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**Copyright c 2010 by Nob Hill Publishing, LLC
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1

General Mole Balance

R

j

V

Q

1

c

j1

Q

0

c

j0

Conservation of mass

¸

¸

¸

¸

¸

¸

rate of

accumulation

of component j

¸

¸

¸

¸

¸

¸

¸

=

rate of inﬂow

of component j

−

rate of outﬂow

of component j

+

¸

¸

¸

¸

¸

¸

rate of generation

of component j by

chemical reactions

¸

¸

¸

¸

¸

¸

¸

(1)

2

General Mole Balance

R

j

V

Q

1

c

j1

Q

0

c

j0

Conservation of mass

d

dt

V

c

j

dV = Q

0

c

j0

−Q

1

c

j1

+

V

R

j

dV (2)

3

General Mole Balance

d

dt

V

c

j

dV = Q

0

c

j0

−Q

1

c

j1

+

V

R

j

dV

• Equation 2 applies to every chemical component in the system, j =

1, 2, . . . , n

s

, including inerts, which do not take place in any reactions.

• Assuming component j enters and leaves the volume element only by con-

vection with the inﬂow and outﬂow streams, i.e. neglecting diffusional ﬂux

through the boundary of the volume element due to a concentration gradient.

• The diffusional ﬂux will be considered during the development of the material

balance for the packed-bed reactor.

4

Rate expressions

• To solve the reactor material balance, we require an expression for the pro-

duction rates, R

j

R

j

=

¸

i

ν

ij

r

i

• Therefore we require r

i

as a function of c

j

• This is the subject of chemical kinetics, Chapter 5

• Here we use common reaction-rate expressions without derivation

5

The Batch Reactor

R

j

• The batch reactor is assumed well stirred

• Let the entire reactor contents be the reactor volume element

6

Batch Reactor

d

dt

V

c

j

dV = Q

0

c

j0

−Q

1

c

j1

+

V

R

j

dV

• Because the reactor is well stirred, the integrals in Equation 2 are simple to

evaluate,

V

R

c

j

dV = c

j

V

R

V

R

R

j

dV = R

j

V

R

• The inﬂow and outﬂow stream ﬂowrates are zero, Q

0

= Q

1

= 0.

d

c

j

V

R

dt

= R

j

V

R

(3)

7

Reactor Volume

• Equation 3 applies whether the reactor volume is constant or changes during

the reaction.

• If the reactor volume is constant (liquid-phase reactions)

dc

j

dt

= R

j

(4)

• Use Equation 3 rather than Equation 4 if the reactor volume changes signiﬁ-

cantly during the course of the reaction.

8

Analytical Solutions for Simple Rate Laws

• In general the material balance must be solved numerically.

• If the reactor is isothermal, we have few components, the rate expressions

are simple, then analytical solutions of the material balance are possible.

• We next examine derive analytical solutions for some classic cases.

9

First-order, irreversible

• Consider the ﬁrst-order, irreversible reaction

A

k

→ B, r = kc

A

(5)

• The material balance for a constant-volume reactor gives

dc

A

dt

= −kc

A

(6)

• Watch the sign!

10

First-order, irreversible

• We denote the initial concentration of A as c

A0

,

c

A

(t) = c

A0

, t = 0

• The solution to the differential equation with this boundary condition is

c

A

= c

A0

e

−kt

(7)

11

First-order, irreversible

12

0

0.2

0.4

0.6

0.8

1

0 1 2 3 4 5

t

k = 0.5

k = 1

k = 2

k = 5

c

A

c

A0

13

First-order, irreversible

• The A concentration decreases exponentially fromits initial value to zero with

increasing time.

• The rate constant determines the shape of this exponential decrease. Rear-

ranging Equation 7 gives

ln(c

A

/c

A0

) = −kt

14

First-order, irreversible

0.001

0.01

0.1

1

0 1 2 3 4 5

t

k = 0.5

k = 1

k = 2

k = 5

c

A

c

A0

• One can get an approximate value of the rate constant from the slope of the

straight line.

15

• This procedure is a poor way to determine a rate constant and should be

viewed only as a rough approximation (Chapter 9).

16

First-order, irreversible

The B concentration is determined from the A concentration.

1. Solve the material balance for component B,

dc

B

dt

= R

B

= kc

A

(8)

with the initial condition for B, c

B

(0) = c

B0

2. Note that the sum of c

A

and c

B

is constant.

d(c

A

+c

B

)

dt

= R

A

+R

B

= 0

Therefore, c

A

+c

B

is a constant.

17

First-order, reversible

• The value is known at t = 0,

c

A

+c

B

= c

A0

+c

B0

• So we have an expression for c

B

c

B

= c

A0

+c

B0

−c

A

(9)

c

B

= c

B0

+c

A0

(1 −e

−kt

) (10)

18

First-order, reversible

• Consider now the same ﬁrst-order reaction, but assume it is reversible

A

k

1

k

−1

B (11)

• The reaction rate is r = k

1

c

A

−k

−1

c

B

.

• The material balances for A and B are now

dc

A

dt

= −r = −k

1

c

A

+k

−1

c

B

c

A

(0) = cA0

dc

B

dt

= r = k

1

c

A

−k

−1

c

B

c

B

(0) = c

B0

• Notice that c

A

+c

B

= c

A0

+c

B0

remains constante

19

First-order, reversible

• Eliminate c

B

in the material balance for A gives

dc

A

dt

= −k

1

c

A

+k

−1

(c

A0

+c

B0

−c

A

) (12)

• How do we want to solve this one?

• Particular solution and homogeneous solution (see text)

• Laplace transforms (control course)

• Separation!

20

First-order, reversible

dc

A

dt

= ac

A

+b

c

A

c

A0

dc

A

ac

A

+b

=

t

0

dt

1

a

ln(ac

A

+b)

¸

¸

¸

¸

c

A

c

A0

= t

c

A

= c

A0

e

at

−

b

a

(1 −e

at

)

Substitute a = −(k

1

+k

−1

), b = k

−1

(c

A0

+c

B0

)

21

First-order, reversible

c

A

= c

A0

e

−(k

1

+k

−1

)t

+

k

−1

k

1

+k

−1

(c

A0

+c

B0

)

¸

1 −e

−(k

1

+k

−1

)t

¸

(13)

• The B concentration can be determined by switching the roles of A and B and

k

1

and k

−1

in Reaction 11, yielding

c

B

= c

B0

e

−(k

1

+k

−1

)t

+

k

1

k

1

+k

−1

(c

A0

+c

B0

)

¸

1 −e

−(k

1

+k

−1

)t

¸

(14)

22

First-order, reversible

0

0.2

0.4

0.6

0.8

1

0 1 2 3 4 5

t

c

B

(t)

c

A

(t)

c

As

c

Bs

c

Figure 1: First-order, reversible kinetics in a batch reactor, k

1

= 1, k

−1

= 0.5,

c

A0

= 1, c

B0

= 0.

23

Nonzero steady state

• For the reversible reaction, the concentration of A does not go to zero.

• Taking the limit t → ∞ in Equation 13 gives

c

As

=

k

−1

k

1

+k

−1

(c

A0

+c

B0

)

in which c

As

is the steady-state concentration of A.

24

Nonzero steady state

• Deﬁning K

1

= k

1

/k

−1

allows us to rewrite this as

c

As

=

1

1 +K

1

(c

A0

+c

B0

)

• Performing the same calculation for c

B

gives

c

Bs

=

K

1

1 +K

1

(c

A0

+c

B0

)

25

Second-order, irreversible

• Consider the irreversible reaction

A

k

→ B (15)

in which the rate expression is second order, r = kc

2

A

.

• The material balance and initial condition are

dc

A

dt

= −kc

2

A

, c

A

(0) = c

A0

(16)

• Our ﬁrst nonlinear differential equation.

26

Second-order, irreversible

• Separation works here

dc

A

c

2

A

= −kdt

c

A

c

A0

dc

A

c

2

A

= −k

t

0

dt

1

c

A0

−

1

c

A

= −kt

• Solving for c

A

gives

c

A

=

1

c

A0

+kt

¸

−1

(17)

• Check that this solution satisﬁes the differential equation and initial condition

27

Second-order, irreversible

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1

0 1 2 3 4 5

ﬁrst order

second order

c

A

c

A0

• The second-order reaction decays more slowly to zero than the ﬁrst-order

reaction.

28

Another second-order, irreversible

A+B

k

→ C r = kc

A

c

B

(18)

• The material balance for components A and B are

dc

A

dt

= −r = −kc

A

c

B

(19)

dc

B

dt

= −r = −kc

A

c

B

(20)

• Subtract B’s material balance from A’s to obtain

d(c

A

−c

B

)

dt

= 0

29

Another second-order, irreversible

• Therefore, c

A

−c

B

is constant, and

c

B

= c

A

−c

A0

+c

B0

(21)

• Substituting this expression into the material balance for A yields

dc

A

dt

= −kc

A

(c

A

−c

A0

+c

B0

)

• This equation also is separable and can be integrated to give (you should

work through these steps),

c

A

= (c

A0

−c

B0

)

¸

1 −

c

B0

c

A0

e

(c

B0

−c

A0

)kt

−1

, c

A0

≠ c

B0

(22)

30

Another second-order, irreversible

• Component B can be computed from Equation 21, or by switching the roles

of A and B in Reaction 18, giving

c

B

= (c

B0

−c

A0

)

¸

1 −

c

A0

c

B0

e

(c

A0

−c

B0

)kt

−1

(23)

• What about component C? C’s material balance is

dc

C

dt

= kc

A

c

B

and therefore, d(c

A

+c

C

)/dt = 0. The concentration of C is given by

c

C

= c

A0

−c

A

+c

C0

31

Another second-order, irreversible

• Notice that if c

A0

> c

B0

(Excess A), the steady state

c

As

= c

A0

−c

B0

c

Bs

= 0

c

Cs

= c

B0

+c

C0

• For c

B0

> c

A0

(Excess B), the steady state is

c

As

= 0

c

Bs

= c

B0

−c

A0

c

Cs

= c

A0

+c

C0

32

nth-order, irreversible

The nth-order rate expression r = kc

n

A

33

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

5

0 0.5 1 1.5 2 2.5 3

c

A

r

n = 3

2

1

1/2

0

34

nth-order, irreversible

A

k

→ B r = kc

n

A

dc

A

dt

= −r = −kc

n

A

• This equation also is separable and can be rearranged to

dc

A

c

n

A

= −kdt

• Performing the integration and solving for c

A

gives

c

A

=

¸

c

−n+1

A0

+(n−1)kt

¸

1

−n+1

, n ≠ 1

35

nth-order, irreversible

• We can divide both sides by c

A0

to obtain

c

A

c

A0

= [1 +(n−1)k

0

t]

1

−n+1

, n ≠ 1 (24)

in which

k

0

= kc

n−1

A0

has units of inverse time.

36

nth-order, irreversible

0

0.2

0.4

0.6

0.8

1

0 1 2 3 4 5

t

1

2

3

4

n = 5

c

A

c

A0

• The larger the value of n, the more slowly the A concentration approaches

zero at large time.

37

nth-order, irreversible

• Exercise care for n < 1, c

A

reaches zero in ﬁnite time.

0

0.2

0.4

0.6

0.8

1

0 0.5 1 1.5 2

t

c

A

c

A0 n = 2

1

1/2

0

−1/2 −1 −2

38

Negative order, inhibition

• For n < 0, the rate decreases with increasing reactant concentration; the

reactant inhibits the reaction.

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

5

0 0.5 1 1.5 2 2.5 3

c

A

r

0

−1/2

−1

n=−2

39

Negative order, inhibition

• Inhibition reactions are not uncommon, but watch out for small concentra-

tions. Notice the rate becomes unbounded as c

A

approaches zero, which is

not physically realistic.

• When using an ODE solver we may modify the right-hand sides of the material

balance

dc

A

dt

=

−kc

n

A

, c

A

> 0

0, c

A

= 0

• Examine the solution carefully if the concentration reaches zero.

40

Two reactions in series

• Consider the following two irreversible reactions,

A

k

1

→ B (25)

B

k

2

→ C (26)

• Reactant A decomposes to form an intermediate B that can further react to

form a ﬁnal product C.

• Let the reaction rates be given by simple ﬁrst-order rate expressions in the

corresponding reactants,

r

1

= k

1

c

A

r

2

= k

2

c

B

41

Two reactions in series

• The material balances for the three components are

dc

A

dt

= R

A

= −r

1

= −k

1

c

A

dc

B

dt

= R

B

= r

1

−r

2

= k

1

c

A

−k

2

c

B

dc

C

dt

= R

C

= r

2

= k

2

c

B

• The material balance for component A can be solved immediately to give

c

A

= c

A0

e

−k

1

t

as before.

42

Two reactions in series – B

• The material balance for B becomes

dc

B

dt

+k

2

c

B

= k

1

c

A0

e

−k

1

t

Oops, not separable, now what?

• Either Laplace transform or particular solution, homogeneous equation ap-

proach produces

c

B

= c

B0

e

−k

2

t

+c

A0

k

1

k

2

−k

1

¸

e

−k

1

t

−e

−k

2

t

¸

, k

1

≠ k

2

(27)

43

Two reactions in series – C

• To determine the C concentration, notice from the material balances that

d(c

A

+c

B

+c

C

)/dt = 0. Therefore, c

C

is

c

C

= c

A0

+c

B0

+c

C0

−c

A

−c

B

44

Two reactions in series

0

0.2

0.4

0.6

0.8

1

0 1 2 3 4 5

t

c

A

(t)

c

B

(t)

c

C

(t)

c

Figure 2: Two ﬁrst-order reactions in series in a batch reactor, c

A0

= 1,

c

B0

= c

C0

= 0, k

1

= 2, k

2

= 1.

45

Two reactions in parallel

• Consider next two parallel reactions of A to two different products, B and C,

A

k

1

→ B (28)

A

k

2

→ C (29)

• Assume the rates of the two irreversible reactions are given by r

1

= k

1

c

A

and

r

2

= k

2

c

A

.

