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www.thalamus.ro The Thalamus neuroscience & medicine for students, specialists, neuroscientists, neurologysts,
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The Thalamus
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interested researchers in the field and www.thalamus.ro deep brain stimulation mechanism GPe fibers projecting to

deep brain stimulation mechanism

GPe fibers projecting to the STN are

activated by STN stimulation. This inhibits STN neurons (Alexander et al.1990; DeLong 1990).This decreases the activity of inhibitory GPi neurons, result in increased thalamocortical neuro- nal activities. TRANSLATIONAL PHYSIOLOGY Single Pulse Stimulation of the Human Subthalamic Nucleus Facilitates the Motor Cortex at Short Intervals Ritsuko Hanajima et al, Neurophysiol 2004.

HFS in GPi does not necessarily lead to decreased

inhibitory pallidal output and facilitation of thalamic targets. HFS in GPi appeared to reduce the number of bursts and the number of spikes per burst. It is a posib.ility that the symp- tomatology is an abnormal pattern of activity, rather than a reduction in thalamic activity as a result of an increase in mean pallidal discharge rate. It may be that the beneficial effects are a consequence of the interruption of abnormal patterns of activity in corticothalamic circuits. MARJORIE E. et alJ Neurophysiol, 2003,Effects of High-Frequency Stimulation in the Internal Globus Pallidus on the Activity of Thalamic Neurons in the Awake Monkey

A possibility is that the STN stimulation

activates STN projection fibers to GPe

. This pathway facilitates the GPe neurons

When a voluntary movement is about to be initiated by cortical networks, a signal is sent from the motor cortex through the cortico-subthalamo-pallidal pathway to activate GPi neurons exten- sively. Ther result is the inhibitionf of their targets .

Another signal through cortico- striato-pallidal pathway (direct pathway) is sent to the GPi to inhibit a specific population of pallidal neurons. A cen- tral population of pallidal neurons disinhibit their target neurons in the thalamus . Thus only the selected motor “software” is executed at the selected timing, Excitatory Cortical Inputs to Pallidal Neurons Via the Sub- thalamic Nucleus in the Monkey ATSUSHI NAMBU et al, J Neurophysiol, 2000.

Deep Brain Stimulation Research Review 7 web pages and 17 A4 pdfs on DBS mechanism
Deep Brain Stimulation Research Review
7 web pages and 17 A4 pdfs on DBS
mechanism on www.thalamus.ro in
Thalamus in Neurology, Neurosurger
and Pharmacology Site Section
!

Deep Brain Stimulation Neuronal & Network Mechanism on www.thalamus.ro More on:

and

caused disinhibition of the thalamocorti-

cal

pathway. TRANSLATIONAL PHYSIOLOGY

Single Pulse Stimulation of the Human Subtha- lamic Nucleus Facilitates the Motor Cortex at Short Intervals Ritsuko Hanajima et al, Neuro- physiol 2004.

cortex, thalamic CM/Pf glutamate STN neuron two types of dendrites large small 2 1 substantia
cortex, thalamic CM/Pf
glutamate
STN neuron
two types
of dendrites
large
small
2
1
substantia nigra
dopamine
dorsal raphe
serotonine
tegmentum
acetylcholine
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