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[aka rhabdomyolysis] · Contraindications: Girl during pregnancy/ Growing children · Interactions: Coumarin/ Cyclosporine
Antiarrhythmics: class III members BIAS: Bretylium Ibutilide Amiodarone Sotalol
Beta-blockers: main contraindications, cautions ABCDE: Asthma Block (heart block) COPD Diabetes mellitus Electrolyte (hyperkalemia)
Clopidogrel: use CLOPIdogrel is a drug that prevents CLots, an Oral Platelet Inhibitor (OPI).
Amiodarone: action, side effects 6 P's: Prolongs action potential duration Photosensitivity Pigmentation of skin Peripheral neuropathy Pulmonary alveolitis and fibrosis Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism
Beta blockers: members "The NEPAL Prime Minister": Timolol Nadolol Esmolol Pindolol Atenolol Labetalol Propranolol Metoprolol
Ca++ channel blockers: uses CA++ MASH: Cerebral vasospasm/ CHF Angina Migranes Atrial flutter, fibrillation Supraventricular tachycardia Hypertension · Alternatively: "CHASM":
Monitor Xa concentration. monitoring EnoXaprin only acts on factor Xa.Cererbral vasospasm / CHF Hypertension Angina Suprventricular tachyarrhythmia Migranes Beta-blockers: nonselective beta-blockers "Tim Pinches His Nasal Problem" (because he has a runny nose...H.L --- .): Timolol Pindolol Hismolol Naldolol Propranolol Antiarrhythmics: classification I to IV MBA College· In order of class I to IV: Membrane stabilizers (class I) Beta blockers Action potential widening agents Calcium channel blockers Enoxaprin (prototype low molecular weight heparin): action. rather than APTT anti hyprtensive safe for pregnancy are--My N.
... L-labetalol..... orthostatic hypotension P = Parkinsonism A = Anemia [+ve coomb's test] sodium nitroprusside clinical uses: MR. CHIEF SURGERY IN EMERGENCY Quote: Mr.... drowsiness O = oedema... N-nifedipine.. methyldopa Quote: M = mental retardation E = electrolyte imbalance T = tolerance H = headache/ hepatotoxicity... Saurav Ganguly HELP Quote: S-sodium nitroprusside G-GTN H-hydralazine E-esmolol L-labetalol P-phentolamine Anticholinergic side effects "Know the ABCD'S of anticholinergic side effects": .Quote: M-methyl dopa.. = Acute MI chief = Acute CHF Surgery = maintain hemostasis during surgeries emergency = hypertensive emergencies antihypertensives used in emergencies. H-hydralazine. rebound HTN Y = psYchological upset D = dry mouth.
action "Inhibits Parasympathetic And Sweat": Quote: Ipratropium Pirenzepine Atropine Scopolamine _Muscarinic receptors at all parasympathetic endings sweat glands in sympathetic.Quote: Anorexia Blurry vision Constipation/ Confusion Dry Mouth Sedation/ Stasis of urine Antimuscarinics: members. Aspirin: side effects ASPIRIN: Quote: Asthma Salicyalism Peptic ulcer disease/ Phosphorylation-oxidation uncoupling/ PPH/ Platelet disaggregation/ Premature closure of PDA Intestinal blood loss Reye's syndrome Idiosyncracy Noise (tinnitus) Benzodiazapines: ones not metabolized by the liver (safe to use in liver failure) LOT: Quote: Lorazepam Oxazepam Temazepam Benzodiazepenes: antidote .
not alphabungarotoxin--alpha has different mechanism).Quote: "Ben is off with the flu": Benzodiazepine effects off with Flumazenil. Cholinergics (eg organophosphates): effects If you know these. Scotty": Quote: Beta blockers: Esmolol Atenolol Metropolol Botulism toxin: action. you will be "LESS DUMB": or SLUDGE . Beta selective blockers "BEAM ONE up. Benzodiazepenes: drugs which decrease their metabolism "I'm Overly Calm": Quote: Isoniazid Oral contraceptive pills Cimetidine _ These drugs increase calming effect of BZDs by retarding metabolism. Benzodiazepines: actions "Ben SCAMs Pam into seduction not by brain but by muscle": Quote: Sedation anti-Convulsant anti-Anxiety Muscle relaxant Not by brain: No antipsychotic activity. related bungarotoxin Quote: Action: "Botulism Bottles up the Ach so it can't be the released": Related bungarotoxin: "Botulism is related to Beta Bungarotoxin (beta-.
lidocaine) Urinary incontinence drugs (anticholinergics) Theophylline Ethanol Corticosteroids H blockers Antiparkinsonian drugs Narcotics (esp. mepridine) Geriatric psychiatric drugs ENT drugs Insomnia drugs NSAIDs (eg indomethacin. naproxin) Muscle relaxants Seizure medicines Direct sympathomimetic catecholamines DINED: Quote: Dopamine Isoproterenol Norepinephrine Epinephrine Dobutamine Inhalation anesthetics SHINE: . penicillin.Quote: Lacrimation Excitation of nicotinic synapses Salivation Sweating Diarrhea Urination Micturition Bronchoconstriction Delerium-causing drugs ACUTE CHANGE IN MS: Quote: Antibiotics (biaxin. ciprofloxacin) Cardiac drugs (digoxin.
