Jordan University of

Faculty of
Science and
Pharmacy
Technology

Jordan University of Science & Technology

Faculty of Pharmacy
Department of Medicinal Chemistry and Pharmacognosy
Year: 2010/2011 Semester: 2

Course Information
Course Title Medicinal Chemistry I
Course Number Phar 321
Course Credits 3
Course Time Mon Wed: Sec 1, 11.15 -12.45
Prerequisites Pharmaceutical Organic Chemistry II, (Phar 222)
Instructor Dr. Qosay Al-Balas
Office Location P2 Level -2
Office Phone Dr. Al-Balas: 72010 00 Ext. 23416
Office Hours Mon-Wed: 9:45-11:15
E-mail qabalas@just.edu.jo

Text Book
Title Introduction to Medicinal Chemistry
Author(s) Graham Patrick
Publisher
Year 2009
Edition 4th
References Foye's Principles of Medicinal Chemistry, David A Williams, William
O Foye and Thomas L Lemke, 6th Edition, 2008, Lippincott Williams &
Wilkins

Assessment Policy
Assessment Type Expected Due Date Weight
First Exam TBA 30%
Second Exam TBA 30%
Final Exam TBA 40%
 Intended Learning Outcomes (ILOs)
After completing this course successfully, the student is expected to:

1. Learn the influence of the physico-chemical properties of a drug on its absorption,

distribution and elimination.
2. Understand the chemical basis of drug action and drug metabolism.
3. Know the basic principles of rational drug design.

Teaching & Learning Methods

1. Class lectures and lecture notes are designed to achieve the course objectives.
2. You should read the assigned chapters before class and participate in class and do
whatever it takes for you to grasp this material. Ask questions. Ask lots of questions.
3. You are responsible for all material covered in the class.
4. Please communicate any concerns or issues as soon as practical either in class, by
phone or by Email.

Course Content
Week Chapter in
Topics
Text
1 1. Introduction to Medicinal Chemistry.
1.1 What is Medicinal Chemistry? Introduction
1.2 Classification of Drugs
2-4 2. Drug Absorption and Distribution
2.1 Gastrointestinal Tract and Biomembranes
2.2 Mechanisms of Drug Absorption 7
2.3 Physicochemical Properties of Drugs
2.4 Drug Distribution
5-8 3. Structural Medicinal Chemistry
3.1 Definitions
3.2 Receptors
3.3 Drug-Receptor Interaction
4,5
3.4 Factors Affecting Drug-Receptor Interaction
3.5 Bioisosterism
3.6 From Functional Groups to Molecular Chemistry
3.7 Molecular Mechanism of Drug Action
9-12 4. Drug Metabolism and Excretion
4.1 Introduction
8
4.2 Structure-Metabolism Relationships (SMR)
4.3 Metabolic Reactions
4.4 Factors Affecting Metabolism.
4.5 Drug Excretion
13,14 5. Drug Development 2
 Additional Notes
Exams • The format for the exams is generally (but NOT always) as
follows: Multiple-choice and short essay questions.
• Grades will not be given out via e-mail
Makeup Exams • Makeup exam should not be given unless there is a valid
excuse.
• Arrangements to take an exam at a time different than the one
scheduled MUST be made prior to the scheduled exam time.
Drop Date • Last day to drop the course is before the twelve (12 th) week of
the current semester.
Cheating The commitment of the acts of cheating and deceit such as copying
during examinations, altering examinations for re-grade, plagiarism of
homework assignments, and in any way representing the work of others
as your own is dishonest and will not be tolerated. Standard JUST policy
will be applied

‫ضبط الطالب أثناء المتحان أو الختبار متلبسا ً بالغش فتوقع عليه‬ُ ‫ إذا‬:7 ‫المادة‬
:‫العقوبات التالية مجتمعة‬
.‫ اعتباره راسبا ً في ذلك المتحان أو الختبار‬-‫أ‬
.‫ الغاء تسجيله في بقية المساقات المسجل لها في ذلك الفصل‬-‫ب‬
‫ و هو الفصل التالي للفصل‬،‫ فصله من الجامعة لمدة فصل دراسي واحد‬-‫جـ‬
.‫الذي ضبط فيه‬
Attendance • Excellent attendance is expected.
• JUST policy requires the faculty member to assign ZERO
grade (35) if a student misses 10% of the classes that are not
excused.
• If you miss class, it is your responsibility to find out about any
announcements or assignments you may have missed.
Workload • Average work-load student should expect to spend is 6
hours/week
Graded Exams • Instructor should return exam papers graded to students not
after the week after the exam date.