46

Two reactions in parallel

• The material balances for the components are

dc

A

dt

= R

A

= −r

1

−r

2

= −k

1

c

A

−k

2

c

A

dc

B

dt

= R

B

= r

1

= k

1

c

A

dc

C

dt

= R

C

= r

2

= k

2

c

A

47

Two reactions in parallel

• The material balance for A can be solved directly to give

c

A

= c

A0

e

−(k

1

+k

2

)t

(30)

• Substituting c

A

(t) into B’s material balance gives

dc

B

dt

= k

1

c

A0

e

−(k

1

+k

2

)t

• This equation is now separable and can be integrated directly to give

c

B

= c

B0

+c

A0

k

1

k

1

+k

2

1 −e

−(k

1

+k

2

)t

(31)

48

Two reactions in parallel

• Finally, component C can be determined from the condition that c

A

+c

B

+c

C

is constant or by switching the roles of B and C, and k

1

and k

2

in Equation 31,

c

C

= c

C0

+c

A0

k

2

k

1

+k

2

1 −e

−(k

1

+k

2

)t

(32)

49

Two reactions in parallel

0

0.2

0.4

0.6

0.8

1

0 0.5 1 1.5 2 2.5 3

t

c

A

(t)

c

B

(t)

c

C

(t)

c

Figure 3: Two ﬁrst-order reactions in parallel in a batch reactor, c

A0

= 1,

c

B0

= c

C0

= 0, k

1

= 1, k

2

= 2.

50

Two reactions in parallel

• Notice that the two parallel reactions compete for the same reactant, A

• The rate constants determine which product is favored

• Large values of k

1

/k

2

favor the formation of component B compared to C and

vice versa

51

Conversion, Yield, Selectivity

There are several ways to deﬁne selectivity, yield and conversion, so be clear

about the deﬁnition you choose.

Point selectivity: The point (or instantaneous) selectivity is the ratio of the production rate of

one component to the production rate of another component.

Overall selectivity: The overall selectivity is the ratio of the amount of one component pro-

duced to the amount of another component produced.

Yield: The yield of component j is the fraction of a reactant that is converted into component

j.

Conversion: Conversion is normally deﬁned to be the fraction of a component that has been

converted to products by the reaction network. Conversion has several deﬁnitions and

conventions. It is best to state the deﬁnition in the context of the problem being solved.

52

The Continuous-Stirred-Tank Reactor (CSTR)

Q

c

j

Q

f

c

jf

R

j

Writing the material balance for this reactor gives

d

c

j

V

R

dt

= Q

f

c

jf

−Qc

j

+R

j

V

R

, j = 1, . . . , n

s

(33)

53

CSTR – Constant Density

• If the reactor volume is constant and the volumetric ﬂowrates of the inﬂow

and outﬂow streams are the same, Equation 33 reduces to

dc

j

dt

=

1

τ

(c

jf

−c

j

) +R

j

(34)

• The parameter

τ = V

R

/Q

f

is called the mean residence time of the CSTR.

• We refer to this balance as the constant-density case. It is often a good ap-

proximation for liquid-phase reactions.

54

CSTR – Steady State

• The steady state of the CSTR is described by setting the time derivative in

Equation 33 to zero,

0 = Q

f

c

jf

−Qc

j

+R

j

V

R

(35)

• Conversion of reactant j is deﬁned for a steady-state CSTR as follows

x

j

=

Q

f

c

jf

−Qc

j

Q

f

c

jf

(steady state) (36)

• One can divide Equation 35 through by V

R

to obtain for the constant-density

case

c

j

= c

jf

+R

j

τ (steady state, constant density) (37)

55

Transient behavior of the CSTR

• Consider a ﬁrst-order, liquid-phase reaction in an isothermal CSTR

A

k

→ 2B r = kc

A

the feed concentration of A is c

Af

= 2 mol/L, the residence time of the reactor

is τ = 100 min, and the rate constant is k = 0.1 min

−1

.

1. Find the steady-state concentration of A in the efﬂuent for the given feed.

2. Plot the concentration of A versus time for constant feed concentration c

Af

= 2 mol/L if

the reactor is initially ﬁlled with an inert so c

A0

= 0 mol/L.

3. Plot the concentration of A versus time for constant feed concentration c

Af

= 2 mol/L if

the reactor is initially ﬁlled with feed so c

A0

= 2 mol/L.

56

Transient CSTR Solution. Part 1

• Liquid phase: assume the ﬂuid density is constant.

c

A

= c

Af

+R

A

τ

• Substituting the production rate R

A

= −kc

A

and solving for c

A

gives the

steady-state concentration

c

As

=

c

Af

1 +kτ

• Substituting in the numerical values gives

c

As

=

2 mol/L

1 +(0.1 min

−1

)(100 min)

= 0.182 mol/L

57

Parts 2 and 3

dc

A

dt

=

1

τ

c

Af

−c

A

−kc

A

(38)

c

A

(0) = c

A0

• This equation is also separable. The analytical solution is

c

A

(t) = c

A0

e

−(1/τ+k)t

+

c

Af

1 +kτ

¸

1 −e

−(1/τ+k)t

¸

(39)

58

Parts 2 and 3

0

0.5

1

1.5

2

0 10 20 30 40 50 60 70 80

t (min)

c

A

(

t

)

(

m

o

l

/

L

)

c

A0

= 0

c

A0

= 2

c

As

= 0.182

• Both solutions converge to the same steady-state even though the starting

conditions are quite different.

59

Phenol production in a CSTR

• Consider the reaction of cumene hydroperoxide (CHP) to phenol and acetone

(C

6

H

5

)C(CH

3

)

2

OOH → (C

6

H

5

)OH+(CH

3

)

2

CO (40)

CHP → phenol + acetone (41)

• The reaction is pseudo-ﬁrst-order

r = kc

CHP

• Find the reactor volume to achieve 85% conversion of CHP at steady state.

The ﬂowrate into the reactor is Q

f

= 26.9 m

3

/hr and k = 4.12 hr

−1

.

60

Phenol production

• Liquids at 85

◦

C, so assume constant density and Q = Q

f

.

c

A

= c

Af

+R

A

τ

R

A

= −kc

A

, and solving for the CHP concentration gives

c

A

=

c

Af

1 +kτ

(42)

61

Phenol production

• The conversion of CHP (for Q = Q

f

) is

x

A

=

c

Af

−c

A

c

Af

= 1 −

c

A

c

Af

x

A

=

kτ

1 +kτ

• Solving this equation for τ gives

τ =

1

k

x

A

1 −x

A

62

Phenol production

• Substituting the relation τ = V

R

/Q

f

and solving for V

R

gives

V

R

=

Q

f

x

A

k(1 −x

A

)

• Substituting in the known values gives the required CSTR volume

V

R

=

(26.9 m

3

/hr)(0.85)

(4.12 hr

−1

)(0.15)

= 37 m

3

63

The Semi-Batch Reactor

• The semi-batch reactor is a cross between the batch reactor and CSTR.

• The semi-batch reactor is initially charged with reactant, like the batch reac-

tor, but allows a feed addition policy while the reaction takes place, like the

CSTR.

• Normally there is no outﬂow stream.

64

The Semi-Batch Reactor

• We set Q = 0 in the CSTR material balance to obtain

d

c

j

V

R

dt

= Q

f

c

jf

+R

j

V

R

, j = 1, . . . , n

s

(43)

• One may choose to operate a semi-batch reactor to control the reaction rate

or heat release during reaction by slowly adding one of the reactants in the

feed stream.

• Compared to the batch reactor, the semi-batch reactor provides more com-

plete use of the reactor volume in reactions such as polymerizations that

convert from lower density to higher density during the course of the reac-

tion.

65

Volume Change Upon Reaction

d

c

j

V

R

dt

= Q

f

c

jf

−Qc

j

+R

j

V

R

(44)

• Equation 44 covers both the batch, CSTR and semi-batch reactors, depending

on how we specify Q

f

and Q.

• If we multiply Equation 44 by the molecular weight of species j and sum over

all species we obtain,

d(

¸

j

c

j

M

j

V

R

)

dt

= Q

f

¸

j

c

jf

M

j

−Q

¸

j

c

j

M

j

+

¸

j

R

j

M

j

V

R

(45)

• The term

¸

j

c

j

M

j

is simply the mass density of the reactor contents, which

66

we denote ρ

ρ =

n

s

¸

j=1

c

j

M

j

(46)

67

Volume Change Upon Reaction

• The term

¸

j

c

jf

M

j

is the mass density of the feedstream, ρ

f

.

• We knowthat conservation of mass in chemical reactions implies

¸

j

R

j

M

j

= 0

(see Chapter 2). Substitution into Equation 45 leads to

d(ρV

R

)

dt

= Q

f

ρ

f

−Qρ (47)

• Equation 47 is clearly a total mass balance, in which the total mass in the

reactor changes in time due to the inﬂow and outﬂow of mass.

• Notice that chemical reactions play no role in the total mass balance.

68

Equation of state for the mixture

• If we have a single-phase system at equilibrium, the intensive variables c

j

, T,

P, completely specify all intensive variables of the system.

• In this chapter we consider T and P to be known, ﬁxed quantities. Therefore,

the density of the reaction mixture, which is an intensive variable, is known

if the c

j

are known.

• This relationship is one form of the equation of state for the mixture

ρ =

`

f(T, P, c

1

, c

2

, . . . , c

n

s

)

• Substituting the deﬁnition of density, we can express the equation of state

as

f(c

1

, c

2

, . . . , c

n

s

) = 0

69

Equation of state for the mixture

• For example, we could express the equation of state in terms of the partial

molar volumes as

¸

j

c

j

V

j

= 1

in which V

j

is the partial molar volume of component j in the mixture.

• The partial molar volumes are functions of T, P and c

j

.

70

Equation of state for the mixture — Ideal mixture

• If we assume an ideal mixture, this reduces to

¸

j

c

j

V

◦

j

= 1, ideal mixture

in which V

◦

j

is the speciﬁc volume of pure component j, which is a function

of only T and P.

• We assume that a thermodynamic equation of state is valid even when the

reactor is not at equilibrium.

71

Constant density

• Because the reaction mixture density, ρ, is independent of composition, it

does not vary with time either and we can set it to the feed value,

ρ = ρ

f

(48)

• The total mass balance then reduces to

dV

R

dt

= Q

f

−Q (49)

which is sometimes referred to as a “volume balance.”

• This terminology should be avoided.

72

Constant density

dV

R

dt

= Q

f

−Q

• Batch reactor. For the batch reactor, Q = Q

f

= 0. We can therefore conclude

from Equation 49 that a batch reactor with constant density has constant

volume.

• CSTR (dynamic and steady state). If the outﬂow of the CSTR is regulated so

that the CSTR has constant volume, then we can conclude from Equation 49

that Q = Q

f

.

• Semi-batch reactor. In the semi-batch reactor, the reactor is ﬁlled during

operation so Q

f

is speciﬁed and positive for some time and Q = 0. The

solution to Equation 49 then determines the change in volume of the reactor

during the ﬁlling operation.

73

Nonconstant density

Unknowns.

• In the general case, consider the following variables to fully determine the

state of the reactor: T, P, n

j

, V

R

.

• We also require the value of Qto specify the right-hand sides of the material

balances.

• The set of unknowns is n

j

, V

R

, Q.

• We therefore have n

s

+2 unknowns.

Equations.

• We have the n

s

equations from the component mole balances.

• The equation of state provides one additional equation.

• The ﬁnal equation is provided by a statement of reactor operation.

74

Nonconstant density – reactor operation

1. Constant-volume reactor. The constant-volume reactor can be achieved by

allowing overﬂow of the reactor to determine ﬂowrate out of the reactor. In

this situation, V

R

is speciﬁed as the additional equation.

2. Constant-mass reactor. The constant-mass reactor can be achieved if a dif-

ferential pressure measurement is used to control the ﬂowrate out of the

reactor and the reactor has constant cross-sectional area. In this situation

ρV

R

is speciﬁed as the additional equation.

3. Flowrate out of the reactor is speciﬁed. This type of operation may be

achieved if the ﬂowrate out of the reactor is controlled by a ﬂow controller.

In this case Q(t) is speciﬁed. A semi-batch reactor is operated in this way

with Q = 0 until the reactor is ﬁlled with the reactants.

75

Nonconstant density – reactor operation

• See the text for the derivation.

dV

R

dt

= Q

f

¸

j

f

j

c

jf

¸

j

f

j

c

j

−Q+

¸

i

∆f

i

r

i

V

R

¸

j

f

j

c

j

(50)

• in which f

j

is

f

j

=

∂f

∂c

j

• and ∆f

i

is

∆f

i

=

¸

j

ν

ij

f

j

=

¸

j

ν

ij

∂f

∂c

j

which is a change in a derivative property upon reaction.

76

Nonconstant density – idea mixture

• For the ideal mixture we have f(c

j

) =

¸

j

c

j

V

◦

j

−1 = 0.

f

j

= V

◦

j

the pure component speciﬁc volumes

• The ∆f

i

are given by

∆f

i

= ∆V

◦

i

the change in speciﬁc volume upon reaction i.

• So the reactor volume can be calculated from

dV

R

dt

= Q

f

−Q+

¸

i

∆V

◦

i

r

i

V

R

77

Nonconstant density

Unknowns (n

s

+2): V

R

, Q, n

j

, j = 1, . . . , n

s

Component balances:

dn

j

dt

= Q

f

c

jf

−Qc

j

+R

j

V

R

, j = 1, . . . , n

s

Deﬁned quantities: n

j

= c

j

V

R

ρ =

¸

j

c

j

M

j

∆V

◦

i

=

¸

j

ν

ij

V

◦

j

(i) constant density: ρ = ρ

0

(ii) ideal mixture:

¸

j

c

j

V

◦

j

= 1

1. vol V

R

= V

R0

Q = Q

f

V

R

= V

R0

Q = Q

f

+

¸

i

∆V

◦

i

r

i

V

R

2. mass V

R

= V

R0

Q = Q

f

dV

R

dt

= Q

f

(1 −ρ

f

/ρ) +

¸

i

∆V

◦

i

r

i

V

R

Q = Q

f

ρ

f

/ρ

3. Q

dV

R

dt

= Q

f

−Q Q speciﬁed

dV

R

dt

= Q

f

−Q+

¸

i

∆V

◦

i

r

i

V

R

Q speciﬁed

Table 1: Reactor balances for constant-density and ideal-mixture assumptions.

