DIABETES MELLITUS TYPE 2

Destruction of alpha and beta cells of the pancreas Increase ketones

Insulin resistance Production of excess glucagon

acidosis

Elevated blood glucose Production of glucose from fat stores ACETONE BREATH

Increase osmolality due to glucose Chronic elevations in blood glucose

Wasting of lean body mass FATIGUE, WEIGHT LOSS

Polydipsia Glycoprotein call wall deposits

WEIGHT
Polyuria LOSS

polyphagia
Small vessel disease Accelerated atherosclerosis Impaired immune function

Diabetic retinopathy
Diabetic neuropathy
Diabetic neuropathy Hypertension
Infection

Symmetrical loss of Autonomic neuropathy Loss of vision,

protective sensation END-STAGE RENAL FAILURE blindness Increased LDL levels
DELAYED WOUND HEALING

Dry cracked skin

CORONARY HEART DISEASE
Numbness and tingling
in the extremities gastroparesis

Wasting of intrinsic impotenc

muscles e

NEUROGENIC BLADDER
CHARCOT CHANGES IN DIABETIC
THE JOINTS FOOT
ULCERATION