Concept of Formulation Design: a) Preformulation: Introduction, General consideration, Preliminary evaluation & molecular optimization, Bulk characteristics, Solubility analysis, Stability analysis. b) Design of Dosage Form: Principles, Dosage form design, Biopharmaceutical & Therapeutic aspects of dosage form design. c) Study of excipients: Introduction, classification & selection criteria Stability studies:Concept of stability studies. a) cGMP & ICH guidelines for Accelerated stability Testing. b) Interaction of containers & closure Compatibility Testing
III. Solid Dosage Forms: A. Tablets: Introduction, Advantages & Disadvantages, Types of tablets. Formulation development: Preformulation of drugs & additives. Introduction to tablet additives. Need of granulation. Mechanisms, Manufacturing processes and Equipments for Wet granulation and Dry granulation processes. Advanced granulation techniques ± Extrusion, spheronization, Pelletization, Spherical crystallization, Fluidized bed granulation, Melt solidification & granulation. Characterization and Evaluation of granules. Mechanism, Manufacturing process and Equipments for Direct compression technique. Physics of Tablet compression. Tablet compression machines. Formulation and manufacture of Chewable tablets, Effervescent tablets, Dispersible tablets, Mouth dissolving tablets, Layered & Compression coated tablets. Manufacturing problems & remedies thereof. Packaging & labelingstrip, blister & bulk packaging. IPQC for tablets. Evaluation of tablets as per
IP, BP, USP
Tablet Coating: Introduction and concept of tablet coating. Types of tablet coating including Sugar, Film & Enteric coating. Material, processes employed & equipments for tablet coating. Manufacturing problems & remedies during tablet coating. Evaluation of coated tablets. Layout of tablet manufacturing section. B. Capsules:a) Raw material for capsule shell: Manufacturing of gelatin for capsule. Introduction and concept of size selection of capsules. Selection criteria
54 and size selection of capsules (with examples) b) Hard gelatin capsules: Preparation of hard gelatin capsule shell, standards & defects thereof. Formulation & development: Filling, processing & capsule filling equipments. Problems in capsule filling & remedies thereof. In process quality control & quality control parameters. Soft gelatin capsules: formulation and development, manufacturing, processing & equipment. In process quality control & quality control parameters. Packaging & labeling of capsules: Strip, Blister & Bulk Packaging. SECTION- II
Disperse systems:Free energy consideration, thermodynamic v/s kinetic stability. Classification of disperse system. A) Suspensions: Physicochemical principles. Theory of suspension: DLVO theory. Wetting, Sedimentation, Flocculated & Deflocculated system. Structured vehicle, particle size, particle charges & caking in suspensions. Importance of changes in solubility because of changes in particle size, polymorphic form, temp. Preformulation data. Formulation development, manufacturing, packaging & equipments employed for the same. Rheology of suspensions. Formulations of pharmaceutical suspensions (oral & topical), suspending agents, wetting agents, dispersants, deflocculating & flocculating agents. Evaluation of suspensions. Quality control standards. B) Emulsions: Physicochemical principles. Theory of emulsification. Creaming, coalescence, cracking, destabilization kinetics, role of viscosity, energy barriers to coalescence. Film barriers, steric stabilization. Emulsifier & choice of emulsifier, HLB value & phase inversion temperature. Multiple emulsions. Evaluation of emulsion, stress testing. Packaging of emulsions. C) Suspension & emulsion manufacturing equipments: Mechanical stirrers, homogenizers, colloid mill, foaming removal.
D) Layout and designing of manufacturing facility for suspension and
eye liner. paste and gels. cold. Percutaneous absorption. Formulation. Manicure products: Nail lacquer. antiperspirants.
III ) Cosmetics & Cosmeceuticals: A) Cosmetics: Cosmetics v/s drug formulation. In process quality control & quality control parameters. shaving preparations. Definition and difference from cosmetics. skin irritation test. Hair products: Shampoos. Formulation and development. manufacturing of Ointment. Processing equipments for ointment. Cream. face pack. beta
. Skin products: Moisturising. Lip product: Lipstick. Eye products: Eye mascara.& sunscreen preparations. hydroxyl acids. hair tonics. anti wrinkle.Retinoids. 8
3. Type of cosmetics. cleaning. eyebrow pencil. vanishing. Selection of bases and additives for ointment. Cosmeceutical Agents. Lacquer remover. suntan. hair dyes. deodorants. packaging & labeling.
55 2. Paste and Gels. 12
B) Cosmeceuticals: Introduction. semisolid bases and additives. cream. Semisolids: Properties of drugs. History of cosmeceuticals. eye shadow. paste and gels. depilatories. manufacturing & safety testing & quality control of following cosmetics. cream.emulsion.
Stability.hydroxyl acids. Viscosity. Preparation and Evaluation of the following dosage forms. pH. Emulsions
Liquid paraffin oral Emulsion
y y o
1. Organoleptic Properties. Suspensions
Milk of Magnesia
Evaluation Parameters: Sedimentation volume. and assay of any one preparation
y y o
(Practical) 90 Hrs. Antioxidants and others. Recent developments in Cosmeceuticals. (3 hrs/week) I) Raw material testing of any 5 Experiments II) Formulation.
Formulation of Emulsion (HLB Consideration)
Evaluation Parameters: Organoleptic Properties. Globule size. pH. and assay of any one preparation
y y o
Non staining Iodine ointment with Methyl Salicylate Evaluation Parameters: pH. Spreadability. Tablets
Aspirin ± Using non aqueous binder solution
. Organoleptic properties and assay of any one preparation
y y o
Paracetamol ± By Wet granulation
Chewable. Assay and Uniformity of content of any one preparation. Tablet Coating (Demonstration) 7. Friability. Dissolution time. Effervescent Tablets
Evaluation of granules. Particle size. dissolution time
y y y o
y y o
5. Disintegration time. Densities and Carr¶s Index
Evaluation of Tablets: Hardness. Evaluation of capsule. Cosmetics
Ferrous Fumerate Capsules
Evaluation of Empty and Filled Hard gelatin capsule shell.Weight variation. Tablet porosity. Weight variation.Angle of repose.
