Irritable Bowel Syndrome Final | Irritable Bowel Syndrome | Gastrointestinal Tract

What is Irritable Bowel Syndrome(IBS) ?
“A functional bowel disorder in which abdominal pain is associated with defecation or a change in bowel habit, with features of disordered defecation and distention.”

Effects of Irritable Bowel Syndrome
• Muscles do not contract in normal way resulting in spasms.i.e. PAIN • If movement of food is slower then the person is constipated. • If movement is rapid, then the person gets diarrhea.

IBS Patients Categorization
• Abdominal Pain- Diarrhea-predominant (IBS-D) • Constipation Constipation-predominant (IBS-C) • Alternating stool pattern (IBS-A)

HOW ARE FEACES FORMED? .

INTRODUCTION TO LARGE INTESTINE .

LARGE INTESTINE • Last part of digestive system: the final stage of the alimentary canal in vertebrate animals. • Most liquids and minerals are absorbed from digested food. • The colon is about 1. • The colon ends at the anus. . as well as a few remaining nutrients.5 meters long. which is about one-fifth of the whole length of the intestinal canal.

• Anal Canal.PARTS OF LARGE INTESTINE • Cecum. and the gut in others. ascending colon of the large intestine and the ileum • Colon. the large intestine.It is situated between the rectum and anus. terminating in the anus. below the level of the pelvic diaphragm.The anal canal is the terminal part of .Part of the intestine from the cecum to the • Rectum-The rectum is the final straight portion of the large intestine in some mammals.The cecum is a pouch connected to the rectum.

What does colon do? • Absorb water. nutrients. and impulses in the colon muscles. • Colon motility -controlled by nerves. and salts from the partially digested food. • Contractions move the contents inside the colon . hormones.

Altered GI motility 2.Pathophysiology • IBS is not an organic disorder. .Altered intestinal secretion 3.Enhanced visceral sensitivity. • Three main physiologic abnormalities: 1.

PERISTALSIS MOVEMENT IN COLON .

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 Serotonin (5-HT) appears to be the common link involved in motility. which is produced and stored mainly in the gut (95%)  Serotonin has been responsible for the symptoms of IBS.  Serotonin.  Among 5HT receptor: ---5HT3 & 5HT4 receptor are responsible for GI motility . and perception of pain. intestinal secretion.

early satiety Non-GI Symptoms Dysmenorhea Backache Fatigue Headache Difficulty falling/staying asleep Urinary urgency Taste alterations Muscle stiffness and aching IBS = Irritable bowel syndrome.SYMPTOMS OF IBS Secondary Primary IBS Symptoms Symptoms Supportive of GI Symptom IBS Diagnosis Abdominal pain Altered bowel habits (constipation or diarrhea) Hard/lumpy stools Loose watery stools Straining during bowel movements Bloating Sensations of urgency Heartburn Dyspepsia Indigestion Nausea Vomiting. GI = gastrointestinal .

ALSO INCLUDES:      Fewer than three bowel movements a week More than three bowel movements a day Urgency (having to rush to have a bowel movement) Feeling of incomplete bowel movement Passing mucus (white material) during a bowel movement .

. • BOTH CENTRAL AND PERIPHERAL FACTORS INCLUIDNG PSYCHOSOCIAL FACTORS. AND VISCERAL HYPERSENSITIVITY ARE THOUGHT TO CONTRIBUTE TO THE SYMPTOMS. ABNORMAL GI MOTILITY AND SECRETION.CAUSES OF IBS • STILL INCOMPLETELY KNOWN.

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DIAGNOSIS 4. THE ROME PROCESS . MANNING CRITERIA 2.

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stool microbiology.DIFFERENTIAL DIAGNOSIS Sigmoidoscopy or Colonoscopy Esophagogastroduodenoscopy Abdominal ultrasound or CT scan Blood tests: complete blood count and Erythrocyte sedimentation rate.  Stool chemistry . fecal fat.     .

