C345B4D59A396EAF25882C246DCE400
A73900F72781589A66AF710E9B7EB05BA2EC80AC11ECC82FEAC3D7D8572578C555BC9D8EEC3497B2
F74CAF114B6E3C3FA5DA416E0BC12B26623960879201F63D6BB2F04C97779E1868B5441736F1CDB6
D9E601FCC4C646739E45705A3EAEF05BC926AD05BC858B61141023E3EF63D73D45755E1EBF5D3AE2
D6D6D5CBDBDDB7CD1ED1B413D4A63D29D2AB69FBCF4618AA7FBBF756A76E80468A91AAA2A7DD5500
05FA7A532E5AE05A5CB5A792D7623262F3CE109F7EF521003AA492C71B31DA039C127E9DCD6249E2
ED120B69267BA989491A3689132D91D78FF1AF43489E42E693EE71526A92F8C5916F9163BC870160
8E5C472A8EF86EF9E2AFDBDCDB7D88DBCA019E18F62C76D9057FC456F1934CF165B457BA53F95796
ABCA4D1842037F7B15ABA5E9C34CB322710CB7072DE66C0481E99AE29509CAA3773BBEB118C396DB
1CFD86957F7A56EDACE3B4836EEB895A3C3C910E405E383F5AE43C43E21D22FB4FD4668B4086CAE3
CC114137960171CE770CF5FA56D78DBC612C3750D958DCCD148B21059B0AA411C06039207B5725AB
DB4D0E8497E15263E70FB444EB978891C71E87D6B1A95209722D4ECC2D3727ED25A1CF6937D259C9
C23222AED0AC06D6CFF7ABA287579ED67B686D9A4B2B77653716EA0805B3E82B22CADDD49D42670A
BD2280A93BDBB0FA57731F87FC3969E1682F355D662178065C453062CC7A02319CD654F99CAF13B3
1128463691E916B7D1DF69705DC4084618C1EB4CB81E744C010242A551BAE09AA5A2C617C3366CA1
C6E1BB0DD4D3351675D36FB6707CA3920E0A8EE6BD84DF2EA7CCD4FE2591CEE91E128F49B3B8106A
1672EA2C59EE13EFA95E7851D7EA6B3F47B5934BB8636D0BBC7731B2C6421664F5031DFD2B3BC096
B1A6AB79AA5C5F5C66D62262495FE59013D3269353D46E6D111EDE6BC5092F98F124A5091FEC953C
5439D92BEC77D0751294626541797316B177686D2E07972112F980E17D0FB55D9374AAA583798700
74008F53E9542E6FF51D4B4D9E0B2916389A550DE702669467F8CF53F855944B95411B3AFCA07987
27D7A0F5AE5AD4ECEE8F4E84E728FBC423505B79038BE623236ED7DCC31DAAC7FC244DFF003FB71F
F7C7FF005EAE691159C3777CF24713B2FCC071839C5697DAAC7FE7D13FF1DAD634928ABB3395769D
B9464B12AA48582B30CFCA0023713DAAB5A46B637D7333DA492C6E0E1D7397F66CD59796301550EE
0E7248E768A25B978A0C2C6D90412189E7EB8ACA0ECD3612BCA3EA57B36264B89248E540E4796B23
738F53538D3DE665537F3C71AEECAA9E483E9EFCD44AD24B7023DF1AB48998D557EF1EE3FA7D6962

9BCCB712893957C3051C83ED9EF572728BE626CA5EEA356D21B3D22E6166C4A6642912E7700A3B51
ABDF589B451159C42500B0609B8F5E95465BF7D832CA4C606303073DF9ACB6699A604F9815DB8723
81F53512924ACB76553A0F9B9A4CDAB29A2431054902E3EF2630DEB9FC6B95BF9351B2F1206D3E26
3BC82F215254FF00F5AB7AD262613188DBE5E14BAF207F935A9B1FCAE8E5CE303049403D7A534FDD
B16BDD96BD45D3756D3F4D8E6BCB6B6920BD9D732A37DC563D768EBF9D64EA7AA0B8467980396C80
075F719E94EBCB5B84CBBC4CC9B7E62AB59B3C4A2EA0926595A2070EA0FCA4543A926D456C3A74A9
C5F3EEC5478D9647DB93C7DEE80FD2A8B588BBBC11888132B72E883763D456A470CB7DAA3ADBC432
D9FA0EDC9AEB741F0DFD96E85C4CC58818009E95528B4ED12A78A54E1796E59F07693FD99A7B97B7
9E2798065F3483B474C7B1AE85DC471BC9B90051C33B6173EF49232C3199646DA89CE7D78AE2F5DD
7E5BFC5B5AAE20E4119C6E39EF5D1CD0A51D4F0A30A98AA9745C5B88354D4AF74799A1912781A40F
29CED95483853E9D7AD79D78BB4A7D2B5E8E08F4E76F342B00132B27B0C7535D5E90D143AF5B4F72
D8F2817C96E59BA62AEDAEA08CC6DC39B974E91C8776C6CF6CFDDFC28A752356373AEA519509DE3A
A48CBD3BC357767E1ABFD1B524F26CA49A3B886588FF00AD63FC0722B77C3DA7497F35D5BEAAE92D
E69F8F2630A0C48B8EDC648AAF7CA2F34F06FA4BF0C1C7FC7B92CFF82D5893C429A7EEBC86164B36
8FCB40F08595CFFB669CE9A7BEC66A739AD16A73AF25DF86218ECA4D3EDAF2499DF8540FB07A2FF7
6B774BF1859E93A44767358C125D060BE4D863257AE5B38AE5E4F1145A878852FEF23F2E0CE33103
819AEB671A5467ED10E996509457686465C0C76DE4F5C9E95C49CE136D6C74D6A568A8CD6ACE94DB
D9EB36B0CDE5C86375C0CE0ED1D48FAD707E798A2BD874C4C47E6E05C5CAEDC73C9C8E87EB5A5A0D
FCF7BAA5CDA5B4BF3C0AB23C8E76C4801E580EC315BB3EB5A04A65812E2C9C48C55BCD4023973EF8
E7EB5AB846B2E7B599CB094A84B977479F35D5BDC5FEA125DC0CDA72C2B0068E3C32C9FDEDC781C7
5A65BDC5C886FF00C895C3C0156DDD0E02C79E4F4E0F1D6B72F3C35AA5B4F1C1A6B4B268F349992D
918338C8C31391C8F4CD6FE93E18B1D32167BC0859D7CB7DEE36EDC600FC6B9E3466E4ACBE6764F1
34E31EE79FEAFE214D4AF2669DAE3ED8ADB02E48E71F790678A893508E6BCB6BB8623B92155B8332
656EA4EDF2E706B5F53B78AFC4266D36D6D136931DEC287180707731E4FB62B1EC348BA95D19ADAE
EDE10C0468E981CF4C0EDED59559D44EDB9BD1F67C97D8EF7E1F5B4B69E196171E43DC3CA5E49A37
0E4FA0CF5FCEB7AE353B7B63FBD73907181EBE954B48B54D0B4E6336C88C843B81C0151DD40B7722
CB12131391F46F735E8AA928D35DCF1AA28CEA37D0E5752D3E3D4B5FBC920B58DA329E72BCC779C7
05B69FE1C5625E68B224315D4B25CCCBA8362485493228F563E9D39AB7AC5C5CDC78AAF12C639058
F966DD0C309DA5B68C86FC6AEDC8B5B3B0B2B278A47BAD9E7B4EAD844CF1E51F63E9FAD79EE1ABBB
3D5A73E58C5A30F56D1353B3B492DE396D244701A278096DBFECE71C1A8D7C302C16C9AF17ED2B77
1AC8E625F9D3DB9E86B6B4AD4ADA4BCDF25BDDCB1EC2D24514618211DC64D3F559A1BBB74B824EF0
DBD25B618079F9430FA751529D93699ACAA372E568EF740B8B0BDD021934E790DBA395C4AD970476
3CD73BE3AD62E34B4B7B18605922BE46595D8104631C023EBFA55DF04C1343A5DD4B298B6CCE0A85
F979EFC74AADF102546D2AD6D012D7324DBA3553F305E84FD2BD7A526E9A678BECD3C458F37D5F53
9B4BBB768964B7575788C4870BB011CFD69A2E96F6DC4E9E60C2F29D4F15D2BD9E81AD5DAD9DFCF3
24D244648C99146303007BE4D65C3E1C6D32FA2D3EDDE699E51905C720FA7159D48BB2563D6C3D5A
516E3D4AD691C84AEC5914019038F947A7FF00AAA6796E22631202DB57E60573B47F3AB374861636
B32ED9E26C85070C3F0A8515DAFD0BCEB0C6C992F9E71D306A15F9EDD0D9CA36E68976D7139F2FEC
F1076182AC9C9FA7BD5AFECA4FF9F43FF7CD5332C705F155C31190D2267AFA83563EDC3FE7BC9FF7
D9A5CCA2ECCB8A52572CDEE9B6D6518314AE2E23DA197A0606A496C649611E5331270E32C3923B13
55AD2DAF66BA56BC95A56CE143127207F5F5AE99ED8411AB07CE57236F208FC6AA6A33F87A1E7B9C
A9AE593BB39BB786DB4D9FED7399DEE63398E271DF9A6DB9695DDDE18D1E52599557007E7EDCD68D
C6D9E4FBF82A0E3FDA359AF6F733CBF7C4518E32588DDEDD294A4E5A1AD356BCBA8B3C6C76A1C904
F2C3A0F6FAD4B0D8DCAC9B487319FBEABF363DC6781F8D5DB4315B955DC8EA381D49CF7273DEB4FE
D713214758554FCCE33B77FD6B3504DEA13AF38AB2462C2AB14FE5431472331072C4903EB8AD7B3B
3B86567986C51D0EFE5BD69CFA8E9D6719786288331E7DBF2AC2BEF125E5E4C638D4AC6BC92063F9
56AA2A3A98FEF2AECADE6CEA5A185ADF6B618D504D223B9C248A064F033D6ACF87ACE67B457B9DC5
8FF09FFEBD6CCE12251B7CB53BBBAF22B451538A672CAB4A949C62EEC8AC347B6B2C32AFCE7AB11C
D5D9658EDD7323950338C9EB59F36BF6D6B0920990A9DBB80C8CE3A75AE46F35892FEE4E0BB28247
CA3BFB5394A34D682A787AB8895E5B173C45E236909B6B7D86420B007381C565D8CC66B12F288C4A
09048FAD56BAB79C3AC84A2700E71CE3A54F6F0ACB1C36B0FC8A4E19C0E7FF00D75C15EF522AFB9E
C52A51A30D3629DD5CCEB7089628D35D3FCB1AA8C827D4FB56D787F476D0D25FB7B86BA72AD23EE1
CE79E09AD5B416DA4EA10D859DA2CB7BB15AE66906E099FE11EE3BD67F8A67F2EEC26EF9C63A1ADE
847D9AB1CB3AB2C44FD9A564CD49A550FE508A4195DCA88BCE4F231ED51B5B477F6C2D6754C1382A
14600EB55F45B982FB4F5178583C5F22329C3633CE4FB56986B482DD8A4A599F2327822BB14948F3
274A74A6D2E873DFF086D880F12BCBE59203860307E9C71571ED2CED63482E2633476F0F0B3302A4
7B823F2ABD2C720B30D2178C3B600C90C7FC6B0B5BB05D4A2FB2F9E82ECC209DA49DABD8B9EDED53
2A5169D91BD2C44E725ED25A12787D0CDA2EA9FE8D247218BC8F354FDF42467BF27D2B35AE26D3ED
CDB5DC2C2168C98849190001D0E0F6FA54BE1BB5BAB7B792C4CB134E1F73A48E46E4C70CBF4ABBE2
3937416FA74D2C123C30A4A6E13E6791893F2A96E807715E754A5251EC91DA947DADB7B91693E39B