After shave lotion
Evaluation Parameters: Organoleptic properties for all preparation. Eye liner.
Eye shadow. Foam test for shampoo and shaving cream
Film formation test for lipstick and eye preparation.
www. 57 2. H. 1987.B. Chichester. 7.K.L. Vol. N. 2005.S. Marcel Dekker.Schwart ³Pharmaceutical dosage forms: Tablets´ Marcel Dekker.A.
. James J.1. H. II.Lachman. Philadelphia. ELBS Publication. G. K. J. Mumbai 1991. M.1. 5. / Special Indian edition. I.Poporich. 10. L.banker. L.Ridgway ³Hard Capsules Development and Technology´ The Pharmaceutical Press.ich.Lachman and J. Wolters kluwer/ Lippincott Williams and wilkins. J. 9. R. 1998. UK.C. Remington ³The science and practice of pharmacy´ 21st edition.E. 1996. L.Swarbrick. Churchil livingstone.Liberman.V. J. 2009.Chalmers ³Pharmaceutics and Pharmacy Practice ³J. 11.G.A. London.Wells ³ Pharmaceutical Preformulation : The physicochemical properties of drug substances ³ Ellis Horwood. 1982.B.Lieberman. Verghese publishing House. 2007.C. III 1998.Boylan´ Encyclopedia of pharmaceutical technology´ Vol. 8.1988 3.Ansel.Lippincott Company. Mack publishing company. H. 8th edition. PA. Bentley¶s ³Test book of Pharmaceutics´ Bailliere Tindall. 6.Allen ³Pharmaceutical dosage forms and Drug
Delivery systems´ 9th edition.Kanig ³The Theory and Practice of Industrial Pharmacy´ 3rd edition.org
4. UK. 2009.Aulton ³Pharmaceutics ±The design and nanufacture of medicines´ 3rd edition.
B. Government of India. L. ³USP 30 NF 25 The United States Pharmacopoeia´ 2007.Moore ³Harry¶s Cosmetology´ 7th edition. 23. IV. Hoag ³Pharmaceutical Dosage Forms: Tablets´ 3rd edition. W. II. I. UK. Wilkinson. ³Harry¶s Cosmetology´. Riser and Banker ³Pharmaceutical Dosage forms and Disperse system´ Marcel Dekker. Ministry of Health and Family Welfare. J. III 2008.Knowlton and S.
17. Vol. Indian Pharmacopoeia Commision. P. II. P. Moore. National formulary publication of US Pharmacopoeia. Vandana publication. Informa Healthcare.Wilkinson and R.Thosmssen´ Modern cosmetics Universal Publishing Corporation. 22. Manufacturing and Quality Control´ 7th edition. 7th edition. ³Indian Pharmacopoeia´ 2007. W. I. 24. Lieberman. III.
18. L. Sharma. Stationary office on behalf of
15. Longman science and technical. London 1982. Elsevier science publisher. III. I. oxford. Dr.G. I. 2001. Cosmetics and Soaps´ Vol. Chapman and Hall 21. II. 13.III. ³British Pharmacopoeia´ 2005. Vol. Vol.Pocher´ Poucher¶s Perfumes. III. Vol. fragrance and flavours´ Micelle press 20. Longman Scientific and Technical.12. J.A. II. ³Cosmetic Formulation. B.J. Vol. L. 1994 19. 16. J. S. R. Laba ³Rheological properties of cosmetics and toiletries´ Marcel Dekker. 14. E. I.Appell ³The formulation and preparation of cosmetics. III 1988. Augsberger. II.Rearce ³ Handbook of cosmetic science and technology´ 1st
polymerase. Restriction Fragment Length Polymorphism (RFLP). expression vectors (expression vectors in brief). Human Gene therapy. alkaline phosphatase. Gel electrophoresis. Selection of clones ( screening methods).2 Genetic Engineering techniques :Isolation of DNA.
Introduction to Biotechnology. (2 hrs per week)
TopicNo SECTION-I Hrs. Genomic & cDNA libraries.Introduction. reverse transcriptase). Gene sequencing methods.
Gene transfer: ± Introduction & Types (Direct & Indirect gene transfer methods) Ti & Ri plasmid mediated gene transfer.
1. polymerase chain reaction (PCR) Site directed mutagenesis. S1 nuclease.2 PHARMACEUTICAL BIOTECHNOLOGY (Theory) 60 Hrs.
. 58 3.1 Recombinant DNA technology :Gene cloning :. ligase. transformation & growth of cells. Blotting techniques. types of cloning vectors. Gene synthesis & gene machine. DNA fingerprinting.Medicine and Healthcare Product Regulatory Agency (MHRA). enzymes acting on DNA (restriction endonucleases. Scope.
Genetic Engineering : 2. DNA Hybridization. 2. Potential & Achievements
Future directions. suspension. Method. Role of blood plasma & serum.Callus. preparing cells in culture.2 Hybridoma technology.2 Types of cultures:.
Immunotechnology 5.1 Vaccines Why vaccines? How it works? Traditional vaccine approaches. anther cultures /Pollen grains (Introduction.3. Edible vaccines 5.1 Introduction. mammalian serum & embryo extract. Preparation of chicken serum.4 Germplasm storage & cryopreservation
4. root-tip.3 Protoplast culture & protoplast fusion & application Transgenic Plants introduction. Preparation of Monoclonal Antibodies and its
Animal Cell Culture 4. Application) 3. Subculture and recombinant vaccines.II
5.2 Introduction to transgenic animals and their applications
SECTION.1 Introduction to plant cell. media & laboratory requirements for tissue culture 3. established cell lines. meristem. culture media for animals. 4. methodology & applications of above types) 3.