78

Nonconstant density

Unknowns (n

s

+2): V

R

, Q, n

j

, j = 1, . . . , n

s

Component balances:

dn

j

dt

= Q

f

c

jf

−Qc

j

+R

j

V

R

, j = 1, . . . , n

s

Deﬁned quantities: n

j

= c

j

V

R

ρ =

¸

j

c

j

M

j

∆f

i

=

¸

j

ν

ij

∂f

∂c

j

Equation of state: f(c

1

, c

2

, . . . , c

n

s

) = 0

DAEs ODEs

1. vol V

R

= V

R0

f(c

j

) = 0 V

R

= V

R0

Q = Q

f

¸

j

f

j

c

jf

¸

j

f

j

c

j

+

¸

i

∆f

i

r

i

V

R

¸

j

f

j

c

j

2. mass ρV

R

= ρ

0

V

R0

f(c

j

) = 0

dV

R

dt

= Q

f

¸

j

f

j

c

jf

¸

j

f

j

c

j

−Q+

¸

i

∆f

i

r

i

V

R

¸

j

f

j

c

j

Q = Q

f

ρ

f

/ρ

3. Q Q speciﬁed f(c

j

) = 0

dV

R

dt

= Q

f

¸

j

f

j

c

jf

¸

j

f

j

c

j

−Q+

¸

i

∆f

i

r

i

V

R

¸

j

f

j

c

j

Q speciﬁed

Table 2: Reactor balances for general equation of state.

79

Semi-batch polymerization

• Consider a solution polymerization reaction, which can be modeled as a ﬁrst-

order, irreversible reaction

M

k

→ P r = kc

M

• A 20 m

3

semi-batch reactor is initially charged with solvent and initiator to

half its total volume.

• A pure monomer feed is slowly added at ﬂowrate Q

f0

= 1 m

3

/min to ﬁll the

reactor in semi-batch operation to control the heat release.

80

Semi-batch polymerization

• Consider two cases for the subsequent reactor operation.

1. The monomer feed is shut off and the reaction goes to completion.

2. The monomer feed is adjusted to keep the reactor ﬁlled while the reaction

goes to completion.

• Calculate the total polymer mass production, and the percentage increase in

polymer production achieved in the second operation.

81

The physical properties

• You may assume an ideal mixture

• The densities of monomer and polymer are

ρ

M

= 800 kg/m

3

ρ

P

= 1100 kg/m

3

• The monomer molecular weight is M

M

= 100 kg/kmol

• The rate constant is k = 0.1 min

−1

.

82

Semi-batch polymerization

• While the reactor is ﬁlling, the monomer mole balance is

d(c

M

V

R

)

dt

= Q

f0

c

Mf

−kc

M

V

R

in which c

Mf

= ρ

M

/M

M

is given, and Q

f

= Q

f0

is constant during the ﬁlling

operation.

• We denote the total number of moles of monomer by M = c

M

V

R

, and can

write the monomer balance as

dM

dt

= Q

f0

c

Mf

−kM (51)

M(0) = 0

83

Semi-batch polymerization

• For an ideal mixture, the volume is given by

dV

R

dt

= Q

f0

+∆VkM (52)

V

R

(0) = 10 m

3

in which ∆V = (1/ρ

P

−1/ρ

M

) M

M

84

The polymer mass production

• To compute the polymer mass, we note from the stoichiometry that the mass

production rate of polymer

`

R

P

is

`

R

P

= −R

M

M

M

• The mass balance for total polymer

`

P is given by

d

`

P

dt

=

`

R

p

V

R

= kc

M

M

M

V

R

= (kM

M

)M (53)

85

Semi-batch polymerization

• The text solves this problem analytically. Instead, let’s solve it numerically.

• Let t

1

be the time that the reactor ﬁlls.

• We need an ODE solver that is smart enough to stop when the reactor ﬁlls,

because we do not know this time t

1

. The ODE solver needs to ﬁnd it for us.

• dasrt is an ODE solver with the added capability to ﬁnd the time at which

some event of interest occurs.

86

Finding the time for ﬁlling the reactor

• The ODE solver ﬁnds the time at which V

R

= 20 m

3

t

1

= 11.2 min

• Note the reactor would have ﬁlled in 10 min if the density were constant.

• The extra time reﬂects the available volume created by converting some of

the monomer to polymer during ﬁlling.

• After t

1

we consider the two operations.

87

Operation 1.

• In the ﬁrst operation, Q

f

= 0 after t

1

.

• Notice the reactor volume decreases after t

1

because ∆V is negative.

88

Semi-batch polymerization

89

0

5

10

15

20

0 10 20 30 40 50

time (min)

V

R

(

m

3

)

2

1

Figure 4: Semi-batch reactor volume for primary monomer addition (operation

1) and primary plus secondary monomer additions (operation 2).

90

-0.2

0

0.2

0.4

0.6

0.8

1

0 10 20 30 40 50

time (min)

Q

f

(

m

3

/

m

i

n

)

2

1

Figure 5: Semi-batch reactor feed ﬂowrate for primary monomer addition (op-

eration 1) and primary plus secondary monomer additions (operation 2).

91

0

1000

2000

3000

4000

5000

6000

0 10 20 30 40 50

time (min)

m

o

n

o

m

e

r

(

k

g

)

2

1

Figure 6: Semi-batch reactor monomer content for primary monomer addition

(operation 1) and primary plus secondary monomer additions (operation 2).

92

0

2000

4000

6000

8000

10000

12000

0 10 20 30 40 50

time (min)

p

o

l

y

m

e

r

(

k

g

)

2

1

Figure 7: Semi-batch reactor polymer content for primary monomer addition

(operation 1) and primary plus secondary monomer additions (operation 2).

93

Operation 2.

• Because the reactor volume is constant, we can solve Equation 52 for the feed

ﬂowrate during the secondary monomer addition

Q

f

= −∆VkM

• Operation 2 is also shown in the ﬁgures.

• Notice the ﬁnal polymer production is larger in operation 2 because of the

extra monomer addition.

94

Polymer production rate

• We can perform an independent, simple calculation of the total polymer in

operation 2. Useful for debugging the computation.

• In operation 2, 10 m

3

of polymer are produced because in an ideal mixture,

the volumes are additive. Therefore

`

P

2

= (V

R

−V

R0

)ρ

P

= 10 m

3

×1100 kg/m

3

= 11000 kg

in good agreement with the long-time solution for operation 2.

• The increase in production rate is

`

P

2

−

`

P

1

`

P

1

×100% = 22.5%

95

• By using the volume of the reactor more efﬁciently, the total polymer produc-

tion increases 22.5%.

96

The Plug-Flow Reactor (PFR)

• Plug ﬂow in a tube is an ideal-ﬂow assumption in which the ﬂuid is well mixed

in the radial and angular directions.

• The ﬂuid velocity is assumed to be a function of only the axial position in the

tube.

• Plug ﬂow is often used to approximate ﬂuid ﬂow in tubes at high Reynolds

number. The turbulent ﬂow mixes the ﬂuid in the radial and angular direc-

tions.

• Also in turbulent ﬂow, the velocity proﬁle is expected to be reasonably ﬂat in

the radial direction except near the tube wall.

97

Thin Disk Volume Element

Given the plug-ﬂowassumption, it is natural to take a thin disk for the reactor

volume element

Q

c

j

Q(z +∆z)

c

j

(z +∆z)

Q(z)

c

j

(z)

Q

f

c

jf

z

R

j

∆V

z +∆z

. .. .

98

Thin Disk Volume Element

• Expressing the material balance for the volume element

∂

c

j

∆V

∂t

= c

j

Q

¸

¸

¸

z

− c

j

Q

¸

¸

¸

z+∆z

+R

j

∆V (54)

• Dividing the above equation by ∆V and taking the limit as ∆V goes to zero

yields,

∂c

j

∂t

. .. .

accumulation

= −

∂

c

j

Q

∂V

. .. .

convection

+ R

j

....

reaction

(55)

99

Length or volume as independent variable

• If the tube has constant cross section, A

c

, then velocity, v, is related to vol-

umetric ﬂowrate by v = Q/A

c

, and axial length is related to tube volume by

z = V/A

c

,

• Equation 55 can be rearranged to the familiar form [1, p.584]

∂c

j

∂t

= −

∂

c

j

v

∂z

+R

j

(56)

100

Steady-State Operation

• Setting the time derivative in Equation 55 to zero gives,

d(c

j

Q)

dV

= R

j

(57)

• The product c

j

Q = N

j

is the total molar ﬂow of component j. One also can

express the PFR mole balance in terms of the molar ﬂow,

dN

j

dV

= R

j

(58)

101

Volumetric Flowrate for Gas-Phase Reactions

• To use Equation 58 for designing a gas-phase reactor, one has to be able to

relate the volumetric ﬂowrate, Q, to the molar ﬂows, N

j

, j = 1, 2, . . . , n

s

.

• The important piece of information tying these quantities together is, again,

the equation of state for the reaction mixture, f(T, P, c

j

) = 0.

• Because the molar ﬂow and concentration are simply related,

N

j

= c

j

Q (59)

the equation of state is also a relation between temperature, pressure, molar

ﬂows, and volumetric ﬂowrate.

102

Ideal Gas Equation of State

• The ideal-gas equation of state, c = P/RT, can be stated in terms of molar

concentrations, c

j

, as

¸

j

c

j

=

P

RT

• In terms of molar ﬂows, the equation of state is

¸

j

N

j

Q

=

P

RT

• One can solve the previous equation for the volumetric ﬂowrate,

Q =

RT

P

¸

j

N

j

(60)

103

Ideal Gas Equation of State

• To evaluate the concentrations for use with the reaction rate expressions, one

simply rearranges Equation 59 to obtain

c

j

=

N

j

Q

=

P

RT

N

j

¸

j

N

j

(61)

104

Volumetric Flowrate for Liquid-Phase Reactions

• Consider the equation of state for a liquid-phase system to be arranged in

the form

ρ = f(T, P, c

j

)

• The mass density is related to the volumetric ﬂowrate and total mass ﬂow,

M =

¸

j

N

j

M

j

, via

M = ρQ (62)

• Multiplying Equation 58 by M

j

and summing on j produces

dM

dV

= 0, M(0) = M

f

in which M

f

is the feed mass ﬂowrate.

• The total mass ﬂow in a PFR is constant.

105

Volumetric Flowrate for Liquid-Phase Reactions

• We can solve for the volumetric ﬂowrate by rearranging Equation 62

Q =

M

f

ρ

(63)

• If the liquid density is considered constant, ρ = ρ

f

, then

Q = Q

f

, constant density (64)

and the volumetric ﬂowrate is constant and equal to the feed value.

• Equation 64 is used often for liquid-phase reactions.

106

Volumetric Flowrate for Liquid-Phase Reactions

• If we denote the time spent in the tube by τ = V/Q, if Q is constant, we can

rewrite Equation 57 as

dc

j

dτ

= R

j

, constant ﬂowrate (65)

which is identical to the constant-volume batch reactor.

• For the constant-ﬂowrate case, the steady-state proﬁle in a PFR starting from

a given feed condition is also the transient proﬁle in a batch reactor starting

from the equivalent initial condition.

107

Single Reaction Systems – Changing ﬂowrate in a PFR

• A pure vapor stream of A is decomposed in a PFR to form B and C

A

k

→ B +C (66)

• Determine the length of 2.5 cm inner-diameter tube required to achieve

35% conversion of A. The reactor temperature is 518

◦

C and the pressure is

2.0 atm. Assume the pressure drop is negligible.

• The reaction rate is ﬁrst order in A, k = 0.05 sec

−1

at the reactor temperature,

and the feed ﬂowrate is 35 L/min.

108

Changing ﬂowrate in a PFR

• The mole balance for component A gives

dN

A

dV

= R

A

• The production rate of A is R

A

= −r = −kc

A

.

• Substituting the production rate into the above equation gives,

dN

A

dV

= −kN

A

/Q (67)

• The volumetric ﬂowrate is not constant, so we use Equation 60, which as-

sumes an ideal-gas equation of state,

Q =

RT

P

(N

A

+N

B

+N

C

) (68)

109

Changing ﬂowrate in a PFR

• The ideal-gas assumption is reasonable at this reactor temperature and pres-

sure.

• One can relate the molar ﬂows of B and C to A using the reaction stoichiom-

etry. The mole balances for B and C are

dN

B

dV

= R

B

= r

dN

C

dV

= R

C

= r

• Adding the mole balance for A to those of B and C gives

d(N

A

+N

B

)

dV

= 0

d(N

A

+N

C

)

dV

= 0

• The stoichiometry does not allow the molar ﬂow N

A

+N

B

or N

A

+N

C

to change

with position in the tube.

110

Changing ﬂowrate in a PFR

• Because N

A

+N

B

and N

B

+N

C

are known at the tube entrance, one can relate

N

B

and N

C

to N

A

,

N

A

+N

B

= N

Af

+N

Bf

N

A

+N

C

= N

Af

+N

Cf

• Rearranging the previous equations gives,

N

B

= N

Af

+N

Bf

−N

A

N

C

= N

Af

+N

Cf

−N

A

• Substituting the relations for N

B

and N

C

into Equation 68 gives

Q =

RT

P

2N

Af

+N

Bf

+N

Cf

−N

A

111

Changing ﬂowrate in a PFR

• Because the feed stream is pure A, N

Bf

= N

Cf

= 0, yielding

Q =

RT

P

2N

Af

−N

A

**• Substituting this expression in Equation 67 gives the ﬁnal mole balance,
**

dN

A

dV

= −k

P

RT

N

A

2N

Af

−N

A

• The above differential equation can be separated and integrated,

N

A

N

Af

2N

Af

−N

A

N

A

dN

A

=

V

0

−

kP

RT

dV

112

Changing ﬂowrate in a PFR

• Performing the integration gives,

2N

Af

ln

N

A

/N

Af

+

N

Af

−N

A

= −

kP

RT

V

• The conversion of component j for a plug-ﬂow reactor operating at steady

state is deﬁned as

x

j

=

N

jf

−N

j

N

jf

• Because we are interested in the V corresponding to 35% conversion of A, we

substitute N

A

= (1 −x

A

)N

Af

into the previous equation and solve for V,

V = −

RT

kP

N

Af

[2ln(1 −x

A

) +x

A

]

113

Changing ﬂowrate in a PFR

• Because Q

f

= N

Af

RT/P is given in the problem statement and the tube

length is desired, it is convenient to rearrange the previous equation to obtain

z = −

Q

f

kA

c

[2ln(1 −x

A

) +x

A

]

• Substituting in the known values gives

z = −

35 ×10

3

cm

3

/min

0.05 sec

−1

60 sec/min

¸

4

π(2.5 cm)

2

¸

[2ln(1 −.35) +.35]

z = 1216 cm= 12.2 m

114

Multiple-Reaction Systems

• The modeler has some freedomin setting up the material balances for a plug-

ﬂow reactor with several reactions.