8B3B08EC67B7B791E341B2690F453CFCDCE49F4E2BA39F58B2D57C213DE4CE2205943220F99589C2
E3DCF38AF3D3A3DEDFDC465A30C93BE3CE5C8525719C9F6CFE95D1DB4168BA35FC124ED047398922
693A0743BB737B1E4645142BD492B4F6B19E230D46324E1B952D666B64FB14C5665BA5DA2364DC20
543B83127800F4E2BA9D1FC410DC5B4715C98C5C338542830180E075E78AE5403343692BDBA86814
A11BF69619F94363B7AD1A78CB34B342812DA392492556F995BAE171DBEB534E6D3562AAD2528EAC
EBBC4DF6992C16DA0837ACB9DCFB58E0AE38E3903AF38AC6B6F162C31AE9422093904C6AC4EF2AB9
CB1ED8F4358F79AC5D5EC89246F2890478C444E187A63A9F7ACD179FE94C4846936ED578C02EAA7A
804F38F6AAA9885CFCD1F4268E09F25A47557325ADB5A4B3C12B472EFC36E2595C91C9C8EF58D09D
36E61B8B8844A6F0000EE1B9703F84FE1CD477924B7653ED114BB63500A94F97818C81DFDEA0B045
32DDA477518631868977002521BA2E392707A562E4A73B25D0E88D3E485DB27D3D6DE3999DE678A3
E63915386C1C722B5E2B8D0350CAAC9A8DBC8AE48309403D71D3AFD6B2A486442F1CF0B0DB92E5C7
381D01A8DF50B7220B91180C22C615400CC38CB014A33B277439C1CDA699DEF86AEFED5A56D50C16
395A34571B5CAF62DDB26B9BF1F49259EA3A7DFF009594117241C1386FBBF8D5BF04DD131CF111B1
370755931BB07B54BE3CB64BC82CED77EC9253B8EE5C801390457AB466A74E2D9E559D2AE79A78A6
DA517D6F7916D8D5D7F76506D2A3AFE15A76B7B79BA3BC790ACF1A8F9BB7D4D5ED76D65D42C6365C
1911C64AF2990318C735269565E55DDAFF00685B92B2AE0851C11F4356D6A91E8C251F64E525AEA3
AE124D4DE1921B68DFED29B27B80BCA49EB9ED8A86DB459AE829750F85F9C28E9C7F2AD59E1B8D3F
51B98A0F322B7B85201DBC1E3AF4AD7F0EDB096D91D08CA9E73C714DC53DCE48D574A2E4B6311FC3
A82DE46497909B4157F9973F875ACCFF00847AE7FE7EEEFF005AF43B9B08C6E900DABB58304C039E
D59DF668FD6EFF00EFAAC650B3D8D218D76DC5B5B3820417170C01191B73EBFD6A1BFD52370C8AB9
55EBC74C7AFA5655EEA21917CC94A29539619201ACB86E6362804D9DD9C8C1EFEB59BA8A2AD12E9E
15C9F3CC96F2E046E5D430C0E33EBD6AA2ADD4D6E6E0C8FF007412BCFCB535C4266765F30302A000
DEB5359D85D8568C96FB314C312396E6A61CAE5AA3B1FBB1490DB40C91A49BC0F405BA9A69B992EA
6F2A38E462A338552726A791A0B619F378C16C1192DF4A8E2BB8EDEE9668D86D236646463DEAE0BA
3264DDAE919F2C4482AC5803FC2C38CFB574BA168E93CDE749B4C2A7201C64FD7D6B362867BFBE17
0C8446A718CF04E7AD763A658A5AA19A403701B5474DA3BD5B8272B2D8E6C462251A76EACB41FC98
3CD932AA725477F615CF6A1A83DCCEC08942805880393F4A9EFEEA49E6C64819C0E6B2A50CCEC428
51C00C0F27DA8A93E88CB0B87B3E6919777BA5322AE122439F949C1A6799E4AC691A6C1D09DBC0E3
F9530DE5ADC47218243E5A361C9520861EDDEAB5F2BA5B44EAB3CE8AC72216C3118E38AE3926E48F
6E16512F2DE89108DFB82E15B23EED747E15B02CE6497E611FDD723018F5CD72BA0D94FA85F0408F
B580243761EF5E89737F6DA5DB0B7F943F0BB456F18B72D76479D8DA965ECA1BB2AA5BA69F2DD5D1
72D24D2EF25DB27F0AE2F5398DD5F333920F603BD6D5F5F99C32890B139DB939CD5082D4C6CD24E5
7CCC6006C0C1C7157269683C2D3E4F7A5B95E2BA7B4B4751F33B1C2A9E49EE6AEDA9C3AA5CF9AB2A
38DCB2021A974A4857529277E90C5232A11F78E71C52EAD78F73776375E4A210C791825C7BE288C5
4973055A97A9C896E6A6AF1DEDCEAB11865DD016036163F2B0E323FD9A97EC42DE49CAB1F99FF7CC
A7993D01F6F41525C6A315BC31CC62127CA0633D40A8F4ED456FED2E257451F36703B0AE98B8AD2F
B9E54E35254EF6D114F50D3C4EF0CB6723477500CACB9E9C679F6AE76E64BDD4350669E3822B88F2
9E5471B09371FE2C7A1F6AE8B578E516D7A96AD806D986E53DC9C01594745BD8745B692E32F771AB
39997224519E9BB3DAA6B535520D33AF05512769FC8DCF0BB89236D3EEA0C40F2A9292654ABF723D
01F4AAFAFE877F90F035AC9042ED16C4386C16C8181E9595A16A3F6AB39E1BCDE649189FB434BCB3
641CFB62BAA8B4C58740BB9A6D41CF980C92488BBB683DF839CD712A5270E463AF7A15798E3A5B89
044624DC140224914F53F875AE834DB1596C6E2DA23296312C7745611B59DB9055BBE31CD5EFEC0D
384D7335BCC9E504058942123DC32081FE14DD22EC5968D3A42FE75D23052790338ED9ACE8D274E4
F9F6E82AB514E3EE1CD5BE95AAA6AA6DFECD3E7F8668E260A9FF00021DAA85FE979D5E48A48841C1
8DB79E848E48C76F4CD6BDAEA9ABDBDD34EDA85C796F2EF78198950BFDDC74AEA6F61B4F1268AFA8
D9C205D856546039DC38E73D6B38D285457A6F546CF11529C97B45A1C24B3599611DB35D48AB1156
79186EDFD32A075155F4D36335D289E5C7D9DD373260B424743ECDEB514F0BE9CD0A4A1CBEEF377B
C654E01C7F3A9ED52D2D80548D44A2512CB201F7F8E037AF359B9B52BEC755AF0D1E84CF25DDDBCD
2B5DC72C6D2615CB9DA54679C8EF50DAC82DEEF64AAAD6D20E491828DEA3DAA396E24B1B59250E17
CBC9F940C1C9F4AD3D2B4C4D46E5E332B3B20076480A9C119CD4ABCDDE226E34E3A9D7F87ED95E47
BA1E49270098F904E3B51E20B7135F4459981F242A7B65B26B42C2CE0D134C72C4469CBB30E067B6
0561CFAB24987B927E585B2075CE08C57B54A1CB0499E0569F3D46D1C76A5A85C68DA9BC10206899
83EF1D41F4AD39AE25D4D3CC6C875208D808C57357FE303648C3C888DDB6D8E4F31412A07420FBD6
DE93249786DD8DC792F21DB12E0912363382474A4F99CD247A91F76179AB1A2F34F3C6269E4DCCA0
4615092A3F0AD2F0F4ED0BCCABF7769C6473C5556B56BB899F0C9B49F3427661F4A9B4B8245BB588
34854823711DBB55293B915610549A47426E5844CD2A28C025B68FC73553FB463FF9E757AEACE496
D1633210C89B48C75AC9FEC66F54FCA954938BB2479F49536B538757729244623F30C84CF4C9EB9A
B9A6C0D3CC91C10FCF2F1B77745EDD6ACE3CD8958461B7024638E9FCAB4A0BDD3347D3DAFEF6611A
E4A440293B88FD7AD71C6939BB1ED55AFC9076356D059D8E14B02CD9CC879E73D8556D6638E0B548
8BA83D540E81BD3D6B9CD2B5F8E491EE9796C1C907A376C7E74CB9BD9EF350523E6E4647BFAD6AAA

4526AC72D3C3D494D49BF5279ED84E0966FBC783E9562DF4E8D047E780DC6029EDF95568E5677CA8
02351F3337F09F4AE874FD39A7815EE09238E16A69EBA1D55EA3A71DCBB696BE6C285180887240E3
247F85477F7E98F291B207F17AD49A9DE2DA5A79318C606D181DF15CDC776269B7B8C91CE07AD6D2
938688F3A8D3755B94899EE0E46D3F3638CFA554919A6DA21CB4818678FBDD88A8A7DB34DE50CC92
2BE1803B42FE3DEB722B64D36C1EE810ED8C2FA163D0FE158C79A52B23D294E34A2BBB316EE34B62
10B1329E0E0FDD3555772C4C5705CF03E99C53A6BB8998823793F31727193EC2A6806EBB80740885
87CBF740EA7DEB25535B2475EAA1766E5822E87A5AB1E6F271BD8607CA2B9DBBBC9AE2E4C9C1C7CD
8ED56EFF0052FED0B81E512BB102E0F5F4155A211411B4D704173F7463F135AB4EFCBD0E7A10514E
A4FE262497A6DA25C9CB9C08D37724923A7F9ED5CF5DF8BA2875158D6D24992290E66F376E4E7A81
8EC3D6BA96896EEDE294B0DC54A95EE9D801F81AE20784AF20BF30C8A9F65C31597A8C13D38EFCF7
F4A89594B535566AE752D20CC53248C1FAC6F8E581FF003DE9DB7CF9235562F23617A7016A47B75B
7B551E6967DA065BAFE43E95A1A5429F6988ED3F331C81E80714479B6B8AACA0A3CF6D4AFA8EE2B1
C4549F25831F7E2AA47E7C286649CC68580202F519C7F5ADED46D00B99A5B83E5FC9953BB39F4AC5
9A490DA15CFEEFD3BE7D6B6A9684AECCE84954872A475D656EE5567544FB3223BC887392CA322B91
FF00849A04BEF2A58985B1046DCF0C7EB5AD63E297B2D3E681A0133BE4052D83C8E6B1AE347B0D5B
4CBC3046566E309824AB13D739AD79F9AC96E71470FC9293A91F40BBB496FC472D9C43ED522E6586
36E197D474E94D12EA30690E2DE676593E57010678E7A1EB57B4CB4FB2980120CF19298DD83851CF
E756AEB4F8751C02E60319DD06C19193F781AD796EB41BC528B54EAEA97532B42BB69F4B68CCFE62
E76C90953903B7E54B6ABE6F9F019DD8C0BBD179E7EA474A65D787F50B4B766D3EE0F9864DF22818
E7F1A56D61ECA264BA817CC9E3D92B6402FCD79F530ADBBA67429427770D4A4D786D6C97CE8D240B
2EDDEC49E09FF66BBEB6D7ACAC6C74E816222DEE10ED9633B7CB3D718EA6B8086F6096711C44C285
86013B909F7AEAF4FF00B0BF95FDA57C98C71B558E4F4C67159E1E955A6DD919E2E9C5C5736C45AC
DBCFAADEF9C2693ECD71B5A391573818E98AADA76813C50DC4F708BE6444C70AB021A4E3938F4FAD
74F36B90410B1B27DD0C2301361CE07A71546FBC636D6901BB251A3F286C18C31933FE7AD6AF0F1E
7E69BD4E6854ADCAA34D6841A4F8344C892EB2CB293CFD9E3C80DE84915B9A8F882CF4A447963DF3
E36A22E0363B649AF3BB5F895AB5E6A0D116608E08C2E381DBB55F3A01D496496F4A4D24E991264A
98C76C0CE0D7553A6A1F0A26AD29AD6BBB23744B7775712BEA4E81244DCB8705117D38A8F53D3352
1A5993499A3B8B99880262CA3A73800F1D6B1F4FB78745B516724B24A543CAC76E3A9E3F0AE96274
B8D36D26D3E30B14597C21E198FF007B3E95AD96C70CD352BC568798C9E1992E26DDAC944BA88832
22E3F7A7FBBF2F1F8D6F68F73169B700309157A28033C1C647D47AD5FD481B8D4D9E46CAA0F988E0
127FFAD54A29234919776093D71DBDAB89D7E5A965D0F7A147DAD05ED0DCD1AF658AF5C6325DC93E
F5D55B224DB2E228C0668C02ABCE3BD723A701F6B8CFDE5C8048E3157EEDA48EED3CA69044003B73
83D6B7A72D2ECF3715439A768E9A1D0DC4F1C1099186E6E36A6704D52FED55FF009F63FF007F47F8
5656A57735DC25A2919843D1B1FD3AD63FDAEFBFE7B2FE55A73DFA18C30726B5661A6A9344FF00BA
0CAACC0962339FAD5DD5174FF10451D84B7EB1EA11A6E11B231043739CF4CFB6691A0887EEC7CF21
C2E7079A896CCC133DDECCCCCB856DDD3D38AE78FBAFDD67B0A119BBECD156D6D0DA04D3AD26C394
F31E455DD939FD3F0A548EE62BC7B4F34972410DB4723350092E23B87B8B765460327B83ED5B1A1D
9B9517B70C3CE6E0600181DB8A529464ADD4D25CF4DB93D8BF0E9EED2AC272636C1600918F7AE9EE
265B2FB3D9A600209273C8F4E2A3B5B626E7DB3CE7F8B8A7EA712CB2A0182C0E47BD690872EA8F1A
BD6F692516739ACDC3ADC798A0B1E4AE4D645A2CB206F3810589D9D06476E95BD75A74F34AEC1F72
75248EF5634DD3625F36EDD46C8D4851EBEF584A1394AC7A11AF4E953D08347D31A59016FBE1892D
ED52F88AED23B536F1A61114E003D7DEB52DCA43613CCEC15A4F9540E31E86B99BF55B9766DC0F5C
13C678E95A691565D4CA95EB56E696C8E5E7B3124D1BC73057C8C460673CF2727A568FDBA28DD908
F99000CC3B01DBDF9A955A3B7B5C445172B962075AAFA55B477705D89AE634662044AC3077672572
7F9D61493A93BB3D4A928C21764F6617ED0F2101BCE6C9F72453E6121B85B7112B8DA7CD3B8EE03B
01F8D49A069925C426EA5562B1F2075EE4E7F2C53AC2ED22B9B992567209CBBEE1C8FEE8AE94B5D4
CA55136F97A152CEE37318F6169986EDA5BF0C5744FA74B0E9C8F20E588382C38FF1AABA169E24BC
5B8894ED3F7588FBA2B67C4B23A34312670AA188C8C66A5C63AB7D0E59D693A8A11F99CD5F3FEF98
22A8DAB9049EE6B4F428FED124492317C648E7A8F4FC2B12E954C5246B2AABED2433A67E6ED5634C
B795A586637662915549DABC118F4358539A6EE75578FEEAC75BE20B6096EA5620C88BC76C8AE5FC
9FB6C4F02A71B09E1B9C56BEAD732DC08924919C7DD03F1E69DE14D92C9392DBFCB7E39EA3A60D55
68FB4A91B6C7261E52A187727B9CD4504105A892605AE37957C9FB83B67EB556DEE64281F7B02DF2
311DC66B7B57B516F7F711C72345F38FBA382074E2B29238618044A3727626955AB14D452D51DB85
529FBD2D531DF683657492AE25C8FBBF7720D68A42B3AA48B32B248379619041EE3D45604D71690E
A71D9C93399D9828C2FCB9233C9EC6B5A08E7B684DFDB60AC5F2C91B1E4D6D43129E8D18E3B071AA
AF1DCE9048C6201A612A85EAC0A9CFF5AA72DAA4D346D24692467874201E3DB3D29F6FA9D9DCC42E
0A0F3541CAB13F2FA7D6B3575657B833A4004087006ECFE35D729C4F1E9E1AB26F955AC5B7B3B658
3CCB7B48E67E57681B7047F155E45859137C5E5C8F191B07F08CF1C53D352B79E6428DB770CEE6E8
DC75F63ED52DE1F2753595CAED9A1DA878E003D6856E86552A4F69EE64EA96573239FB2BE005DA30
3A03CD738FE179D9DD2E9C32315DA7701B81EBF95760EE82646550201201B8F718A6EA6F15A4D1C7

