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NUCLEIC ACIDS

1.
a)
b)
c)
d)
e)
f)
g)
h)

T/F
Histones are required for the formation of nucleosomes.
Supercoiling of cellular DNA is achieved by over-winding of the DNA helix.
Topoisomerase alters the supercoiling of DNA.
Specific lysine residues of histones are reversibly acetylated.
The highest level of DNA packaging is observed at cell division.
The backbone of DNA is positively charged.
If the cytosine content is 20% of total bases Adenosine content is 60%.
Melting temperature of DNA depends on guanine & cytosine content.RNA contains
modified bases.
i) RNA does not form secondary structures.
j) RNA contains modified bases.
2.
a)
b)
c)
d)
e)

Denaturation of DNA occurs as a result of


Breakage of the phosphodiester bonds.
Increase of temperature.
Increasing the pH.
Increasing salt concentration.
Adding ethanol.

3.
a)
b)
c)
d)
e)

Regarding DNA
Uracil is a component of DNA.
Sugar phosphate back bone is a common feature of nucleic acid.
DNA replication is semi conservative.
Purines pair with pyrimidines.
Complementary nature is necessary for accurate replication of DNA.

4.
a)
b)
c)
d)
e)

RNA differs from DNA


As the RNA is microscopic single stranded structure.
In the type of purine bases it contains.
In the type of pyrimidine bases it contains.
In the types it attains by release into cytoplasm.
As it is transported across the nuclear membrane.