Remaining NEPHRONS undergoes changes to compensate for those damaged nephrons

Increase Filtration of Concentrated blood by the remaining Nephrons

Hypertrophy of Nephrons

Exhaustion of the remaining nephron

Further damage of the nephrons

STAGE 3 RENAL FAILURE
GFR (30-59 mL/min/1.73 m2)

Predisposing Factors: ETIOLOGY: HYPERTENSION Modifiable: Diet, Lifestyle Non-Modifiable: Age, Gender, Family History

Renal Artery Atherosclerosis

Impaired Blood Flow in the Kidney

Decrease O2 supply in the kidney

Kidney Cell Death

Glomerulosclerosis

Decrease GFR

Renal Blood

Proteinuria
(GLOMERULAR FILTRATION RATE)

STAGE I DIMINISHED RENAL RESERVED GFR (•90 mL/min/1.73 m2) Normal BUN, Creatinine

STAGE II RENAL INSUFFICIENCY
GFR (60-89 mL/min/1.73 m2)

BUN, Creatinine Begin to Increase