P. 1


|Views: 344|Likes:
Published by Stephen
concise presentation on hepatitis.
concise presentation on hepatitis.

More info:

Categories:Types, School Work
Published by: Stephen on Aug 02, 2010
Copyright:Attribution Non-commercial


Read on Scribd mobile: iPhone, iPad and Android.
download as PPTX, PDF, TXT or read online from Scribd
See more
See less







What Is Hepatitis?
y y

Hepatitis means inflammation of the liver
Hepat (liver) + itis (inflammation)= Hepatitis

Viral hepatitis means there is a specific virus that is causing your liver to inflame (swell or become larger than normal)

The Liver

‡Cleans the blood ‡Regulates hormones ‡Helps with blood clotting ‡Produces bile ‡Produces important proteins ‡Maintains blood sugar levels ‡And much, much, more

‡ The liver is essential for life !

Viral Hepatitis 5 types: A: fecal-oral transmission B: sexual fluids & blood to blood C: blood to blood D: travels with B
E: fecal²oral transmission
Adapted from Corneil, 2003

Vaccine Preventable

Hepatitis B virus
y y

50-100 times more infectious than HIV Chronic HBV infection develops in 90% of those infected as infants and 1-10% infected as adults Chronic infection can lead to chronic liver disease, cirrhosis, liver failure and liver cancer (usually over 20-30+ years) Premature death from liver disease occurs in 15-25% of chronically infected people >350 million people chronically infected worldwide Vaccine preventable ² universal infant vaccination introduced in Ireland in 2008



y y

Contagious disease of the liver Acute to chronic, mild to severe Acute: short term, self-limiting, <6 months Chronic: >6months, often lifelong
x Strongly assoc. with age x 90% infants

CDC. 2009. Hepatitis B FAQs for the Public. 2010 Levinson,W. 2006. Review of Medical Microbiology and Immunology. McGraw-Hill, USA

Global Burden of Hepatitis B Disease 2 billion with markers of current or past infection y 350 million chronic carriers

130 million Chinese (1 in 10) have chronic HBV 15%-25% will die from cirrhosis or liver cancer

10th leading cause of death
600,000 to 1 million preventable deaths / year Second only to tobacco in cause of cancer deaths


Risk of dying from liver cancer 100 greater for carriers than non-carriers
Lavanchy D., J Viral Hepat. 2004 Mar;11(2):97-107. WHO. www.who.int/csr/disease/hepatitis/en/

y y

US: 43,000 reported cases in ·07
0.8 to 1.4 million chronic

Canada: 2.3/100,000 (700/yr) y Worldwide: 350 million, 620,000 deaths/yr

CDC. 2009. Hepatitis B FAQs for the Public. 2010 Zhang, J., S. Zou, and A. Giulivi. 2001. Hepatitis B in Canada. Canada Communicable Disease Report. 27S3:.

Progression of Liver Disease
Time frame: years to decades


BC Hepatitis Services, 2003


Infectivity outside host can last 7 days y Percuaneous ² e.g. injection drug use y Sexual y Vertical ² mother to infant y Not commonly spread by food (HAV), nor breastfeeding y Co-infection can affect severity (HCV, HIV)
Tepper, M. L., and P. R. Gully. 1997. Hepatitis B. CMAJ. 156:1033-1034. Zhang, J., S. Zou, and A. Giulivi. 2001. Hepatitis B in Canada. Canada Communicable Disease Report. 27S3 CDC. 2009. Hepatitis B FAQs for the Public. 2010

HBV Infection: Major Risk Factors in Canada

Other, 22.70% Injection Drug Use, 34%

Sexual, 43.30%

HBV Infection: breakdown of risk factors in Canada. Created from data by Zhang, J. et. al.

Common to be asymptomatic, esp. children y If symptomatic: 6 wks ² 6 months post exposure

General flu-like symptoms Joint pain, dark urine, jaundice Last weeks ² months

Many asymptomatic for many years 15-25% develop serious liver conditions

Control and prevention

Recommended for anyone at risk 3-4 shots over 6 months


All pregnant women tested for HBsAg Infants born to HBsAg +ve mothers receive HBIg immediately + vaccinate >90% effective

Zhang, J., S. Zou, and A. Giulivi. 2001. Hepatitis B in Canada. Canada Communicable Disease Report. 27S3 Eleftheriou,A., G. Kalakoutis, and N. Pavlides. 1998.Transfusional transmitted viruses in pregnancy. J. Pediatr. Endocrinol. Metab. 11 Suppl 3:901-914

Never share tooth brushes/razors or any personal hygiene articles that have blood on them (even tiny amounts). y Abstain/Practice safer sex

You're Reading a Free Preview

/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->