Professional Documents
Culture Documents
Platform 1
Fast-Moving Consumer
Goods for Adult Smokers
Platform 2
Platform 3
Consumer
Electronics
Platform 4
Scientific
Substantiation
Electronics
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The RRPs depicted are subject to ongoing
development and therefore the descriptions are illustrative and do not necessarily represent the latest stages of product development
Platform 1
Platform 2
Platform 3
Platform 4
R&D and
RRPs
Marketing and
Scientific Substantiation
Regulation
Commercialization
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The RRPs depicted are subject to ongoing
development and therefore the descriptions are illustrative and do not necessarily represent the latest stages of product development
Agenda
R&D capabilities and assets
RRPs portfolio
Scientific substantiation
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Bologna, Italy
Devices:
- PMIs technology developed with external partners
- Scale up and manufacturing by third-party
- Manufacturing for pilot launches commenced
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. Visual execution is for illustrative purposes only
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Agenda
R&D capabilities and assets
RRPs portfolio
Scientific substantiation
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
10
Platform 1
Platform 2
Platform 3
Platform 4
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The RRPs depicted are subject to ongoing
development and therefore the descriptions are illustrative and do not necessarily represent the latest stages of product development
11
Source: Baker R. R., 1975, High Temp. Sci., 7, 236-247 and PMI Research & Development
12
Platform 2
13
E-Vapor Products
Current e-vapor product challenges:
- Satisfaction
- Consistency
- Manual manufacturing
PMIs approach:
- Enter e-vapor product category in 2014
- Develop innovative NCP delivery technology addressing current challenges
14
15
Platform 3
16
Agenda
R&D capabilities and assets
RRPs portfolio
Scientific substantiation
17
Systems Toxicology
Assessment
Standard Toxicology
Assessment
18
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
19
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
20
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
21
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
22
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
23
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
24
Disease Risk
From
Epidemiology
Time
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The descriptions in the chart are for illustrative
purposes only
Source: IOM (Institute of Medicine), 2012, Scientific Standards for Studies on Modified Risk Tobacco Products. Washington, DC: The National Academies Press
25
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Evidence Package
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
27
100
90
80
70
Platform 1
Platform 2
60
50
40
30
20
10
(a) Aerosol collection with Intense Health Canadas Smoking Regime (55 mL puff volume, 2 second puff duration, 30 second interval puff)
(b) < LOQ in Platform 1
(c) < LOQ in Platform 1 and Platform 2
(d) < LOQ in Platform
Note: These data alone do not represent a claim of reduced exposure or reduced risk. LOQ refers to the Limit of Quantification
Source: PMI Research and Development
28
Evidence Package
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
29
Number of
Revertants
Mean SE
100%
TPM
GVP
3R4F
Platform 1 Regular
Platform 1 Menthol
600
400
50%
200
7.4
0%
3R4F
12.8
Regular
9.6
11.6
Menthol
Platform 1
1,000
2,000
3,000
TPM (g/plate)
Note: These data alone do not represent a claim of reduced exposure or reduced risk. 3R4F reference cigarette. TPM refers to Total Particulate Matter. GVP refers to Gas Vapor Phase
Source: PMI Research and Development
30
Cell
Proliferation
Cell Stress
DNA Damage
Apoptosis
Autophagy
Necroptosis
Senescense
Cigarette Smoke
Start
Source: PMI Research and Development
Month 1
Month 7
31
Group
Exposure
CC
Combustible Cigarette
Cessation
CC
Air
Switching
CC
Platform 2 Prototype
Platform 2 Prototype
Platform 2 Prototype
Reference: Air
Start
Note: CC is a 3R4F reference combustible cigarette
Source: PMI Research and Development
Air
Month 2
Month 7
32
Time (months)
3
Combustible Cigarette
Cessation
Platform 2 Use
Note: These data alone do not represent a claim of reduced exposure or reduced risk. Prototype of Platform 2
Source: PMI Research and Development
33
Time (months)
3
Combustible Cigarette
Cessation
Combustible Cigarette
Platform 2 Prototype (Switching)
Platform 2 Use
Note: These data alone do not represent a claim of reduced exposure or reduced risk. Prototype of Platform 2
Source: PMI Research and Development
34
Time (months)
3
Combustible Cigarette
Cessation
Combustible Cigarette
Platform 2 Prototype (Switching)
35
Tissue Changes:
Lung Emphysema
Total Cells
(x105)
30
Physiological Changes/Disease:
Lung Function
Emphysema
Index
4
After 7 months
Relative Loss of
Lung Function
After 7 months
After 7 months
3
20
10
1
CC
Cess. Switch.
