Neuroscience 9/21/10 Discussion Synaptic Transmission 1. 2. 3. 4.

synthesis release effect on postsynaptic cell termination

quantum = one vesicle, discreet variable ESPS / ISPS Receptors on the post-synaptic membrane -40 -65 NT Receptors ‡Ligand/NT/Chemically(what binds to the channel) Gated Channel ‡G-Protein Neurotransmitters ACh Na+ Glutamate Na+ GABA ClGlycine ClDepol EXCITATORY Depol EXCITATORY Hyper INHIBITORY Hyper INHIBITORY

G-Protein Coupled Receptors 1. What are they good for?‡More widespread signal, slower, diverse 2. How do they work? 3. Ex. 1 Nonepinephrine(NT) binds to receptor G-protein activates adenocyclase(effector/enzyme) which converts ATP *cyclic AMP(second msger) activates protein kinasephosphorylates K+channel which closes

4. Back up, zoom in pg. 159 G-Protein Complex gamma + beta + alpha(GDP) drop GDP, picks up GTP, two subunits split in opposite directions, alpha which has GTP breaks down to GDP which terminates it, and subunits come back together

2 pg. Ex. ligand makes it open/close voltage-gated has positive/negative Synaptic Integration combination of action potentials Temporal Spatial Logarithmic decay Shunting Inhibition @37% Distance .5. 162 like Adenocyclase PLC(effector) splits PIP2 into *DAG stimulate PKC *IP3 simulate release of *Ca++ activates CamK memory *secondmsgers DAG IP3 Ca++ CAMP G-Protein complex either activates ion channel or enzyme. What comes after the ion channel = effector which creates the second msger Transmitter Gated Vs Voltage both let in ions gated chemical attaches to change conformation.

Search neuro1 exams study aids .Increasing the length constant makes it more effective +length constant ‡More voltage gated Na sodium ‡fatter dendrite ‡fewer atom channels Neuroanatomy (*Do self quizzes) Anterior Rostral ^ Cv In the brain. ventral is anterior and dorsal is posterior. rostral + anterior = same caudial is posterior Posterior In spinal cord.

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