• The most straightforward method is to write the material balance relation for

every component,

dN

j

dV

= R

j

, j = 1, 2, . . . , n

s

R

j

=

n

r

¸

i=1

ν

ij

r

i

, j = 1, 2, . . . , n

s

• The reaction rates are expressed in terms of the species concentrations.

• The c

j

are calculated from the molar ﬂows with Equation 59

• Q is calculated from Equation 60, if an ideal-gas mixture is assumed.

115

Benzene pyrolysis in a PFR

• Hougen and Watson [3] analyzed the rate data for the pyrolysis of benzene

by the following two reactions.

• Diphenyl is produced by the dehydrogenation of benzene,

2C

6

H

6

k

1

k

−1

C

12

H

10

+H

2

2B

D + H

116

Benzene pyrolysis in a PFR

• Triphenyl is formed by the secondary reaction,

C

6

H

6

+C

12

H

10

k

2

k

−2

C

18

H

14

+H

2

(69)

B + D

T + H (70)

• The reactions are assumed to be elementary so that the rate expressions are

r

1

= k

1

c

2

B

−

c

D

c

H

K

1

¸

(71)

r

2

= k

2

c

B

c

D

−

c

T

c

H

K

2

¸

(72)

117

Benzene pyrolysis in a PFR

• Calculate the tube volume required to reach 50% total conversion of the ben-

zene for a 60 kmol/hr feed stream of pure benzene.

• The reactor operates at 1033K and 1.0 atm.

• Plot the mole fractions of the four components versus reactor volume.

118

Benzene pyrolysis in a PFR

• The rate and equilibrium constants at T = 1033K and P = 1.0 atm are given

in Hougen and Watson,

k

1

= 7 ×10

5

L/mol · hr

k

2

= 4 ×10

5

L/mol · hr

K

1

= 0.31

K

2

= 0.48

119

Benzene pyrolysis in a PFR

• The mole balances for the four components follow from the stoichiometry,

dN

B

dV

= −2r

1

−r

2

(73)

dN

D

dV

= r

1

−r

2

(74)

dN

H

dV

= r

1

+r

2

(75)

dN

T

dV

= r

2

(76)

• The initial condition for the ODEs are N

B

(0) = N

Bf

and N

D

(0) = N

H

(0) =

N

T

(0) = 0.

120

Benzene pyrolysis in a PFR

• The total molar ﬂux does not change with reactor volume.

Q =

RT

P

N

Bf

(77)

• The rate expressions are substituted into the four ODEs and they are solved

numerically.

• The total conversion of benzene, x

B

= (N

Bf

− N

B

)/N

Bf

, is plotted versus

reactor volume in Figure 8.

• A reactor volume of 404 L is required to reach 50% conversion. The compo-

sition of the reactor versus reactor volume is plotted in Figure 9.

121

0

0.1

0.2

0.3

0.4

0.5

0.6

0 200 400 600 800 1000 1200 1400 1600

V (L)

x

B

Figure 8: Benzene conversion versus reactor volume.

122

0

0.2

0.4

0.6

0.8

1

0 200 400 600 800 1000 1200 1400 1600

V (L)

y

B

y

H

y

T

y

D

y

j

Figure 9: Component mole fractions versus reactor volume.

123

Ethane pyrolysis in the presence of NO

• See the text for another worked PFR example.

124

Some PFR-CSTR Comparisons

• We have two continuous reactors in this chapter: the CSTR and the PFR.

• Let’s compare their steady-state efﬁciencies in converting reactants to prod-

ucts.

• For simplicity, consider a constant-density, liquid

A

k

→ B r = kc

n

A

(78)

• For this situation, the steady-state PFR material balance is given by Equa-

tion 65

dc

A

dτ

= −r(c

A

)

125

Some PFR-CSTR Comparisons

• We rearrange and solve for the time required to change from the feed condi-

tion c

Af

to some exit concentration c

A

τ =

c

A

c

Af

1

r(c

A

)

dc

A

• The area under the curve 1/r(c

A

) is the total time required to achieve the

desired concentration change.

1

r(c

A

)

c

Af

c

A

c

A

PFR

CSTR

126

Some PFR-CSTR Comparisons

• To achieve this same concentration change in the CSTR, we start with Equa-

tion 37, and solve for τ giving

τ =

c

Af

−c

A

r(c

A

)

• This result also can be interpreted as an area. Notice that this area is the

height, 1/r(c

A

), times the width, c

Af

−c

A

, of the rectangle.

1

r(c

A

)

c

Af

c

A

c

A

PFR

CSTR

127

Some PFR-CSTR Comparisons

• If 1/r(c

A

) is a decreasing function of c

A

, or, equivalently, r(c

A

) is an increas-

ing function of c

A

, to achieve the same conversion, the PFR time (or volume,

V

R

= Q

f

τ) is less than the CSTR time (volume).

• The PFR reaction rate varies with length. The rate is high at the entrance to the

tube where the concentration of A is equal to the feed value, and decreases

with length as the concentration drops. At the exit of the PFR, the rate is the

lowest of any location in the tube.

• Now considering that the entire volume of the CSTR is reacting at this lowest

rate of the PFR, it is intuitively obvious that more volume is required for the

CSTR to achieve the same conversion as the PFR.

128

Some PFR-CSTR Comparisons

• If the reaction order is positive (the usual case), the PFR is more efﬁcient. If

the reaction order is negative, the CSTR is more efﬁcient.

1

r(c

A

)

c

Af

c

A

c

A

CSTR

PFR

129

The PFR versus CSTR with separation

• The PFR achieves higher conversion than an equivalent volume CSTR for the

irreversible reaction with ﬁrst-order kinetics

A → B r = kc

A

• Consider the case in which we add separation.

• Find a single CSTR and separator combination that achieves the same con-

version as the PFR.

130

The PFR versus CSTR with separation

• The issue is to increase the CSTR achievable conversion using separation.

• Education in chemical engineering principles leads one immediately to con-

sider recycle of the unreacted A as a means to increase this conversion.

131

The PFR versus CSTR with separation

N

A0

N

A1

N

A2

N

A

N

A0

N

A

αN

A2

αN

A2

pure B

V

R

V

R

• In the text, we show how to ﬁnd the recycle ﬂowrate so this system achieves

the PFR conversion.

132

CSTR Equivalence Principle.

• This example was motivated by a recent result of Feinberg and Ellison called

the CSTR Equivalence Principle of Reactor-Separator Systems [2].

• This surprising principle states:

For a given reaction network with n

i

linearly independent reactions, any

steady state that is achievable by any reactor-separator design with total

reactor volume V is achievable by a design with not more than n

i

+ 1

CSTRs, also of total reactor volume V. Moreover the concentrations,

temperatures and pressures in the CSTRs are arbitrarily close to those

occurring in the reactors of the original design.

133

Stochastic Simulation of Chemical Reactions

• We wish to introduce next a topic of increasing importance to chemical engi-

neers, stochastic (random) simulation.

• In stochastic models we simulate quite directly the random nature of the

molecules.

• We will see that the deterministic rate laws and material balances presented in

the previous sections can be captured in the stochastic approach by allowing

the numbers of molecules in the simulation to become large.

• The stochastic modeling approach is appropriate if the random nature of the

system is one of the important features to be captured in the model.

• These situations are becoming increasingly important to chemical engineers

as we explore reactions at smaller and smaller length scales.

134

Stochastic Simulation of Chemical Reactions

• For example, if we are modeling the chemical transformation by reaction of

only a few hundreds or thousands of molecules at an interface, we may want

to examine explicitly the random ﬂuctuations taking place.

• In biological problems, we often consider the interactions of only several hun-

dred or several thousand protein molecules and cells.

• In sterilization problems, we may wish to model the transient behavior until

every last organism is eliminated.

135

Stochastic Simulation of Chemical Reactions

• Assume we have only a hundred molecules moving randomly in the gas phase

A

k

1

→ B (79)

B

k

2

→ C (80)

in a constant-volume batch reactor.

• The probability of reaction is assumed proportional to the

r

1

= k

1

x

A

r

2

= k

2

x

B

in which x

j

is the number of component j molecules in the reactor volume.

• Note x

j

is an integer, unlike the deterministic model’s c

j

, which is real.

136

Stochastic Simulation of Chemical Reactions

• The basic idea of the Gillespie algorithm is to: (i) choose randomly the time

at which the next reaction occurs, and (ii) choose randomly which reactions

occurs at that time.

1. Initialize. Set integer counter n to zero. Set the initial species numbers,

x

j

(0), j = 1, . . . n

s

. Determine stoichiometric matrix ν and reaction probabil-

ity laws (rate expressions)

r

i

= k

i

h(x

j

)

for all reactions.

2. Compute reaction probabilities, r

i

= k

i

h(x

j

). Compute total reaction proba-

bility r

tot

=

¸

i

r

i

.

137

Stochastic Simulation of Chemical Reactions

3. Select two random numbers, p

1

, p

2

, from a uniform distribution on the inter-

val (0, 1). Let the time interval until the next reaction be

`

t = −ln(p

1

)/r

tot

(81)

138

Stochastic Simulation of Chemical Reactions

4. Determine reaction m to take place in this time interval. The idea

here is to partition the interval (0,1) by the relative sizes of each

reaction probability and then “throw a dart” at the interval to pick

the reaction that occurs. In this manner, all reactions are pos-

sible, but the reaction is selected in accord with its probability.

p

2

r

1

r

1

+r

2

r

2

r

1

+r

2 0

1

139

Stochastic Simulation of Chemical Reactions

5. Update the simulation time t(n+1) = t(n) +

`

t. Update the species numbers

for the single occurrence of the mth reaction via

x

j

(n+1) = x

j

(n) +ν

mj

, j = 1, . . . n

s

Let n = n+1. Return to Step 2.

140

Stochastic Simulation of Chemical Reactions

• If r

tot

is the total probability for reaction, e

−r

tot

`

t

is the probability that a re-

action has not occurred during time interval

`

t.

• We will derive this fact in Chapter 8 when we develop the residence-time

distribution for a CSTR.

• The next ﬁgure shows the results of this algorithm when starting with x

A

=

100 molecules.

141

Stochastic Simulation of Chemical Reactions

142

0

20

40

60

80

100

0 1 2 3 4 5

t

x

A

x

B

x

C

x

j

143

Stochastic Simulation of Chemical Reactions

• Notice the random aspect of the simulation gives a rough appearance to the

number of molecules versus time, which is quite unlike any of the determin-

istic simulations.

• Because the number of molecules is an integer, the simulation is actually

discontinuous with jumps between simulation times.

• But in spite of the roughness, we already can make out the classic behavior

of the series reaction: loss of starting material A, appearance and then dis-

appearance of the intermediate species B, and slow increase in ﬁnal product

C.

144

Stochastic Simulation of Chemical Reactions

• Next we explore the effect of increasing the initial number of A molecules on

a single simulation. The results for 1000 and 4000 initial A molecules are

shown in the next ﬁgures.

145

Stochastic Simulation of Chemical Reactions

146

0

200

400

600

800

1000

0 1 2 3 4 5

t

x

A

x

B

x

C

x

j

147

Stochastic Simulation of Chemical Reactions

148

0

800

1600

2400

3200

4000

0 1 2 3 4 5

t

x

A

x

B

x

C

x

j

149

Stochastic Simulation of Chemical Reactions

• We see the random ﬂuctuations become less pronounced. Notice that even

with only 4000 starting molecules, the results compare very favorably with

the deterministic simulation shown previously.

• Another striking feature of the stochastic approach is the trivial level of pro-

gramming effort required to make the simulations.

• The biggest numerical challenge is producing the pseudo-random numbers

and many well-developed algorithms are available for that task.

• The computational time required for performing the stochastic simulation

may, however, be large.

150

Hepatitis B virus modeling

151

Hepatitis B virus modeling

nucleotides

cccDNA

−−−−−−→ rcDNA (82)

nucleotides + rcDNA −−−−−−→ cccDNA (83)

amino acids

cccDNA

−−−−−−→ envelope (84)

cccDNA −−−−−−→ degraded (85)

envelope −−−−−−→secreted or degraded (86)

rcDNA + envelope −−−−−−→ secreted virus (87)

152

Hepatitis B virus modeling

• The reaction rates and production rates for Reactions 82–87 are given by

¸

¸

¸

¸

¸

¸

¸

¸

¸

¸

¸

r

1

r

2

r

3

r

4

r

5

r

6

=

¸

¸

¸

¸

¸

¸

¸

¸

¸

¸

¸

k

1

x

A

k

2

x

B

k

3

x

A

k

4

x

A

k

5

x

C

k

6

x

B

x

C

¸

¸

¸

¸

R

A

R

B

R

C

=

¸

¸

¸

¸

r

2

−r

4

r

1

−r

2

−r

6

r

3

−r

5

−r

6

(88)

in which A is cccDNA, B is rcDNA, and C is envelope.

153

Hepatitis B virus modeling

• Assume the systems starts with a single cccDNA molecule and no rcDNA and

no envelope protein, and the following rate constants

¸

x

A

x

B

x

C

¸

T

=

¸

1 0 0

¸

T

(89)

k

T

=

¸

1 0.025 1000 0.25 2 7.5 ×10

−6

¸

(90)

154

Average stochastic is not deterministic.

0

5

10

15

20

25

0 50 100 150 200

t (days)

c

c

c

D

N

A

deterministic

avg. stochastic

0

50

100

150

200

250

0 50 100 150 200

t (days)

r

c

D

N

A

deterministic

avg. stochastic

155

0

2000

4000

6000

8000

10000

0 50 100 150 200

t (days)

e

n

v

e

l

o

p

e

deterministic

avg. stochastic

156

Hepatitis B virus modeling

157

0

5

10

15

20

25

30

35

0 50 100 150 200

t (days)

c

c

c

D

N

A

deterministic

stoch 1

stoch 2

Figure 10: Species cccDNA versus time for hepatitis B virus model; two repre-

sentative stochastic trajectories.

