CBOHCTBA llPO,ll;YKTA "MHKOTOH" C TO~KH 3PEHIDI «I>H3HOJIOrHH llHTAHIDI H ,ll;PyrHE BOllPOCbI

MHKOTOH B xasecrse speaaa IIHIII;eBOH .n:06aBKH 06JIa.n:aeT H m,U0pOBHTeJIbHoro KOMIIJIeKCOM CBOHCTB, u;eHHbIX C TOqKH IUUaHH5J.. 3TOT KOMITJIeKC CBOHCTB 3TO

nporpanaxrasecxoro
6HOIIOJIHMephI H3 rpH6HOH

OIIpe.n:eJI5J.eTC5J.KOMIIJIeKCOM OCHOBHbIX KOMIIOHeHTOB, BXOMIII;HX B COCTaB MHKOTOHa. aarypansrrsre nonysaevsre XHTHH - :HO XHTHH

(~70 %),

rmoxaasr rpaöa

6HOMaCCbI JIeKapCTBeHHOrO IIOJIHCaXapH.n:, conepacanraä

(~20 %) H MeJIaHHHbI (~10 %), F omes fomentarius. asory
OH

narypansasrä
TIDKeJIbIX

B CBOeM COCTaBe a30T. Bnaronapa

XHTHH 06JIa.n:aeT TOKCHqHhIX MarHHIO H

YHHKaJIhHO BbICOKHMH COp6U;HOHHhIMH CBOHCTBaMH IIO OTHOIIIeHHIO K HOHaM MeTaJIJIOB (B TOM qHCJIe pa.n:HOaKTHBHbIX). HaIIpHMep, 06MeH B TO )l(e BpeMJI

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6HOreHHhIM

3JIeMeHTaM,

KaJIHIO, KaJIhU;HIO, HaTpHIO,

np.,

H II03TOMY He napyuraer XHTHH B

MHHepaJIhHbIH

opraaaswa
MOqeBHHe

IIpH ,lJ;JIHTeJIbHOM

YIIorpe6JIeHHH. MeTa60JIHqeCKHM TOKCHqeH

raiose

5J.BJI5J.eTC5J. XOPOIIlliM 6HJIHpy6HHY, II03TOMY ,lJ;03aX H

cop6eHTOM KpeaTHHHHY. CqHTaeTC5J.

IIO OTHOIIIeHHIO KO MHorHM H

IIIJIaKaM, HaIIpHMep, 60JIhIIIHX

zrp.

XHTHH He ,UJI5J.

zrazce

osens

IIepCIIeKTHBHbIM

IIpHMeHeHH5J. B ,UHeTOJIOrHH H Me.n:Hu;HHe. rJIIOKaHbI H3BeCTHbI

rpnöaoro

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5J.BJI5J.IOTC5J. narypansnsnra pa60TY

IIOJIHCaxapH.n:aMH

H

CBOHMH CIIoco6HOCTHMH

KoppHrHpOBaTb

HMMYHHOH CHCTeMbl. C He60JIhIIIOH

TaKHMH

CBOHCTBaMH 06JIa.n:aIOT

nexoropsre

pa3BeTBJIeHHhle

6eTa-rJIIOKaHbI

MOJIeKYJI5J.pHOH

MaCCOH. CBe.n:eHHH 0 IIp05J.BJIeHH5J.X TOKCH:qeCKHXCBOHCTBY

rpnöasrx

rJIIOKaHOB He H3BeCTHO.

MeJIaHHHhI MOJIeKYJIe

-

:HO

caasre

MOIII;Hble

IIpHpO,UHhle qIfCJIa

6HOIIpOTeKTophI.

DJIaro,Uap5J.

HaJIHqHIO rpYIIII

B

MeJIaHHHOB

60JIhIIIOrO

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<PYHKIJ;HOHaJIbHbIX

OHH

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HeHTpaJIH30BaTh

cnocoöaa

CBH3aTb

no
Ilpa

20

CB060,lJ;HblX pa.n:HKaJIOB.