Plant Cell and Tissue Culture:3. isolation of cells. haploid cultures. hairy root.
6. Interferons.1 Study of methods at sterilization details & their applications to Pharmaceutical Manufacturing 7. Down streaming Processing (Product Recovery and Processing). Immobilization of enzyme & its applications
7. Tetracycline).applications 5.Enzyme Linked Immuno Sorbant Assay (ELISA).2 Purification Toxicity studies in establishing safety and efficacy in biotechnological Products.
Healthcare Biotechnology:8. Vitamins (Vitamin B2 and Vitamin B12)
8.3 Immunoassay by different techniques.1 Examples of Biotechnology derived Products: Human insulin. Somatotropin. processing. Accessory components and working.3 Introduction to collection. Radio Immuno Assay (RIA).3 General Application of fermentation in Manufacturing of Antibiotics (penicillin.
Enzyme Technology Introduction to enzyme. 2 Fermentation as a biochemical process ± Fermenter. Biogenetic drugs (Production and uses) 8. Streptomycin. Dextran. Fermentation discharge and Effluent treatment 7. and storage of blood and blood
Fermentation Technology 7. its material of construction.
2004 8. Iganacimuthu. 9.1998
3. P. In-vitro Fertilization & embryo Transplants.The Benjamin Cummins Publishing
California. S. Watson WH Freeman and company N. K.
Biotechnology and Ethics :9. Molecular biotechnology 3rd edition ASM press Washington.Y.1 Social & ethical issue in Pharmacy. Recombinant DNA 2nd edition Holtzbrinck
6. Biotechnology Fundamentals and Applications Student edition Agrobios
. Genetics 5th Edition . Purohit. S. Energy & Environment. 1st CBS Publisher New Delhi. Gliek.2 Humans:-Artificial Insemination (Al). Russel. Rastogi Publication.Rainer Muller. Agriculture. Elements Of Biotechnology. Surrogate motherhood. Gupta.S. Freezing germ cells. Olive Kaiser . 10th edition. Peter J. 2004
2. USA 2003 60 5. Basic Biotechnology ± Tata McGraw Hill Publishers
7. Pharmaceutical Biotechnology: Drug Discovery and
Clinical Application. Wiley VCH publisher. Dr.products
9. Human Embryos and Cloning (Facing Problems and finding solutions)
Total Recommended Books: 1. Vyas and Dixit Pharmaceutical Biotechnology.
Publisher. Pvt. and recent developments of following categories. H. Transduction mechanism. 2007.
History and general aspects of the design & development of drugs includingclassification. Razdan.2002
9. therapeutic uses.I
Hrs. intracellular cyclic nucleotides and other mediators of biological response.3 MEDICINAL CHEMISTRY ±I
(Theory) 90 Hrs. (3 hrs per week)
General considerations: Structure of biological membrane. Introduction to Plant Biotechnology . M. Types of forces involved in drug receptorinteraction. mechanism of action. Pharmaceutical Biotechnology. IBH Publishing Co. Chawala. Biochemical approaches in drug designing wherever applicable should be discussed. Introduction of Plant Biotechnology. solubility. stereo chemical aspects of drug action.
. 2003 11. Ashutosh Kar. New Delhi. nomenclature. S. 2nd edition. Blood brain barrier.
Receptors: Types of receptors. K.H. partition coefficient.
Pvt. Selectedphysicochemical properties affecting drug action. Ltd.
3. Sambamurthy. Bioisosterism. New Delhi. Protein binding. 2nd edition Oxford and IBH Publishing Co. metabolism and elimination. adverse effects. 2nd edition New
AGE International (LP) Limited. structure activity relationship (SAR). distribution. 2002
10. Drug absorption.
3. Antihypertensive agents e. Analeptics and respiratory stimulants b. release and metabolism ofnoradrenaline. Ganglionic blockers and nicotinic receptors. Cholinergic antagonists. its release and metabolism. Antiarrhythemic agents d. Currently used Anti-lipedemic drugs
3. Alzheimer¶s disease Psychotherapeutic agentsa. Sedative & Hypnotic agents c.8
3. Antianginal agents c. General anesthetic agents b. Antimuscarinic agents:Ganglionic Blockers and neuromuscular blockers: Ganglionic stimulants.2
Adrenergic agonists and antagonists: Biosynthesis. Anticonvulsants
SECTION. Ganglionic transmission.3.9
. cholinesterase inhibitors.7
Drugs used in Neurodegenerative diseasesa.6
CNS Depressant Drugsa. Hallucinogens
3. Antipsychotic agents b. Receptor subtypes and their structural features. Cardiotonic drugs b. Anxiolytic agents Local anesthetic agents
3.Biosynthesis of acetylcholine.1
Cholinergic agonists and antimuscarinic agents: Neurotransmitters.Cholinergic agonists: Receptor subtypes and their structural features.II
CNS Stimulant Drugsa. Antidepressant agents c. Parkinson¶s disease b.
Oral hypoglycemic drugs ( including insulin) Prodrugs. imipramine. prazocin. methyldopa. metazepine. Two or more step synthesis of drugs and drug intermediates being studied in theory
. captopril. (3 hrs per batch) 1. atenelol.13 4
Anti-migraine agents Diagnostic agents: Radio Opaque diagnostic agents. rosiglitazone. 7.11 3. trifluperazine. Demonstration of simple QSAR software (Hansch Analysis) 5.3. Miscellaneous diagnostic agent. chlorthiazide. haloperidol. ondansetron. terbutaline. molar refractivity and
RM values of compounds for QSAR analysis. glyburide. lignocaine. soft drugs and hard drugs Scheme of synthesis of following drugs from various therapeutic categories:Carbachol. clofibrate. dantrolene sodium. furosemide. amitryptiline. dissociation constant.3 (P) MEDICINAL CHEMISTRY ±I
(Practical) (90Hrs. hydralazine. salbutamol. Determination of partition co-efficient. diazepam. alprazolam.12 3. sumatriptan. dicyclomine hydrochloride. Resolution of Recemic mixtures of any two APIs by any two methods 4. guanethidine. Purification techniques of solvents/liquids by Fractional distillation and distillation under vacuum 2.10 3. losartan. sodium valproic acid. thiopental sodium. donepezil Total
02 03 05 03 08
3. chlorpromazine. Preparation of acid salts of drugs and evaluation of its physical properties. Agents for organ functiontest.