2B02921DC1B19C62A6518F53B29636B462A103274AF0A43A74134B1408C563DFBDF924FB7D6AEDBD
B4D3DFC79CC6BB032A841F29190464FE18AD3D3AE21DCA88CB241282AE4364A9EC71DAAADCC72413
49F36DF249393CE4638AB564B4392A55A92A969EA62EA097914D765640566217000CAAE391F9D6A5
8EAEB05879320E117040E49AC24779E4F38B1DAC7839C66A50C9BD59B8C9607F98AF3E588973BB6C
7BCF0B074D4648A3717E249A52B939EDB8633DFAF5A9204DCA8CE00382C0E0F1ED51C912C9289A24
2C9D761382BFFD7AB71CDF6648DEE4021DB0A14FDEF41531827EF7566B271845729A166863285986
31B87351789A698E90668834789943B0272A98FCFAD58B1BE0977102B9527857C6473D2B435BB269
7C97B556920BB07E4033B49E7A9ADE29F2D8F3E725ED537B18963A84B1A4174D21E843657EF1EC4D
68FF00C246FF00E50D62DA5AF9286DE5CE038550DD40AB9FD9B6FE91FE7473B47538537AD83518E2
B683CE572AD9001C6722B9D596575DA640541380075AD4D41E6F2A58E40555338F7F5AC4820B8770
A15941E060E78EF59BDB61E1E9DA3CD2624104F7F3A425405072C7BD77D63A7A5A470B020EF0182E
79E3A551D2B4A5B48D15F22561C7CB9207B9ADBBE960D2EDF75CCC8B2B70A48FBB554E0B56CE2C6E
21CDA847627B9BE8620B1E40CF2E4761E95969348D310EC7058807B9AA0D7305D33CC926EE382C70
3E86ACE9D2AB4BBCFCC796FF00EBD129B6EC670C3A8C5BB6A6B02121DACB819E09E7F0A94F970DB3
C6DF2E7208FC69209639628F6AB124E476C7353DF22ED19019801BBDEB68BBAB9C2D5A491CA6B724
BE65BA890AB282BC8E149F51DEB2127445669A4DE1884071D4F4FC2B5F51D92DC16629BD18046C77
ACA5B416C4E5B0A1839038E7AE2B966EF2D3A1EF61E294016D1DADA65276E1BE426A38B43B7B8684
CD866663B867A60FB1AB6AB2DCDE2A14F938C053DC1F5AE8B4ED2C1B847277206DC327BF5AD547B0
ABD6E48BBB2C4205AC51DAC6E3715DEFF2F04F4C7E02B96960673292362B3B724707D8574DADDD47
69049142F9B89B00B7F757A9ACDD3914325B3483686DD8DB9FA539C927CA72506E30750DED0ECD21
3B53A70BCF7C77AE6F5EBC326A13C8DC4687961C8C67B0FA57678169A73C99F9F662B81B96D934AE
4FEE739E39E9DAB3C45E30B216097B4ACEA3325E449EE7CB9E36FB40198B23E4191C671D4F5357A3
9D83CACD1168F1B8B8C7005342178C485705541087AA13EFDFAF7AAB7D7F6DA5E93309222F2B9D98
2F8DF9EBDB8AC68C51EBD47746BDCB85B577DE3A0C6327AD6BF856606695148CB6091EA6B93B1D76
1BFB67812010BE0606FCF438007AFE55D0F84D223AB47B43FC80EDEA3766B58CAD347162217A0C8F
C4D02C9AD3AAF553D3358B2619B695C18C1C7D71DAB5358B8FF89D4C4077DAD9391D39A8D96DAFAD
8CAA33905081C106B1AD5254EA5DAD19D18469528C5BE87057F04D6BA84B733DBB9FB41592165901
8F3C6E3C771E95E811BB490EC9540201C95EFC556B5D3245859223E583217DB8CE49EF575ECE5B60
24F2D8A6393E9C63FC6A9C2A385CB9CE0ED1BEA50636F05C49B4868C0E78E87B0A62C30F9C55CEC8
F692548E871ED4E904935C4704299958F7E01E3834B61A4ADEEA2A248DA39CA175624FCEA3DAB582
725E412A918FC4F52FCF7CFF00F08FF9D0C799A029215CFDFE707F4ADBBC8D357B2B6D42CD59F644
239600BF305EBFA531ECE386008158F665E831D719AC096E6E6D6578629F0AD900ECEA2BAF9B951E
37D59621B71352DE78E4B89AD98F12018CFF00091C707F3ACEF113F9B70A4C98455F988FAD508833
5D87762A07CDF29CF3D2B43C40B8B312AB020282490067BD67CEE513B2186542AC48F4E8EE20486F
ADB706639201E5941ABDA9EA924AA4226DF34618F4DA2B3EC6D105AC76C2122E7C9F356E0CA79CF3
8C7414B6B0DC6AD6D027DE3D1B3DBB5124D46C9916A73A9CF25B19936AD6BF6B8EC7CC1B80FDE3E3
E54FFF005FE9579985BC2DB80DC0EFF4FC6B90D5B41D5F49D5E48523FB45B4CC49973F7B3EBE95D1
416C16DE0B36C3305F2CB11D457328461689DE9F3ABAD8D3910DAE993DD162A4C6ACCCCA70F9078E
7A73819AAF75B545B3CF0B148F96039C67A62ADB3DF7922DD4E21650ACA4820AE39EBCF4E6B521B4
8EEBC39BC26C786729F373C638ADE4D292E5381C9C53E7EACC49EEE1B9BB49ADA10B1853181BB191
F5F535AB65A96A4964B6B1DD18CAB60465738EE57FFAF596CC96F1BC6F6ECDF375C9C13EB8AB1A7D
C66E0C92228100C17CE7CCE3D2A6EDD4BA359423ECF95ABD8D3BFB65BB89A65654956401B6A9C648
E0FE159FF61BDFF9FCFF00C70FF8D696A31C579224D6876830867EDF377ACFFB1BFF00CF4144B733
A327CA47E23189EE87FBD54B4B551A8400018C9EDF5A28ACEAFF00159A50FE0A3A18C9376809E31F
D2AAF8D39B353DF62D1456BFCC79CBF8B032EDD542C2001830F231D7A55DD13FD77FDB16FE74515C
D1EA7A954E861FF591FF009EF56A4E5FFE054515D5D0F1EAFC671F280649F23F841A863FF8F694FF
00D34A28AE65F133DAA7F0A36AC6343141945FBC7B7BD5FB2E1D07FB14515BD338B17FA181A81CDF
4A0FB7F2A974103FB47A0FBA3F9D14562FE366EBFDDBE4769AC0C694F8FEF57033002C2CF0319B88
F3EFD68A2B7C47439F2FF85FA93CEA3ECC9C0E635CFE95CB78A95446381C5B4A7A77C0A28AE65F1A
3D586CC3C2C8A347B52140261E4E3AFCE2BB8F0C01FDA909EFE49E7F1A28AD23F19862BF82CA9201
FF00095CE30306E0023D7AD674402CF7A14607DA7A0A28A789FE12F531C36FF237ACC0100007A56C
CCAA748BBE074F4FF64D145747D967356FE22F538CB4E7C41600F3F38FE55A90331F14E98C4924C4
F939EB4515186FE19B633F8BF2372FB99957F877AF1F8572BAC2A8B9E140E4F6F7A28ABA9B3232F3
1E427EDA833C62AEDE127475C9FE21FC8D145443E13D1AFF00122CE9648F0A5D004E3C95FF00D045
4BE1227ED49CFF0007F4A28ADDEC8F3E9FF0EA0D601ACEE0B0C927A9FA56743FEB6134515C957F88
8EFA1F01BF6EA0B0C81FE5AB5AC001E1C83000CDDF3EF451497C679D89F8519D7A4EE6E7FE5BB7F5
A82E805D4AEC2803AF4A28AAFB6CE9A5F0A28DD7CBA7A6DE3F747A5646F6FEF1FCE8A2AAA6E3A7B1
FFD9}
}}}}
{\shp{\*\shpinst\shpleft6360\shptop9053\shpright10853\shpbottom12053\shpfhdr0\sh

pwr3\shpwrk0\shpfblwtxt1\shplid2079\shpz28\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 4493}}
{\sp{\sn geoBottom}{\sv 3000}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;5;(0,0);(0,3000);(4493,3000);(4493,0);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;12;16384;45824;1;45824;1;45824;1;45824;1;45824;2457
7;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 12700}}
{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7013\shptop8973\shpright7880\shpbottom9466\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2080\shpz29\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 867}}
{\sp{\sn geoBottom}{\sv 493}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(866,493);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft10053\shptop8973\shpright10480\shpbottom9413\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2081\shpz29\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 427}}
{\sp{\sn geoBottom}{\sv 440}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(426,453);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}

{\sp{\sn fArrowheadsOK}{\sv 0}}

{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7600\shptop10973\shpright7946\shpbottom12146\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2082\shpz29\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 346}}
{\sp{\sn geoBottom}{\sv 1173}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,1173);(346,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7800\shptop10386\shpright9693\shpbottom12106\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2083\shpz29\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 1893}}
{\sp{\sn geoBottom}{\sv 1720}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(1893,1733);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7826\shptop9400\shpright7933\shpbottom9506\shpfhdr0\shpw
r3\shpwrk0\shpfblwtxt1\shplid2084\shpz30\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 107}}
{\sp{\sn geoBottom}{\sv 106}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(106,106);(66,0);(53,13);(40,40);(26,53);(13,80);(0
,93);(106,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}

{\sp{\sn fillColor}{\sv 1704162}}

{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft10386\shptop9333\shpright10480\shpbottom9453\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2085\shpz31\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 94}}
{\sp{\sn geoBottom}{\sv 120}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(93,106);(93,0);(80,13);(53,26);(40,40);(13,53);(0,
66);(93,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7560\shptop11786\shpright7600\shpbottom12133\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2086\shpz32\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 40}}
{\sp{\sn geoBottom}{\sv 347}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(40,346);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7506\shptop11733\shpright7626\shpbottom11826\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2087\shpz33\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 120}}
{\sp{\sn geoBottom}{\sv 93}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(53,0);(0,93);(26,93);(40,93);(66,93);(93,80);(120,
80);(53,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45

824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7880\shptop10933\shpright8000\shpbottom11040\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2088\shpz34\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 120}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(93,0);(0,66);(26,66);(40,80);(66,93);(93,93);(106,
106);(93,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft8213\shptop10973\shpright9693\shpbottom12093\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2089\shpz35\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 1480}}
{\sp{\sn geoBottom}{\sv 1120}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(1480,1120);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft8160\shptop10933\shpright8266\shpbottom11040\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2090\shpz36\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 106}}
{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}

{\sp{\sn pVerticies}{\sv 8;8;(0,0);(26,106);(40,93);(53,66);(66,53);(93,40);(106

,13);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft7786\shptop10360\shpright7880\shpbottom10466\shpfhdr0\sh
pwr3\shpwrk0\shpfblwtxt1\shplid2091\shpz37\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 94}}
{\sp{\sn geoBottom}{\sv 106}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(0,0);(26,106);(40,93);(53,66);(66,53);(93,40);(106
,13);(0,0);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft10066\shptop8986\shpright10746\shpbottom10493\shpfhdr0\s
hpwr3\shpwrk0\shpfblwtxt1\shplid2092\shpz38\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}
{\sp{\sn geoRight}{\sv 680}}
{\sp{\sn geoBottom}{\sv 1507}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;2;(0,0);(680,1506);}}
{\sp{\sn pSegmentInfo}{\sv 2;5;16384;45824;1;45824;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 0}}
{\sp{\sn lineWidth}{\sv 19050}}
{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineDashing}{\sv 0}}
{\sp{\sn fLine}{\sv 1}}{\sp{\sn lineColor}{\sv 1704162}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}
{\shp{\*\shpinst\shpleft10680\shptop10413\shpright10786\shpbottom10520\shpfhdr0\
shpwr3\shpwrk0\shpfblwtxt1\shplid2093\shpz39\shpbxpage\shpbypage
{\sp{\sn shapeType}{\sv 0}}
{\sp{\sn fFlipH}{\sv 0}}
{\sp{\sn fFlipV}{\sv 0}}
{\sp{\sn rotation}{\sv 0}}