158

Hepatitis B virus modeling

• The simulation of the deterministic model and an average of 500 stochastic

simulations are not the same.

• Figure 10 shows two representative stochastic simulations for only the cc-

cDNA species.

• Notice the ﬁrst stochastic simulation does ﬂuctuate around the deterministic

simulation as expected.

• The second stochastic simulation, however, shows complete extinction of the

virus. That is another possible steady state for the stochastic model.

159

Average stochastic is not deterministic.

• In fact, it occurs for 125 of the 500 simulations. So the average stochastic

simulation consists of 75% trajectories that ﬂuctuate about the deterministic

trajectory and 25% trajectories that go to zero.

0

5

10

15

20

25

0 50 100 150 200

t (days)

c

c

c

D

N

A

deterministic

avg. stochastic

160

Summary

• We have introduced four main reactor types in this chapter.

• the batch reactor

• the continuous-stirred-tank reactor (CSTR)

• the semi-batch reactor

• the plug-ﬂow reactor (PFR).

161

Summary

BATCH

d(c

j

V

R

)

dt

= R

j

V

R

(91)

constant volume

dc

j

dt

= R

j

(92)

CSTR

d(c

j

V

R

)

dt

= Q

f

c

jf

−Qc

j

+R

j

V

R

(93)

constant density

dc

j

dt

=

1

τ

(c

jf

−c

j

) +R

j

(94)

steady state c

j

= c

jf

+R

j

τ (95)

SEMI-BATCH

d(c

j

V

R

)

dt

= Q

f

c

jf

+R

j

V

R

(96)

PFR

∂c

j

∂t

= −

∂(c

j

Q)

∂V

+R

j

(97)

steady state

d(c

j

Q)

dV

= R

j

(98)

constant ﬂowrate

dc

j

dτ

= R

j

, τ = V/Q

f

(99)

162

Summary

We also have introduced some of the basic reaction-rate expressions.

• ﬁrst order, irreversible

• ﬁrst order, reversible

• second order, irreversible

• nth order, irreversible

• two ﬁrst-order reactions in series

• two ﬁrst-order reactions in parallel

• two second-order, reversible reactions

163

Summary

• We developed the equations required to compute the volume of the reactor if

there is a signiﬁcant volume change upon reaction. We require an equation

of state for this purpose.

• Several of these simple mass balances with basic rate expressions were solved

analytically.

• In the case of multiple reactions with nonlinear rate expressions (i.e., not

ﬁrst-order reaction rates), the balances must be solved numerically.

• A high-quality ordinary differential equation (ODE) solver is indispensable for

solving these problems.

164

Summary

• We showed that the PFR achieves higher conversion than the CSTR of the

same volume if the reaction rate is an increasing function of a component

composition (n > 0 for an nth-order rate expression).

• Conversely, the CSTR achieves higher conversion than the same-volume PFR

if the rate is a decreasing function of a component composition (n < 0).

• Finally, we introduced stochastic simulation to model chemical reactions oc-

curring with small numbers of molecules.

165

Summary

• The stochastic model uses basic probability to compute reaction rate. A given

reaction’s probability of occurrence is assumed proportional to the number

of possible combinations of reactants for the given stoichiometry.

• Two pseudo-random numbers are chosen to determine: (i) the time of the

next reaction and (ii) the reaction that occurs at that time.

• The smooth behavior of the macroscopic ODE models is recovered by the

random simulations in the limit of large numbers of reacting molecules.

• With small numbers of molecules, however, the average of the stochastic

simulation does not have to be equal to the deterministic simulation. We

demonstrated this fact with the simple, nonlinear hepatitis B virus model.

166

References

[1] R. B. Bird, W. E. Stewart, and E. N. Lightfoot. Transport Phenomena. John

Wiley & Sons, New York, second edition, 2002.

[2] M. Feinberg and P. Ellison. General kinetic bounds on productivity and se-

lectivity in reactor-separator systems of arbitrary design: I. Principles. Ind.

Eng. Chem. Res., 40(14):3181–3194, 2001.

[3] O. A. Hougen and K. M. Watson. Chemical Process Principles. Part Three:

Kinetics and Catalysis. John Wiley & Sons, New York, 1947.

167

General Mole Balance

Rj V Q0 cj0 Q1 cj1

Conservation of mass

rate of accumulation = of component j

rate of inﬂow of component j

−

rate of outﬂow of component j

rate of generation of component j by + chemical reactions

(1)

2

General Mole Balance

Rj V Q0 cj0 Q1 cj1

Conservation of mass d dt

V

cj dV = Q0cj0 − Q1cj1 +

V

Rj dV

(2)

3

which do not take place in any reactions. j = 1.General Mole Balance d dt V cj dV = Q0cj0 − Q1cj1 + V Rj dV • Equation 2 applies to every chemical component in the system. ns . neglecting diffusional ﬂux through the boundary of the volume element due to a concentration gradient. including inerts. . • Assuming component j enters and leaves the volume element only by convection with the inﬂow and outﬂow streams. .e. 4 . 2. i. . . • The diffusional ﬂux will be considered during the development of the material balance for the packed-bed reactor.

Rj Rj = i νij ri • Therefore we require ri as a function of cj • This is the subject of chemical kinetics.Rate expressions • To solve the reactor material balance. we require an expression for the production rates. Chapter 5 • Here we use common reaction-rate expressions without derivation 5 .

The Batch Reactor Rj • The batch reactor is assumed well stirred • Let the entire reactor contents be the reactor volume element 6 .

the integrals in Equation 2 are simple to evaluate. VR cj dV = cj VR VR Rj dV = Rj VR • The inﬂow and outﬂow stream ﬂowrates are zero.Batch Reactor d dt V cj dV = Q0cj0 − Q1cj1 + V Rj dV • Because the reactor is well stirred. Q0 = Q1 = 0. d cj V R dt = Rj VR (3) 7 .

Reactor Volume • Equation 3 applies whether the reactor volume is constant or changes during the reaction. 8 . • If the reactor volume is constant (liquid-phase reactions) dcj = Rj dt (4) • Use Equation 3 rather than Equation 4 if the reactor volume changes signiﬁcantly during the course of the reaction.

• If the reactor is isothermal. • We next examine derive analytical solutions for some classic cases. we have few components.Analytical Solutions for Simple Rate Laws • In general the material balance must be solved numerically. 9 . the rate expressions are simple. then analytical solutions of the material balance are possible.

First-order. irreversible • Consider the ﬁrst-order. k r = kcA (5) • The material balance for a constant-volume reactor gives dcA = −kcA dt • Watch the sign! (6) 10 . irreversible reaction A → B.

irreversible • We denote the initial concentration of A as cA0. t=0 • The solution to the differential equation with this boundary condition is cA = cA0e−kt (7) 11 .First-order. cA(t) = cA0.

irreversible 12 .First-order.

2 k=2 k=5 0 1 2 3 4 5 0 t 13 .1 0.6 0.5 k=1 0.8 cA cA0 0.4 k = 0.

First-order, irreversible

• The A concentration decreases exponentially from its initial value to zero with increasing time. • The rate constant determines the shape of this exponential decrease. Rearranging Equation 7 gives ln(cA/cA0) = −kt

14

First-order, irreversible

1

k = 0.5 k=1

0.1

cA cA0

0.01

k=2

k=5

0.001 0 1 2 3 4 5

t

• One can get an approximate value of the rate constant from the slope of the straight line.

15

• This procedure is a poor way to determine a rate constant and should be viewed only as a rough approximation (Chapter 9).

16

cA + cB is a constant. 1. Solve the material balance for component B. dcB = RB = kcA dt with the initial condition for B. cB (0) = cB0 2. irreversible The B concentration is determined from the A concentration. Note that the sum of cA and cB is constant. 17 (8) . d(cA + cB ) = RA + RB = 0 dt Therefore.First-order.

First-order. cA + cB = cA0 + cB0 • So we have an expression for cB cB = cA0 + cB0 − cA cB = cB0 + cA0(1 − e−kt ) (9) (10) 18 . reversible • The value is known at t = 0.

• The material balances for A and B are now dcA = −r = −k1 cA + k−1 cB dt dcB = r = k1 cA − k−1 cB dt • Notice that cA + cB = cA0 + cB0 remains constante cA (0) = cA0 cB (0) = cB0 k1 k−1 B (11) 19 . but assume it is reversible A • The reaction rate is r = k1 cA − k−1 cB . reversible • Consider now the same ﬁrst-order reaction.First-order.

reversible • Eliminate cB in the material balance for A gives dcA = −k1cA + k−1(cA0 + cB0 − cA) dt • How do we want to solve this one? • Particular solution and homogeneous solution (see text) • Laplace transforms (control course) • Separation! (12) 20 .First-order.

b = k−1(cA0 + cB0) 21 .First-order. reversible dcA = acA + b dt dcA = cA0 acA + b 1 ln(acA + b) a cA = cA0eat − cA cA t dt 0 =t cA0 b (1 − eat ) a Substitute a = −(k1 + k−1).

yielding cB = cB0e −(k1 +k−1 )t k1 + (cA0 + cB0) 1 − e−(k1+k−1)t k1 + k−1 (14) 22 . reversible cA = cA0e−(k1+k−1)t + k−1 (cA0 + cB0) 1 − e−(k1+k−1)t k1 + k−1 (13) • The B concentration can be determined by switching the roles of A and B and k1 and k−1 in Reaction 11.First-order.

reversible 1 0. k1 = 1.6 c 0. reversible kinetics in a batch reactor.First-order. cA0 = 1. k−1 = 0.5. 23 . cB0 = 0.4 cAs cB (t) 0.8 cA (t) cBs 0.2 0 0 1 2 3 4 5 t Figure 1: First-order.

• Taking the limit t → ∞ in Equation 13 gives k−1 (cA0 + cB0) = k1 + k−1 cAs in which cAs is the steady-state concentration of A. the concentration of A does not go to zero. 24 .Nonzero steady state • For the reversible reaction.

Nonzero steady state • Deﬁning K1 = k1/k−1 allows us to rewrite this as cAs 1 = (cA0 + cB0) 1 + K1 • Performing the same calculation for cB gives cBs K1 (cA0 + cB0) = 1 + K1 25 .

irreversible • Consider the irreversible reaction k A → B 2 in which the rate expression is second order.Second-order. dt • Our ﬁrst nonlinear differential equation. r = kcA. cA(0) = cA0 (16) 26 . (15) • The material balance and initial condition are dcA 2 = −kcA.

irreversible • Separation works here dcA 2 = −kdt cA cA t dcA 2 = −k cA0 cA 1 1 − = −kt cA0 cA • Solving for cA gives 1 + kt cA = cA0 dt 0 −1 (17) • Check that this solution satisﬁes the differential equation and initial condition 27 .Second-order.

4 0.7 0. 28 .1 0 0 1 2 3 4 5 ﬁrst order second order • The second-order reaction decays more slowly to zero than the ﬁrst-order reaction.Second-order.8 0.6 cA cA0 0.3 0.2 0. irreversible 1 0.9 0.5 0.

Another second-order. irreversible A+B → C k r = kcAcB (18) • The material balance for components A and B are dcA = −r = −kcAcB dt dcB = −r = −kcAcB dt • Subtract B’s material balance from A’s to obtain d(cA − cB ) =0 dt (19) (20) 29 .

cA − cB is constant. cB0 (cB0−cA0)kt cA = (cA0 − cB0) 1 − e cA0 −1 (21) . cA0 ≠ cB0 (22) 30 . and cB = cA − cA0 + cB0 • Substituting this expression into the material balance for A yields dcA = −kcA(cA − cA0 + cB0) dt • This equation also is separable and can be integrated to give (you should work through these steps).Another second-order. irreversible • Therefore.

d(cA + cC )/dt = 0. or by switching the roles of A and B in Reaction 18. irreversible • Component B can be computed from Equation 21. The concentration of C is given by cC = cA0 − cA + cC0 −1 (23) 31 .Another second-order. giving cA0 (cA0−cB0)kt e cB = (cB0 − cA0) 1 − cB0 • What about component C? C’s material balance is dcC = kcAcB dt and therefore.

the steady state cAs = cA0 − cB0 cBs = 0 cCs = cB0 + cC0 • For cB0 > cA0 (Excess B). the steady state is cAs = 0 cBs = cB0 − cA0 cCs = cA0 + cC0 32 .Another second-order. irreversible • Notice that if cA0 > cB0 (Excess A).

nth-order. irreversible n The nth-order rate expression r = kcA 33 .

5 1 1.5 0 0 0.5 1 0.5 4 3.5 3 34 .5 2 1.5 4.5 cA 2 1 1/2 0 2.5 3 n=3 2 r 2.

irreversible A → B k n r = kcA dcA n = −r = −kcA dt • This equation also is separable and can be rearranged to dcA n = −kdt cA • Performing the integration and solving for cA gives −n+1 cA = cA0 + (n − 1)kt 1 −n+1 .nth-order. n≠1 35 .

= [1 + (n − 1)k0t] cA0 n≠1 (24) in which n−1 k0 = kcA0 has units of inverse time. 36 . irreversible • We can divide both sides by cA0 to obtain 1 cA −n+1 .nth-order.

the more slowly the A concentration approaches zero at large time.4 4 3 2 1 0.nth-order.2 0 0 1 2 3 4 5 t • The larger the value of n. irreversible 1 0.8 cA cA0 0. 37 .6 n=5 0.

8 cA cA0 0.5 2 38 .4 n=2 1 0.nth-order. cA reaches zero in ﬁnite time.6 0.2 −2 −1 0 0 0. irreversible • Exercise care for n < 1. 1 0.5 −1/2 0 1/2 1 t 1.

5 3 39 .5 0 0 0. the rate decreases with increasing reactant concentration.5 1 0.Negative order. the reactant inhibits the reaction.5 n=−2 −1 −1/2 0 1 1.5 4 3.5 2 1.5 cA 2 2. 5 4. inhibition • For n < 0.5 3 r 2.

which is not physically realistic. cA > 0 dcA = 0. 40 .Negative order. inhibition • Inhibition reactions are not uncommon. but watch out for small concentrations. • When using an ODE solver we may modify the right-hand sides of the material balance n −kcA . cA = 0 dt • Examine the solution carefully if the concentration reaches zero. Notice the rate becomes unbounded as cA approaches zero.

r1 = k1cA r2 = k2cB 41 .Two reactions in series • Consider the following two irreversible reactions. • Let the reaction rates be given by simple ﬁrst-order rate expressions in the corresponding reactants. k1 k2 A → B B → C (25) (26) • Reactant A decomposes to form an intermediate B that can further react to form a ﬁnal product C.

