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MCQ Pharmacology

MCQ Pharmacology


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Published by Ibrahim Negm

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Published by: Ibrahim Negm on Apr 24, 2010
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001. Alcohol may cause:
a) CNS depression
b) Vasodilatation
c) Hypoglycemia

d) All of the above

002. Alcohol:

a) Increases body temperature
b) Decreases body heat loss

c) Increases body heat loss

d) Does not affect body temperature
003. It is undesirable to take alcohol before going outdoors when it extremely cold, but it may be harmless to take some after
coming into a warm place from the cold.

a) True

b) False
004. The most common medical complication of alcohol abuse is:
a) Liver failure including liver cirrhosis
b) Tolerance and physical dependence
c) Generalized symmetric peripheral nerve injury, ataxia and dementia

d) All of the above

005. Effect of moderate consumption of alcohol on plasma lipoproteins is:

a) Raising serum levels of high-density lipoproteins

b) Increasing serum concentration of low-density lipoproteins
c) Decreasing the concentration of high-density lipoproteins
d) Raising serum levels of very low-density lipoproteins
006. Which of the following metabolic alterations may be associated with chronic alcohol abuse?
a) Hyperglycemia
b) Increased serum concentration of phosphate

c) Severe loss of potassium and magnesium

d) Decreased serum concentration of sodium
007. Alcohol potentiates:
a) SNS depressants
b) Vasodilatators
c) Hypoglycemic agents

d) All of the above

008. Which of the following drugs is most commonly used for causing a noxious reaction to alcohol by blocking its

a) Naltrexone

b) Disulfiram

c) Diazepam
d) Morphine


009. Which of the following agents is an inhibitor of aldehyde dehydrogenase?
a) Fomepizole
b) Ethanol

c) Disulfiram

d) Naltrexone
010. Indicate the drug, which alters brain responses to alcohol:

a) Naltrexone

b) Disulfiram
c) Amphetamine
d) Chlorpromazine
011. Which of the following agents is an opioid antagonist?
a) Amphetamine

b) Naltrexone

c) Morphine
d) Disulfiram
012. Alcohol causes an acute increase in the local concentrations of:
a) Dopamine
b) Opioid
c) Serotonine

d) All of the above

013. Management of alcohol withdrawal syndrome contains:
a) Restoration of potassium, magnesium and phosphate balance
b) Thiamine therapy
c) Substituting a long-acting sedative-hypnotic drug for alcohol

d) All of the above

014. Indicate the drug, which decreases the craving for alcohol or blunts pleasurable “high” that comes with renewed drinking:

a) Disulfiram
b) Amphetamine

c) Naltrexone

d) Diazepam
015. The symptoms resulting from the combination of disulfiram and alcohol are:
a) Hypertensive crisis leading to cerebral ischemia and edema

b) Nausea, vomiting

c) Respiratory depression and seizures
d) Acute psychotic reactions
016. The combination of disulfiram and ethanol leads to accumulation of:
a) Formaldehyde
b) Acetate
c) Formic acid

d) Acetaldehyde

017. The combination of naltrexone and disulfiram should be avoided since both drugs are potential hepatotoxins.

a) True

b) False
018. Indicate the “specific” modality of treatment for severe methanol poisoning:
a) Dialysis to enhance removal of methanol
b) Alkalinization to counteract metabolic acidosis
c) Suppression of metabolism by alcohol dehydrogenase to toxic products

d) All of the above

019. Which of the following agents may be used as an antidote for ethylene glycol and methanol poisoning?

a) Disulfiram

b) Fomepizol

c) Naltrexone
d) Amphetamine
020. The principal mechanism of fomepizol action is associated with inhibition of:
a) Aldehyde dehydrogenase
b) Acethylholinesterase

c) Alcohol dehydrogenase

d) Monoamine oxidase


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