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Osteosarcoma- is an aggressive cancerous neoplasm arising from primitive transformed cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid. It is the most common form of primary bone cancer. Incidence Osteosarcoma is the eighth most common form of childhood cancer, comprising 2.4% of all malignancies in pediatric patients, and approximately 20% of all bone cancers. Incidence rates for osteosarcoma in U.S patients under 20 years of age are estimated at 5.0 per million per year in the general population. Causes The cause of osteosarcoma are not known Symptoms Many patients first complain of pain that may be worse at night, and may have been occurring for some time. If the tumor is large, it can appear as a swelling. The affected bone is not as strong as normal bone and may fracture with minor trauma. Diagnostic exam X-RAY CBC TISSUE BIOPSY Treatment
Current standard treatment is to use neoadjuvant chemotherapy (chemotherapy given before surgery) followed by surgical resection. . Amputation is the initial treatment.Patients with osteosarcoma are best managed by a medical oncologist and an orthopedic oncologist experienced in managing sarcomas.