MAST CELL STABILIZER

By: Hannah A. Santillan

BSN 3-D
 MAST CELL STABILIZERS
• Can be used to treat mild to moderate
inflammation in the bronchial tubes and other
allergy symptoms. Can also be used to prevent
asthma symptoms.
• Mast cell stabilizers block a calcium channel
essential for mast cell degranulation, stabilizing the
cell and thereby preventing the release of histamine
and related mediators.
• Mast cell stabilizers are not rescue medicines.
• Example of these are CROMOLYN and
NEDOCROMIL
 HOW DO MAST CELL
STABILIZERS WORK?
• it acts by inhibiting the release of histamine and
reacting substances of anaphylaxis from mast cells,
stabilizing the cell membrane and reducing the
allergic response and inflammatory reaction.
• it is prophylactically prescribed to prevent bronhial
asthma.
• Mast cell stabilizers work to prevent allergy
cells called mast cells from breaking open and
releasing chemicals that help cause
inflammation. They make the airways less
sensitive to many asthma triggers.
 INDICATION
– As inhalers they are used to treat asthma, as
nasal sprays to treat hay fever (allergic
rhinitis) and as eye drops for
allergic conjunctivitis. Finally in oral form
they are used to treat the rare condition of
mastocytosis.
 SIDE EFFECTS
• Throat irritation
• Coughing
• Skin rashes
• Blurred vision
• Headache
• Drowsiness
• Urinary frequency
• Nausea
• Diarrhea