Air
P2
CC
Cess. Switch.
Air
P2
CC
Note: These data alone do not represent a claim of reduced exposure or reduced risk. Cess. is Cessation, Switch. is Switching and P2 is Platform 2 (Prototype)
Source: PMI Research and Development
Cess. Switch.
Air
P2
36
Evidence Package
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
37
Pharmacokinetics /
Pharmacodynamics
Reduced Exposure
Exposure Response
Measures:
Measures:
Measures:
Nicotine Uptake
Biomarkers of Exposure
Subjective Effects
Product Use
1 week in a clinic
1 week in a clinic
3 months at home
Platform 1
16
Nicotine (ng/mL)
14
12
10
8
6
4
2
0
10
20
30
40
50
60
70
80
90
100
110
120
Time (min)
Note: These data alone do not represent a claim of reduced exposure or reduced risk
Source: PMI Research & Development
39
5
4
3
2
1
Baseline
3-hydroxypropylmercapturic acid
(ng/mg creat)
3500
3000
2500
2000
1500
1000
500
0
Switched to
Platform 1
Quit during study
Benzene
4000
Day 1
Day 2
Day 3
Day 4
Day 1
Day 2
Day 3
Day 4
Day 5
COHb levels
S-PMA levels
Acrolein
1200
1000
800
600
400
200
0
Baseline
Baseline
Day 5
Monohydroxybutenyl mercapturic
acid (pg/mg creat)
Continued smoking
Carboxyhemoglobin (%)
Day 1
Day 2
Day 3
Day 4
Day 5
1,3-Butadiene
3500
3000
2500
2000
1500
1000
500
0
Baseline
Day 1
Day 2
Day 3
Day 4
Day 5
3-HPMA levels
MHBMA levels
Note: These data alone do not represent a claim of reduced exposure or reduced risk
Source: PMI Research & Development
40
(3-month Ambulatory)
Ambulatory
Multiple ethnicities
Evidence Package
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
42
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
43
44
Evidence Package
Post-Market Studies
& Surveillance
Systems Toxicology
Assessment
Standard Toxicology
Assessment
45
RRPs
Regulation
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Marketing and
Commercialization
46
Platform 1
Platform 2
Platform 3
Platform 4
R&D and
RRPs
Marketing and
Scientific Substantiation
Regulation
Commercialization
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The RRPs depicted are subject to ongoing
development and therefore the descriptions are illustrative and do not necessarily represent the latest stages of product development
47
48
49
RRPs Regulation
Uncharted territory
Marketing and
Commercialization
PMI well-positioned
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
50
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Platform 1
Platform 2
Platform 3
Platform 4
R&D and
RRPs
Marketing and
Scientific Substantiation
Regulation
Commercialization
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The RRPs depicted are subject to ongoing
development and therefore the descriptions are illustrative and do not necessarily represent the latest stages of product development
52
Commercialization of RRPs
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
53
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
54
"Cartomizer" Products
55
Developing markets:
- France (11.9%), Spain (2.0%), Denmark (7.6%), Netherlands (3.8%)
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
Source: PMI RRP Market Research (% of adult smokers using e-vapor products in the past 7 days)
56
96
Awareness of
e-vapor products
39
Trial
(past 12 months)
15
Purchase
(past 12 months)
Usage
(past 7 days)
79
70
40
13
10
16
5
0
Oct
Nov
Dec
Jan
Feb
Mar
Apr
2012
Note: n ~ 2,300 for each wave
Source: PMI RRP Market Research (3 months moving, no fieldwork in July and August)
May
Jun
Sept
Oct
Nov
Dec
2013
57
RRPs Commercialization
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
59
P4 like
60
P1 like
P4 like
61
P2 like
P1 like
P4 like
62
P1 like
P2 like
P3 like
P4 like
63
9.1
8.7
100%
95%
3.3
36%