Tpaönsre

MeJIaHHHhI

OTJIHqaIOTC5J. OT )l(HßOTHhIX MeJIaHHHOB

OTCYTcTBHeM TOKCHqHOCTH. HCIIOJIb30BaHHH B IIHTaHHH B

xaxecrse

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<PYHKIJ;HH,Ba)l(HbIX ,lJ;JI5J. HOpMaJIH3aU;HH <pH3HOJIOrHH IIHTaHH5J.. Ilonanaa TpaKT H IIPOXO.n:5J. repes TOKCHqeCKHe OC~060JI\.lJaT:bC5J. UPlJ IIHIueBapHTeJIhHblX OKOJIO

aero

BMeCTe C IIHIII;eH XHTHH MHKoTOHa

aztcopönpyer
IIHTbeBOH KpOBH. B

KOMIIOHeHTbI,

xoropsre

MorYT

conepacarscs

B

ncpesapasamra
npeaasc

rm:ll.TE. KpOMe

roro, -repea

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CJIIOHbI

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qeJIOBeKa

H3 KPOBH BbI,lJ;eJIHeTCH

10 JIHrpOB

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KOHTaKTa C MHKOTOHOM, KOTOPbIH HaXO,lJ;HTCH 3TO BpeMJI B B OqHIII;aeTC5I OT pa3JIHqHbIX CHCTeM qeJIOBeKa. TOKCHHOB H HeT

:>KH,lJ;Ka5J. cppaKIJ;H5I raxace paöora scex opranos H cnocoöasrx nepenapnaarr, XHTHH. II03TOMY

Y

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Ha HeM TOKCHHaMH BhIBO,lJ;HTCH H3

opraaaaua

eCTeCTBeHHhIM IIYTeM.

rJIIOKaHhI qeJIOBeKa

MHKoTOHa H B H

MorYT

qaCTHqHO

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snzte
nanee

6HOJIOrHqeCKH

aKTHBHhIX OJIHrOCaXapH,lJ;OB IIOIIa.n:aIOT B BOPCHCTbIH CJIOH

KHIIIeqHHKa

B KpOBb. B BOPCHCTOM CJIoe KHIIIeqHlIKa KJIeTOK. B3aHMo.n:eHCTBYH HX C

cocpenoro-reaa

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HMMYHOKOMIIeTeHTHbIMH

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MeJIaHHHbI,

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B MliKoTOHe,

li nponyxrst

ax

öaonerpanana»
li He

06JIa.naIOT MOIIl,HhIMH

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)U!K. Kpoxre roro,

He TOJIbKO OT TOKCliHOB namesapeaas,

HO li OT YJIbTPaq>MOJIeTOBoro

arax naTOreHHbIX 6aKTepßH ß BßPYCOB. ueHHbIMIf AM JIIOAeH, Y KOTOPbIX ßMeIOTCH rpaxra, xorna OCJIa6JIeHbI 3TO

CBOHCTBa MMKOTOHa HBMIOTCH ocoöenno B paöore rreseaa, nonex,

aapymenaa

xcenyzto-rao-xanre-raoro aapynrenaa

eCTeCTBeHHble «PYHKl(lili ynanenaa TaK)l(e Ba)l(HO ):(M JIIOAeH noaoororo JIIOAeH, xoropsre rrpOXOAHT

TOKCliHOB li MeTa60JIß"llecKßX IIlJIaKOB as opraaasaa. B03paCTa, xorna

BbmeJIliTeJIbHbIX li 3aIl(liTHbIX neseans, pazmoreparran ß

«PYHKl(liH YXYAlIIaeTCH npa CTapeHMM opraanaaa. xypcsr xmraorepanaa npenaparos aeoöxonaao

MMKOTOH rrOJIe3eH KaK Ao6aBKa K mrranmo

MeAßKaMeHT03Horo

AM ycxopennoro BbIBeAeHßH TOKCli"llHbIX rrpOAYKTOB pacnazta JIeKapCTBeHHbIX li TOKCMHOB, COrrpOBO)l()J,aIOmMX rraronorasecxae nponeccsr. MliKOTOH asoznrn, B pannos li JIIOAeH C OCTPbIMli npn BliPYCHbIMli rparme, li 6aKTepliarrbHbIMM CIII1,lt HeHTparrH3aUHH li 3a60JIeBaHßHMß, nanpasrep, renararax,