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OTHER TREATMENTS: • YOGA • HYPNOSIS • TRADITIONAL CHINESE TREATMENT .HERBS .DOSHAS • CLEANING OF COLON .ENEMAS FOR CONSTIPATION .ACUPUNCTURE • AYURVEDIC MEDICINE .

Yoga Posture Sequence for IBS 1. Hero Pose .Reclining Bound Angle 3.Corpse Pose 2.

Seated Wide Angle Pose 6.4. Bound Angle Pose 5. Upward Facing Dog 7.Downward Facing Dog .

8.Shoulder Stand (Inversion) 9.Cobra . Bridge Pose 10.

FOR Eg. MENSTRUATION . • ABOUT 75-80% ARE THE CONSULTERS.WOMEN AND IBS • FEMALE PATIENTS ARE SEEN THREE TIMES AS COMMONLY AS MEN. • WOMEN ARE MORE SENSITIVE TO IBS WHICH OBVIOUS BIOLOGICAL REASON THAT DO NOT APPLY FOR MEN.

• BRAIN-GUT AXIS HAS PROVED SOMEWHAT EFFECTIVE FOR EXPLANATION OF CAUSE OF IBS.HOPE THROUGH RESEARCH • EXACT CAUSE IS NOT KNOWN FOR IBS TILL NOW. . • PROBIOTICS HAVE PROVED EFFECTIVE IN PREVENTING THE SYMPTOMS OF IBS.

ROLE OF PHARMACIST • PHARMACISTS CAN PLAY AN IMPORTANT ROLE IN IMPROVING THE LIVES OF PATIENTS WITH IBS. • PROACTIVE QUESTIONING BY PHARMACISTS WILL ALLOW THEM TO GIVE APPROPRIATE OTC THERAPIES. • PATIENTS SHOULD BE WARNED AGAINST SELF-MEDICATION. . • PROPER GUIDANCE SHOULD BE GIVEN.

Cash BD Irritable bowel syndrome: update on colonic neuromuscular dysfunction and treatment.RESEARCH ARTICLES 1) Chey WD. .

and evidence of clinical efficacy.RESEARCH ARTICLES 2) Camilleri M Probiotics and irritable bowel syndrome: rationale. putative mechanisms. .

RESEARCH ARTICLES 3) W Grant Thompson Tegaserod and IBS: a perfect match? .

 IBS does not harm the intestines and does not lead to cancer.  Awareness of the true facts of IBS to every individuals in modern day life holds the key success for the prevention of IBS.CONCLUSION  IBS is not a organic disease. It is not related to Crohn’s disease or ulcerative colitis. IBS is a disorder  IBS is a common disorder found more often in women than men.  IBS is diagnosed by its signs and symptoms and by the absence of other diseases. .  No screening methods have been established for the cure of disease.

Sr. no.649 157. Name of Book Editon Author Page no. 18 th Hunter & Boon 668-670 5. 7 th Siddharth N. 5 th Niraj Ahuja 111.J.Bennett M.159 3.112 4. Shah 560-1. 1 2.14211422 6.N. Clinical Pharmacology The Pharmacologic al Basis of Therapeutics A Short Textbook of Psychiatry Davidson’s Principles and Practice of Medicine Harrison’s Principles of Internal Medicine API Textbook of Medicine 9 th 9 th P. 13 th Volume – 2 Wilson and Kasper 1342.Brown Goodman & Gilman 648.1397 .

nih.com/ lessons/200307-01.pharmacytimes.WEB SITES • http://en.ibs-researchupdate.wikipedia.helpforibs.helpforibs.niddk.asp .html • https://secure.asp • http://www.com/hypnosi s/ • http://www.org.uk/ibs/woman1ie4.org/wiki/Irritabl e_bowel_syndrome • http://digestive.gov/ddis eases/pubs/ibs_ez/ • http://www.com/yoga/po ses.

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