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ENDOCRINOLOGY

HORMONE GH

NATURE Peptide 22kD 191 AA

SYNTHESI S Protein synthesis

RECEPTO R Cytokine receptor

MECH OF ACTION GH GHRJAK2 Tyr Kinase. Activates STAT, Src (RAS MAPK), IRS, PLC -docAMP pathway

PRL TSH

Peptide 23kD 198 AA Peptide, 2 subunits (α and β), (30kD) -do(25kD) POMC, 39 AA POMC 91 AA POMC 31 AA POMC

-doProtein synthesis

-doGPCRs

LH, FSH, hCG ACTH β-Lipotropin

-do-do-do-

-do-do-do-

-docAMP with Ca pathway -do-

Endorphin

-do-

-do-

-do-

MSH

-do-

-do-

-do-

Vasopressin (ADH) HORMONE

Peptide 9 AA NATURE

Peptide synthesis SYNTHESI S

V1 and V2 receptors (Cell surface) RECEPTO R

cAMP, adenylyl cyclase MECH OF ACTION

Oxytocin

-do-

-do-

Cell surface receptors DNA Binding (Nuclear)

?

Thyroxine

Tyrosine derivative

MIT, DIT & Iodine in thyroid follicular cell Peptide synthesis

Enhance or repress gene transcription

PTH

Peptide 84 AA

Single membrane receptor ptn - 70kD Steroid family receptor with DNA having Zn Finger motif

cAMP, adenylyl cyclase + Calcium Steroidal mechanism (Binding to nuclear receptors and then to HREs following plasma membrane diffusion) -do-

Calcitriol

Steroid derivative

Cholesterol catabolism

Cortisol, Testosterone, Oestrogen, Progesterone Epinephrine, norepinephrin e and Dopamine Relaxin

-do-

-do-

-do-

Catecholamin e

Tyr metabolism

βadrenergic receptors GPCRs

cAMP, adenylyl cyclase cAMP

Peptide

Peptide synthesis Peptide synthesis

Insulin

Peptide

Cell surface receptors

cAMP, IP3, Glut 4

HORMONE

NATURE

SYNTHESI S

RECEPTO R

MECH OF ACTION

Glucagon

Peptide

Peptide synthesis Acetyl choline and calcium – NOS Peptide synthesis Glu metabolism

RTKS

cAMP, IP3, Glut 4 cGMP

NO

Inorganic gas

Cell surface receptors

Atrial natriuretic peptide GABA

Peptide

Cell surface receptors Cell surface receptors

cGMP

Glu derivative

Chloride