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Hemodialysis
Hassan El Hajj, F1
Nephrology Department
HHUMC
Common Complications
Hypotension (20% - 30%)
Cramps (5% - 20%)
Nausea and Vomiting (5% - 15%)
Headache (5%)
Chest pain (2% - 5%)
Back pain (2% - 5%),
Itching (5%)
Fever and Chills (<1%)
Hypotension
It’s the most common acute complication of HD.
Incidence : 20 – 50% .
Contributing factors:
Elevations in CPK levels.
Hypomagnesemia.
Hypocalcemia
Predialysis hypokalemia
Muscle cramps
Management :
Nifedipine (10 mg) has also been found to reverse cramping (should be
reserved for cramping in hemodynamically stable patients).
Prevention :
Avoidance of hypotension during dialysis is of prime importance.
Persistent symptoms unrelated to hemodynamics may benefit from
metoclopramide.
Sometimes a single predialysis dose of 5 -10 mg is sufficient.
Headache
Etiology :
Cause is largely unknown.
May be a subtle manifestation of the disequilibrium syndrome.
Caffeine Withdrawal.
With atypical or particularly severe headache, a neurologic cause
(particularly a bleeding event precipitated by anticoagulation) should be
considered.
Mg deficient
Management :
Acetaminophen can be given during dialysis.
Prevention :
Decreasing dialysis solution sodium also may be helpful in patients being
treated with high sodium levels.
A cup of strong coffee may help prevent (or treat) caffeine withdrawal
symptoms.
A cautious trial of magnesium supplementation may be indicated
Chest pain and Back pain
Incidence : 1% to 4%.
Etiology :
? May be a manifestation of low-grade hypersensitivity to dialyzer or
blood circuit components.
Itching may simply be present chronically.
Viral (or drug-induced) hepatitis should not be overlooked as a potential
cause of such itching.
Management :
Standard symptomatic treatment using antihistamines is useful.
Chronically, general moisturizing and lubrication of the skin using
emollients is recommended.
Ultraviolet light therapy may be of help
Recent small, randomized studies have suggested beneficial effects for
gabapentin
Clinical Manifestations:
Early : headache, nausea, disorientation, restlessness,
blurred vision, and asterixis.
More severely affected patients progress to confusion,
seizures, coma, and even death.
Dialysis disequilibrium syndrome
Management:
In an acute dialysis setting:
One should not prescribe an overly aggressive treatment session.
The target reduction in the BUN should initially be limited to about 40%.
Use of a low-sodium dialysis solution dialysis solution (more than 2 - 3
mM less than the plasma sodium level) may exacerbate cerebral edema
and should be avoided.
In hypernatremic patients, one should not attempt to correct the plasma
sodium concentration and the uremia at the same time.
It is safest to dialyze a hypernatremic patient initially with a dialysis
solution sodium value close to the plasma level and then to correct the
hypernatremia slowly postdialysis by administering 5% dextrose.
Daily dialysis for 3 to 4 days with gradual increases in dialysis time and blood
flow often prevents symptoms and signs of disequilibrium.
Cardiac Tamponade:
Unexpected or recurrent hypotension during dialysis can be a sign of
pericardial effusion or impending cardiac tamponade.
Intracranial Bleeding:
Underlying vascular disease and hypertension combined with heparin
administration can sometimes result in the occurrence of intracranial,
subarachnoid, or subdural bleeding during the dialysis session.
Seizures:
Children, patients with high predialysis plasma urea nitrogen levels, and
patients with severe hypertension are the most susceptible to seizures
during dialysis.
Seizure activity can be one manifestation of the disequilibrium syndrome
Hemolysis
Presentation : chest pain, chest tightness, or back pain.
If hemolysis is not recognized early, severe hyperkalemia may ensue and lead to
death.
Clamp the blood lines (do not return the blood to avoid increasing the
risk of hyperkalemia),
Prepare to treat hyperkalemia and the potentially severe anemia.
Symptoms :
the seated patient with an air embolism may lose consciousness and seize
while the recumbent patient may initially develop dyspnea, cough, and
perhaps chest tightness.
Prevention:
Oxygen administration will prevent (as well as treat) hypoxemia.
In high-risk patients, one might consider avoiding dialyzer
membranes made of unsubstituted cellulose
and using a bicarbonate-containing dialysis solution with a
bicarbonate concentration low enough to avoid alkalemia.
Thank You