Slide 1 SG1 Sidharth Gandhi. 3/23/2011 .

so as to transfer the information's between themselves with the help of signal pathways so as to accomplish various biological processes.Definition: y Cell communication is the process by which various cells work together and coordinate. .

IMPORTANCE OF CELL SIGNALLING It affects every aspect of cell structure and function. y The combined effects of multiple signals determine cell response. y . y Cell-to-cell communication is essential for multi-cellular organisms.


CELL SIGNALLING AND MECHANISM: StepStep-1 Release of ´Extra Cellular Messenger Moleculeµ. .

.StepStep-2 Binding of the messenger molecule by the ´receptorsµ on the extra cellular surface . and relaying of the signal through the receptor cytoplasmic domain.

Types of Receptors .

Fig. 11-6-3 StepStep-3 Transmitting of signal into the cell interior. EXTRACELLULAR FLUID CYTOPLASM Plasma membrane 2 Transduction 3 Response 1 Reception Receptor Activation of cellular response Relay molecules in a signal transduction pathway Signaling molecule .

.StepStep-4 Reaching of transmitted signal through signaling pathways to the target proteins.

. 4) Death of the cell . 2) Increase or decrease of cell mobility. 3) Activation of DNA synthesis.StepStep-5 Accomplishment of cellular process which can be:1) Change in gene expression.


.Definition of Signal Transduction It is the overall process in which the information which is carried by the extracellular messenger molecule is translated in to the changes that occur inside a cell .is referred as signal transduction.

Overall process .

y Ligand gated channels. y Steroid hormone receptors. y .Types of Receptors G-protein coupled receptors. y B & T cell receptors. y Receptor protein tyrosine kinases.

G-Protein-Linked Receptors Protein- .

Ion-ChannelIon-Channel-Linked Receptors .

y Any Questions???? .

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