3. Demonstration of construction of stereo models of drugs (minimum two) 6. tolbutamide. propranolol. fluoxetine. amiloride. phenytoin.
. Vol. Vol. 9 Exploring QSAR Vol. Lippincot Co.Recommended Books for Theory and Practicals 62 1 An Introduction to the Chemistry of Heterocyclic Compounds.2.
11 Foye¶s Principles of Medicinal Chemistry by Foye. 32nd reprint 2005. Pearson Education.3. Marcel Dekker New York. II: hydrophobic. Vol I & II. John Wiley & Sons INC. 5 Wilson and Gisvold¶s Textbook of Organic Medicinal and Pharmaceutical Chemistry by Wilson and Gisvold. by Acheson RN.
10 Organic Chemistry by Finar IL. 1. 7 The Organic Chemistry of Drug Synthesis. I & II. 6 Stereochemistry of Carbon Compounds by Eliel EL. Interscience Publishers New York. 8 Profiles in Drug Synthesis Vol 1 & 2 by Gogate. Varghese Publishing House.
3 Inorganic Medicinal and Pharmaceutical Chemistry by Block & Roche. Philadelphia. I Fundamentals and Applications in Chemistry and Biology by C Hansh and A Leo Vol. Lippincott William Wilkins. J. A Leo and D Hockman ACS Book Catalog. TATA McGraw Hill. 1st edition. 2 Bentely and Driver¶s Textbook of Pharmaceutical Chemistry by Atherden LM.4 by Lednicer Daniel. 8th
edition Oxford University Press London.
. 1st edition. 6th edition. 4 A Textbook of Pharmaceutical Chemistry by Chatten LG. Electronic and Steric Constants by C Hansh.
4 edition. NY 16 Burger¶s Medicinal Chemistry by Wolff ME. Taylor & Francis New
York. 3 edition.
22 Structure based Drug Design by Veerapandian. 13 Quantitative Drug Design. Thieme Publications. Oxford. 17 Antibacterial Chemotherapeutic Agents by SL Dax. 14 Medicinal Chemistry-A Biochemical Approach by Nogrady T. London. Vol. 18 Principles of Medicinal Chemistry by Kadam SS.
Willey-VCH Publication 1997. Vol IV. 19 Introduction to Medicinal Chemistry¶ ± How Drugs Act and Why by Alex Gringauz. by Pops and Perruns.
23 Pharmaceutical Substances by Kleeman & Engel. I and II. Vol. Blackie Academic and Professional Publications.
20 Drug Design by Bothara KG & Kulkarni VM.
21 An Introduction to Drug Design by SN Pandeya & IR Dimmock. Chapman and Hall. 10th Edition.A Critical Introduction by Martin YC. Oxford University Press New York. Elsevier Pergamon. New York. New York. John Wiley & Sons. 4th
24 Practical Pharmaceutical Chemistry by Beckett AH & Stenlake JB. Mahadik KR. 1st edition. I & II. 1st edition. Nirali Prakashan. Nirali Prakashan. New
Age International Publishers. Academic Press. 1997.12 Comprehensive Medicinal Chemistry by Hansh C. Marcel Dekker Inc. 15 Computer Aided Drug Design. Bothara KG.
Part-I. New York.4 (T) PHARMACEUTICAL ANALYSIS-II
(Theory) 90 Hrs./week)
.2nd Edition. 27 Computer Software Application in Chemistry by Jurs PC. The ELBS Longman. The English Language Book Society and Longman Group Limited. (3 Hrs. 26 Textbook of Practical Organic Chemistry.
33 Vogel¶s Elementary Practical Organic Chemistry Small Scale Preparation by Arthur
I. McGraw Hill Book Co. The
English language book society and Longman group limited. 25 Steric Constants by C Hansch. London. CBS Publisher & Distributor. New York. 1st edition. London. 30 Quantitative Drug Design ± A Critical Introduction by Martin YC. ACS Book Catalog. New York. A Leo and D Hockman.edition. 28 Jenkins¶s Quantitative Pharmaceutical Chemistry by Knevel AM and Digangi FE.
32 Advanced practical Medicinal Chemistry by Ashutosh Kar.
31 Vogel¶s A Text book of Practical Organic Chemistry by Vogel. John Wiley & Sons. Marcel Deckker
Inc. 3rd edition.. New Age International Publications.
3. 63 29 Practical Organic Chemistry by Mann FC & Saunders BC. CBS Publication. London.
half wave potential. advantages and disadvantages. Principle. advantages and disadvantages. Spectrofluorometry Instrumentation. Linear Scan& Differential Pulse Polarography. measurement offluorescence. factors affecting fluorescence.TopicNo
Hrs. Polarogram. Titrimetricmethods. Flame types. Instrumentation. Instrumentation. applications covering nonaqueous polarography
Fluorimetry and phosphorimetry: ± Molecular luminescence.
Electrophoresis ± Principle. applications. Complexometric reactions and titrations). Various types of Developments
Polarography: ± Introduction. different Interference and their Corrections. Measurementof RI (angle of refraction). applications. Refractive index. (Gravimetric methods.
Introduction to analytical methods. Instrumentation and Pharmaceuticalapplications
Refractometry: Specific and molar refraction. Instrumentation and applications. Advantages and disadvantages of instrumental methods of analysis and respective problems.
