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Curcumin- Biological and Medicinal Properties

Curcumin- Biological and Medicinal Properties

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Published by: Dr Dushyant Kamal Dhari on Aug 27, 2010
Copyright:Attribution Non-commercial


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expression of various cell surface adhesion molecules such as intercellular cell adhesion
molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1 on
endothelial cells is absolutely critical for tumor metastasis (Ohene-Abuakwa and Pignatelli, 2000).
The expression of these molecules is in part regulated by NF-κB (Iademarco et al., 1995). We have
shown that the treatment of endothelial cells with curcumin blocks the cell surface expression of
adhesion molecules, and this accompanies the suppression of tumor cell adhesion to endothelial
cells (Kumar et al., 1998). We have demonstrated that downregulation of these adhesion molecules
is mediated through the downregulation of NF-κB activation (Kumar et al., 1998). Gupta and Ghosh
(1999) reported that curcumin inhibits TNF-induced expression of adhesion molecules on human

7034_book.fm Page 308 Friday, October 20, 2006 9:32 AM

Curcumin — Biological and Medicinal Properties


umbilical vein endothelial cells (HUVECs). Jaiswal et al. (2002) showed that curcumin treatment
causes p53- and p21-independent G(2)/M phase arrest and apoptosis in colon cancer cell lines.
Their results suggest that curcumin treatment impairs both Wnt signaling and cell–cell adhesion
pathways, resulting in G(2)/M phase arrest and apoptosis in HCT-116 cells.


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