12 Calcium Hydroxide Topical Solution Official, External, USP 31
PROCEDURE: 1. Slake CaO for 5 mins. (place in mortar or evaporating dish,
Formula Ingredients CaOH Water, qs ad OA 3g 1000mL CA 0.09g 30mL
sprinkle with 3-5 gtts of water, cover with watch glass. Let it stand for 5 mins.) 2. Add 30 mL cold water
Slaking CaO + 5gtts H2O -> Ca(OH)2
56g/mol 74 g/mol
3. Agitate for 30 mins in an ice bath 4. Filter, collect filtrate 5. Transfer in container (liniment bottle) 6. Add cold water up to the brim
X:56g/n :: 0.09g:74g/n X= 0.07 g of CaO
**there should be no bubbles in bottle because it indicates presence of carbon dioxide.
STIR FOR 15 mins. WHY?? --to increase the solubility of CaOH in water **avoid too much exposure to air AVOID BUBBLES?? Hydrogen + O2 we were preventing the formation of CaCO3 (white precipitate)
Ca(OH)2 + CO2 CaCO3 (white ppt)
USES: y y Astringent Protective
Calcium hydroxide is less soluble in hot water than cold so cold purified water is the solvent. SYNONYMS:
FINAL RESULT: Clear solution, no bubbles inside your bottle. Add enough cold water up the brim of the container.
lime water Liquor calcis
CONTAINER && STORAGE: Soln should be stored in well-filled, tightly stappered containers to deter the absorption of CO2 & should be kept in a cool place to maintain an adequate concentration of dissolved solute, white clear solution.
Preparation no 13 Strong Iodine Solution Official, external, USP 31
Solubility of 1g of I2 will be dissolved in 2950 mL H2O ; it is very slightly soluble.
USES: FORMULA Ingredients Iodine KI Water, qs ad OA 50g 100g 1000mL CA 1.5g 3g=3mL 30mL y y Antiseptic Disinfectant
Solubilizing agent Converts iodine to triiodocomplex form which is more water soluble PHYSICAL APPEARANCE:
PROCEDURE 1. Dissolve KI in 2.5 mL of p.H2O 2. Dissolve Iodine crystals in KI soln 3. Add sufficient amt of H2O to obtain 15mL.
SYNONYMS: y Lugol s solution
METHOD OF PREPN: y Simple solution Method
Potassium Iodide or sodium iodide Used as solubilizing agent for iodine
PRECAUTION: 1. Do not use stainless spatula bec iodine is very corrosive & reactive, use the porcelain instead. 2. Watch glass should be used in weighing 3. Avoid holding the iodine crystals bec it would stain your hands & jewelries.
Preparation no 14 Magnesium Citrate Oral Solution Official, Internal, USP 31
STORAGE: It should be stored in a cool place, preferably refrigerator. Keep the bottle on its side so the cork or rubber liner of the cap is kept moist &
FORMULA Ingredients MgCO3 Anhydrous Citric Acid Syrup Talc Lemon Oil KHCO3 p.H2O qs ad 60 mL 5g 0.1 mL 2.5 g 350 mL 8.57 mL 0.71 g 0.01 mL 0.36 g 50mL OA 15 g 27.4 g CA 2.14 g 3.91 g
swollen, thereby maintaining the air tight seal between the cap & the bottle.
Magnesium Citrate Oral Solution is a colorless to slightly yellow, clear, effervescent liquid having a sweet, acidulous taste, a lemon flavor. It is commonly referred to as citrate or ascapate of magnesia.
Cotton for the exchange of gas
EXPECTED RESULT: POP!
PROCEDURES: ***Refer to your notes.
Flavoring and sweetening agent y Lemon Oil and Syrup
Aluminum Foil Talc Dispersing agent for lemon oil Clarifying agent w/c will remove impurities Is used to avoid formation of molds
USES: y Saline Cathartic
HEAT y y To allow reaction to take place Prevent the formation of molds
Preparation no 15 Saponated Cresol Solution Official, External, Poison
Ester vegetable oil (fatty acid)
SAPONIFICATION Conjugation process
FORMULA Ingredients Cresol Vegetable Oil Potassium OH Alcohol P.H2O, qs ad OA 500mL 350mL 73 g 55mL 1000mL CA 15mL 10.5mL 2.19 g 1.65 mL 30mL
Hydrolysis of ester by an alkaloid
*Upon addition of cresol, it will bcome clear, yellow solution after stir.
METHOD OF PREPN y Chemical or Simple
**Use hot plate with temperature not more than 90c
Saponification process Is complete if the solution is clear; formation of bubbles, no oil globules Is incomplete has globules
TO CONFIRM: **Test mixture using 1mL water + 1 drop of mixture
Cresol Poisonous Immiscible in water(soap to dissolve) Responsible for disinfecting Caustic like phenol, can burn skin
*wash with alcohol or ethanol if put in skin KOH saponifying agent