Contents…………

Titles 1. Introduction 2. Definition 3. Correlation between Preformulation and formulation 4. Steps in Preformulation Process Pharmaceutical Research 4.1. Stability 4.2. Solid State Compatibility 4.3. Physico-chemical Properties 4.4. Physico-mechanical Properties 4.5. In Vitro Availability Properties 4.6. Other Studies 5. Preformulation drug characterization program 5.1 UV Spectroscopy 5.2 Solubility Determination 5.3 Melting Point 5.4 Particle Size, Shape and Surface Area 5.5 Power Flow Properties 5.6 Chemical stability profile 5.7 Compatibility studies 5.8 Solution phase stability 5.9 Absorption behavior 6. Conclusion References 19 20 05 Page No. 01 01 02 03

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