Two reactions in series • The material balances for the three components are dcA = RA = −r1 = −k1cA dt dcB = RB = r1 − r2 = k1cA − k2cB dt dcC = RC = r2 = k2cB dt • The material balance for component A can be solved immediately to give cA = cA0e−k1t as before. 42 .

homogeneous equation approach produces cB = cB0e −k2 t k1 + cA0 e−k1t − e−k2t . now what? • Either Laplace transform or particular solution. k2 − k1 k1 ≠ k2 (27) 43 . not separable.Two reactions in series – B • The material balance for B becomes dcB + k2cB = k1cA0e−k1t dt Oops.

Therefore. cC is cC = cA0 + cB0 + cC0 − cA − cB 44 .Two reactions in series – C • To determine the C concentration. notice from the material balances that d(cA + cB + cC )/dt = 0.

cA0 = 1.8 cA (t) 0.4 cB (t) 0.2 0 0 1 2 3 4 5 t Figure 2: Two ﬁrst-order reactions in series in a batch reactor. k1 = 2.Two reactions in series 1 0. cB0 = cC0 = 0.6 cC (t) c 0. k2 = 1. 45 .

B and C. A → B A → C k2 k1 (28) (29) • Assume the rates of the two irreversible reactions are given by r1 = k1cA and r 2 = k 2 cA .Two reactions in parallel • Consider next two parallel reactions of A to two different products. 46 .

Two reactions in parallel • The material balances for the components are dcA = RA = −r1 − r2 = −k1cA − k2cA dt dcB = R B = r1 = k 1 cA dt dcC = R C = r2 = k 2 cA dt 47 .

Two reactions in parallel • The material balance for A can be solved directly to give cA = cA0e−(k1+k2)t • Substituting cA(t) into B’s material balance gives dcB = k1cA0e−(k1+k2)t dt • This equation is now separable and can be integrated directly to give cB = cB0 + cA0 k1 1 − e−(k1+k2)t k1 + k2 (31) (30) 48 .

cC = cC0 + cA0 k2 1 − e−(k1+k2)t k1 + k2 (32) 49 .Two reactions in parallel • Finally. and k1 and k2 in Equation 31. component C can be determined from the condition that cA + cB + cC is constant or by switching the roles of B and C.

2 0 0 0.Two reactions in parallel 1 0.8 cA (t) 0. 50 .6 cC (t) c 0. k1 = 1. cB0 = cC0 = 0. cA0 = 1. k2 = 2.5 1 1.5 3 Figure 3: Two ﬁrst-order reactions in parallel in a batch reactor.4 cB (t) 0.5 t 2 2.

Two reactions in parallel • Notice that the two parallel reactions compete for the same reactant. A • The rate constants determine which product is favored • Large values of k1/k2 favor the formation of component B compared to C and vice versa 51 .

Conversion has several deﬁnitions and conventions. It is best to state the deﬁnition in the context of the problem being solved. yield and conversion. 52 . Yield. Conversion: Conversion is normally deﬁned to be the fraction of a component that has been converted to products by the reaction network. Selectivity There are several ways to deﬁne selectivity.Conversion. Overall selectivity: The overall selectivity is the ratio of the amount of one component produced to the amount of another component produced. so be clear about the deﬁnition you choose. Point selectivity: The point (or instantaneous) selectivity is the ratio of the production rate of one component to the production rate of another component. Yield: The yield of component j is the fraction of a reactant that is converted into component j.

j = 1. . . ns (33) 53 . .The Continuous-Stirred-Tank Reactor (CSTR) Qf cjf Rj Q cj Writing the material balance for this reactor gives d cj V R dt = Qf cjf − Qcj + Rj VR . .

It is often a good approximation for liquid-phase reactions.CSTR – Constant Density • If the reactor volume is constant and the volumetric ﬂowrates of the inﬂow and outﬂow streams are the same. • We refer to this balance as the constant-density case. (34) 54 . Equation 33 reduces to dcj 1 = (cjf − cj ) + Rj dt τ • The parameter τ = VR /Qf is called the mean residence time of the CSTR.

CSTR – Steady State • The steady state of the CSTR is described by setting the time derivative in Equation 33 to zero. 0 = Qf cjf − Qcj + Rj VR (35) • Conversion of reactant j is deﬁned for a steady-state CSTR as follows xj = Qf cjf − Qcj Qf cjf (steady state) (36) • One can divide Equation 35 through by VR to obtain for the constant-density case cj = cjf + Rj τ (steady state. constant density) (37) 55 .

56 . Plot the concentration of A versus time for constant feed concentration cAf = 2 mol/L if the reactor is initially ﬁlled with an inert so cA0 = 0 mol/L. 1. the residence time of the reactor is τ = 100 min.Transient behavior of the CSTR • Consider a ﬁrst-order. and the rate constant is k = 0. 3. Find the steady-state concentration of A in the efﬂuent for the given feed.1 min−1. 2. Plot the concentration of A versus time for constant feed concentration cAf = 2 mol/L if the reactor is initially ﬁlled with feed so cA0 = 2 mol/L. liquid-phase reaction in an isothermal CSTR A → 2B k r = kcA the feed concentration of A is cAf = 2 mol/L.

1 min−1)(100 min) 57 . Part 1 • Liquid phase: assume the ﬂuid density is constant. cA = cAf + RAτ • Substituting the production rate RA = −kcA and solving for cA gives the steady-state concentration cAf cAs = 1 + kτ • Substituting in the numerical values gives cAs 2 mol/L = = 0.182 mol/L 1 + (0.Transient CSTR Solution.

Parts 2 and 3 1 dcA = cAf − cA − kcA dt τ cA(0) = cA0 • This equation is also separable. The analytical solution is cA(t) = cA0e−(1/τ+k)t + cAf 1 − e−(1/τ+k)t 1 + kτ (38) (39) 58 .

5 cA (t) (mol/L) 1 cA0 = 2 0.5 cAs = 0.Parts 2 and 3 2 1. 59 .182 0 0 cA0 = 0 10 20 30 40 50 t (min) 60 70 80 • Both solutions converge to the same steady-state even though the starting conditions are quite different.

60 . The ﬂowrate into the reactor is Qf = 26.Phenol production in a CSTR • Consider the reaction of cumene hydroperoxide (CHP) to phenol and acetone (C6H5)C(CH3)2OOH → (C6H5)OH + (CH3)2CO CHP → phenol + acetone (40) (41) • The reaction is pseudo-ﬁrst-order r = kcCHP • Find the reactor volume to achieve 85% conversion of CHP at steady state.9 m3/hr and k = 4.12 hr−1.

Phenol production • Liquids at 85◦C. so assume constant density and Q = Qf . and solving for the CHP concentration gives cA = cAf 1 + kτ (42) 61 . cA = cAf + RAτ RA = −kcA.

Phenol production • The conversion of CHP (for Q = Qf ) is cAf − cA cA xA = =1− cAf cAf xA = kτ 1 + kτ • Solving this equation for τ gives 1 xA τ= k 1 − xA 62 .

Phenol production • Substituting the relation τ = VR /Qf and solving for VR gives VR = Qf xA k(1 − xA) • Substituting in the known values gives the required CSTR volume VR = (26.15) = 37 m3 63 .9 m3/hr)(0.85) (4.12 hr−1)(0.

like the CSTR. • The semi-batch reactor is initially charged with reactant. like the batch reactor.The Semi-Batch Reactor • The semi-batch reactor is a cross between the batch reactor and CSTR. • Normally there is no outﬂow stream. but allows a feed addition policy while the reaction takes place. 64 .

• Compared to the batch reactor. . the semi-batch reactor provides more complete use of the reactor volume in reactions such as polymerizations that convert from lower density to higher density during the course of the reaction. j = 1. . . ns (43) • One may choose to operate a semi-batch reactor to control the reaction rate or heat release during reaction by slowly adding one of the reactants in the feed stream.The Semi-Batch Reactor • We set Q = 0 in the CSTR material balance to obtain d cj VR dt = Qf cjf + Rj VR . . 65 .

• If we multiply Equation 44 by the molecular weight of species j and sum over all species we obtain. depending on how we specify Qf and Q.Volume Change Upon Reaction d cj VR dt = Qf cjf − Qcj + Rj VR (44) • Equation 44 covers both the batch. which 66 . CSTR and semi-batch reactors. d( j cj Mj VR ) dt = Qf j cjf Mj − Q j cj Mj + j Rj Mj VR (45) • The term j cj Mj is simply the mass density of the reactor contents.

we denote ρ ρ= ns cj M j j=1 (46) 67 .

j • We know that conservation of mass in chemical reactions implies (see Chapter 2).Volume Change Upon Reaction • The term j cjf Mj is the mass density of the feedstream. 68 . ρf . Substitution into Equation 45 leads to d(ρVR ) = Qf ρf − Qρ dt Rj Mj = 0 (47) • Equation 47 is clearly a total mass balance. in which the total mass in the reactor changes in time due to the inﬂow and outﬂow of mass. • Notice that chemical reactions play no role in the total mass balance.

**Equation of state for the mixture
**

• If we have a single-phase system at equilibrium, the intensive variables cj , T , P , completely specify all intensive variables of the system. • In this chapter we consider T and P to be known, ﬁxed quantities. Therefore, the density of the reaction mixture, which is an intensive variable, is known if the cj are known. • This relationship is one form of the equation of state for the mixture ρ = f (T , P , c1, c2, . . . , cns ) • Substituting the deﬁnition of density, we can express the equation of state as f (c1, c2, . . . , cns ) = 0

69

Equation of state for the mixture

**• For example, we could express the equation of state in terms of the partial molar volumes as cj V j = 1
**

j

in which V j is the partial molar volume of component j in the mixture. • The partial molar volumes are functions of T , P and cj .

70

Equation of state for the mixture — Ideal mixture

**• If we assume an ideal mixture, this reduces to
**

◦ cj Vj = 1, j ◦ in which Vj is the speciﬁc volume of pure component j, which is a function of only T and P .

ideal mixture

• We assume that a thermodynamic equation of state is valid even when the reactor is not at equilibrium.

71

it does not vary with time either and we can set it to the feed value.” • This terminology should be avoided. ρ. (49) 72 . ρ = ρf (48) • The total mass balance then reduces to dVR = Qf − Q dt which is sometimes referred to as a “volume balance. is independent of composition.Constant density • Because the reaction mixture density.

If the outﬂow of the CSTR is regulated so that the CSTR has constant volume. the reactor is ﬁlled during operation so Qf is speciﬁed and positive for some time and Q = 0.Constant density dVR = Qf − Q dt • Batch reactor. In the semi-batch reactor. 73 . We can therefore conclude from Equation 49 that a batch reactor with constant density has constant volume. • CSTR (dynamic and steady state). For the batch reactor. then we can conclude from Equation 49 that Q = Qf . Q = Qf = 0. • Semi-batch reactor. The solution to Equation 49 then determines the change in volume of the reactor during the ﬁlling operation.

Q. • In the general case. • We therefore have ns + 2 unknowns. • We also require the value of Q to specify the right-hand sides of the material balances. • The set of unknowns is nj . • The ﬁnal equation is provided by a statement of reactor operation. • The equation of state provides one additional equation. • We have the ns equations from the component mole balances. Equations. VR . P .Nonconstant density Unknowns. consider the following variables to fully determine the state of the reactor: T . 74 . nj . VR .

In this situation ρVR is speciﬁed as the additional equation. In this situation. In this case Q(t) is speciﬁed.Nonconstant density – reactor operation 1. The constant-volume reactor can be achieved by allowing overﬂow of the reactor to determine ﬂowrate out of the reactor. 2. Constant-mass reactor. VR is speciﬁed as the additional equation. 75 . The constant-mass reactor can be achieved if a differential pressure measurement is used to control the ﬂowrate out of the reactor and the reactor has constant cross-sectional area. This type of operation may be achieved if the ﬂowrate out of the reactor is controlled by a ﬂow controller. Flowrate out of the reactor is speciﬁed. Constant-volume reactor. 3. A semi-batch reactor is operated in this way with Q = 0 until the reactor is ﬁlled with the reactants.

dVR = Qf dt • in which fj is fj = • and ∆fi is ∆fi = j j fj cjf j fj cj −Q+ i ∆fi ri VR j f j cj (50) ∂f ∂cj ∂f ∂cj νij fj = j νij which is a change in a derivative property upon reaction.Nonconstant density – reactor operation • See the text for the derivation. 76 .

• So the reactor volume can be calculated from dVR = Qf − Q + dt ∆Vi◦riVR i 77 . ◦ fj = Vj the pure component speciﬁc volumes • The ∆fi are given by ∆fi = ∆Vi◦ the change in speciﬁc volume upon reaction i.Nonconstant density – idea mixture • For the ideal mixture we have f (cj ) = j ◦ cj Vj − 1 = 0.

j = 1. . 78 . . ns j = 1.Nonconstant density Unknowns (ns + 2): Component balances: VR . . Q. . ns ◦ j νij Vj dnj = Qf cjf − Qcj + Rj VR . dt nj = cj VR ρ= j cj Mj Deﬁned quantities: ∆V ◦ = i ◦ j cj Vj = 1 (i) constant density: ρ = ρ0 (ii) ideal mixture: 1. vol VR = VR0 VR = VR0 dVR = Qf − Q dt Q = Qf Q = Qf Q speciﬁed VR = VR0 dVR = Qf (1 − ρf /ρ) + dt dVR = Qf − Q + dt ◦ i ∆Vi ri VR Q = Qf + ◦ i ∆Vi ri VR 2. mass Q = Qf ρf /ρ Q speciﬁed 3. . . nj . Q ◦ i ∆Vi ri VR Table 1: Reactor balances for constant-density and ideal-mixture assumptions. . .

ns ∂f j νij ∂c j dnj = Qf cjf − Qcj + Rj VR . mass Q = Qf ρf /ρ Q speciﬁed 3. 79 . Q. . ns j = 1. Q Table 2: Reactor balances for general equation of state. c2 . . . . cns ) = 0 DAEs ODEs 1. . . . . dt nj = cj VR ρ= j cj Mj Deﬁned quantities: ∆fi = Equation of state: f (c1 . . . vol VR = VR0 ρVR = ρ0 VR0 Q speciﬁed f (cj ) = 0 f (cj ) = 0 f (cj ) = 0 dVR = Qf dt dVR = Qf dt VR = VR0 j fj cjf −Q+ j fj cj j fj cjf −Q+ j fj cj i ∆fi ri VR j f j cj i ∆fi ri VR j f j cj Q = Qf j fj cjf + j fj cj i ∆fi ri VR j fj cj 2. j = 1.Nonconstant density Unknowns (ns + 2): Component balances: VR . . . nj .

which can be modeled as a ﬁrstorder. • A pure monomer feed is slowly added at ﬂowrate Qf 0 = 1 m3/min to ﬁll the reactor in semi-batch operation to control the heat release. 80 .Semi-batch polymerization • Consider a solution polymerization reaction. irreversible reaction M → P k r = kcM • A 20 m3 semi-batch reactor is initially charged with solvent and initiator to half its total volume.

