IMUNOLOGI

Assalamu¶alaikum.. Hi semua,, udahbeberapaharininggaada posting baru, nah kali iniAne mw posting satutopik yang pentingtukteman-temansemua,, Nah teman-temansemuatentunya dong apaituimunologi, jadiAne rasa nggaperludijelasinlagiapatuimunologi,, So dalam posting kali iniAnemauberbagisamatemansemuaklo yang satuinikyknyperludiketahuidanpentinguntukdipahamiapalagibagi yang lagibelajartentangpenyakit yang berkaitandengan system imun,,, Silakan di baca and semogabermanfaat, amin,,

TABLE 42-1 -- CLUSTER OF DIFFERENTIATION (CD) MARKERS AND THEIR FUNCTIONS CD Antigen Main Cellular Expression Ligand Major Function CD1a±e Cortical thymocytes, dendritic T-cell receptor cells, B cells, intestinal epithelium (CD1d) T cells, thymocytes, NK cells Thymocytes, T cells CD48, CD58 MHC class I±like molecules, presentation of nonpeptide antigens to T cells T-cell activation, adhesion; also called LFA-2 Associated with the T-cell antigen receptor, T-cell signaling complex MHC class II molecules Coreceptor to T-cell receptor, signal transduction Coreceptor to T-cell receptor, signal transduction Pairs with CD18 to form LFA-1 (integrin), cell adhesion and migration Pairs with CD18, -chain of complement receptor CR3, cell adhesion Pairs with CD18, -chain of complement receptor CR4, cell adhesion Associates with TLR4, cell activation Cell activation, phagocytosis,

CD2 CD3

CD4 CD8 CD11a

Helper T cells, monocytes, macrophages

Cytotoxic T cells, NK cells ( - MHC class I chain) molecules T cells, B cells, NK cells, monocyte/macrophage, neutrophils Dendritic cells, monocytes/macrophages, NK cells, neutrophils Dendritic cells, monocytes, neutrophils Monocytes/macrophages, neutrophils NK cells, ICAM-1 to -4

CD11b

ICAM-1, complement component iC3b ICAM-1, complement component iC3b LPS IgG Fc

CD11c

CD14 CD16

neutrophils Ligand Major Function ATCC CD18 T cells. dendritic cells Lymphocytes. also called PECAM-1 Low-affinity Fc receptor Fc RII. endothelial cells B cells. oxidized LDL CD154 (CD40 ligand) Hyaluronic acid Coreceptor for B-cell activation. collagens. B cells. neutrophils B cells B cells B cells ICAM Cell adhesion CD19 CD20 CD21 Coreceptor for B-cell receptor. endothelial cells Monocytes/macrophages. complement receptor 2 Low-affinity Fc receptor for IgE. follicular dendritic cells Activated T and B cells. platelets. Matrix components Also called VLA-1 through - . signal transduction Regulates B-cell activation Complement component C3d. memory T cells.CD Antigen Main Cellular Expression monocytes/macrophages. monocytes/macrophages. alternative splicing produces multiple isoforms that correlate with cell differentiation CD49a±f B cells. EBV IgE IL-2 CD70 CD80/CD86 CD38 IgG CD62 (L-selectin) Thrombospondin. naïve T cells. NK cells T cells. eosinophils. NK cells. NK cells T cells Endothelial cells. monocytes. augments signaling. B cells Myeloid cells. myeloid cells. myeloid cells Leukocytes CD40 CD44 CD45 B cell/dendritic cell costimulation Leukocyte homing Tyrosine phosphatase. B-cell activation Growth factor receptor Costimulation Costimulation Adhesion. phagocytosis Adhesion Scavenger receptor CD23 CD25 CD27 CD28 CD31 CD32 CD34 CD36 Mature B cells. B cells Hematopoietic stem cells.

adhesion E-selectin. monocytes Platelets. T cells. CD152 (CTLA-4) MHC class I molecules CD28. T cells. macrophages. phagocytic activity Associated with the B-cell antigen receptor. B cells. monocytes Activated T cells Activated T cells CD28. CD86 CD40 Adhesion. dendritic cells. activated B cells T cells. adhesion. mediates rolling of neutrophils High-affinity Fc receptor (Fc RI) Cytoplasmic localization. associates with CD29 to form integrins. rhinovirus Adhesion molecule.CD Antigen Main Cellular Expression monocytes Ligand Major Function 6. endothelial cells Monocytes/macrophages Monocytes/macrophages. also called ICAM2 Negative regulatory signal. NK cells Wide distribution Endothelial cells. CD152 (CTLA-4) HLA-E Costimulatory ligand ILT family. activated B cells T cell subsets. mediates leukocyte rolling L-selectin. B cells. mostly inhibition Costimulatory ligand Inhibition of cell activation CD86 CD94 CD95 CD102 CD152 CD154 CD178 (Fas-ligand) Induces apoptosis. also called Fas CD11a/CD18 CD80. NK cells. neutrophils B cells CD11a/CD18. endothelial cells NK cells Hematopoietic. also called ICAM-1 Adhesion CD56 CD58 CD62E CD62L CD62P CD64 CD68 CD79a/b CD2 Sialyl-Lewis X CD34 Sialyl-Lewis X IgG LDL LFA-3. macrophages. also called CTLA-4 Provides costimulatory signal . adhesion CD54 T cells. monocytes/macrophages Dendritic cells. endothelial and epithelial cells Endothelial cells B cells. adhesion. B cells. monocytes/macrophages. adhesion. NK cells. signal transduction CD80 CD85 Dendritic cells. mediates rolling P-selectin. modulates cell activation.