{\sp{\sn geoRight}{\sv 106}}

{\sp{\sn geoBottom}{\sv 107}}
{\sp{\sn shapePath}{\sv 4}}
{\sp{\sn pVerticies}{\sv 8;8;(93,106);(106,0);(80,13);(66,26);(40,26);(26,40);(0
,53);(93,106);}}
{\sp{\sn pSegmentInfo}{\sv 2;18;16384;45824;1;45824;1;45824;1;45824;1;45824;1;45
824;1;45824;1;45824;24577;32768}}
{\sp{\sn fFillOK}{\sv 1}}
{\sp{\sn fFilled}{\sv 1}}
{\sp{\sn fillColor}{\sv 1704162}}
{\sp{\sn fLine}{\sv 0}}{\sp{\sn lineColor}{\sv 0}}
{\sp{\sn lineType}{\sv 0}}
{\sp{\sn fArrowheadsOK}{\sv 0}}
{\sp{\sn fBehindDocument}{\sv 1}}
{\sp{\sn fLayoutInCell}{\sv 1}}}}\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn13
3\margtsxn666\margbsxn253\cols2\colno1\colw2560\colsr-0\colno2\colw8533\pard\li1
106\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1106\ri0\sl-213\slmult0 \fs18\cf0\pa
r\pard\li1106\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1106\ri0\sl-213\slmult0 \f
s18\cf0\par\pard\li1106\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1106\ri0\sl-346\
slmult0 \fs16\cf0\f1\charscalex100 {(a)}\par\column\pard\li0\ri0\sl-213\slmult0
\fs18\cf0\par\pard\li0\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Efecto a
ntioxidante y hepatoprotector del Petroselinum sativum (perejil) en ratas}\i0 \p
ar\pard\li2133\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li2133\ri0\sl-213\slmult0 \
fs18\cf0\par\pard\li2133\ri0\sl-426\slmult0 \*\tx3120\fs16\cf0\f1\charscalex100
{(b)}\tab \fs22\cf0\f0\charscalex100 {de necrosis entre moderada y severa (Figur
a 3). Por}\par\pard\li3120\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {otro l
ado, se pudo observar, histolgicamente, en}\par\pard\li3120\ri0\sl-253\slmult0 \f
s20\cf0\f0\charscalex100 {los hgados de ratas tratadas con paracetamol y pe-}\par
\pard\li3120\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {rejil, que mayorment
e permanecan sin alteraciones}\par\pard\li3120\ri0\sl-240\slmult0 \fs20\cf0\f0\ch
arscalex100 {o con signos de necrosis leve, presentando algunas}\par\pard\li3120
\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de ellas signos de necrosis mode
rada acompaados}\par\pard\li3120\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {d
e regeneracin celular marcada (Figura 4). Se}\par\pard\li3120\ri0\sl-253\slmul
t0 \fs20\cf0\f0\charscalex100 {encontr diferencia histolgica estadsticamente}\pa
r\pard\li3120\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {significativa entre
los grupos, a un}{ }\fs22\cf0\f0\charscalex100\i {p}\i0 \fs22\cf0\f0\charscalex
100 {<0,05.}\par\pard\li4813\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li4813\ri0\sl
-213\slmult0 \fs18\cf0\par\pard\li4813\ri0\sl-320\slmult0 \fs22\cf0\f0\charscale
x100\b {DISCUSIN}\b0 \par\pard\li3400\ri0\sl-400\slmult0 \fs22\cf0\f0\charscalex1
00 {La toxicidad heptica producida por la adminis-}\par\pard\sect\sectd\sbknone\p
gwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols3\colno1\colw3613\colsr-0\col
no2\colw2066\colsr-0\colno3\colw5413\pard\li1400\ri0\sl-253\slmult0 \fs16\cf0\f1
\charscalex100 {(c)}\par\column\pard\li0\ri0\sl-280\slmult0 \fs16\cf0\f1\charsca
lex100 {(d)}\par\column\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {
tracin de paracetamol ha sido descrita por diversos}\par\pard\li0\ri0\sl-253\slmu
lt0 \fs22\cf0\f0\charscalex100 {autores. Existen estudios que muestran que el pa
-}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\c
ols2\colno1\colw5680\colsr-0\colno2\colw5413\pard\li800\ri0\sl-240\slmult0 \fs18
\cf0\f0\charscalex100 {Figura 2. Hgado de rata con tratamiento: paracetamol. (a)}
\par\pard\li1080\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {Necrosis severa,
(b) aprecindose restos nucleares.}\par\pard\li693\ri0\sl-240\slmult0 \fs18\cf0\f
0\charscalex100 {(c) Retencin biliar. (d) Hipertrofia de las clulas de Kupffer.}\p
ar\pard\li1440\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {Coloracin: hematoxi
lina eosina, (40 X).}\par\pard\li640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li640
\ri0\sl-320\slmult0 \fs22\cf0\f0\charscalex100 {Los hgados de ratas control (sin
tratamiento) no}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {p
resentaron alteraciones histolgicas (Figura 1). En}\par\pard\li640\ri0\sl-240\slm
ult0 \fs20\cf0\f0\charscalex100 {cambio, en las ratas que recibieron el tratamie
nto}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {con paraceta

mol se observ signos de necrosis}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf

0\f0\charscalex100 {severa (Figura 2). As mismo, los hgados de ratas}\par\pard\li6
40\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {tratadas con paracetamol y FHP
mostraron signos}\par\column\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscale
x100 {racetamol se metaboliza a nivel heptico por varias}\par\pard\li0\ri0\sl-253
\slmult0 \fs22\cf0\f0\charscalex100 {vas, conduciendo una de ellas a la reaccin de
}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {conjugacin con el ci
do glucurnico, mientras que}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charsca
lex100 {la segunda va se conjuga con el sulfato, reaccio-}\par\pard\li0\ri0\sl-25
3\slmult0 \fs22\cf0\f0\charscalex100 {nes que tornan inocuo al paracetamol. En c
ambio,}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {existe otra
reaccin que lo conduce a la formacin}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0
\charscalex100 {de N-acetil imidoquinona, compuesto que tiene}\par\pard\li0
\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {la propiedad de realizar un ataq
ue nucleoflico a}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {div
ersos componentes celulares. Los compuestos}\par\pard\li0\ri0\sl-253\slmult0 \fs
22\cf0\f0\charscalex100 {dadores de grupos sulfidrilo, como el glutatin,}\par\par
d\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {ejercen un eficiente efecto
protector heptico, por}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marg
lsxn666\margrsxn133\cols7\colno1\colw1560\colsr-0\colno2\colw1920\colsr-0\colno3
\colw2733\colsr-0\colno4\colw640\colsr-0\colno5\colw2080\colsr-0\colno6\colw333\
colsr-0\colno7\colw1826\pard\li1306\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1306
\ri0\sl-333\slmult0 \fs16\cf0\f0\charscalex100 {(c)}\par\column\pard\li0\ri0\sl213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0
\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0
\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard
\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\
pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\
par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\
cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \f
s18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult
0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-293\sl
mult0 \fs16\cf0\f0\charscalex100 {(b)}\par\column\pard\li0\ri0\sl-213\slmult0 \f
s18\cf0\par\pard\li0\ri0\sl-333\slmult0 \fs16\cf0\f0\charscalex100 {(d)}\par\par
d\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par
\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0
\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18
\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \
fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmul
t0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\s
lmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-2
13\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-400\slmult0 \fs16\cf0\f0\charscalex100
{(a)}\par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-333\s
lmult0 \fs16\cf0\f0\charscalex100 {(b)}\par\column\pard\li0\ri0\sl-213\slmult0 \
fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmul
t0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\s
lmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-2
13\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\
sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\
ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\
li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\p
ard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\p
ar\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-293\slmult0 \fs16\c
f0\f0\charscalex100 {(a)}\par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\p
ard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\p
ar\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\c
f0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs
18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0
\fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slm
ult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213

\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl

-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri
0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-306\slmult0 \fs16\cf0\f0\charscal
ex100 {(c)}\par\column\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl
-333\slmult0 \fs16\cf0\f0\charscalex100 {(d)}\par\pard\sect\sectd\sbknone\pgwsxn
11893\pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw5826\colsr-0\colno2\c
olw5266\pard\li1000\ri0\sl-306\slmult0 \fs18\cf0\f0\charscalex100 {Figura 3. Hgad
o de rata con tratamiento: paracetamol}\par\pard\li946\ri0\sl-253\slmult0 \fs18\
cf0\f0\charscalex100 {y }\fs18\cf0\f0\charscalex100\i {Purinor}\i0 \fs18\cf0\f0\c
harscalex100 { (FHP). (a) Necrosis severa con ausencia de}\par\pard\li666\ri0\sl
-240\slmult0 \fs18\cf0\f0\charscalex100 {membrana citoplasmtica de hepatocitos y
(b) homogenizacin}\par\pard\li866\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {
de la cromatina nuclear, (c) mostrndose la membrana del}\par\pard\li640\ri0\sl-24
0\slmult0 \fs18\cf0\f0\charscalex100 {ncleo de los hepatocitos ligeramente engros
ada. (d) Se observa}\par\pard\li920\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex10
0 {pigmento pardo amarillento localizado en el citoplasma.}\par\pard\li1480\ri0\
sl-240\slmult0 \fs18\cf0\f0\charscalex100 {Coloracin: hematoxilina eosina, (40 X)
.}\par\column\pard\li93\ri0\sl-413\slmult0 \fs18\cf0\f0\charscalex100 {Figura 4.
Hgado de rata con tratamiento: paracetamol y}\par\pard\li160\ri0\sl-253\slmult0
\fs18\cf0\f0\charscalex100\i {Petroselinum sativum}\i0 \fs18\cf0\f0\charscalex10
0 { (perejil). (a) Necrosis moderada}\par\pard\li40\ri0\sl-240\slmult0 \fs18\cf0
\f0\charscalex100 {con retencin de pigmento pardo amarillento. (b) Espacio}\par\p
ard\li0\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {portal normal. (c) Clulas
de Kupffer normales. (d) Signos}\par\pard\li13\ri0\sl-240\slmult0 \fs18\cf0\f0\c
harscalex100 {de regeneracin por presencia de hepatocitos binucleados.}\par\pard\
li653\ri0\sl-240\slmult0 \fs18\cf0\f0\charscalex100 {Coloracin: hematoxilina eosi
na, (40 X).}\par\pard\li1493\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1493\ri0\sl
-213\slmult0 \fs18\cf0\par\pard\li1493\ri0\sl-400\slmult0 \*\tx4146\fs18\cf0\f0\
charscalex100 {An Fac Med Lima 2007; 68(4) }\tab \fs20\cf0\f0\charscalex100 {339
}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\pa
rd\sect\sectd\sbkpage\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\margtsxn66
6\margbsxn253\pard\li4226\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li4226\ri0\sl-33
3\slmult0 \fs18\cf0\f0\charscalex100\i {Luzmila Troncoso y col.}\i0 \par\pard\se
ct\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\co
lw5280\colsr-0\colno2\colw5813\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\
li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-426\slmult0 \fs22\cf0\f
0\charscalex100 {cuyo motivo la administracin de N-acetil cistena}\par\pard\li240\
ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {por va endovenosa permite evitar e
l efecto nocivo}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {q
ue ejercen los radicales libres generados por los}\par\pard\li240\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {metabolitos del paracetamol (}\fs12\cf0\f0\char
scalex100 {34}\fs22\cf0\f0\charscalex100 {).}\par\pard\li520\ri0\sl-400\slmult0
\fs22\cf0\f0\charscalex100 {El paracetamol es un medicamento que, admi-}\par\par
d\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {nistrado a elevadas dosis
, causa dao heptico. Este}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscal
ex100 {proceso se realiza por generacin de radicales libres.}\par\pard\li240\ri0\
sl-253\slmult0 \fs22\cf0\f0\charscalex100 {En tal sentido, la administracin de su
stancias con}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {prop
iedades antioxidantes podra evitar o disminuir}\par\pard\li240\ri0\sl-240\slmult0
\fs20\cf0\f0\charscalex100 {el efecto txico de la mencionada droga. El dao a}\par
\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {nivel heptico puede se
r evaluado de diversas for-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\char
scalex100 {mas; una de ellas lo constituye la medicin de la ac-}\par\pard\li240\r
i0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tividad srica de enzimas como GPT,
GOT o GGT,}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {cuya e
levacin en el plasma pondra en evidencia el}\par\pard\li240\ri0\sl-253\slmult0 \fs
22\cf0\f0\charscalex100 {dao celular que causa el paracetamol.}\par\pard\li520\ri
0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {En nuestro estudio, el incremento d
el nivel s-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {rico d
e transaminasas que observamos en aquellas}\par\pard\li240\ri0\sl-253\slmult0 \f

