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Unit Planning for the Integration of Technology Template

Section 1
Content Area: Immunology
Unit Title: Immunology and Disease
Name of Course/Programme Level: Immunology and Disease/ Level 2
Unit Summary
This unit focuses on fostering lifelong understanding of the application and concepts of innate and
adaptive immunology, in addition to the role of the immune system in human diseases. Major topics
covered include (i) the immune response (protective as well as harmful aspects) with emphasis on
immunity, immunization, hypersensitivity, autoimmunity and immunodeficiency, (ii) tissue/organ
transplantation, tumor immunology and diagnostic immunology/serology.
Primary interdisciplinary connections:
Immunology and Disease is not a solitary unit and will make connection with other disciplines such as
Biochemistry, Hematology, Call biology and Chemistry
Themes/Focus Questions:
What is the immune system?
How is the immune system structured and what is the function of its components?
How does vaccines work?
How does the immune system relate to disease?
What is the effect of the immune system on organ transplantation?
Unit Rationale:
Immunology is the study of how the body defends itself against disease. This course is designed to help
students understand how the immune system works and how it is tricked into attacking its own tissue,
leading to diseases like rheumatoid arthritis, diabetes or allergy

Section 2
Learning/Attainment Targets (Broad goals)

Related Content (write brief content


statements)

1: Students should know the components of the


immune system and how their synchronous activity
protects the body

The immune system is composed of cells, organs


and tissues whose cumulative action is to protect
the body from infection.

2: Students should know and demonstrate an


appreciation for innate and acquired immune response

The innate arm of the immune acts as the first


line of defense while the acquired arm develops
after exposure to pathogens. Acquired immune
response are more specific and more aggressive
with subsequent exposure

3: Students should demonstrate an understanding of


the impact of the immune system on organ transplant

Successful tissue transplant requires matching


tissue been transplanted to a recipient with the
closest HLA match to reduce the chance of
rejection

Section 3
Content Statement #
1. Hypersensitivity
reaction

Related Topics
Immunoglobulins

2. Autoimmunity

Tolerance

3. Immunodeficiency

Agammaglobulinemia

4. Transplant
immunology
Topic#
1. Hypersensitivity
reactions

Graft versus host disease

2. Autoimmunity

Sequestered antigens

3. Immunodeficiency

HIV

4. Transplant
Immunology

Major histocompatibility complex

Lesson #

Specific Objectives (Measurable terms)


At the end of this lesson students will be able to

1.Immune Response

-Explain the structure of the antibody


-Describe the interactions of antibody with antigen
-Explain what is meant by epitope and hapten

2.Immunity

-Explain what is meant by innate, acquired, humoral and cell mediated


immunity
-Demonstrate knowledge of the variations between innate, acquired, humoral
and cell mediated immunity

3. Types of T-Cells
Cytokines, Chemokines,
Lymphokines
Antibody production
4.Use of immune
response antibody
production to diagnose
diseases

-Demonstrate knowledge of the types of T-Cells


-Outline the difference between cytokines, chemokines and lymphokines
-Explain the and apply the concepts of booster and memory

5. Hypersensitivity
6.Autoimmunity
7. Autoimmunity

Related Lesson
Antibody antigen reactions

-Differentiate between primary and secondary immune response


-Explain, how IgM can be used in the early diagnosis of infection
-Highlight how the antibody antigen concept can be applied to diagnostics
-Explain the 4 types of hypersensitivity giving examples of each
-Explain possible mechanisms for the development of autoimmune diseases
-Describe the testing methods available for diagnosis of auto immune diseases
-Explain what is meant by plasmapheresis
-Be able to explain the clinical features and diagnostic options for the
following autoimmune diseases: Graves disease, Hashimotos thyroiditis,

Rheumatoid Arthritis, Systemic Lupus Erythematosus, Polymyositis,


Dermatomyositis, Scleroderma (Systemic Sclerosis), Pernicious Anaemia,
Autoimmune Hepatitis, Acute Glomerulonephritis, Goodpastures syndrome,
Acute Rheumatic Fever, Type 1 Diabetes Mellitus, Multiple sclerosis,
Myasthenia gravis, Sjogrens syndrome, Ulcerative colitis, Crohns disease.
8. Immunodeficiency

10. Innate and adaptive


immune disorders

-Define immunodeficiency
-Explain the difference between innate and acquired immunodeficiency giving
examples

1.
2.
3.
4.
5.

Explain how the disease in the list below occur:


Chronic granulomatous disease
Chediak-Higashi syndrome
Jobs syndrome
T cell: DiGeorges Syndrome (Congenital thymic aplasia),
Nezelofs syndrome
B cell: Brutons agammaglobulinemia

11. Acquired
Immunodeficiency
syndrome
Complications of
immunodeficiency
12. Transplantation
immunology

-Explain acquired Immunodeficiency syndrome and its complications using


HIV as a model

Related Content #

Technology Integration

Required Resources & Equipment

Questions and
Answers

Whats App

Mobile phone

Presentations

Podcasts

Camtasia editing software

Presentation of
content

Digital stories

Digital movie maker software

Presentation

Microsoft PowerPoint

Computer, laser pointer and


projector

-Explain the relationship between organ transplantation and HLA

Section 4
General Learning Outcomes (Attainment Targets)
At the end of the course of study students will

Students will understand of the application and concepts of innate and adaptive immunology, in
addition to the role of the immune system in human diseases:
(i)
the immune response (protective as well as harmful aspects) with emphasis on
immunity, immunization, hypersensitivity, autoimmunity and immunodeficiency,
(ii)
tissue/organ transplantation, tumor immunology and diagnostic immunology/serology.
3

ence of Learning
Formative Assessment (X days)
Presentations will include a topic related video which will be discussed within the class period, also
question slides will be placed at random intervals to test students grasp content completed.

Continuous Assessment
Online quiz in a controlled environment at the end of lesson 6 and lesson 12

Summative Assessments

Oral examination
50 Multiple choice questions
10 Short answer questions

Section 5
Lesson
Lesson 1
Immune Response
Lesson 2
Immunity
Lesson 3
Types of T-Cells
Cytokines, Chemokines, Lymphokines
Antibody production
Lesson 4
Use of immune response antibody production to
diagnose diseases
Lesson 5
Hypersensitivity
Lesson 6
Autoimmunity
Lesson 7
Autoimmunity
Lesson 8
Immunodeficiency
Lesson 9
Immunodeficiency
Lesson 10
Innate and adaptive immune disorders
Lesson 11
Acquired Immunodeficiency syndrome
Complications of immunodeficiency

Timeframe
4 hours/Week
4 hours/Week
4 hours/Week

4 hours/Week
4 hours/Week
4 hours/Week
4 hours/Week
4 hours/Week
4 hours/Week
4 hours/Week
4 hours/Week

Lesson 12
Transplantation immunology
Teachers Notes

4 hours/Week

Technological Resource:
1. Google drive
2. Google share
2.Google circle
3. Whats App
4. Microsoft PowerPoint
5. Projector
6. Computer
7. YouTube

Instructions for Use:


Microsoft power point will be used as the major
presentation tool, google drive will be used to share
presentations while giving students the ability to
comment on posted materials. Google sharing option
will be used to share you tube videos with material
relevant to the course. Microsoft power point will
also be used as a tool to generate animations to
explain processes