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Chronic Lymphocytic

Leukemia
SANCHEZ, Kenneth Xavier, O.
3BIO6

Chronic Lymphocytic
Leukemia

Lymphoproliferative disorder involving CD5-positive B cells,


considered as neoplasm
Cell of origin: B-lymphocyte
Abnormal growth in number of leukemic cells, crowding
healthy white blood cells
May complicate into more aggressive form (Richters
syndrome)

Comparison
Healthy vs. Leukemic Tissue

RBCs

Figure A. A normal blood smear with


erythrocytes (RBCs), a lymphocyte (A)
and a neutrophil (B).

Figure A
Figure B

Figure B. This smear shows the


presence of small neoplastic
lymphocytes (A) and smudge cells (B).
The neoplastic lymphocytes are
relatively small but slightly larger than
normal small lymphocytes and show
negligible cytoplasm and clumped
chromatin.

Organ Morphology

Figure C. Bone marrow aspirate slide of


CLL, showing cells with thin cytoplasm.

References:

Figure D. Bone Anatomy showing the


origin of white blood cells from blood
stem cell. Blood stem cell of
lymphocytes are lymphoid blasts.

http://hematologyinprogress.net/?p=1575
http://www.dana-farber.org/images/pdq/CDR0000755927.jpg
http://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-le
ukemia-cll-cancer
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