. Dropping Mercury Electrode andOther Mercury Electrodes. Instruments for analysis. quantitative aspects of fluorescence. Neutralization titrations and its applications. synchronous fluorescence. Pharmaceutical applications
Flame Photometry: Principles.
Atomic Absorption Spectroscopy: Theory. Excitation and emission spectra.Doppler effect. optical bleachers. Instrumentation line broadening.
Instrumentation. preparation. molecular analysis. advantages and disadvantages. Amperometric titration apparatus. Variations in Coulometric techniques. ring and similar types of electrodes
. Column Chromatography: Principle. Biamperometric titrations and its applications. theory. elemental analysis.origin and theory of UVspectra. Capacity factor and other performance parameters. classification of instrumental methods. applications. grain direction. Applications of UV. Centrifugal TLC
Electromagnetic spectrum. Single beam and double beam UV ± Visible Spectrophotometer. Coulometric Analysis: ± Introduction. apparatus and general techniques. Different types of paper. Thin Layer Chromatography: Principle.
64 High Performance Thin Layer Chromatography (HPTLC): Theory. Spectrophotometric titration. types ofCoulometric analysis. General characteristics of Coulometric techniques. Development of TLC. techniques. applications. application.Visible spectrophotometry. generalprocedure. Labeling of TLC. Development. Fundamental laws of absorption. Horizontal TLC and other development modes. Coulorimetry at controlled potential.7
Chromatography: Introduction. Column packing. Brief history. Ultraviolet and Visible absorption spectroscopy:. Rotating Disc. selecting an analytical method. Automated Multiple Development. Amperometry: ± Principles. application. Derivative Spectrophotometry. Efficiency of column. Activity of Adsorbents. techniques for color comparison. classification. Optimum conditions for Spectrophotometric measurements. ascent number. classification of analytical methods. applications. Van Deemter Equation in detail. Coulorimetric methods.Instrumentation and Applications. Chromatographic selection ofmethod. Paper Chromatography: Technique. Adsorbents. Interaction of Electromagnetic radiation withmatter.
fats and other similar samples also. Paper chromatography ascending. two exercises each for available filter 5. Calcium and Lithium estimation from formulations by Flame Photometry.12
Thermal Analysis: Differential Scanning Calorimetry (DSC) Definition. Three exercises 2. Nepheloturbidimetric estimation of few analytes containing ions. per batch) 1.H. applications. Beckett and J. John Wiley and
. Thermogravimetric Analysis (TGA): Introduction. Conners.Types. 3rd edition. Principle Instrumentation. Types. Principle. 4 Edition. K+. Thin Layer chromatography Three exercises Recommended Books for Theory and Practicals 65
1 Practical Pharmaceutical Chemistry (Part I & Part II) by A. Differential Thermal Analysis (DTA): Introduction. CBS Publisher & Distributor New Delhi.A. Instrumentation.4 (P) PHARMACEUTICAL ANALYSES-II (Practical) (75 Hrs. Na+. Use oils . UV spectrophotometric estimations of API and same from their formulations Four exercises 3.
Staenlake. Determination of refractive index by Abbe¶s Refractometer Molar refraction calculations. Definition.
2 A Textbook of Pharmaceutical Analysis by K.
3. Isothermal titration calorimetry Nephelometry and Turbidometry: Introduction Principle.Applications.B. Definition. applications. alkaloids Three exercises 6. applications. Instrumentation. Principle. vitamins. Radial Three exercises each 7. Instrumentation. Minimum Three exercises 4. Flurometric estimation of few florescent compounds.
12 Instrumental Methods of Analysis by Willard Merit.
11 Handbook of Instrumental Techniques for Analytical Chemistry by Frank Settle. 1st edition. K. Goel Publishing House. 5th edition. New York.
10 Macmillan Textbook of Physical Chemistry by Samuel Glasstone. 6 Introduction to Chromatography (Theory and Practice) by VK Srivastav and KK Shrivastav. Ashkar. Vol I & II. Practice Hall Publications.
7 Pearson¶s Analysis of Foods by Ronald Kiek and Ronald Sawyer (Longman). Chatten. Thomson Brookslcole.
15 Analytical Chemistry: Principles. 7th edition.
. 5th edition. 2nd edition. 3rd edition.
8 Radio bioassays (Vol. Dean Settle. I and II). CBS Publisher & Distributor. Kennedy.
9 Vogel¶s A Text book of Practical Organic Chemistry by Vogel. 2 edition. by Faud S. The
English language book society and Longman group limited. John Wiley & Sons
14 Instrumental Methods of Chemical Analysis by BK Sharma. John. H. Nirali
5 Principles of Chromatography by KR Mahadik.
3 Principles of Instrumental Analysis by Skoog. 4 A Textbook of Pharmaceutical Chemistry by L. Marcel
Decker. KG Bothara.y
13 Analytical Chemistry by Gary D Christian.
Hrs. CBS Publisher & Distributors.
18 Indian Pharmacopoeia. II. 20th edition. Lippincott Williams
& Wilkins. New Delhi First Edition. symptoms and treatment of poisoning) and Clinical Management of diseases and drugs acting on following categories: Autonomic Nervous System a) Autonomic Nervous system-General Considerations b) Cholinergic system and drugs
1. Vol. Valli
Manickam. Pharma Med Press. A Textbook of Analytical Chemistry. 22. mechanism of action.
Basic pharmacology (classification. contraindications./week)
Sr. Anjaneyulu. K.
3. pharmacokinetics. drug interaction.16 Remington The Science and Practice of Pharmacy. 4th edition. (3 Hrs. latest edition 19 British Pharmacopoeia.
