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ScienceDaily (Aug. 18, 2010) ‫ چ‬Researchers at Queen's University

Belfast and the Belfast Health and Social Care Trust have
developed a groundbreaking test for meningitis which could help
save lives.

A rapid diagnostic test for meningococcal bacteria that can

produce results within an hour has been developed by scientists
from Queen's Centre for Infection and Immunity and the Trust. The
speed of this new test is a vital factor in the treatment of
young children with meningococcal meningitis and septicaemia who
become very ill over a short period.
This research has been supported by the Meningitis Research
Foundation (MRF).

Professor Mike Shields, of Queen's University and the Belfast

Trust, explained: "The first symptoms of meningococcal infections
are the same as a simple viral infection, making it difficult to
diagnose in the early stages. Parents often use the 'tumbler
test' on their children's bodies, but the non-blanching rash that
is associated with a positive outcome of this test is a late sign
and is not always present in children who have meningitis.
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"Currently doctors will admit and treat with antibiotics any

child that they suspect of having meningococcal disease while
they await the traditional test results that take between 24 and
48 hours. Some children are not diagnosed in the early stages
while others are admitted and treated 'just in case' when they
don't actually have the disease.

"With the development of a small piece of equipment, which

resembles a portable home printer, a sample of blood or a
secretion such as saliva, can be tested quickly by the machine.
This produces a colour reading that determines if the patient has
meningitis or not."
Alongside saving lives, early detection can potentially improve
outcomes for meningitis patients who are often left with life-
altering conditions such as deafness and cerebral palsy.
The machine is now being trialled in the A&E Department of the
Royal Victoria Hospital for Sick Children in Belfast.

Professor Shields explained how the breakthrough is a great

example of research benefitting patients.

"There is no other rapid test that can confirm the diagnosis in

such a short time. The current tests are expensive and take up to
two days to obtain. Speedy identification of the cause of
infection can enable doctors to make life-saving decisions about
the treatment of patients. If we have the results within an hour
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we will be able to start the appropriate course of treatment

right away."

The new test is very different to standard culture based

detection methods that have been used up until now.

Professor Shields: "In recent years molecular diagnostic tests,

that use the DNA finger print from 'bugs' for diagnosis, have
been developed, but they still require the specimen sample to be
transported to the laboratory and takes a considerable time to
get the result back to the doctor. This means that doctors have
to make clinical decisions before results are available.

"The new test called 'loop mediated isothermal amplification'

also utilises a molecular method to detect genes that are common
to all strains on the meningococcus. The real advantage of the
new LAMP test is that it has the potential to be a simple bedside
test that is rapid, cheap, easy to use and doesn't require
laboratory trained staff."

Currently there are 1,200 to 1,500 laboratory confirmed cases of

meningococcal disease in the UK each year and it is thought that
actual numbers could be higher.

The medical team behind this breakthrough was recognised for its
work in June of this year when they won an Elevations Diagnostics
idea of the year award, organised by HSC innovators, a panel of
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experts from industry, healthcare and business support

organisations.
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Queen's University, Belfast (2010, August 18). Meningitis

research breakthrough could save children‫ڊ‬s lives. c
 
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Retrieved September 2, 2010, from http://www.sciencedaily.com
/releases/2010/08/100818085930.htm



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It is good to know that researches regarding early detection of

meningitis are made and funded. Especially, the speed of this new
test is a very important factor in the treatment of young
children with meningococcal meningitis and Septicaemia who become
very ill over a very short period. Under the traditional testing
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methods, they have to wait for 24 to 48 hours for the test

results but this new test which is done with a small piece of
equipment resembling a home printer which tests a sample of blood
or urine and produces a color reading that determines whether a
person has meningitis or not.

Rapid detection of the cause of infection can enable doctors to

make life-saving decisions about the treatment of patients.
Because we could never know, a simple rash on a patient may be
fatal and it could be too late when the result from a diagnosis
is achieved.

Furthermore this test, according to them is cheap, simple, rapid,

easy to use and does not require trained personnel. This may be
said as a boon because it not only saves lives but also improves
the outcomes of people suffering with meningitis who are often
left with very difficult conditions such as deafness and cerebral
palsy.