HH«peKIIHOHHbIMli

carrbMOHeJIJIe3aX, nacöaicrcpaosax BbIBe,neHliH öaxrepaansnsrx

zrp. OH cnocoöcrsyer

YCKopeHliIO

li BliPYCHbIX TOKCHHOB,a raiose BOCCTaHOBJIeHliIOHMMYHHTeTa

opraaaaua.
MliKOTOH npomen )l(ßßOTHbIX B KJIMHMKax KHeBa, mapoxaä xpyr JIa60paTOpHbIX ß Me,nßKo-6liOJIOrß"lleCKßX ßCCJIe.n;OBaHMH Ha OH TeCTlfpOBaH B rrpeACTaBJIeHbI Ha pe3YJIbTaTaM MCCJIeAOBamrn: CBOHCTB MMKOTOHa

naysasrx liHCTßTYTax Yspaaasr ß POCCßli, rro PHAY narrpaaneaaä
)J;OHeUKa M JIbBOBa. IIo

orry6JIHKOBaHo 60JIee 100 naysnsrx C006meHHH:. Pe3YJIbTaTbI 6bIJIH raiose MHOrMX Me)l()J,YHapOAHbIXHaY"llHbIX xompepeanaax. KOMrrOHeHTbI Mmcorona B nponecce

rrpOM3BOACTBaHe rrOABepraIOTC5I KaKOH-JIH60 XlfMM"lleCKOH as 6lfOMaCCbI yrJIeBOAOB M

MO.n;lf$liKaUHH. CYTb TeXHOJIOrßli rronysenas Maxoroaa COCTOHTB ynaneaaa rpaöa HeHY)l(HbIX KOMrrOHeHTOB: rrpOTeMHOB, JIMrrMAOB, Hß3KOMOJIeKYMpHbIX ztpyrnx rpaönoä

JIerKO pacraopaasrx KOMrrOHeHTOB. PaCTBopeHHe rrpOBOAHTCH nyreu KHIlH1:JeHliH 6HOMaCCbI B Il(eJIO"llHOM pacrsope H rrOCJIe.n;YIOm;eH MHorOKpaTHOH npOMbIBKOH BO.n;OH,

01:JHm;eHHOH Ha MeM6paHHbIX «pHJIbTpax. OCTaBIIIa5IC5I TBepAa5I nacrs rpH6HOH 6HOMaCCbI CYlIIliTC5I H pa3MaJIbIBaeTC5I AO rropoIIIKo06pa3HOrO COCT05IHIDI, a 3aTeM paC«paCOBbIBaeTC5IB rroTpe6HTeJTbCK)'lO rapy OHOXlfMH"lleCKliH COCTaB Mmcorona o-reas CJIO)l(Hbrn: xarnn rrpeACTaBJIeH JIliHeHHbIMH

MaKpOMOJIeKYJIaMH, xoropsre coöpansr B nysxa rro 150 - 250 MliKpo«pli6PHJIJIbI. 3a C1:JeT TaKOrO crpoenas COp6l(liOHHa5I rrosepxaocrs - 60JIee 1000 xsaztparasix MeTPOB Ha rpasor KMCJIOTaX M OpraHlf1:JeCKMX pacraoparensx. MliKoTOHa.

MOJIeKYJI H 06Pa3YIDT xaraaa oseas 60JIbIlla5I

XM:THH He paCTBOpHeTCH B uienosax, MO)l(eT npOliCXOAHTb

B HaTMBHOM COCT05fHMMXMTMH 01:JeHb MHep-rHbIH
OJIHrOMepbI XHTliHa 06JIaAaIOT BbICOKOH

MaTepliarr li 6HOJIOrH"lleCKOHaKmBHOCTbIO He 06JIa)J,aeT. Ero paanozceane C yaacraess $epMeHTOB XHTHHa3. 06pa30BaBIillfeCH 6HOJIOrli"lleCKOH aKTliBHOCTbIO. Fmoxansr MHKOTOHa npencraanerrsr

60JThIllHM KOMTTJIeKCOM MaKpOMOJTeKYJIPa3JTWfHOß MaCChT

H c pa3HbIM xapaxrepon pa3BeTBJIeHMii:. Pa3JIHqaIOT aonopacrsopaasre, menoxepacrsopmrsrc lf aepacrnopmssre rJIIOKaHbI. B MMKoToHe rrpe06JIaAaIOT nepacrsopmrsre rJIIOKaHbI, KOBarreHTHO CBH3aHHble C XHTHHOM. 3TH rJIIOKaHbI non .n;eliCTBHeM rrarnesaparensasrx «pepMeHTOB xenonexa MorYT nerpanapoears no pacrsopaasrx 6HOJIOrH1:JeCKliaKTliBHbIX onarocaxapanos.