. Y. 2001. No
SECTION. Quantitative Analysis of Pharmaceutical Formulations by PD Sethi. pharmacologicalactions.5 (T) PHARMACOLOGY
(Theory) 90 Hrs. adverse effects.Chandreshekhar. 17 Practical Pharmaceutical Chemistry by Beckett AH & Stenlake JB. latest edition 20 United States Pharmacopoeia latest edition 21 High Performance Thin layer Chromatography. therapeutic uses. CBS Publisher & Distributor and I.
Alcohol. tobacco.II 3 Drugs acting on Respiratory tractDrugs for cough and bronchial asthma 04
Drugs acting on gastrointestinal tract a) Drugs for peptic ulcers b) Emetics and antiemetics
Drugs acting on Central Nervous System
a) Aliphatic alcohol b) General anesthetics
c) Sedative and Hypnotics d) Antiepileptic drugs
e) Anti-Parkinsonian drugs f) Drugs used in Mental illness (Psychopharmacological drugs)Antipsychotic. anti-mania drugs
g) Opioid analgesics and antagonists h) NSAIDs i) CNS stimulants and nootropic j) Drug dependence
k) Introduction to Patient addiction rehabilitation Center and Principle of rehabilitation of drug addicts. opioids. antidepressant.
SECTION.c) Anti-cholinergic drugs d) Neuromuscular blocking agents e) Adrenergic system and drugs f) Anti-adrenergic drugs g) Ganglion stimulants and blockers
Oral hypoglycemic agents. animal welfare and introduction of
CPCSEA and its guidelines.
4. Introduction to animal physiology with their biochemical reference values in various animal species.c) Drugs for constipation and diarrhea
Hormones and Hormones antagonists a) Anterior and Posterior Pituitary hormones b) Corticosteroids and corticosteroid antagonists c) Thyroid and antithyroid drugs. antifertility agents f) Oxytocin and drugs acting on uterus. Study of various anesthetics employed to anesthetize laboratory animals.5 PHARMACOLOGY. Vitamine D d) Insulin. OECD guidelines.
Pharmacotherapy of gout. 2.II
(Practical) (90 hrs: 3 hrs/week) 1. drugs regulating calcium homeostasis. Introduction to commonly used instruments in experimental pharmacology.
. 3. parathyroid hormones. glucagon e) Gonadal hormones and Oral contraceptives. rheumatoid arthritis and osteoarthritis. Care and handling of common laboratory animals.
Bioassay-Definition. body fluids and urine from experimental animals. 7. Computer simulations of following experiments through computerized simulated software programme using software such as X-Pharma. types.
a) Record and interpret the concentration response of acetylcholine/histamine using suitable isolated tissues.
b) Study of synergism using isolated tissues. Behavioral pharmacology demonstrations using various instruments preferably by simulations on computers (A small number of mice (3) to be used for each the following experiments and the animals should not be sacrificed). 9.
d) Study of muscle relaxant property of drug using rotarod. stunning and pithing 8. d) Study of the miotic and mydriatic effect of drugs using rabbit eyes e) To study effects of various cardiovascular drugs on following heart preparations. Introduction to the techniques of Euthenesia. a) Study of analgesic activity of drugs using Eddy¶s hot plate analgesiometer. c) Study of drug antagonism using isolated tissues. Study of physiological salt solutions. advantages of various methods 11. drug solution and use of molar solution in various animal experiments. Study of various routes of drug administration 6. Study of various methods for collection of blood.67 5. c) Study of anticonvulsant activity of drug using maximal electroshock/
pentyleneterazol/ strychnine/INH method. b) Study of locomotor activity of drug using actophotometer. 10. Bioassay of Acetylcholine and histamine using suitable animal preparation 12. X-cology etc. tail immersion. Principle.
Jaypee. Lange Medical Publisher. Satoskar . 11. M. Churchill Livingston. Pune. A textbook of Pathophysiology. Katzung. Lewis. SL and Vyawahare. K. General Pharmacology Basic Concepts. B. Boston 4. James and. Barar.L.M. New York) 5.. Bombay).e) Study of various drugs on sleeping time using suitable animals. ( HILTON and Co.s Modern Concepts on pharmacology and Therapeutics. Bodhankar. Das. S. f) Study of local anesthetic effect of drugs using suitable animal.G. Modern Pharmacology. R. Sharma K.P. Tripathi K. : R. Recommended Books 1. M. Calcutta ) 6. Chand and Company. and Bhandarkar S. Pharmacology and Pharmacotherapeutics (Popular Prakashan. Basic and Clinical Pharmacology. New Delhi 2. Crossland. Ghosh.D. 68
. 10. D. H. and Dale. and Dutta S. NS. g) Study of Haloperidol/ Clonidine/ Petazocin induced catalepsy using suitable animal.. Goodman and Gilman. Little Brown and Co. B. USA 8. Rang.. Craig. Medical Pharmacology. Essentials of Pharmacotherapeutics. Pharmacology. Paras Publication. 3.R.K. Sharma H.S. F. (Pergamon Press. Pharmacological Basis of Therapeutics. UK 9. C. McGraw-Hill 7.E. and Stitzel. Nirali Prakashan.s Pharmacology Basis of Therapeutics. K. M.S.
3. collection and extraction Glycosides ± Introduction.
. 12 20
1. occurrence. occurrence. definition.uses . properties. occurrence.
Note: ± Drugs mentioned in Bold must be studied in detail for their cultivation. general methods of extraction and evaluation of volatile oils. uses. general biogenetic pathway. dioscorea . Anthraquinones ± Senna. properties. chemistry. (3 Hrs. shatavari Bitter. classification./week)
Sr. A) Terpenoids ± Introduction. chemistry. Kalmegh. general biogenetic pathway. classification.Quassia. uses.6 (T) PHARMACOGNOSY
(Theory) 90 Hrs. Rhubarb Cardioactive ± Digitalis. General extraction and isolation methods. Coumarin/ furocumarin ± Psoralea Lactone ± Artemesia 2. No
SECTION. Squill Saponins ± Liquorice. chirata Cynogenetic ± Bitter almond Isothiocyanate ± Black mustard Flavonoid ±Orange peels. properties. classification . B) Volatile Oils ± Introduction. Aloe.I
Bahera. Cannabis.Pale catechu .
