Generic Name

Furosemide Brand Name Classification Dosage Mode of Action Indication Lasix, Furoside, Apo-Furosemide, Novosemide, Anti-hypertensive, Diuretic 40mg Inhibits Sodium abd water reabsorption in the loop of henle and increases urine formation. To reduce edema caused by cirrhosis, heart failure, and renal disease, including nephritic syndrome.

Contraindication

Anuria unresponsive to furosemide

Hypersensitivity to furosemide

Sulphonamides

Drug interactions

Drug- drug • • • • • Increased risk of ototoxicity with ACE inhibitors Increased risk of arrhythmias from hypokalemia with amiodarone Increased risk of digitalis toxicity realted to hypokalemia with digoxin Increased risk of lithium toxicity with lithium Decreased dieresis with NSAIDS

Adverse Effects

Adverse Effects CNS: Diziness, feverm headache, paresthesia, restlessness, vertigo, weakness CV: Orthostatic hypotension, shock, thrombophlebitis GI: abdominal cramps, anorexia, constipation, diarrhea, gastric irritation, indigestion, jaundice

Nursing Responsibilites

1. Obtain patient’s weight before and periosically during furosemide therapy to monitor fluid loss 2. For once a day dosing, give the drug in the morning so patient’s sleep won’t be interrupted by by the increased need to urinate. 3. Expect patient to have periodic hearing tests during prolonged or high-dose IV therapy. 4. Monitor blood pressure and hepatic renal functionas well as BUN, Bblood glucose, and serum creatinine, electrolyte, and uric acid levels, as appropriate. 5. Expect to discontinue furosemide at maximum dosage if oliguria persisits for more than 24 hours. 6. Be aware that the elderly patients are more susceptible to hypotensive, and electrolytealtering effects and thus at a greater risk for shock and thromboembolism.

7. If patient is at a high risk for hypokalemia, give potassium supplements along with furosemide as prescribed. 8. Be aware that furosemide may worsen left ventricular hypertrophy and adversely affect glucose tolerance and lipid metabolism.

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