s20\cf0\f0\charscalex100 {ratas que recibieron el tratamiento con paracetamol}\p

ar\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {constituye una prue
ba del dao heptico que ha}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscal
ex100 {ejercido este medicamento. Dicho efecto se corro-}\par\pard\li240\ri0\sl253\slmult0 \fs20\cf0\f0\charscalex100 {bora con el estudio histopatolgico, que p
ermite}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {mostrar si
gnos de necrosis hepatocelular severa. Se}\par\pard\li240\ri0\sl-253\slmult0 \fs
20\cf0\f0\charscalex100 {ha descrito, en otros trabajos, que una sobredosis}\par
\pard\li240\ri0\sl-266\slmult0 \fs20\cf0\f0\charscalex100 {de paracetamol causa
una necrosis heptica aguda}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charsc
alex100 {(}\fs12\cf0\f0\charscalex100 {35}\fs22\cf0\f0\charscalex100 {), ocasio
nada, probablemente, por productos}\par\pard\li240\ri0\sl-240\slmult0 \fs20\c
f0\f0\charscalex100 {derivados del metabolismo del paracetamol (}\fs10\cf0\f0\ch
arscalex100 {36}\fs20\cf0\f0\charscalex100 {).}\par\pard\li240\ri0\sl-253\slmult
0 \fs20\cf0\f0\charscalex100 {Adems, el grupo de ratas al que se le administr}\par
\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {FHP, compuesto que ti
ene propiedades hepatopro-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\chars
calex100 {tectoras, mostr mayormente necrosis entre mode-}\par\pard\li240\ri0\sl253\slmult0 \fs22\cf0\f0\charscalex100 {rada y severa, presentando, as mismo, los
mayores}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {valores
en AST, ALT y GGT, lo que nos indicara}\par\pard\li240\ri0\sl-253\slmult0 \fs20\c
f0\f0\charscalex100 {muy poca o ninguna proteccin heptica contra el}\par\pard\li24
0\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {dao inducido por paracetamol, qu
e genera radica-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {
les libres en su mecanismo de accin. En cambio,}\par\pard\li240\ri0\sl-240\slmult
0 \fs20\cf0\f0\charscalex100 {las ratas tratadas con perejil no mostraron mayore
s}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {alteraciones ti
sulares. Esta observacin mantiene}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0
\charscalex100 {correlacin con los niveles de transaminasas, prin-}\par\pard\li24
0\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {cipalmente con GGT y ALT, donde
hay diferencia}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {e
stadsticamente significativa, que fueron los ms}\par\pard\li240\ri0\sl-253\slmult0
\fs20\cf0\f0\charscalex100 {bajos, lo que indicara que este alimento ejerci}\par\
pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {un mejor efecto hepato
protector.}\par\pard\li520\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {En un
estudio realizado con ratas tornadas dia-}\par\pard\li240\ri0\sl-240\slmult0 \fs
20\cf0\f0\charscalex100 {bticas pudo observarse cambios degenerativos en}\par\par
d\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {sus hepatocitos, modifica
ciones que fueron reduci}\fs20\cf0\f0\charscalex100 {-}\par\pard\li240\ri0\sl-25
3\slmult0 \fs20\cf0\f0\charscalex100 {das significativamente en las ratas que re
cibieron}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tratamie
nto con }\fs20\cf0\f0\charscalex100\i {Petroselinum crispum}\i0 \fs20\cf0\f0\cha
rscalex100 {. As mismo,}\par\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li2
40\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\
pard\li240\ri0\sl-266\slmult0 \*\tx1000\fs20\cf0\f0\charscalex100 {340}\tab \fs1
8\cf0\f0\charscalex100 {An Fac Med Lima 2007; 68(4)}\par\column\pard\li0\ri0\sl213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0
\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {las ratas diabticas mostraron elevado
s niveles de}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {ALT y
fosfatasa alcalina. En cambio, el grupo}\par\pard\li0\ri0\sl-240\slmult0
\fs22\cf0\f0\charscalex100 {de ratas a las que se les administr}{ }\fs22\cf0\f0\c
harscalex100\i {Petroselinum}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\c
harscalex100\i {crispum}\i0 \fs22\cf0\f0\charscalex100 { tuvo niveles significat
ivamente ms bajos}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de
las enzimas antes citadas (}\fs12\cf0\f0\charscalex100 {37}\fs22\cf0\f0\charsca
lex100 {).}\par\pard\li293\ri0\sl-413\slmult0 \fs20\cf0\f0\charscalex100 {La va d
e las pentosas tiene como principal fun-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\
cf0\f0\charscalex100 {cin proporcionar ribosa-5-fosfato necesaria para la}\par\pa
rd\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {sntesis}{ }\fs22\cf0\f0\cha
rscalex100\i {de novo}\i0 \fs22\cf0\f0\charscalex100 { de cidos nucleicos y compu

estos}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {reductores (N

ADPH) requeridos en las reacciones}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0
\charscalex100 {biosintticas; estos procesos son importantes en}\par\pard\li
0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {la mucosa intestinal, glndula
mamaria y tejido}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {
adiposo. La glucosa-6-fosfato deshidrogenasa es}\par\pard\li0\ri0\sl-253\slmult0
\fs22\cf0\f0\charscalex100 {una enzima que participa en la va de las pentosas}\p
ar\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {encargada de generar
NADPH, por cuyo motivo,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex
100 {su determinacin es importante, especialmente en}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {el hgado, a causa de la funcin que cumple este}\p
ar\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {rgano frente a la accin
de agentes hepatotxi-}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex10
0 {cos, para cuyo propsito, se requiere apreciables}\par\pard\li0\ri0\sl-253\slmu
lt0 \fs22\cf0\f0\charscalex100 {cantidades de NADPH y ribosa-5-fosfato para los}
\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {procesos de activac
in y desintoxicacin, as como,}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charsca
lex100 {para la sntesis y reparacin de cidos nucleicos.}\par\pard\li293\ri0\sl-426\
slmult0 \fs20\cf0\f0\charscalex100 {Se ha descrito que la administracin de tioace
ta-}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {mida a ratas du
rante un periodo de 60 das ocasiona}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0
\charscalex100 {un incremento de la actividad de glucosa-6-fosfato}\par\pard\li0
\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {deshidrogenasa a las 4 semanas d
e tratamiento, no}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {h
abindose observado un incremento perceptible de}\par\pard\li0\ri0\sl-253\slmult0
\fs22\cf0\f0\charscalex100 {dicha actividad en la primera semana de aplicacin}\pa
r\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {del hepatotxico, result
ado, que es, en cierto modo,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\chars
calex100 {similar al que hemos encontrado (}\fs12\cf0\f0\charscalex100 {38}\fs22
\cf0\f0\charscalex100 {). En este trabajo,}\par\pard\li0\ri0\sl-253\slmult0 \fs2
2\cf0\f0\charscalex100 {el incremento que se observa en la actividad de la}\par\
pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {glucosa-6-fosfato deshid
rogenasa se produce como}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscale
x100 {consecuencia de la necesidad que tiene la clula de}\par\pard\li0\ri0\sl-240
\slmult0 \fs22\cf0\f0\charscalex100 {generar compuestos reductores (NADPH),
para}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {protegerse de
la accin txica del paracetamol. En}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\c
harscalex100 {cambio, el grupo de ratas que recibi el tratamiento}\par\pard\li0\r
i0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {con perejil no present incremento s
ignificativo al}\fs22\cf0\f0\charscalex100 {-}\par\pard\li0\ri0\sl-240\slmult0 \
fs22\cf0\f0\charscalex100 {guno. Mientras que, el grupo de ratas que recibi el}\p
ar\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {tratamiento con el he
patoprotector (FHP), mostr un}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\chars
calex100 {incremento de la actividad de esta enzima, inclusive}\par\pard\li0\ri0
\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {mayor que el grupo de ratas que solo
recibi el para-}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {cet
amol, efecto que guarda relacin}{ }\fs22\cf0\f0\charscalex100 {con el incremento}
\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de TBARS que se obs
erva en los grupos de ratas que}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\ch
arscalex100 {recibieron los tratamientos solo con paracetamol y}\par\pard\li0\ri
0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {con paracetamol y el FHP. En cambio
, se observa}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {una di
sminucin de TBARS en los grupos que se}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0
\f0\charscalex100 {les administr paracetamol y perejil, resultado que}\par\pard\l
i0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {evidencia el efecto antioxidan
te de este alimento.}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\margls
xn666\margrsxn133\pard\sect\sectd\sbkpage\pgwsxn11893\pghsxn15866\marglsxn666\ma
rgrsxn133\margtsxn666\margbsxn253\pard\li2560\ri0\sl-213\slmult0 \fs18\cf0\par\p
ard\li2560\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Efecto antioxidante
y hepatoprotector del Petroselinum sativum (perejil) en ratas}\i0 \par\pard\sect

\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw
5680\colsr-0\colno2\colw5413\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li
920\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li920\ri0\sl-426\slmult0 \fs22\cf0\f0\
charscalex100 {Normalmente, se puede ingerir con la dieta sus-}\par\pard\li640\r
i0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tancias naturales con capacidad an
tioxidante, como}\par\pard\li640\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {
flavonoides del tipo de isoflavonas (genistena, daid}\fs22\cf0\f0\charscalex100 {
-}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {zena), myricetin
a, quercetina; polifenoles, taninos,}\par\pard\li640\ri0\sl-266\slmult0 \fs22\cf
0\f0\charscalex100 {\uc1\u946X}\fs22\cf0\f0\charscalex100 {-caroteno, vitamina E
, vitamina C, entre otros (}\fs12\cf0\f0\charscalex100 {2,10}\fs22\cf0\f0\charsc
alex100 {).}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {Es as
como, un equipo de investigadores estudi la}\par\pard\li640\ri0\sl-240\slmult0 \f
s22\cf0\f0\charscalex100 {capacidad antioxidante de los extractos metanlicos}\par
\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {de frutos, corteza y
hojas de laurel (}\fs20\cf0\f0\charscalex100\i {Laurus nobilis}\i0 \fs20\cf0\f0\
charscalex100 {)}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {
frente al sistema Fe}\fs10\cf0\f0\charscalex100 {2+}\fs20\cf0\f0\charscalex100 {
/ascorbato midiendo TBARS y}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\char
scalex100 {encontraron que la corteza presentaba mucha mayor}\par\pard\li640\ri0
\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {capacidad antioxidante (}\fs12\cf0\f
0\charscalex100 {39}\fs22\cf0\f0\charscalex100 {).}\par\pard\li920\ri0\sl-426\sl
mult0 \fs22\cf0\f0\charscalex100 {Como se ha sugerido, la administracin de pa-}\p
ar\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {racetamol ejerce un
efecto daino a nivel heptico}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\char
scalex100 {mediante la formacin de radicales libres los cuales}\par\pard\li640\ri
0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tienen la propiedad de oxidar a los
lpidos de las}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {mem
branas plasmticas y como consecuencia de}\par\pard\li640\ri0\sl-253\slmult0 \fs20
\cf0\f0\charscalex100 {ello se forman sustancias, como el malondialde-}\par\pard
\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {hdo, que reaccionan con el c
ido tiobarbitrico,}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100
{por cuyo motivo, la determinacin de TBARS en}\par\pard\li640\ri0\sl-253\slmult0
\fs20\cf0\f0\charscalex100 {el homogenizado de hgado constituye una de las}\par\p
ard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {maneras de evaluar el e
fecto nocivo ejercido por}\par\pard\li640\ri0\sl-240\slmult0 \fs22\cf0\f0\charsc
alex100 {el Paracetamol.}\par\pard\li920\ri0\sl-426\slmult0 \fs22\cf0\f0\charsca
lex100 {En el presente trabajo, la generacin de especies}\par\pard\li640\ri0\sl-2
53\slmult0 \fs20\cf0\f0\charscalex100 {reactivas al tiobarbitrico (TBARS) muestra
dife-}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {rencias es
tadsticamente significativas en todos los}\par\pard\li640\ri0\sl-253\slmult0 \fs2
0\cf0\f0\charscalex100 {grupos experimentales, correspondiendo el valor}\par\par
d\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {ms bajo para los grupos qu
e recibieron el trata-}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscale
x100 {miento con perejil, resultado que podra indicar}\par\pard\li640\ri0\sl-253\
slmult0 \fs20\cf0\f0\charscalex100 {una accin antioxidante, aunque algo moderada.
}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {Los niveles de l
a superxido dismutasa, enzima}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\cha
rscalex100 {que participa en la transformacin del radical}\par\pard\li640\r
i0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {anin superxido, en citosol heptic
o, fraccin}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {posmit
ocondrial, fue mayor en todos los grupos}\par\pard\li640\ri0\sl-253\slmult0 \fs2
0\cf0\f0\charscalex100 {experimentales con relacin al grupo control, ya}\par\pard
\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {sea que hubiesen recibido
el tratamiento solo con}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0\charscal
ex100 {paracetamol o, ms an, con esta droga y perejil o}\par\pard\li640\ri0\sl-253
\slmult0 \fs20\cf0\f0\charscalex100 {FHP. Adems, la actividad de la catalasa, enz
ima}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {que participa
en las reacciones de transformacin}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\
f0\charscalex100 {del perxido de hidrgeno, fue mayor en el grupo}\par\pard\li640\r

i0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {que recibi solamente paracetamol, m