Resins and resins combinations ± introduction. Shellac. Kaolin. Arjuna . adulteration. uses.
8. chemicaltests and general method of extraction. Wool fat. general biogenetic pathway. Cod liver oil. properties. Black catechu
6. uses. Benzoin. tulsi. dill. classification. Bromelin.
Plant pesticides ± Pyrethrum. fennel. lavender. Amala. Turmeric. properties. cassia.
. classification. Linseed oil. Guggul
7.Castor oil. cinnamon. Fixed Oils.
Enzymes and proteins ± Papain.Cardamom. Asafoetida. Urokinase . Fullers earth. methods ofextraction. nutmeg. evaluation. Ashoka . coriander. classification. Streptokinase.chemical composition extraction.
Tannins ± introduction. gelatin. and uses.II
5. Neem. Myrobalon . Derris root. Ginger. Seasame oil.
Lipids ± introduction. soya oil. Kokum butter Waxes ± Bees wax. Colophony. clove. Podophyllum. properties. Drugs of mineral origin ± Shilajit. caraway. Shark liver oil.Fats ± Cocoa butter. eucalyptus. olive oil.
General methods to study the biogenetic pathways with special reference toTracer Technique and its application in the biogenetic investigations with suitable examples. definition. occurrence. Calamine. Capsicum. Tobacco. Carnauba wax
4. Bentonite. SECTION.
Pune.10. 8. Kokate. Hybridisation. Supercritical fluid extraction. Applications of Medicinal Plant Tissue Culture in Pharmacognosy. Conservation of Endangered species through micropropagation. The British Pharmacopoeia. : Textbook of Pharmacognosy: CBS Publisher and Distributor 4. Chemistry of Organic Natural Products by O.P agrawal. 15/ Ed. London. Rangari: Pharmacognosy: Career Publications 6. 9. Froth floating technique. 5. Brady and Robbers: Pharmacognosy: CBS Publisher and Distributors. Transgenic plants . The Indian Pharmacopoeia. A. Recommended Books 1. Purohit..
Extraction of Plant Material. Droplet-countercurrentExtraction. 1996 & 2007. Iyangar: Study of Crude Drug.
. Chemodemes. Cultivation of Medicinal Plant Cells Production of Secondary Metabolites Bioconversions Using Plant Cells Plant Cell Immobilization Genetic manipulation: Mutation. M. 2. Gokhale: Pharmacognosy: Nirali Prakashan. Trease and Evans: Pharmacognosy. Gowel Publication house 7. New Delhi 3.Soxhlet extraction.Polyploidy. Saunders Company. 12
of herbal extract. Wallis T. Tyler. E.
chemical and micro chemical tests for following crude drugs in entire and in powdered form (including surface preparation wherever required). 20. A. Manipal. T.Fennel/ Caraway/ Dill/ Coriander/ Cardamom/ Capsicum. S. Satyanarayana ³Biotechnology´. 16. E.. Seed.Oxford publisher 18. stomata. Kalia A. INC.10.II
(Practical) (90 hrs: 3 hrs/week) 1) Study of plant tissues.An Introduction to Plant Tissue Culture. 13.Books and Allieds Pvt Ltd. trichomes.
3. 12. Rainerat and Bajaj. London. 15.G.A. Mohammad Ali. Ramstad: Modern Pharmacognosy: McGraw Hill Book Company. digitalis. N: Indiustrial Pharmacognosy. Martindale: The Extra Pharmacopoeia.
2) Analytical study of morphological and microscopical characters. S. G.S. Iyengar.6 Pharmacognosy.Isapghula/ Linseed
. K Nayak ³Pharmacognosy Lab Manual´.
y y y y
Leaf ± Senna. 19. Laddha ³Herbal Drug Microscopy´ Yucca Publication. 11. Manipal. Street H E.K Nayak ³Anatomy of Crude Drugs´ Manipal press. starch grains and calcium oxalate crystals. Tissue culture and plant science. Pharmacognosy/ 14..Cassia/ Cinnamon Fruit.M. M.Manipal Press. Razdan M. Eucalyptus (Comparitive study) Bark. Iyengar.K. plant tissue culture. Academic press. Vasudevan & K. 17. M.
Shellac. Agar. Purohit. Catechu. 7) A) Identification of crude drugs mentioned in theory syllabus from their morphological and physical characters and preparation of herbarium for one medicinal plant. Kokate. Crude fibre (by dutch method) 5) Estimation of Acid Value! Saponification value! Iodine Value 6) Identification of natural fibres by general chemical tests and microscopical examination.Quassia Stem ± Kalmegh/ Chirata Root and Rhizomes ± Liquorice. Veinlet termination no. Pune.
. Asafoetida. Castor oil. Determination of length. Foaming index. Gokhale. B) Identification of unorganized drugs by physical characteristics and chemical Tests.Clove Wood. Nirali Prakashan.Stomatal number and Stomatal index. Vein-islet no. width and diameter of cellular material! cell contents. Colophony.y y y y
Flower bud. aloe. Determination of Leaf constant. (Comparitive study)
70 3) Quantitative microscopy: . Pharmacognosy. Benzoin. Determination of % purity of crude drugs by lycopodium spore method
4) Experiments on ± Sampling of crude drug for analysis. Determination of foreign matters.. Moisture cotent (Loss on drying! Toluene Distillation) Ash Values. Honey.Ginger. Tragacanth Detection of adulteration in oils 9) Visit to a tissue Culture Laboratory. Guggul. Palisade ratio. Acacia. Swelling index. Extractive values. Recommended Books 1. . Shatavari.
ii) Planning: Nature and purpose of planning. S.