1.5
17%
Adult
Smokers
Awareness of
E-vapor Products
Trial
(past 12 months)
Purchase
(past 12 months)
0.4(a)
3%
Usage
(past 7 days)
64
0.4
Note: The RRPs depicted are subject to ongoing development and therefore the descriptions are
illustrative and do not necessarily represent the latest stages of product development. Number of adult smokers: Italy n ~ 2300
Source: PMI RRP Market Research (3 months-moving average, February 2014 April 2014)
No Tobacco
Platform 4
65
Taste satisfaction
Convenience, less smell, no ash
Electronics
3.0
0.4
Note: The RRPs depicted are subject to ongoing development and therefore the descriptions are
illustrative and do not necessarily represent the latest stages of product development. Number of adult smokers: Italy n ~ 2300
Source: PMI RRP Market Research (3 months-moving average, February 2014 April 2014)
No Tobacco
Platform 4
e-vapor product users
Tobacco
Platform 1
66
5.4
Platform 1
Taste satisfaction
Convenience, less smell, no ash
Electronics
3.0
0.4
Note: The RRPs depicted are subject to ongoing development and therefore the descriptions are
illustrative and do not necessarily represent the latest stages of product development. Number of adult smokers: Italy n ~ 2300
Source: PMI RRP Market Research (3 months-moving average, February 2014 April 2014)
No Tobacco
Platform 4
e-vapor product users
Tobacco
55.0%
67
Taste satisfaction
Convenience, less smell, no ash
Electronics
3.0
0.4
Note: The RRPs depicted are subject to ongoing development and therefore the descriptions are
illustrative and do not necessarily represent the latest stages of product development. Number of adult smokers: Italy n ~ 2300
Source: PMI RRP Market Research (3 months-moving average, February 2014 April 2014)
No Tobacco
Platform 4
e-vapor product users
Taste satisfaction
Convenience, less smell, no ash
Cigarette-like ritual
5.4
Platform 1
Tobacco
55.0%
Platform 2
68
55.0%
5.4
Platform 2
Taste satisfaction
Convenience, less smell, no ash
Cigarette-like ritual
Platform 1
Taste satisfaction
Convenience, less smell, no ash
Electronics
Tobacco
# of Adult
Smokers
(millions)
Platform 3
Improved taste satisfaction
Next Gen. Platform 4 Electronics
3.0
0.4
Platform 4
Note: The RRPs depicted are subject to ongoing development and therefore the descriptions are
illustrative and do not necessarily represent the latest stages of product development. Number of adult smokers: Italy n ~ 2300
Source: PMI RRP Market Research (3 months-moving average, February 2014 April 2014)
No Tobacco
69
RRPs Commercialization
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
70
Introducing The
System
72
Kit Packaging
73
Kit Packaging
74
75
Components Line-Up
76
77
78
79
campaign
Leverage current infrastructure
New capabilities and channels
80
campaign
Leverage current infrastructure
New capabilities and channels
86
87
Digital Platform:
- 24/7 online platform providing end-to-end service
Integrated e-commerce platform for adult consumers
Video tutorials, hotline, troubleshooting, FAQ
Testimonials
Customer Care:
Mobile App
Electronics:
91
: Launch Plan
92
Platform 4
93
94
95
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm
96
Platform 1
Platform 2
Platform 3
Platform 4
R&D and
RRPs
Marketing and
Scientific Substantiation
Regulation
Commercialization
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm. The RRPs depicted are subject to ongoing
development and therefore the descriptions are illustrative and do not necessarily represent the latest stages of product development
97
Note: Reduced-Risk Products ("RRPs") is the term we use to refer to products that have the potential to reduce individual risk and population harm