ientras que,}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {en l
os grupos restantes, incluido el grupo control,}\par\pard\li640\ri0\sl-253\slmul
t0 \fs20\cf0\f0\charscalex100 {la actividad de esta enzima estuvo ms baja. Mien-}
\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tras tanto, en ot
ros estudios, la administracin de}\par\pard\li640\ri0\sl-240\slmult0 \fs20\cf0\f0
\charscalex100 {una dosis nica de tioacetamida, compuesto que}\par\pard\li640\ri0
\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tambin produce dao heptico a travs de la
ge-}\par\pard\li640\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {neracin de ra
dicales libres, ocasiona una dismi-}\par\pard\li640\ri0\sl-253\slmult0 \fs22\cf0
\f0\charscalex100 {nucin de las actividades de superxido dismutasa }\par\column\pa
rd\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\pa
r\pard\li0\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {y catalasa en hgado de
rata, siendo ms notable}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex1
00 {esta cada de la actividad a las 48 horas de haberse}\par\pard\li0\ri0\sl-253\
slmult0 \fs22\cf0\f0\charscalex100 {administrado el hepatotxico (}\fs12\cf0\f0\ch
arscalex100 {40}\fs22\cf0\f0\charscalex100 {).}\par\pard\li280\ri0\sl-426\slmult
0 \fs22\cf0\f0\charscalex100 {Al estudiar los investigadores en un grupo de}\par
\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {ratas el efecto hepa
totxico del tetracloruro de}\par\pard\li0\ri0\sl-266\slmult0 \fs22\cf0\f0\char
scalex100 {carbono, se observ una disminucin en la alb-}\par\pard\li0\ri0\sl-253\sl
mult0 \fs22\cf0\f0\charscalex100 {mina srica y protenas totales acompaadas de
}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {un incremento en A
ST, ALT y fosfatasa alcalina;}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\char
scalex100 {tambin, hubo alteraciones hepticas, como estea-}\par\pard\li0\ri0\sl-25
3\slmult0 \fs22\cf0\f0\charscalex100 {tosis, degeneracin hidrpica y necrosis. Al m
ismo}\par\pard\li0\ri0\sl-306\slmult0 \fs22\cf0\f0\charscalex100 {tiempo, admini
straron a otro grupo de ratas, CCl}{\sub \fs12\cf0\f0\charscalex100 {4}}\par\par
d\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {y un extracto de }\fs22\cf0
\f0\charscalex100\i {Centella asitica}\i0 \fs22\cf0\f0\charscalex100 { (L) y obse
rvaron}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {una accin hep
atoprotectora, que fue atribuida a}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0
\charscalex100 {la presencia de asiaticsido (14,5%) en el extrac-}\par\pard\li0\r
i0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {to (}\fs12\cf0\f0\charscalex100 {4
1}\fs22\cf0\f0\charscalex100 {). Otros estudios comprobaron en ratones el}\par\p
ard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {efecto antioxidante y ant
iinflamatorio del extracto}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charsca
lex100 {etanlico de las flores de la }{ }\fs22\cf0\f0\charscalex100\i {Taber
naemontana}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100\i {co
ronaria}\i0 { }\fs22\cf0\f0\charscalex100 {(L) R. Br (}\fs12\cf0\f0\charscalex10
0 {42}\fs22\cf0\f0\charscalex100 {). As mismo, otros inves-}\par\pard\li0\ri0\sl253\slmult0 \fs22\cf0\f0\charscalex100 {tigadores estudiaron en ratas y ratones
la actividad}\par\pard\li0\ri0\sl-253\slmult0 \*\tx3720\fs22\cf0\f0\charscalex10
0 {antioxidante del extracto etanlico de}\tab \fs22\cf0\f0\charscalex100\i {Tephr
osia}\i0 \par\pard\li0\ri0\sl-320\slmult0 \*\tx946\fs22\cf0\f0\charscalex100\i {
purpurea}\i0 \tab \fs22\cf0\f0\charscalex100 {Linn frente al CCl}{\sub \fs12\cf0
\f0\charscalex100 {4}}\fs22\cf0\f0\charscalex100 {y pudieron mostrar}\par\pard\l
i0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {una significativa inhibicin de
la lipoperoxidacin y}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100
{de la generacin de radical anin superxido (}\fs12\cf0\f0\charscalex100 {43}\fs22\c
f0\f0\charscalex100 {).}\par\pard\li280\ri0\sl-400\slmult0 \*\tx3946\fs20\cf0\f0
\charscalex100 {En otro estudio, se comunic que el}\tab \fs20\cf0\f0\charscalex10
0\i {Rosma-}\i0 \par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100\i {r
inus officinalis}\i0 \fs22\cf0\f0\charscalex100 { (}\fs22\cf0\f0\charscalex100
\i {Lamiaceae}\i0 \fs22\cf0\f0\charscalex100 {) puede aliviar la}\par\pard\li
0\ri0\sl-306\slmult0 \fs22\cf0\f0\charscalex100 {hepatotoxicidad aguda inducid
a por el CCl}{\sub \fs12\cf0\f0\charscalex100 {4}}\fs22\cf0\f0\charscalex100
{ en}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {ratas, posibl
emente evitando la formacin de radi-}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f
0\charscalex100 {cales libres generados durante el metabolismo del}\par\pard\li0

\ri0\sl-293\slmult0 \fs22\cf0\f0\charscalex100 {CCl}{\sub \fs12\cf0\f0\charscale

x100 {4}}\fs22\cf0\f0\charscalex100 {. Su principio activo sera el carnosol, uno}
\par\pard\li0\ri0\sl-240\slmult0 \*\tx3546\fs22\cf0\f0\charscalex100 {de los pri
ncipales constituyentes del}\tab \fs22\cf0\f0\charscalex100\i {Rosmarinus}\i0 \p
ar\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100\i {officinalis}\i0 \fs
22\cf0\f0\charscalex100 { (}\fs22\cf0\f0\charscalex100\i {Lamiaceae}\i0 \fs22\cf
0\f0\charscalex100 {) que ha mostrado actividad}\par\pard\li0\ri0\sl-240\slmult0
\fs22\cf0\f0\charscalex100 {antioxidante (}\fs12\cf0\f0\charscalex100 {44}\fs22
\cf0\f0\charscalex100 {).}\par\pard\li280\ri0\sl-400\slmult0 \fs22\cf0\f0\charsc
alex100 {En relacin al contenido de grupos sulfidrilos en}\par\pard\li0\ri0\sl-25
3\slmult0 \fs22\cf0\f0\charscalex100 {citosol de hgado de rata, fraccin posmitocon
drial,}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {observamos,
en el presente estudio, que es mayor}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\
f0\charscalex100 {en el grupo que recibi solo paracetamol que en el}\par\pard\li0
\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {grupo control, y el grupo que re
cibi, adems de}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {parace
tamol, perejil, mostr valores menores, an}\par\pard\li0\ri0\sl-253\slmult0 \fs22\c
f0\f0\charscalex100 {que el grupo control, lo que sugiere que el trata-}\par\par
d\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {miento con este alimento in
hibi el incremento en}\par\pard\li0\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100
{el contenido de los grupos sulfidrilos ocasionado}\par\pard\li0\ri0\sl-253\slm
ult0 \fs22\cf0\f0\charscalex100 {probablemente por el paracetamol y otras noxas.
}\par\pard\li280\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {Un hecho similar
ocurre en el suero, donde es}\par\pard\li0\ri0\sl-253\slmult0 \fs22\cf0\f0\char
scalex100 {posible apreciar que los niveles de grupos sulfidrilos}\par\pard\li0\
ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {son mayores en el grupo con parac
etamol que en los}\par\pard\li1640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1640\
ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1640\ri0\sl-213\slmult0 \fs18\cf0\par\pa
rd\li1640\ri0\sl-266\slmult0 \*\tx4293\fs18\cf0\f0\charscalex100 {An Fac Med Lim
a 2007; 68(4) }\tab \fs20\cf0\f0\charscalex100 {341}\par\pard\sect\sectd\sbknone
\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\pard\sect\sectd\sbkpage\pgwsxn1
1893\pghsxn15866\marglsxn666\margrsxn133\margtsxn666\margbsxn253\pard\li4226\ri0
\sl-213\slmult0 \fs18\cf0\par\pard\li4226\ri0\sl-333\slmult0 \fs18\cf0\f0\charsc
alex100\i {Luzmila Troncoso y col.}\i0 \par\pard\sect\sectd\sbknone\pgwsxn11893\
pghsxn15866\marglsxn666\margrsxn133\cols2\colno1\colw5280\colsr-0\colno2\colw581
3\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs1
8\cf0\par\pard\li240\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100 {diferentes g
rupos experimentales y el control, lo que}\par\pard\li240\ri0\sl-253\slmult0 \fs
20\cf0\f0\charscalex100 {sugerira que el paracetamol podra ser el causante}\par\pa
rd\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {de este incremento. O
tros autores describen que,}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\c
harscalex100 {despus de la administracin de tioacetamida, se}\par\pard\li240
\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {observa una disminucin de niveles
intracelulares de}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100
{grupos sulfidrilos de las protenas de hepatocitos de}\par\pard\li240\ri0\sl-240
\slmult0 \fs22\cf0\f0\charscalex100 {ratas a las 24 y 48 horas postratamiento (}
\fs12\cf0\f0\charscalex100 {40}\fs22\cf0\f0\charscalex100 {).}\par\pard\li520\ri
0\sl-413\slmult0 \fs20\cf0\f0\charscalex100 {Finalmente, el estudio histopatolgic
o realizado}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {pudo
corroborar que los hgados de las ratas que}\par\pard\li240\ri0\sl-240\slmult0 \fs
20\cf0\f0\charscalex100 {recibieron solamente paracetamol fueron los que}\par\pa
rd\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {presentaron mayores sign
os de necrosis severa, es}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charsc
alex100 {decir, fueron ms daados. As mismo, el grupo}\par\pard\li240\ri0\sl-253\slm
ult0 \fs20\cf0\f0\charscalex100 {que recibi, adems de paracetamol, el FHP, mos-}\p
ar\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {tr signos de necrosi
s entre moderada y severa, lo}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\ch
arscalex100 {que indicara una mnima hepatoproteccin. Estos}\par\pard\li240\ri0\sl-2
53\slmult0 \fs20\cf0\f0\charscalex100 {daos hubieran sido mayores an si las ratas
hu-}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {bieran presen

tado signos de desnutricin aguda, la}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0

\f0\charscalex100 {cual hubiera afectado su metabolismo, el volumen}\par\pard\li
240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {de distribucin y la depura
cin (}\fs22\cf0\f0\charscalex100\i {clearance}\i0 \fs22\cf0\f0\charscalex100 {)
de}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {una dosis ter
aputica que haran ms severas las}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\ch
arscalex100 {lesiones (}\fs12\cf0\f0\charscalex100 {45}\fs22\cf0\f0\charscalex10
0 {).}\par\pard\li520\ri0\sl-400\slmult0 \fs22\cf0\f0\charscalex100 {En cambio,
el grupo que recibi paracetamol}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\c
harscalex100 {y perejil mostr algunos signos de necrosis hep-}\par\pard\li240\ri0\
sl-253\slmult0 \fs20\cf0\f0\charscalex100 {tica leve o ausencia de ellos y, adems
, signos de}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {regen
eracin parenquimal, con lo cual se estara}\par\pard\li240\ri0\sl-240\slmult0 \fs20
\cf0\f0\charscalex100 {evidenciando el gran efecto hepatoprotector de los}\par\p
ard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {componentes de este ali
mento.}\par\pard\li520\ri0\sl-413\slmult0 \fs22\cf0\f0\charscalex100 { En los es
tudios de otros investigadores se pudo}\par\pard\li240\ri0\sl-253\slmult0 \fs20\
cf0\f0\charscalex100 {observar que la sustancia natural PFL presenta}\par\
pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {actividad antioxidante
tanto}{ }\fs20\cf0\f0\charscalex100\i {in vitro}\i0 \fs20\cf0\f0\charscalex100
{ como}{ }\fs20\cf0\f0\charscalex100\i {in vivo}\i0 \par\pard\li240\ri0\sl-253\s
lmult0 \fs20\cf0\f0\charscalex100 {y protege contra la hepatotoxicidad inducida
por}\par\pard\li240\ri0\sl-306\slmult0 \fs20\cf0\f0\charscalex100 {CCl}{\sub \fs
10\cf0\f0\charscalex100 {4}}\fs20\cf0\f0\charscalex100 {, en dos semanas de trat
amiento, evaluado me-}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex
100 {diante valores de AST, ALT, examen histolgico y}\par\pard\li240\ri0\sl-240\s
lmult0 \fs20\cf0\f0\charscalex100 {la medicin de malondialdehdo, producto de lipo}\par\pard\li240\ri0\sl-240\slmult0 \fs22\cf0\f0\charscalex100 {peroxidacin (}\fs
12\cf0\f0\charscalex100 {46}\fs22\cf0\f0\charscalex100 {). As mismo, otros invest
igadores}\par\pard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {estudiar
on la sustancia de origen vegetal LIV-52,}\par\pard\li240\ri0\sl-240\slmult0 \fs
20\cf0\f0\charscalex100 {la cual mostr efecto hepatoprotector evaluado por}\par\p
ard\li240\ri0\sl-240\slmult0 \fs20\cf0\f0\charscalex100 {transaminasas, al igual
que por estudios histopato-}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\cha
rscalex100 {lgicos en los animales tratados (}\fs12\cf0\f0\charscalex100 {47}\fs2
2\cf0\f0\charscalex100 {).}\par\pard\li520\ri0\sl-413\slmult0 \fs22\cf0\f0\chars
calex100 {Podemos concluir, de todo lo observado en el}\par\pard\li240\ri0\sl-25
3\slmult0 \fs20\cf0\f0\charscalex100 {presente estudio de investigacin, que el pe
rejil}\par\pard\li240\ri0\sl-253\slmult0 \fs22\cf0\f0\charscalex100 {ejerce un
efecto antioxidante y hepatoprotector}\par\pard\li240\ri0\sl-253\slmult0 \fs
20\cf0\f0\charscalex100 {efectivo a nivel heptico en ratas con intoxicacin}\par\pa
rd\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charscalex100 {inducida por paracetam
ol, evidenciado a travs}\par\pard\li240\ri0\sl-253\slmult0 \fs20\cf0\f0\charsc
alex100 {de ALT, GGT, glucosa-6-fosfato deshidrogenasa,}\par\pard\li240\ri0\sl-2
40\slmult0 \fs22\cf0\f0\charscalex100 {TBARS y observaciones histopatolgicas.}\pa
r\pard\li240\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li240\ri0\sl-213\slmult0 \fs1
8\cf0\par\pard\li240\ri0\sl-440\slmult0 \*\tx1000\fs20\cf0\f0\charscalex100 {342
}\tab \fs18\cf0\f0\charscalex100 {An Fac Med Lima 2007; 68(4)}\par\column\pard\l
i466\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li466\ri0\sl-213\slmult0 \fs18\cf0\pa
r\pard\li466\ri0\sl-426\slmult0 \fs22\cf0\f0\charscalex100\b {REFERENCIAS BIBLIO
GRFICAS}\b0 \par\pard\li0\ri0\sl-360\slmult0 \fs18\cf0\f0\charscalex100 {1. Martn
-Sanz P, Cascales M. Metabolismo de frmacos en}\par\pard\li293\ri0\sl-213\slmult0
\fs16\cf0\f0\charscalex100 {hgado y sus alteraciones. En: Cascales M y col. Hepa
tologa.}\par\pard\li293\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {Madrid: C
onsejo Superior de Investigaciones Cientficas;}\par\pard\li293\ri0\sl-226\slm
ult0 \fs18\cf0\f0\charscalex100 {1990.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf
0\f0\charscalex100 {2. Yu BP. Cellular defenses against damage from reactive ox
ygen}\par\pard\li293\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {species. Phy
siologycal Reviews. 1994;74(1):139-62.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf
0\f0\charscalex100 {3. Cheeseman K, Slater T. An introduction to free radicals

