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Pa Tho Physiology of Chronic Renal Failure

Pa Tho Physiology of Chronic Renal Failure

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Published by joanibaby

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Published by: joanibaby on Nov 21, 2010
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02/03/2012

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Pathophysiology of Chronic Renal Failure Risk Factors

MODIFIABLE NON MODIFIABLE

 Increased obesity –related to hypertension  And Diabetes Mellitus in sedentary  Lifestyle Hypertension)  Smoking  alcohol drinking

Age ( 55 and above) Family History ( Diabetes Mellitus

Thickening and/or an in the amount of collagen in the basement membranes of the small vessels

Impaired sluggish blood flow

Glomerulosclrerosis

Renal Blood Proteinuria

(Decrease GFR) - - - Glomerular Filtration Rate - - -

More than 75% damaged Normal BUN Creatinine

-

- - - Diminished Renal Reserve - - (GFR 50%)

Creatinine (GFR 20-50%) levels begin to rise Remaining nephrons undergo changes to compensate for those damage nephrons Filtration or more concentrated blood by the remaining nephrons --- Hypertrophy of the nephrons Intolerance and exhaustion of the remaining nephrons Further damage of the nephrons Stage III Renal Failure (GFR 10-20%) --90% Damage Impaired Renal Function --Uremia 80- .Stage II Renal Insufficiency BUN.

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Increase Obesity relate to Hypertension .

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