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Ovarian Cancer

SMF OBSTETRI-GYNECOLOGY
FK UNUD / RSUP SANGLAH
2014

Risk factors for Ovarian tumors



Nulliparity and low parity
White race
Family history
Genetic mutations
 BRCA1 and BRCA2 (serous cystadenocarcinomas)
 Estimated risk of ovarian cancer in women bearing BRCA1
or BRCA2 mutations is 20 to 60 % by the age of 70 years

 30% HER2 gene overexpression
 p53 mutations
 p53 mutations are found in 50% of ovarian cancers

29 1.0 0.2 0.75 0.7 0.5 0.6-0.5 .Ovarian Cancer Risk Factors: Decreased Risk Factor Pregnancies None 1 full term pregnancy >5 full term pregnancies Use of birth control pills Never Ever 3 mo-4 yrs >10 years Bilateral Tubal Ligation Hysterectomy Relative Risk 1.6 0.0 0.

Ovarian Cancer Risk Factors: Increased Risk  Age .

0 One 1st Degree Relative 3.1 Personal History 10 Hx of Ovarian Cancer None 1.1 >2 1st Degree Relatives 4-15 Hereditary Cancer Syndrome 12-30 .0 1st Degree Relative 2.Ovarian Cancer Risk Factors: Increased Risk Factor Relative Risk Hx of Breast Cancer None 1.

Colon.Examples of Tumour Suppressor Genes APC Colon Cancer BRCA1 Breast & Ovarian Cancer BRCA2 Breast Cancer NF1 Neurofibromatosis (malignant neurofibromas) TP53 Brain. Breast. Sarcomas. Liver. Lung carcinomas RB Retinoblastoma. Bladder .

BRCA 2 Chromosome .BRCA 1 .

Mutasi gen BRCA 3. De Novo (CICs) di dalam stroma ovarium  spontaneous mutasi p53 .Pathogenesis Ovarian Cancer 1. Mutasi K-Ras oncogen Terlibat dalam regulasi siklus sel Inhibisi sel apoptosis Memicu proliferasi sel 2.

William Gynecology 2nd edition .

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a known DNA repair protein  “Caretaker genes” .BRCA 1 and BRCA 2 Function  Tumor suppressor genes  Regulate normal cell growth and proliferation  Counteract stimulatory effects of oncogenes  Play a role in DNA repair  Interact with RAD51.

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Which cell does cancer arise in? .

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Who classification of ovarian tumors         Surface epithelial-stromal tumors Sex cord-stromal tumors Germ cell tumors Mixed germ-cell sex cord-stromal tumors Tumors and related lesions of the rete ovarii Miscellaneous tumors and tumor like lesions Lymphomas and lekaemias Secondary tumors of the ovary .

Surface epithelial-stromal tumors      Serous tumors Mucinous tumors Endometroid tumors Clear cell tumors Transitional cell tumors .

Serous tumors .

Serous tumors .

Mucinous tumors .

Mucinous tumors .

Endometrioid tumors .

Clear cell adenocarcinoma .