in}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {medicine. Brit

Med Bull. 1993;49:481-93.}\par\pard\li0\ri0\sl-226\slmult0 \fs18\cf0\f0\charsca
lex100 {4. Padh H. Vitamin C: Newer insights into its biochemical}\par\
pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {functions. Nutr Rev. 1
991;49(3):65-70.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {5.
Troncoso L. Efecto del ascorbato sobre la ruptura de los}\par\pard\li293\ri0\s
l-226\slmult0 \fs16\cf0\f0\charscalex100 {puentes disulfuro. Tesis para opta
r el Grado Acadmico}\par\pard\li293\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex
100 {de Magster en Nutricin. Lima: Facultad de Medicina,}\par\pard\li293\ri
0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Universidad Nacional Mayor de San M
arcos; 1996.}\par\pard\li0\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {6. Fr
aga C, Shigenaga M, Park J, Degan P, Ames B. Vitaminas}\par\pard\li293\ri0\sl-21
3\slmult0 \fs16\cf0\f0\charscalex100 {antioxidantes: bioqumica, nutricin y par
ticipacin en la}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {
prevencin de ciertas patologas. BEB. 1995;14(1):12-7.}\par\pard\li0\ri0\sl-226\slm
ult0 \fs18\cf0\f0\charscalex100 {7. Guija E, Troncoso L. Radicales libres y env
ejecimiento. Bol}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {
Soc Qum Per. 2000;66:33-51.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscal
ex100 {8. Edgington S. As we live and breathe: Free radicals and aging.}\par\pa
rd\li293\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {Bio Tech. 1994;12:37-40.
}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {9. Singh V, Gab
y S. Premaligmant lesions: role of antioxidant}\par\pard\li293\ri0\sl-226\
slmult0 \fs16\cf0\f0\charscalex100 {vitamins and }\fs16\cf0\f0\charscalex100 {\
uc1\u946X}\fs14\cf0\f0\charscalex100 {-carotene in risk reduction and preve
ntion of}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {maligma
nt transformation. Am J Clin Nutr. 1991;53:386s-90s.}\par\pard\li0\ri0\sl-213\sl
mult0 \fs18\cf0\f0\charscalex100 {10. Halliwell B, et al. How to character
ize a biological}\par\pard\li293\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100
{antioxidant. Free Rad Res Comms. 1990;9(1):1-32.}\par\pard\li0\ri0\sl-213\slmu
lt0 \fs18\cf0\f0\charscalex100 {11. Caigueral S, Vanaclocha B. Usos teraputicos de
l tomillo.}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Rev Fi
tot. 2000;1(1):5-13.}\par\pard\li0\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100
{12. Liu F, Ng TB. Antioxidative and free radical scavenging}\par\pard\li293\ri
0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {activities of selected medicinal he
rbs. Life Sci. 2000;66(8):}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\chars
calex100 {725-35.}\par\pard\li0\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {1
3. Troncoso L, Guija E. Propiedades antioxidantes del perejil}\par\pard\li293\ri
0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {(}\fs16\cf0\f0\charscalex100\i {Pet
roselinum sativum}\i0 \fs16\cf0\f0\charscalex100 {). Rev Soc Qum Per. 2005;71(2):9
9-}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {106.}\par\pard
\li0\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {14. Troncoso L, Guija E, Ron
ceros S, Valdivia F, Flores J, Guija}\par\pard\li293\ri0\sl-213\slmult0 \fs16\cf
0\f0\charscalex100 {H y col. Efecto del camu-camu (}\fs16\cf0\f0\charscalex100\i
{Myrciaria dubia}\i0 \fs16\cf0\f0\charscalex100 {) y perejil}\par\pard\li293\ri
0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {(}\fs16\cf0\f0\charscalex100\i {Pet
roselinum sativum}\i0 \fs14\cf0\f0\charscalex100 {) en plasma sanguneo de pacient
es con}\par\pard\li293\ri0\sl-226\slmult0 \fs16\cf0\f0\charscalex100 {dislipidem
ia y diabetes mellitus tipo 2. Libro de resmenes.}\par\pard\li293\ri0\sl-213\slmu
lt0 \fs16\cf0\f0\charscalex100 {III Jornadas de Investigacin en Salud. Lima: Facu
ltad de}\par\pard\li293\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Medicina,
UNMSM; 2001.}\par\pard\li0\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {15. T
roncoso L, Nolberto V, Oliveira G, Torrealva L, Guija}\par\pard\li293\ri0\sl-213
\slmult0 \fs16\cf0\f0\charscalex100 {H, Quiroz K. Estudio fitoqumico del}{ }\fs16
\cf0\f0\charscalex100\i {Petroselinum sativum}\i0 \par\pard\li293\ri0\sl-213\slm
ult0 \fs16\cf0\f0\charscalex100 {(perejil): Separacin y caracterizacin de fra
cciones con}\par\pard\li293\ri0\sl-226\slmult0 \fs16\cf0\f0\charscalex100 {capa
cidad antioxidante. Libro de resmenes. III Jornadas}\par\pard\li293\ri0\sl213\slmult0 \fs16\cf0\f0\charscalex100 {Cientficas Sanfernandinas y VI Jornadas d
e Investigacin}\par\pard\li293\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {en
Salud. An Fac Med. 2004;65 Supl 1:S20-21.}\par\pard\li0\ri0\sl-213\slmult0 \fs18

\cf0\f0\charscalex100 {16. Troncoso L, Guija E, Oliveira G, Palomino F, Norberto

}\par\pard\li293\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {V, Quiroz K. Eva
luacin toxicolgica aguda del extracto}\par\pard\li293\ri0\sl-226\slmult0 \fs16\c
f0\f0\charscalex100 {acuoso y fraccin B (extraccin con etanol y agua) del
}\par\pard\li293\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {perejil (}\fs16\
cf0\f0\charscalex100\i {Petroselinum sativum}\i0 \fs16\cf0\f0\charscalex100 {) e
n ratas. Libro de resmenes.}\par\pard\li293\ri0\sl-213\slmult0 \fs16\cf0\f0\chars
calex100 {IV Jornadas Cientficas Sanfernandinas y VII Jornadas de}\par\pard\li293
\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {Investigacin en Salud. An Fac Med
. 2005;66 Supl 1:S26.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex10
0 {17. Troncoso L, Guija E, Bernui I, Cairo Y, Oriondo R, Pacheco}\par\pard\li29
3\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {A. Capacidad antioxidante de al
imentos y plantas medicinales.}\par\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15
866\marglsxn666\margrsxn133\pard\sect\sectd\sbkpage\pgwsxn11893\pghsxn15866\marg
lsxn666\margrsxn133\margtsxn666\margbsxn253\pard\li2560\ri0\sl-213\slmult0 \fs18
\cf0\par\pard\li2560\ri0\sl-333\slmult0 \fs18\cf0\f0\charscalex100\i {Efecto ant
ioxidante y hepatoprotector del Petroselinum sativum (perejil) en ratas}\i0 \par
\pard\sect\sectd\sbknone\pgwsxn11893\pghsxn15866\marglsxn666\margrsxn133\cols2\c
olno1\colw5680\colsr-0\colno2\colw5413\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\p
ar\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li920\ri0\sl-400\slmult0 \fs
18\cf0\f0\charscalex100 {Libro de resmenes. Primer Congreso Internacional FITO 20
00}\par\pard\li920\ri0\sl-226\slmult0 \fs16\cf0\f0\charscalex100 {y 1er Congreso
Peruano de Plantas Medicinales y Fitoterapia.}\par\pard\li920\ri0\sl-213\slmult
0 \fs18\cf0\f0\charscalex100 {Lima: Instituto de Fitoterapia Americano; 2000.}\p
ar\pard\li640\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {18. Troncoso L, G
uija E, Quiroz K. Capacidad antioxidante}\par\pard\li920\ri0\sl-213\slmult0
\fs18\cf0\f0\charscalex100 {del \uc1\u8220XChimichurri\uc1\u8221X y sus compone
ntes. Libro de resmenes.}\par\pard\li920\ri0\sl-226\slmult0 \fs18\cf0\f0\charscal
ex100 {Segundo Congreso Internacional FITO 2003 y 2do Congreso}\par\pard\li920\r
i0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Peruano de Plantas Medicinales y F
itoterapia. Lima, Per:}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex
100 {Instituto de Fitoterapia Americano; 2003.}\par\pard\li640\ri0\sl-226\slmult
0 \fs16\cf0\f0\charscalex100 {19. Troncoso L, Guija E, Quiroz K. Capacidad antio
xidante de}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {los c
ondimentos del \uc1\u8220XChimichurri\uc1\u8221X. Libro de resmenes.}\par\pard
\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Segundo Congreso Internaci
onal FITO 2003 y 2do Congreso}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\ch
arscalex100 {Peruano de Plantas Medicinales y Fitoterapia. Lima, Per:}\par\pard\l
i920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Instituto de Fitoterapia Ame
ricano; 2003.}\par\pard\li640\ri0\sl-226\slmult0 \fs16\cf0\f0\charscalex100 {20.
Troncoso L, Guija E, Quiroz K. Efecto de la temperatura}\par\pard\li920\ri0\sl213\slmult0 \fs18\cf0\f0\charscalex100 {sobre la generacin de radicales libr
es y la capacidad}\par\pard\li920\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex1
00 {antioxidante del}{ }\fs16\cf0\f0\charscalex100\i {Capsicum annuum}\i0 { }\fs
16\cf0\f0\charscalex100 {L. (Pimiento). Libro de}\par\pard\li920\ri0\sl-213\slmu
lt0 \fs18\cf0\f0\charscalex100 {resmenes. Segundo Simposium Internacional de
Plantas}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Medicina
les y Fitoterapia. FITO 2004. Lima, Per: Instituto}\par\pard\li920\ri0\sl-226\slm
ult0 \fs18\cf0\f0\charscalex100 {de Fitoterapia Americano; 2004.}\par\pard\li640
\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {21. Troncoso L, Guija E, Quiroz
K. Efecto de la temperatura}\par\pard\li920\ri0\sl-226\slmult0 \*\tx3786\*\tx498
6\fs18\cf0\f0\charscalex100 {sobre la capacidad antioxidante de la}\tab \fs18\cf
0\f0\charscalex100\i {Allium cepa}\i0 \fs18\cf0\f0\charscalex100 { L.}\tab \fs18
\cf0\f0\charscalex100\i {var.}\i0 \par\pard\li920\ri0\sl-213\slmult0 \fs16\cf0\f
0\charscalex100\i {Aggregatum}\i0 \fs16\cf0\f0\charscalex100 { (Cebolla china)
. Libro de resmenes. XXII}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\cha
rscalex100 {Congreso Peruano de Qumica. Lima, Per: Sociedad}\par\pard\li920\
ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {Qumica del Per; 2004.}\par\pard\li6
40\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {22. Troncoso L, Guija E, Quiro
z K. Capacidad antioxidante de la}\par\pard\li920\ri0\sl-213\slmult0 \fs16\cf0\f