1. Modern Pharmacognosy.G. 4. planning process. A. Mc-graw hill Book Company. Vol I. Pharmacognosy & Phytochemistry. Chopra. Iyengar. Pridham J B.R. Iyengar. 11. Management thoughts. British Pharmacopoeia. M. Swain B. Manipal. 7. 6. 14. 9. 3.Nirali Prakashan.K Nayak ³Anatomy of Crude Drugs´ Manipal press.Attal and Kapoor. 13. Academic Press. advantages and limitations. Materia Medica by Nadkami. Shah & Quadry. No
SECTION. Indigenous drugs of India.2. Fundamentals of management i) Management basic Concepts efinition. Wealth of India 8. Need for management. important steps in planning.Pune. M.
3.Practical Pharmacognosy. Biosynthetic pathways in higher plants. Cultivation and utilization of medicinal plants. 5. Career. S. Function of management. (2 Hrs. Rangari V D. Manipal.types of planning. Functions and responsibilities of a manager. K Nayak ³Pharmacognosy Lab Manual´. II./week)
Sr.A. 12. New york.
1. Martindale Extra Pharmacopoeia. Manipal Press. G. Khandelwal K. Contribution of Taylor. A text book of Pharmacognosy. E Ramstad.7 (T) Pharmaceutical Business Management
(Theory) 60 Hrs. Ayurvedic Pharmacopoeia.I
Hrs. 10. Peter Drucker in modern management. Fayol.
Policies. iii) R&D in Pharma industry.1948. Delegation. Manage±ment information system. 3. inventory control. Causes of disputes.C and Q. Drug developmentprocess. Balance sheets 2. advantages and limitations. Job satisfaction. Tribunals.II 1. Introduction to Factories Act. Channels of distribution. SECTION. Trade unions. Network techniques (PERT & CPM).
2 3 3 5
. Current status and growth scenario. Decentralization. Management byobjectives. objectives andprincipals of purchasing. Trade unions Act 1926 and Industrial Disputes Act 1947. Scope. 3. Advantages and Limitations iv) Organizing: Organizational structure. Industrial relations. Wholesale. Pharmaceutical Marketingi) Difference between marketing and selling. Definition and Importanceof decision making. Decision making process vi) Controlling: Concepts and purpose of control techniques.Departmentalization. Line & Staff organization. Lock outs.A. Management audit. iv) Material management: Classification of materials. Clinical research organization. Retail. Importance and function of Q. ii) Operation management in Pharmaceutical Industry: Controlling ofmanufacturing operation. 1. analysis.Sales forecasting methods. Staffing. Break even analysis. Labor law. basic principals of organization. Personal counseling. Drug discovery process. Importance of objective.Meaning. Pharmaceutical industry and operation managementi) Historical perspective of pharmaceutical industry in India. v) Decision making: Types of strategies. Strikes. Departmental. Profit and loss account.
iii) Objectives: Types of objectives. Budgetary andnon budgetary control.
Theory¶s. Export. communication process.Pharmaceutical export. functions.Needs & Methods. Launching a new product. Packaging
vi) Price: Definition.ii) Sales promotions.
3 2 2
. managerial grid iii) Communication: importance. iv) Marketing research: Nature & Importance v) Product management: Product life cycle. 1954. Expectancy theory. Human Resource and Developmenti) Motivation: definition. procedure. concept. Detailing iii) Medical representative: Role & Qualities. Equity or social comparison theory X & Y. importance. regulatory agencies Recommended Books
1) Peter Drucker. Merchandising. New York.Maslow¶s Theory. International market. trait theory. procedure for determination of price. Reinforcement theory.
2. Hertzberg¶s theory. Vroom¶s theory. leadershipstyles. Principles & Techniques.Advertising. Factors affecting . formsof communication. Ethics of sales. ii) Leadership: definition. registration authorities. 72
3 1 2 3
Branding. The Practice of management. types of communication iv) Interview techniques: ± presentation skills .types of price 2. qualities of leadership. Objective. Harper and Row. documentation. 3. recruitment and training 3.group discussion v) Performance appraisal: need and techniques.
N. 1998. Ltd. Introduction to Management Accounting. CBS Publisher & Distributors. & Weihrich H. 12th Edition. Viva Books Pvt. New Delhi. Principals of Management. 2000. J. Prentice
Hall of India Pvt. The world Press Pvt. Principles of Pharmaceutical Marketing. 4) Koontz H. Calcutta. New Delhi. Vidyasagar. Pearson Education Pvt. 8th Edition New Delhi. Management. 10) Mickey Smith. Sundem & Stratton. 11th Edition. 2001. Tripathi & P. 2nd edition. 3rd Edition. 2005. 2005. Tata McGraw Hill publishing Co/ Ltd. 1995. 13) Principles and Methods of Pharmacy Management by Harry Smith. Reddy.C. 10th Edition. 1998. Singapore. Gandhi. New Delhi.2) Harold Koontz. 3) P. 15) Marketing in New Millennium by Dr. Pharma book Syndicate. Ltd.. 5th edition.. M. 14) Marketing Management by Philip Kotlar. 7) Philip Kotler & Gary Armstrong. Tata McGraw Hill publishing Co/ Ltd. 73
. An Introduction to Management. 1980. Ltd. Mickey Smith. 1998. 16) Principles and Management: Koonz O¶ Donnel. Marketing A Managerial Intoduction. 6) G. Xavier. Pharmaceutical Industrial Management. Pharmaceutical Marketing in the 21th Century..
11) Horngren. Hyderabad. Cyril O¶Donnel & Heinz Weihrich.C. 2001. New Delhi. Ltd. Essentials of Management. 12) Cost Accounting & Management Accounting: Everest Publication.. Tata McGraw Hill publishing Co/ Ltd. 7th edition. New Delhi. New Delhi. Principles of Marketing. 5) Satya Saran Chatterjee. 9) J.