1. 2. The monomer feed is adjusted to keep the reactor ﬁlled while the reaction goes to completion. 81 . • Calculate the total polymer mass production.Semi-batch polymerization • Consider two cases for the subsequent reactor operation. The monomer feed is shut off and the reaction goes to completion. and the percentage increase in polymer production achieved in the second operation.

The physical properties • You may assume an ideal mixture • The densities of monomer and polymer are ρM = 800 kg/m3 ρP = 1100 kg/m3 • The monomer molecular weight is MM = 100 kg/kmol • The rate constant is k = 0.1 min−1. 82 .

and can write the monomer balance as dM = Qf 0cMf − kM dt M(0) = 0 (51) 83 .Semi-batch polymerization • While the reactor is ﬁlling. the monomer mole balance is d(cM VR ) = Qf 0cMf − kcM VR dt in which cMf = ρM /MM is given. and Qf = Qf 0 is constant during the ﬁlling operation. • We denote the total number of moles of monomer by M = cM VR .

Semi-batch polymerization • For an ideal mixture. the volume is given by dVR = Qf 0 + ∆V kM dt VR (0) = 10 m3 in which ∆V = (1/ρP − 1/ρM ) MM (52) 84 .

The polymer mass production • To compute the polymer mass. we note from the stoichiometry that the mass production rate of polymer R P is R P = −RM MM • The mass balance for total polymer P is given by dP = R p VR = kcM MM VR = (kMM )M dt (53) 85 .

Semi-batch polymerization • The text solves this problem analytically. • Let t1 be the time that the reactor ﬁlls. let’s solve it numerically. 86 . • dasrt is an ODE solver with the added capability to ﬁnd the time at which some event of interest occurs. because we do not know this time t1. The ODE solver needs to ﬁnd it for us. • We need an ODE solver that is smart enough to stop when the reactor ﬁlls. Instead.

2 min • Note the reactor would have ﬁlled in 10 min if the density were constant. • The extra time reﬂects the available volume created by converting some of the monomer to polymer during ﬁlling. 87 .Finding the time for ﬁlling the reactor • The ODE solver ﬁnds the time at which VR = 20 m3 t1 = 11. • After t1 we consider the two operations.

Operation 1. • Notice the reactor volume decreases after t1 because ∆V is negative. • In the ﬁrst operation. Qf = 0 after t1. 88 .

Semi-batch polymerization 89 .

20 15 2 1 VR (m3 ) 10 5 0 0 10 20 30 time (min) 40 50 Figure 4: Semi-batch reactor volume for primary monomer addition (operation 1) and primary plus secondary monomer additions (operation 2). 90 .

1 0.2 0 10 20 30 time (min) 40 50 2 1 Figure 5: Semi-batch reactor feed ﬂowrate for primary monomer addition (operation 1) and primary plus secondary monomer additions (operation 2).2 0 -0.4 0. 91 .8 Qf (m3 /min) 0.6 0.

6000 5000 monomer (kg) 4000 3000 2000 1000 0 0 10 20 30 time (min) 40 50 2 1 Figure 6: Semi-batch reactor monomer content for primary monomer addition (operation 1) and primary plus secondary monomer additions (operation 2). 92 .

93 .12000 10000 polymer (kg) 8000 6000 4000 2000 0 0 10 20 30 time (min) 40 50 2 1 Figure 7: Semi-batch reactor polymer content for primary monomer addition (operation 1) and primary plus secondary monomer additions (operation 2).

• Because the reactor volume is constant.Operation 2. 94 . we can solve Equation 52 for the feed ﬂowrate during the secondary monomer addition Qf = −∆V kM • Operation 2 is also shown in the ﬁgures. • Notice the ﬁnal polymer production is larger in operation 2 because of the extra monomer addition.

Therefore P 2 = (VR − VR0)ρP = 10 m3 × 1100 kg/m3 = 11000 kg in good agreement with the long-time solution for operation 2. the volumes are additive. • The increase in production rate is P2 − P1 P1 × 100% = 22.Polymer production rate • We can perform an independent. Useful for debugging the computation. 10 m3 of polymer are produced because in an ideal mixture.5% 95 . simple calculation of the total polymer in operation 2. • In operation 2.

96 .5%.• By using the volume of the reactor more efﬁciently. the total polymer production increases 22.

• The ﬂuid velocity is assumed to be a function of only the axial position in the tube. the velocity proﬁle is expected to be reasonably ﬂat in the radial direction except near the tube wall.The Plug-Flow Reactor (PFR) • Plug ﬂow in a tube is an ideal-ﬂow assumption in which the ﬂuid is well mixed in the radial and angular directions. • Plug ﬂow is often used to approximate ﬂuid ﬂow in tubes at high Reynolds number. • Also in turbulent ﬂow. The turbulent ﬂow mixes the ﬂuid in the radial and angular directions. 97 .

Thin Disk Volume Element Given the plug-ﬂow assumption. it is natural to take a thin disk for the reactor volume element Qf cjf Q cj Q(z) cj (z) z ∆V Rj Q(z + ∆z) cj (z + ∆z) z + ∆z 98 .

∂ cj Q ∂cj + Rj (55) =− ∂t ∂V accumulation convection reaction 99 .Thin Disk Volume Element • Expressing the material balance for the volume element ∂ cj ∆V ∂t = cj Q z − cj Q z+∆z + Rj ∆V (54) • Dividing the above equation by ∆V and taking the limit as ∆V goes to zero yields.

Length or volume as independent variable • If the tube has constant cross section. and axial length is related to tube volume by z = V /Ac . is related to volumetric ﬂowrate by v = Q/Ac . Ac . then velocity. • Equation 55 can be rearranged to the familiar form [1.584] ∂ cj v ∂cj =− + Rj ∂t ∂z (56) 100 . p. v.

Steady-State Operation • Setting the time derivative in Equation 55 to zero gives. dNj = Rj dV (58) 101 . One also can express the PFR mole balance in terms of the molar ﬂow. d(cj Q) = Rj dV (57) • The product cj Q = Nj is the total molar ﬂow of component j.

• The important piece of information tying these quantities together is. . again. one has to be able to relate the volumetric ﬂowrate. . pressure. to the molar ﬂows. j = 1. 2. • Because the molar ﬂow and concentration are simply related. . cj ) = 0. Nj . molar ﬂows. ns . Q. . 102 . N j = cj Q (59) the equation of state is also a relation between temperature.Volumetric Flowrate for Gas-Phase Reactions • To use Equation 58 for designing a gas-phase reactor. P . the equation of state for the reaction mixture. and volumetric ﬂowrate. f (T .

cj . as P cj = RT j • In terms of molar ﬂows. can be stated in terms of molar concentrations.Ideal Gas Equation of State • The ideal-gas equation of state. c = P /RT . Q= RT P Nj j (60) 103 . the equation of state is j Nj Q = P RT • One can solve the previous equation for the volumetric ﬂowrate.

one simply rearranges Equation 59 to obtain cj = Nj P = Q RT Nj j Nj (61) 104 .Ideal Gas Equation of State • To evaluate the concentrations for use with the reaction rate expressions.

Volumetric Flowrate for Liquid-Phase Reactions • Consider the equation of state for a liquid-phase system to be arranged in the form ρ = f (T . 105 M(0) = Mf . P . dV in which Mf is the feed mass ﬂowrate. via M = ρQ (62) • Multiplying Equation 58 by Mj and summing on j produces dM = 0. M = j Nj Mj . • The total mass ﬂow in a PFR is constant. cj ) • The mass density is related to the volumetric ﬂowrate and total mass ﬂow.

Volumetric Flowrate for Liquid-Phase Reactions • We can solve for the volumetric ﬂowrate by rearranging Equation 62 Mf Q= ρ • If the liquid density is considered constant. 106 . • Equation 64 is used often for liquid-phase reactions. ρ = ρf . constant density (64) (63) and the volumetric ﬂowrate is constant and equal to the feed value. then Q = Qf .

• For the constant-ﬂowrate case. if Q is constant. the steady-state proﬁle in a PFR starting from a given feed condition is also the transient proﬁle in a batch reactor starting from the equivalent initial condition. dτ constant ﬂowrate (65) which is identical to the constant-volume batch reactor.Volumetric Flowrate for Liquid-Phase Reactions • If we denote the time spent in the tube by τ = V /Q. 107 . we can rewrite Equation 57 as dcj = Rj .

0 atm. and the feed ﬂowrate is 35 L/min.Single Reaction Systems – Changing ﬂowrate in a PFR • A pure vapor stream of A is decomposed in a PFR to form B and C A → B+C k (66) • Determine the length of 2. Assume the pressure drop is negligible. 108 .05 sec−1 at the reactor temperature. • The reaction rate is ﬁrst order in A.5 cm inner-diameter tube required to achieve 35% conversion of A. k = 0. The reactor temperature is 518◦C and the pressure is 2.

so we use Equation 60. which assumes an ideal-gas equation of state.Changing ﬂowrate in a PFR • The mole balance for component A gives dNA = RA dV • The production rate of A is RA = −r = −kcA. • Substituting the production rate into the above equation gives. dNA = −kNA/Q dV (67) • The volumetric ﬂowrate is not constant. RT Q= (NA + NB + NC) P (68) 109 .

• One can relate the molar ﬂows of B and C to A using the reaction stoichiometry.Changing ﬂowrate in a PFR • The ideal-gas assumption is reasonable at this reactor temperature and pressure. The mole balances for B and C are dNB = RB = r dV dNC = RC = r dV • Adding the mole balance for A to those of B and C gives d (NA + NB) =0 dV d (NA + NC) =0 dV • The stoichiometry does not allow the molar ﬂow NA +NB or NA +NC to change with position in the tube. 110 .

NA + NB = NAf + NBf NA + NC = NAf + NCf • Rearranging the previous equations gives. NB = NAf + NBf − NA NC = NAf + NCf − NA • Substituting the relations for NB and NC into Equation 68 gives RT Q= 2NAf + NBf + NCf − NA P 111 . one can relate NB and NC to NA.Changing ﬂowrate in a PFR • Because NA + NB and NB + NC are known at the tube entrance.

yielding Q= RT 2NAf − NA P • Substituting this expression in Equation 67 gives the ﬁnal mole balance.Changing ﬂowrate in a PFR • Because the feed stream is pure A. NA NAf 2NAf − NA dNA = NA V 0 kP − dV RT 112 . NBf = NCf = 0. dNA P NA = −k dV RT 2NAf − NA • The above differential equation can be separated and integrated.

we substitute NA = (1 − xA)NAf into the previous equation and solve for V. 2NAf ln NA/NAf + NAf − NA kP =− V RT • The conversion of component j for a plug-ﬂow reactor operating at steady state is deﬁned as Njf − Nj xj = Njf • Because we are interested in the V corresponding to 35% conversion of A. RT V =− NAf [2 ln(1 − xA) + xA] kP 113 .Changing ﬂowrate in a PFR • Performing the integration gives.

Changing ﬂowrate in a PFR • Because Qf = NAf RT /P is given in the problem statement and the tube length is desired.35) + .35] π (2.2 m 4 [2 ln(1 − .05 sec−1 60 sec/min z = 1216 cm = 12.5 cm)2 114 . it is convenient to rearrange the previous equation to obtain Qf z=− [2 ln(1 − xA) + xA] kAc • Substituting in the known values gives 35 × 103 cm3/min z=− 0.

. . ns • The reaction rates are expressed in terms of the species concentrations. 2. • The most straightforward method is to write the material balance relation for every component. . • The cj are calculated from the molar ﬂows with Equation 59 • Q is calculated from Equation 60. j = 1. . ns dV nr Rj = i=1 νij ri. . dNj = Rj . if an ideal-gas mixture is assumed. .Multiple-Reaction Systems • The modeler has some freedom in setting up the material balances for a plugﬂow reactor with several reactions. . 2. j = 1. . 115 .

k1 k−1 2C6H6 2B C12H10 + H2 D + H 116 . • Diphenyl is produced by the dehydrogenation of benzene.Benzene pyrolysis in a PFR • Hougen and Watson [3] analyzed the rate data for the pyrolysis of benzene by the following two reactions.

Benzene pyrolysis in a PFR • Triphenyl is formed by the secondary reaction. k2 k−2 C6H6 + C12H10 B + D C18H14 + H2 T + H (69) (70) • The reactions are assumed to be elementary so that the rate expressions are 2 r 1 = k 1 cB − r2 = k2 cD cH K1 cT cH cB cD − K2 (71) (72) 117 .

0 atm. • The reactor operates at 1033K and 1. • Plot the mole fractions of the four components versus reactor volume.Benzene pyrolysis in a PFR • Calculate the tube volume required to reach 50% total conversion of the benzene for a 60 kmol/hr feed stream of pure benzene. 118 .

48 119 . k1 = 7 × 105 L/mol · hr k2 = 4 × 105 L/mol · hr K1 = 0.Benzene pyrolysis in a PFR • The rate and equilibrium constants at T = 1033K and P = 1.0 atm are given in Hougen and Watson.31 K2 = 0.

Benzene pyrolysis in a PFR • The mole balances for the four components follow from the stoichiometry. dNB dV dND dV dNH dV dNT dV = −2r1 − r2 = r1 − r2 = r1 + r2 = r2 (73) (74) (75) (76) • The initial condition for the ODEs are NB (0) = NBf and ND (0) = NH (0) = NT (0) = 0. 120 .

