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V Bronchodilators

V ˜  


V orticosteroids
V Y 
 sympathomimetics

V ~    acute phase of asthmatic attacks

V Ãuickly reduce airway constriction

V Stimulate Ʌ2-adrenergic receptors 




 
Phree types

V Nonselective adrenergics

V ñ     ˜   ˜  


 

V  
V Nonselective Ʌ-adrenergics

V ñ    
 ˜  ˜ 

V   



V Selective Ʌ2 drugs

V ñ   
 ˜ 

V   
 
 
Mechanism of Action

V Begins at the specific receptor stimulated#

V Ends with the dilation of the airways

V J   

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andications

V Relief of bronchospasm  


  
   

 
   

V ~     
 acute attacks  !   


V ~   hypotension and shock

V ~ 
produce uterine relaxation to prevent premature labor

V ÔyperkalemiaȄstimulates potassium to shift into the cell


d-Ʌ (epinephrine)

V a

V #   V %  
V 
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V $    V '   

Ʌ1 and Ʌ2 (metaproterenol)

V    
 Vascular headache
V 
 Hypotension
V  
Ʌ2 (albuterol)

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V $   
V 

V Monitor 
   
V (   
V (  !)       
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V Ôave patients demonstrate use of devices

V Monitor for adverse effects


V Albuterol, if used too frequently, loses its Ʌ2-specific actions at larger
doses
V     ˜ 
          
    
  
       

V + medications exactly as prescribed


V No omissions or double doses

V Report insomnia, jitteriness, restlessness, palpitations, chest pain, or


any change in symptoms
V Anti-inflammatory!!!

V ~  w w asthma/  exacerbations

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Mechanism of Action

V Stabilize membranes of cells that release harmful





    

V 
increase responsiveness of bronchial smooth
muscle to Ʌ-adrenergic stimulation
V beclomethasone dipropionate
,
  $

V triamcinolone acetonide (Azmacort)

V dexamethasone sodium phosphate (




  # 

V fluticasone -
  -
 
V Preatment of bronchospastic disorders
  

 
  
 
 




V N P considered first-line drugs 


 

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gargle and rinse the mouth with lukewarm
water afterward to prevent the development of oral fungal
infections

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 the bronchodilator should be used several minutes
before the corticosteroid to provide bronchodilation before
administration of the corticosteroid