0\charscalex100\i {Beta vulgaris }\i0 \fs16\cf0\f0\charscalex100 {L. }\fs16\cf0\

f0\charscalex100\i {var. Crassa}\i0 \fs16\cf0\f0\charscalex100 { (Betarraga). Li
bro de resmenes.}\par\pard\li920\ri0\sl-226\slmult0 \fs16\cf0\f0\charscalex100 {I
Congreso Internacional y VII Congreso Peruano de Nutricin}\par\pard\li920\ri0\sl
-213\slmult0 \fs18\cf0\f0\charscalex100 {\uc1\u8220XAlimentacin y Nutricin para un
a Vida Saludable\uc1\u8221X. Lima,}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\
f0\charscalex100 {Per: Sociedad Peruana de Nutricin; 2004.}\par\pard\li640\ri0\sl226\slmult0 \fs16\cf0\f0\charscalex100 {23. D\uc1\u8217XArcy P. Adverse reaction
s and interactions with herbal}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\c
harscalex100 {medicines. Part II. Drug interactions. Adverse Drug React}\par\par
d\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Toxicol Rev. 1993;12(3):1
47-62.}\par\pard\li640\ri0\sl-226\slmult0 \fs16\cf0\f0\charscalex100 {24. Hernnde
z J, Valero H, Gil R. 23 especies vegetales}\par\pard\li920\ri0\sl-213\s
lmult0 \fs18\cf0\f0\charscalex100 {medicinales de uso frecuente en la poblacin de
Tabay. Rev}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Fac F
arma. 2002;44(2):51-8.}\par\pard\li640\ri0\sl-226\slmult0 \fs16\cf0\f0\charscale
x100 {25. Kreydiyyeh S, Usta J. Diuretic effect and mechanism of}\par\pa
rd\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {action of parsley. J Eth
nopharmacol. 2002;79:353-7.}\par\pard\li640\ri0\sl-213\slmult0 \fs16\cf0\f0\char
scalex100 {26. Frankel S, Reitman S, Sonnenwirth AC, editors. Gradwohl\uc1\u8217
Xs}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Clinical Labor
atory Methods and Diagnosis. 7 Ed. Vol. 1.}\par\pard\li920\ri0\sl-213\slmult0 \fs
18\cf0\f0\charscalex100 {Saint Louis: The C. V. Mosby Company; 1970.}\par\pard\l
i640\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex100 {27. Wahlefeld A, Bergmeyer
, H. En: Bergmeyer H (Ed.).}\par\pard\li920\ri0\sl-213\slmult0 \fs18\cf0\f0
\charscalex100 {Methods of Enzymatic Analysis, Vol. III. 3}\fs10\cf0\f0\charscal
ex100 {rd}\fs18\cf0\f0\charscalex100 { ed. Weinheim:}\par\pard\li920\ri0\sl-213\
slmult0 \fs18\cf0\f0\charscalex100 {Verlag Chemie; 1987.}\par\pard\li640\ri0\sl213\slmult0 \fs16\cf0\f0\charscalex100 {28. Ellman G. Tissue sulphydryl groups.
Arch Biochem Biophys.}\par\pard\li920\ri0\sl-226\slmult0 \fs18\cf0\f0\charscalex
100 {1959;82:70-5.}\par\pard\li640\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100
{29. Wiener lab Group. Vademecum. Reagents for Clinical}\par\pard\li920\r
i0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {laboratories. Rosario: Wiener lab
Group; 2000.}\par\pard\li640\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {30.
Del Maestro R, McDonald W, Anderson R. Superoxide}\par\pard\li920\ri0\sl213\slmult0 \fs16\cf0\f0\charscalex100 {dismutase, catalase and glutathione pero
xidase in experimental}\par\pard\li920\ri0\sl-226\slmult0 \fs18\cf0\f0\charscale
x100 {and human brain tumors. En: Greenwald R, Cohen G, editors.}\par\pard\li920
\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Oxygen Radicals and their Scaven
yer Systems, Vol. 2. New}\par\pard\li920\ri0\sl-226\slmult0 \fs18\cf0\f0\charsca
lex100 {York: Elsevier; 1983.}\par\pard\li640\ri0\sl-213\slmult0 \fs16\cf0\f0\ch
arscalex100 {31. Aebi H. En: Bergmeyer H (Ed.). Methods of Enzymatic}\par\pard
\li920\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Analysis. Vol. III, 3}\fs1
0\cf0\f0\charscalex100 {rd}\fs18\cf0\f0\charscalex100 { ed. Weinheim: Verlag Che
mie; 1987.}\par\pard\li640\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {32. De
utsch J. In: Bergmeyer H (Ed.). Methods of Enzymatic}\par\pard\li920\ri0\sl-213\
slmult0 \fs18\cf0\f0\charscalex100 {Analysis. Vol. III, 3}\fs10\cf0\f0\charscale
x100 {rd}\fs18\cf0\f0\charscalex100 { ed. Weinheim: Verlag Chemie; 1987.}\par\co
lumn\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li0\ri0\sl-213\slmult0 \fs18
\cf0\par\pard\li0\ri0\sl-400\slmult0 \fs18\cf0\f0\charscalex100 {33. Laudicina D
, Marnett L. Enhancement of hydroperoxide-}\par\pard\li280\ri0\sl-213\slmult0 \f
s18\cf0\f0\charscalex100 {dependent lipid peroxidation in rat liver micros
omes by}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {ascorbic
acid. Arch Biochem Biophys. 1990;278:73-80.}\par\pard\li0\ri0\sl-226\slmult0 \f
s18\cf0\f0\charscalex100 {34. Prescott L, Critchley J. Intravenous N-acetil
cistena: the}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {trea
tment of choice for paracetamol poisoning. Brit Med J.}\par\pard\li280\ri0\sl-21
3\slmult0 \fs18\cf0\f0\charscalex100 {1979;2:1097-100.}\par\pard\li0\ri0\sl-213\
slmult0 \fs18\cf0\f0\charscalex100 {35. Davidson D, Eastham W. Acute liver
necrosis following}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex1

00 {overdosage of paracetamol. Brit Med J. 1966;2:497-9.}\par\pard\li0\ri0\sl-21

3\slmult0 \fs18\cf0\f0\charscalex100 {36. Davies M, Labadarios D, Williams
R. Metabolism of}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100
{paracetamol and after therapeutic hepatotoxic doses in man.}\par\pard\li280\ri
0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {J Inter Med Res. 1976;4:40-5.}\par\
pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {37. Bolkent S, Yanardag
R, Ozsoy-Sacan O, Karabulut-Bulan}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f
0\charscalex100 {O. Effects of parsley (}\fs18\cf0\f0\charscalex100\i {Petroseli
num crispum}\i0 \fs18\cf0\f0\charscalex100 {) on the liver}\par\pard\li280\ri0\s
l-213\slmult0 \fs18\cf0\f0\charscalex100 {of diabetic rats: a morphological
and biochemical study.}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charsc
alex100 {Phytother Res. 2004;18(12):996-9.}\par\pard\li0\ri0\sl-213\slmult0 \fs1
8\cf0\f0\charscalex100 {38. Martn-Sanz P, Cascales C, Cascales M. Lipogenes
is}\par\pard\li280\ri0\sl-213\slmult0 \*\tx1960\fs16\cf0\f0\charscalex100 {and c
holesterogenesis}\tab \fs16\cf0\f0\charscalex100\i {de novo}\i0 \fs16\cf0\f0\cha
rscalex100 { in liver and adipose tissue.}\par\pard\li280\ri0\sl-213\slmult0 \fs
18\cf0\f0\charscalex100 {Alterations of lipid metabolism by the effect of shortand}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {long-term t
hioacetamide administration to rats. Carcinog.}\par\pard\li280\ri0\sl-213\sl
mult0 \fs18\cf0\f0\charscalex100 {1989;10(3):477-81.}\par\pard\li0\ri0\sl-213\sl
mult0 \fs18\cf0\f0\charscalex100 {39. Simic M, Kundakovic T, Kovacevic N. Prelim
inary assay}\par\pard\li280\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {on th
e antioxidative activity of}{ }\fs16\cf0\f0\charscalex100\i {Laurus nobilis}\i0
\fs16\cf0\f0\charscalex100 { extracts. Fitot.}\par\pard\li280\ri0\sl-213\slmult0
\fs18\cf0\f0\charscalex100 {2003;74(6):613-6.}\par\pard\li0\ri0\sl-226\slmult0
\fs18\cf0\f0\charscalex100 {40. Sanz N, Diez-Fernandez C, Fernandez-Simon L, Alv
arez}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {A, Cascales
, M. Necrogenic and regenerative responses}\par\pard\li280\ri0\sl-213\slmul
t0 \fs18\cf0\f0\charscalex100 {of liver of newly weaned rats against a sublethal
dose of}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {thioacet
amide. Biochem Biophys Acta. 1998;1384:66-78.}\par\pard\li0\ri0\sl-213\slmult0 \
fs18\cf0\f0\charscalex100 {41. Antony B, Santhakumari G, Merina B, Sheeba V, Muk
kadan}\par\pard\li280\ri0\sl-213\slmult0 \fs16\cf0\f0\charscalex100 {J. Hepatopr
otective effect of}{ }\fs16\cf0\f0\charscalex100\i {Centella asitica}\i0 \fs16\cf
0\f0\charscalex100 { (L) in carbon}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\
f0\charscalex100 {tetrachloride-induced liver injury in rats. Indian J Pharm Sci
.}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {2006;68(6):7726.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {42. Thambi P, Ku
zhivelil B, Sabu M, Jolly C. Antioxidant and}\par\pard\li280\ri0\sl-213\slmult0
\fs16\cf0\f0\charscalex100 {antiinflammatory activities of the flowers of }\fs14
\cf0\f0\charscalex100\i {Tabernaemontana}\i0 \par\pard\li280\ri0\sl-213\slmult0
\fs18\cf0\f0\charscalex100\i {coronaria }\i0 \fs18\cf0\f0\charscalex100 {(L) R.
Br. Indian J Pharm Sci. 2006;68(4):456-60.}\par\pard\li0\ri0\sl-213\slmult0 \fs1
8\cf0\f0\charscalex100 {43. Soni K, Suresh Kumar P, Saraf M. Antioxidant activit
y of}\par\pard\li280\ri0\sl-213\slmult0 \*\tx1146\fs18\cf0\f0\charscalex100 {fra
ction of}\tab \fs18\cf0\f0\charscalex100\i {Tephrosia purpurea}\i0 \fs18\cf0\f0\
charscalex100 { Linn. Indian J Pharm Sci.}\par\pard\li280\ri0\sl-213\slmult0 \fs
18\cf0\f0\charscalex100 {2006;68(3):352-5.}\par\pard\li0\ri0\sl-213\slmult0 \fs1
8\cf0\f0\charscalex100 {44. Sotelo-Felix J, Martinez-Fong D, Muriel P. Protectiv
e effect}\par\pard\li280\ri0\sl-253\slmult0 \fs16\cf0\f0\charscalex100 {of carno
sol on CCl}{\sub \fs8\cf0\f0\charscalex100 {4}}\fs16\cf0\f0\charscalex100 {-indu
ced acute liver damage in rats. Europ}\par\pard\li280\ri0\sl-213\slmult0 \fs18\c
f0\f0\charscalex100 {J Gastr Hepatol. 2002;14(9):1001-6.}\par\pard\li0\ri0\sl-21
3\slmult0 \fs18\cf0\f0\charscalex100 {45. Gonzlez M, Vicua N, Naranjo R, Mora J, M
arquez J, Garca}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {G.
Efectos de la desnutricin aguda sobre el metabolismo del}\par\pard\li280\ri0\sl213\slmult0 \fs18\cf0\f0\charscalex100 {acetaminofn. Rev Fac Farma. 2002;44(2):713.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {46. Prez J, Snche
z N, Bu M. Actividad antioxidante}{ }\fs18\cf0\f0\charscalex100\i {in vivo}\i0 \
fs18\cf0\f0\charscalex100 { e}\par\pard\li280\ri0\sl-213\slmult0 \fs16\cf0\f0\ch

arscalex100\i {in vitro}\i0 \fs16\cf0\f0\charscalex100 { de un extracto natural

de origen vegetal. Rev Cubana}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\ch
arscalex100 {Plant Med. 1998;3(3):19-22.}\par\pard\li0\ri0\sl-240\slmult0 \fs18\
cf0\f0\charscalex100 {47. Shivani P. Hepatoprotective effect of LIV-52 against C
Cl}{\sub \fs10\cf0\f0\charscalex100 {4}}\par\pard\li280\ri0\sl-213\slmult0 \fs18
\cf0\f0\charscalex100 {induced lipid peroxidation in liver of rats. Indian J Exp
Biol.}\par\pard\li280\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {1984;32:67
4-5.}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Manuscrito rec
ibido el 17 de octubre de 2007 y aceptado para}\par\pard\li0\ri0\sl-213\slmult0
\fs18\cf0\f0\charscalex100 {publicacin el 13 de diciembre de 2007.}\par\pard\li0\
ri0\sl-320\slmult0 \fs18\cf0\f0\charscalex100 {Correspondencia: Dra. Luzmila Vic
toria Troncoso Corzo}\par\pard\li0\ri0\sl-213\slmult0 \fs18\cf0\f0\charscalex100
{Centro de Investigacin de Bioqumica y Nutricin.}\par\pard\li0\ri0\sl-213\slmult0
\fs18\cf0\f0\charscalex100 {Facultad de Medicina, UNMSM.}\par\pard\li0\ri0\sl-21
3\slmult0 \fs18\cf0\f0\charscalex100 {Av. Grau 755. Lima 1, Per}\par\pard\li0\ri0
\sl-213\slmult0 \fs18\cf0\f0\charscalex100 {Correo-e: ltroncoso@terra.com.pe}\pa
r\pard\li1640\ri0\sl-213\slmult0 \fs18\cf0\par\pard\li1640\ri0\sl-213\slmult0 \f
s18\cf0\par\pard\li1640\ri0\sl-426\slmult0 \*\tx4293\fs18\cf0\f0\charscalex100 {
An Fac Med Lima 2007; 68(4) }\tab \fs20\cf0\f0\charscalex100 {343}\par}