Benzene pyrolysis in a PFR

• The total molar ﬂux does not change with reactor volume. Q= RT NBf P (77)

• The rate expressions are substituted into the four ODEs and they are solved numerically. • The total conversion of benzene, xB = (NBf − NB )/NBf , is plotted versus reactor volume in Figure 8. • A reactor volume of 404 L is required to reach 50% conversion. The composition of the reactor versus reactor volume is plotted in Figure 9.

121

0.6 0.5 0.4

xB

0.3 0.2 0.1 0 0 200 400 600 800 1000 1200 1400 1600 V (L)

**Figure 8: Benzene conversion versus reactor volume.
**

122

1

0.8

0.6

yB

yj

0.4

yH yD yT

0.2

0 0 200 400 600 800 1000 1200 1400 1600 V (L)

**Figure 9: Component mole fractions versus reactor volume.
**

123

Ethane pyrolysis in the presence of NO • See the text for another worked PFR example. 124 .

Some PFR-CSTR Comparisons • We have two continuous reactors in this chapter: the CSTR and the PFR. consider a constant-density. the steady-state PFR material balance is given by Equation 65 dcA = −r (cA) dτ 125 . • For simplicity. liquid A → B k n r = kcA (78) • For this situation. • Let’s compare their steady-state efﬁciencies in converting reactants to products.

1 r (cA ) PFR cA CSTR cA cAf 126 .Some PFR-CSTR Comparisons • We rearrange and solve for the time required to change from the feed condition cAf to some exit concentration cA cA τ= cAf 1 dcA r (cA) • The area under the curve 1/r (cA) is the total time required to achieve the desired concentration change.

times the width. of the rectangle.Some PFR-CSTR Comparisons • To achieve this same concentration change in the CSTR. cAf − cA. we start with Equation 37. 1 r (cA ) PFR cA CSTR cA cAf 127 . and solve for τ giving cAf − cA τ= r (cA) • This result also can be interpreted as an area. 1/r (cA). Notice that this area is the height.

At the exit of the PFR. • The PFR reaction rate varies with length. it is intuitively obvious that more volume is required for the CSTR to achieve the same conversion as the PFR. • Now considering that the entire volume of the CSTR is reacting at this lowest rate of the PFR. The rate is high at the entrance to the tube where the concentration of A is equal to the feed value. 128 . VR = Qf τ) is less than the CSTR time (volume). r (cA) is an increasing function of cA. and decreases with length as the concentration drops. the PFR time (or volume.Some PFR-CSTR Comparisons • If 1/r (cA) is a decreasing function of cA. to achieve the same conversion. the rate is the lowest of any location in the tube. equivalently. or.

If the reaction order is negative. the CSTR is more efﬁcient. the PFR is more efﬁcient. 1 r (cA ) CSTR cA PFR cA cAf 129 .Some PFR-CSTR Comparisons • If the reaction order is positive (the usual case).

130 .The PFR versus CSTR with separation • The PFR achieves higher conversion than an equivalent volume CSTR for the irreversible reaction with ﬁrst-order kinetics A → B r = kcA • Consider the case in which we add separation. • Find a single CSTR and separator combination that achieves the same conversion as the PFR.

• Education in chemical engineering principles leads one immediately to consider recycle of the unreacted A as a means to increase this conversion. 131 .The PFR versus CSTR with separation • The issue is to increase the CSTR achievable conversion using separation.

The PFR versus CSTR with separation NA0 NA VR NA0 NA1 NA2 NA VR αNA2 αNA2 pure B • In the text. 132 . we show how to ﬁnd the recycle ﬂowrate so this system achieves the PFR conversion.

• This surprising principle states: For a given reaction network with ni linearly independent reactions.CSTR Equivalence Principle. • This example was motivated by a recent result of Feinberg and Ellison called the CSTR Equivalence Principle of Reactor-Separator Systems [2]. 133 . Moreover the concentrations. also of total reactor volume V . any steady state that is achievable by any reactor-separator design with total reactor volume V is achievable by a design with not more than ni + 1 CSTRs. temperatures and pressures in the CSTRs are arbitrarily close to those occurring in the reactors of the original design.

Stochastic Simulation of Chemical Reactions • We wish to introduce next a topic of increasing importance to chemical engineers. • These situations are becoming increasingly important to chemical engineers as we explore reactions at smaller and smaller length scales. 134 . • We will see that the deterministic rate laws and material balances presented in the previous sections can be captured in the stochastic approach by allowing the numbers of molecules in the simulation to become large. • The stochastic modeling approach is appropriate if the random nature of the system is one of the important features to be captured in the model. • In stochastic models we simulate quite directly the random nature of the molecules. stochastic (random) simulation.

Stochastic Simulation of Chemical Reactions

• For example, if we are modeling the chemical transformation by reaction of only a few hundreds or thousands of molecules at an interface, we may want to examine explicitly the random ﬂuctuations taking place. • In biological problems, we often consider the interactions of only several hundred or several thousand protein molecules and cells. • In sterilization problems, we may wish to model the transient behavior until every last organism is eliminated.

135

**Stochastic Simulation of Chemical Reactions
**

• Assume we have only a hundred molecules moving randomly in the gas phase A → B B → C in a constant-volume batch reactor. • The probability of reaction is assumed proportional to the r1 = k1xA r2 = k2 xB

k2 k1

(79) (80)

in which xj is the number of component j molecules in the reactor volume. • Note xj is an integer, unlike the deterministic model’s cj , which is real.

136

Stochastic Simulation of Chemical Reactions

• The basic idea of the Gillespie algorithm is to: (i) choose randomly the time at which the next reaction occurs, and (ii) choose randomly which reactions occurs at that time. 1. Initialize. Set integer counter n to zero. Set the initial species numbers, xj (0), j = 1, . . . ns . Determine stoichiometric matrix ν and reaction probability laws (rate expressions) ri = kih(xj ) for all reactions. 2. Compute reaction probabilities, ri = kih(xj ). Compute total reaction probability rtot = i ri.

137

from a uniform distribution on the interval (0. 1).Stochastic Simulation of Chemical Reactions 3. Select two random numbers. p1. p2. Let the time interval until the next reaction be t = − ln(p1)/rtot (81) 138 .

Stochastic Simulation of Chemical Reactions 4. Determine reaction m to take place in this time interval.1) by the relative sizes of each reaction probability and then “throw a dart” at the interval to pick the reaction that occurs. all reactions are possible. p2 0 r1 r1 +r2 r2 r1 +r2 1 139 . In this manner. The idea here is to partition the interval (0. but the reaction is selected in accord with its probability.

Stochastic Simulation of Chemical Reactions 5. Return to Step 2. Update the simulation time t(n + 1) = t(n) + t. Update the species numbers for the single occurrence of the mth reaction via xj (n + 1) = xj (n) + νmj . Let n = n + 1. . j = 1. . . ns 140 .

• We will derive this fact in Chapter 8 when we develop the residence-time distribution for a CSTR. • The next ﬁgure shows the results of this algorithm when starting with xA = 100 molecules. 141 .Stochastic Simulation of Chemical Reactions • If rtot is the total probability for reaction. e−rtot t is the probability that a reaction has not occurred during time interval t.

Stochastic Simulation of Chemical Reactions 142 .

100 80 xA 60 xC xB xj 40 20 0 0 1 2 3 4 5 t 143 .

the simulation is actually discontinuous with jumps between simulation times. we already can make out the classic behavior of the series reaction: loss of starting material A.Stochastic Simulation of Chemical Reactions • Notice the random aspect of the simulation gives a rough appearance to the number of molecules versus time. • But in spite of the roughness. and slow increase in ﬁnal product C. which is quite unlike any of the deterministic simulations. 144 . • Because the number of molecules is an integer. appearance and then disappearance of the intermediate species B.

145 .Stochastic Simulation of Chemical Reactions • Next we explore the effect of increasing the initial number of A molecules on a single simulation. The results for 1000 and 4000 initial A molecules are shown in the next ﬁgures.

Stochastic Simulation of Chemical Reactions 146 .

1000 800 xA 600 xC xB xj 400 200 0 0 1 2 3 4 5 t 147 .

Stochastic Simulation of Chemical Reactions 148 .

4000 3200 xA 2400 xC xB xj 1600 800 0 0 1 2 3 4 5 t 149 .

Notice that even with only 4000 starting molecules. the results compare very favorably with the deterministic simulation shown previously. be large. however. 150 . • Another striking feature of the stochastic approach is the trivial level of programming effort required to make the simulations.Stochastic Simulation of Chemical Reactions • We see the random ﬂuctuations become less pronounced. • The computational time required for performing the stochastic simulation may. • The biggest numerical challenge is producing the pseudo-random numbers and many well-developed algorithms are available for that task.

Hepatitis B virus modeling 151 .

Hepatitis B virus modeling nucleotides −− → −− − − nucleotides + cccDNA rcDNA cccDNA envelope degraded (82) (83) (84) (85) (86) (87) rcDNA −− → −− − − amino acids −− → −− − − cccDNA −− → −− − − cccDNA envelope −− → secreted or degraded −− − − rcDNA + envelope −− → −− − − secreted virus 152 .

and C is envelope.Hepatitis B virus modeling • The reaction rates and production rates for Reactions 82–87 are given by r1 r2 r3 r4 r5 r6 k1 xA k2 xB k3 xA k4 xA k5xC k6xB xC R r − r4 A 2 RB = r1 − r2 − r6 RC r3 − r5 − r6 (88) = in which A is cccDNA. 153 . B is rcDNA.

25 7.5 × 10−6 154 .Hepatitis B virus modeling • Assume the systems starts with a single cccDNA molecule and no rcDNA and no envelope protein. and the following rate constants xA kT = 1 xB xC T = 1 0 2 0 T (89) (90) 0.025 1000 0.

Average stochastic is not deterministic. stochastic 50 100 t (days) 150 200 deterministic avg. 25 20 cccDNA 15 10 5 0 0 250 200 rcDNA 150 100 50 0 0 50 100 t (days) 150 200 deterministic avg. stochastic 155 .

10000 8000 envelope 6000 4000 2000 0 0 50 100 t (days) 150 200 deterministic avg. stochastic 156 .

Hepatitis B virus modeling 157 .

35 30 25 cccDNA 20 15 10 5 0 0 50 100 t (days) stoch 2 deterministic stoch 1 150 200 Figure 10: Species cccDNA versus time for hepatitis B virus model. two representative stochastic trajectories. 158 .

That is another possible steady state for the stochastic model. • Notice the ﬁrst stochastic simulation does ﬂuctuate around the deterministic simulation as expected. 159 . shows complete extinction of the virus. • The second stochastic simulation. however.Hepatitis B virus modeling • The simulation of the deterministic model and an average of 500 stochastic simulations are not the same. • Figure 10 shows two representative stochastic simulations for only the cccDNA species.

Average stochastic is not deterministic. 25 20 cccDNA 15 10 5 0 0 50 100 t (days) 150 200 deterministic avg. So the average stochastic simulation consists of 75% trajectories that ﬂuctuate about the deterministic trajectory and 25% trajectories that go to zero. it occurs for 125 of the 500 simulations. stochastic 160 . • In fact.

• the batch reactor • the continuous-stirred-tank reactor (CSTR) • the semi-batch reactor • the plug-ﬂow reactor (PFR). 161 .Summary • We have introduced four main reactor types in this chapter.

dτ τ = V /Qf (99) 162 .Summary BATCH d(cj VR ) = Rj VR dt dcj = Rj dt d(cj VR ) = Qf cjf − Qcj + Rj VR dt dcj 1 = (c − cj ) + Rj dt τ jf cj = cjf + Rj τ d(cj VR ) = Qf cjf + Rj VR dt ∂cj ∂(cj Q) = − + Rj ∂t ∂V d(cj Q) dV = Rj (91) constant volume (92) CSTR (93) constant density (94) steady state (95) SEMI-BATCH (96) PFR (97) steady state (98) constant ﬂowrate dcj = Rj .

reversible reactions 163 . • ﬁrst order. irreversible • ﬁrst order. irreversible • nth order.Summary We also have introduced some of the basic reaction-rate expressions. irreversible • two ﬁrst-order reactions in series • two ﬁrst-order reactions in parallel • two second-order. reversible • second order.

not ﬁrst-order reaction rates). • In the case of multiple reactions with nonlinear rate expressions (i. • Several of these simple mass balances with basic rate expressions were solved analytically.e. • A high-quality ordinary differential equation (ODE) solver is indispensable for solving these problems.. the balances must be solved numerically. We require an equation of state for this purpose.Summary • We developed the equations required to compute the volume of the reactor if there is a signiﬁcant volume change upon reaction. 164 .

the CSTR achieves higher conversion than the same-volume PFR if the rate is a decreasing function of a component composition (n < 0). 165 . we introduced stochastic simulation to model chemical reactions occurring with small numbers of molecules. • Finally.Summary • We showed that the PFR achieves higher conversion than the CSTR of the same volume if the reaction rate is an increasing function of a component composition (n > 0 for an nth-order rate expression). • Conversely.

nonlinear hepatitis B virus model. • The smooth behavior of the macroscopic ODE models is recovered by the random simulations in the limit of large numbers of reacting molecules. • With small numbers of molecules. We demonstrated this fact with the simple. 166 . A given reaction’s probability of occurrence is assumed proportional to the number of possible combinations of reactants for the given stoichiometry. the average of the stochastic simulation does not have to be equal to the deterministic simulation. • Two pseudo-random numbers are chosen to determine: (i) the time of the next reaction and (ii) the reaction that occurs at that time.Summary • The stochastic model uses basic probability to compute reaction rate. however.

E. Feinberg and P. Lightfoot. [3] O. Bird. John Wiley & Sons. M. second edition. New York. N. Ellison. John Wiley & Sons. Res. 1947. Hougen and K. Watson. Part Three: Kinetics and Catalysis. Stewart. B. Chem. A.References [1] R. [2] M. and E. Eng. Chemical Process Principles. Principles. 40(14):3181–3194.. 2001. Ind. New York. W. Transport Phenomena. 2002. General kinetic bounds on productivity and selectivity in reactor-separator systems of arbitrary design: I. 167 .

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