MeJIaHRHbI MRKOTOHa rarose pasaoä cpenax R sone, pacrsopaasr cpenax

HBJUlIOTCHKOMTIJIeKCOMOYJeHb60JIbIIIOrO YJHCrraMaKpoMorreKyrr He pacrsopaasr B xacnsrx OCHOBHOM B IIIenOYJHhIX pacrsopax. qeJIOBeKa no 3TlI MenaHlIHhI MorYT ,n;erpa,n;lIpOBaTb B
U 6UOJTorwqeCKOJ,f aKTURHOCThfO.

MaCChi R COCTaBa. OHR CB5.l3aHhIC XHTRHOM H rnIOKaHaMlI,

IIlIIIIeBaplITeJIbHbIX
TPUTeprreHOR),

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06JTa,T{afOTI1UX RhTCOKOW aHTUOKCH~aHTHOW

TaKllM

06Pa30M,

MHKOTOH,

KaK

1I npyrne

narypansasre

nponyxrsr,

lIMeeT

CJIO)l(HhIH

6110XHMlIqeCKlIH COCTaB, KOTOPhIH MO)l(eT B onpeneneansrx npenenax 1I3MeHHThCJI B 3aBlICRMOCTR OT B03paCTa R YCJIOBlIH rrpOR3paCTaHlIJI rpaönoro csrpss. B 3TOM rrnaae lIMeIOTCJI aexoropsre lI3BeCTHble rrp06JIeMhI CTaH,n;apT1I3aIJ,lIlInponysmra.

B CBH311C 3Tl1M npa KOHrpOJIe

KaYJeCTBarrponyxmra COCTaB6HO)l'.M~LI1YJeCKHX KOMrrOHeHTOBM.I1KOTOHa He rrpOBepHeTCJI, TaKOH aHaJIR3 .rpeöyer ztoporocroamero cospeaeaaoro oöopynosaaaa, CrreIJ,lIaJIRCTOB BbICOKOH KBaJIRcpllKaUlIlI, 3aHlIMaeT MHoro speaena 1I CTOllT oseas noporo. KOHTPOJIh xasecrsa OCHOBaHHa nposepxe pernaaearnponaao MRKOTOHa, KaK 1I B CJIyqaJIX C aHaJIOrRYJHOHHaTYPaJIhHOH nponyxnaeä,

conepzcaaaa Pa3JIl1YJHhIX apezmsrx npaueceä.
rocynapcraeaasnra craanapraaa Y xpanasr

Coztepacaaae TaKl:IX npaueceä

1I CrreIJ,lIcpllKaIJ,lleH (TeXHllYJeCKlIMI1 YCJIOBlIJIMI1)Ha

MRKOTOH. 3TI1MI1 )l(e crannapraua onpeneneau 1I MeTO.ll:bI KOHrpOJUl. ITo MlIKOTOHY MhI nepnonasecxa KOHrpOJIRpyeM fionsmoä KOMnJIeKC TaKRX rrOKa3aTeJIeM - 3TO PH,n;TOKCUlJHbIX TH)I(eJIhIX MeTaJIJIOB, OCHOBHbIX pa.n;ROHYKJIR.n;OB, OCTaTOYJHbIX KOJIRqeCTB KOHTpOJIRpyeM aexoropsre HaR60JIee noxasarena pacnpocrpanennsrx neCTlIIJ,lI.n;OB, 3arpJI3HeHHOCTh Pa3JIRqHhIMlI naroreansnra MhI rrpezrsaparensao 6aKTepllJIMI1 1I

np. Kposre caMOH rrpozryxnnn xasecrsa ChIPhJI.

3TlI MephI, a raiose crporoe coömoneaae napauerpos TeXHOnOrlJqeCKOrO npouecca rr03BOJUlIOT oöecneaasars CTa6RJIiHOCTh nOTpe6IUeJIbCKRX KaqeCTB Ml!iKoTOHa. HaqRHaH C 1996 r., xorna MRKOTOH OCPllIJ,llaJIbH6 rrOHBRJICJIHa psrmce YKpaRHhI ,n;o6aBKR, li no HaCTOHIIIero BpeMeHH MbI He rtonyxana nponyxiraa. ITpOep. JI.<I>TOPOBOH B xasecrse 6110JIOrllqeCKlI axrasaoä Hli O,n;HOM pexnassanaa Ha KaqeCTBO

13.08.2010

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