inhibition of TH1 cells . T-cell expressed and secreted. also called PAMPs TLR1±9 CD281± 289 Dendritic cell. CCL = CC chemokine ligand. NK cells HLA-E CD178 CD195 Activated T cells. also called CCR5 CD158a± T-cell subsets. Cell activation. Fc = crystallizable fragment of immunoglobulin. EBV = Epstein-Barr virus. RANTES = regulated on activation. IgG = immunoglobulin G. MIP = macrophage inflammatory protein. HLA = human leukocyte antigen. TABLE 42-2 -. dendritic cells Chemokines CCL19 Chemokine receptor. mast cells Proliferation of T cells. also called CCR7 Microbial products. MIP-1 CD197 Naïve and memory T cells. also called killer immunoglobulin-like receptor Associates with CD94. TLR = toll-like receptor. ICAM = intercellular adhesion molecule. LFA = leukocyte function±associated antigen. IL = interleukin. NK cells k CD159a/c T cell subsets. B cells. LPS = lipopolysaccharide. negative (a) and positive (c) regulatory signal Induces apoptosis Chemokine receptor. monocytes. MHC = major histocompatibility complex. PAMPs = pathogen-associated molecular patterns. CCR = CC chemokine receptor. VLA = vascular leukocyte adhesion molecule. HIV = human immunodeficiency virus. LDL = lowdensity lipoprotein. CTLA = cytotoxic T-lymphocyte antigen.CYTOKINES AND CYTOKINE FUNCTION Cytokines Major Producer Cells Principal Action HEMATOPOIETIN FAMILY IL-2 IL-3 IL-4 T cells T cells T cells. various tissue cells Effector T cells. ILT = immunoglobin-like transcripts. induces migration to peripheral tissue. B cells. and NK cells Early hematopoiesis B-cell activation. neutrophils CD95 RANTES. NK = natural killer. MIP-1 . IgE switch. induces and CCL21 migration to secondary lymphoid tissue. coreceptor for HIV. PECAM = platelet endothelial cell adhesion molecule. monocyte ADCC = antibody-dependent cellular cytotoxicity.CD Antigen Main Cellular Expression Ligand MHC class I molecules Major Function Positive and negative regulatory signals. IgE = immunoglobulin E.

costimulation Suppression of macrophage functions NK cell activation. endothelial activation.Cytokines IL-5 IL-6 IL-7 IL-9 IL-11 IL-13 G-CSF IL-15 GM-CSF Major Producer Cells Principal Action T cells. lymphoid organ development Cell death.T cells. endothelial cell activation. endothelial cells Bone marrow. B cells ) LTOTHERS TGFIL-1 . IL1 IL-10. inhibition of TH1 cells and macrophages Neutrophil development and differentiation Growth of T cells and NK cells Growth and differentiation of myelomonocytic lineage cells Antiviral. B cells . T cells.(LT. lymphoid organ development Anti-inflammatory. induces IgA secretion Acute phase response. monocytes. TH1 cell differentiation Chemoattractant for CD4 T cells. increases MHC class I expression Antiviral. dendritic cells T cells. inhibits cell growth. fever. induction of acute phase proteins Growth of pre-B cells and pre-T cells Stimulates mast cells and TH2 cells Hematopoiesis B-cell growth and differentiation. macrophages Macrophages. Ig class switching. T cells TNF. inhibition of TH2 cells Induction of proinflammatory cytokines. T cells Macrophages. mast cells Macrophages. increases MHC class I expression Macrophage activation. T cells Eosinophil growth and differentiation T-cell and B-cell growth and differentiation. and INTERFERON FAMILY IFNIFNIFNLeukocytes Fibroblasts T cells. endothelial cells T cells. NK cells. thymic epithelium T cells Stromal fibroblasts T cells Fibroblasts and monocytes Non-T cells Macrophages. apoptosis Cell death. mast cells. macrophage activation. increases expression of MHC molecules. IL1 IL-12 IL-16 Monocytes. NK cells TNF FAMILY TNFMacrophages.

MHC = major histocompatibility complex. TH = helper T lymphocyte. G-CSF = granulocyte colony-stimulating factor. TNF = tumor necrosis factor. endothelia. GM-CSF = granulocyte-macrophage colony-stimulating factor.production by T cells and NK cells CD = cluster of differentiation. IFN = interferon. . IL = interleukin.Cytokines IL-17 IL-18 Major Producer Cells Principal Action eosinophils CD4 memory cells Macrophages eosinophils Cytokine production by epithelia. TGF = transforming growth factor. NK = natural killer. and fibroblasts IFN. Ig = immunoglobulin. LT = lymphotoxin.

Sign up to vote on this title
UsefulNot useful