Chlorpromazine Indications

Chlorpromazine is classified as a low-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder as well as amphetamine-induced psychoses.

Adverse effects
These include sedation, dry mouth, constipation, urinary retention, possible lowering of seizure threshold, uncontrollable movements of the tongue, face, lips, arms, or legs, muscle spasms of the face or neck, and severe restlessness or tremor. Appetite may be increased with resultant weight gain, Glucose tolerance may be impaired.[1] Photosensitivity may occur, resulting in increased risk of sunburn.

Indications
The management of psychotic disorders including manifestations of manic depressive illness, manic phase and severe behavioral problems in children; nausea and vomiting due to stimulation of the chemoreceptor trigger zone.

Contraindications
Comatose or depressed states due to CNS depressants; blood dyscrasias; bone marrow depression; liver damage. Hypersensitivity to chlorpromazine. Cross allergenicity with other phenothiazines may occur. Should be avoided in children or adolescents with signs or symptoms suggestive of Reye's Syndrome. Its antiemetic effect may mask the signs and its CNS effect may be confused with the signs of Reye's Syndrome or other encephalopathies. ACTION Chlorpromazine is an aliphatic phenothiazine. Phenothiazines are thought to elicit their antipsychotic and antiemetic effects via interference with central dopaminergic pathways in the mesolimbic and medullary chemoreceptor trigger zone areas of the brain, respectively.