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Hongfei Fang BIMM 110

Problem Set 1

1. How are diseases broadly defined?

2. What is the difference between a familial and sporadic genetic disease?

3. What is the difference between Genotype and Phenotype?

4. How does cell division in Gametes and Somatic cells differ?

5. Identify the following Chromosomal Abnormalities

6. What does t(2,5)(q13;q12) mean?

7. What is aneuploidy?

8. Identify the following hereditary disease pedigrees

9. The doctor characterizes two different types of diseases within two different
family pedigrees. For Disease A, the doctor noticed that only male members
were affected by the disease. Furthermore, all the sons of affected fathers
were affected. While unaffected mothers in the same family were not able to
pass the disease on. The family pedigree for disease B was shown to have all
unaffected individuals until two first cousins had children together. These
inbred children became affected even though their parents were not. What
are the modes of inheritance for each of these diseases?

10.What type of hereditary profile does Hemophilia have and distinguish

between Hemophilia A and Hemophilia B.

11.How do lethality, mitochondrial inheritance, and incomplete penetrance

affect traditional pedigrees?