Lead poisoning: presentation ABCDEFG: Quote: Anemia Basophilic stripping Colicky pain Diarrhea Encephalopathy Foot drop Gum (lead line) Lithium: side effects LITH: Quote: Leukocytosis Insipidus [diabetes insipidus. so it behaves like Atropine.Quote: Sevoflurane Halothane Isoflurane Nitrous oxide Enflurane _ If want the defunct Methoxyflurane too. . make it MoonSHINE. Ipratropium: action Atropine is buried in the middle: iprAtropium. _ Note MAOI is inside MelAnchOlIc. tied to polyuria] Tremor/ Teratogenesis Hypothyroidism MAOIs: indications MAOI'S: Quote: Melancholic [classic name for atypical depression] Anxiety Obesity disorders [anorexia. bulemia] Imagined illnesses [hypochondria] Social phobias _ Listed in decreasing order of importance.
since MAOs treat depression.Methyldopa: side effects METHYLDOPA: Quote: Mental retardation Electrolyte imbalance Tolerance Headache/ Hepatotoxicity psYcological upset Lactation in female Dry mouth Oedema Parkinsonism Anaemia (haemolytic) Monoamine oxidase inhibitors: members "PIT of despair": Quote: Phenelzine Isocarboxazid Tranylcypromine _ A pit of despair. Morphine: effects MORPHINES: Quote: Miosis Orthostatic hypotension Respiratory depression Pain supression Histamine release/ Hormonal alterations Increased ICT Nausea Euphoria Sedation Morphine: effects at mu receptor PEAR: Quote: Physical dependence Euphoria .
ophenadrine) L-Dopa + peripheral decarboxylase inhibitor (carbidopa. neostigmine LMNOP: Quote: Lipid soluble Miotic Natural Orally absorbed well Physostigmine _ Neostigmine.Analgesia Respiratory depression Narcotic antagonists Quote: The Narcotic Antagonists are NAloxone and NAltrexone. pergolide) Phenytoin: adverse effects PHENYTOIN: Quote: P. ataxia. Parkinsonism: drugs SALAD: Quote: Selegiline Anticholinenergics (trihexyphenidyl. _ Important clinically to treat narcotic overdose.interactions Hirsutism Enlarged gums Nystagmus Yellow-browning of skin Teratogenicity Osteomalacia Interference with B metabolism (hence anemia) Neuropathies: vertigo. headache Physostigmine vs. benzhexol. is: Water soluble . benserazide) Amantadine Dopamine postsynaptic receptor agonists (bromocriptine. lisuride. on the contrary.
amphetamine "MorPHINE: Fine. Amphetamine overdose: pupils dilated (fat). then Sucks ions in through open pore. Serotonin syndrome: components Causes HARM: Quote: Hyperthermia Autonomic instability (delirium) Rigidity Myoclonus Sodium valproate: side effects VALPROATE: Quote: Vomiting Alopecia Liver toxicity Pancreatitis/ Pancytopenia Retention of fats (weight gain) Oedema (peripheral oedema) Appetite increase Tremor Enzyme inducer (liver) Succinylcholine: action. AmPHETamine: Fat": Quote: Morphine overdose: pupils constricted (fine). the CIA is after me": Quote: Clomipramine Imipramine .Used in myesthenia gravis Synthetic Poor oral absorption Pupils in overdose: morphine vs. Tricyclic antidepressants: members worth knowing "I have to hide. and drug is used for intubation. You Suck stuff in through a mouth-tube. use Quote: Succinylcholine gets Stuck to Ach receptor.
urinary retention. MI. the DNDis also after me: Desipramine Norrtriptyline Doxepin Tricyclic antidipressents (TCA): side effects TCA'S: Quote: ThrombocytopeniaCardiac (arrhymia.Amitrptyline _ If want the next worth knowing. stroke) Anticholinergic (tachycardia. etc) Seizures Vigabatrin: mechanism Vi-GABA-Tr-In: Quote: Via GABA Transferase Inhibition Antibiotics contraindicated during pregnancy MCAT: Quote: Metronidazole Chloramphenicol Aminoglycoside Tetracycline Busulfan: features ABCDEF: Quote: Alkylating agent Bone marrow suppression s/e CML indication Dark skin (hyperpigmentation) s/e Endrocrine insufficiency (adrenal) s/e Fibrosis (pulmonary) s/e Metabolism enzyme inducers "Randy's Black Car Goes Putt Putt and Smokes": Quote: Rifampin Barbiturates Carbamazepine .
urinary retention) Nausea Emesis Therapeutic index: formula TILE: Code: TI = LD / ED Zero order kinetics drugs (most common ones) "PEAZ (sounds like pees) out a constant amount": Quote: Phenytoin Ethanol Aspirin Zero order _ Someone that pees out a constant amount describes zero order kinetics (always the same amount out) Asthma drugs: leukotriene inhibitor action Quote: zAfirlukast: Antagonist of lipoxygenase zIlueton: Inhibitor of LT receptor Beta.vs Beta. .receptor location "You have heart and lungs": Quote: Beta.are therefore primarily on heart.Grisoefulvin Phenytoin Phenobarb Smoking cigarettes Morphine: side-effects MORPHINE: Quote: Myosis Out of it (sedation) Respiratory depression Pneumonia (aspiration) Hypotension Infrequency (constipation.
Beta-blockers: main contraindications.Beta. making them acceptable for use in some diabetics or asthmatics despite the fact that they are non-seletive beta blockers..primarily on lungs. beta ABCD: Quote: Alpha = Constrict. Beta = Dilate. cautions ABCDE: Quote: Asthma Block (heart block) COPD Diabetes mellitus Electrolyte (hyperkalemia) Beta-blockers: nonselective beta-blockers "Tim Pinches His Nasal Problem" (because he has a runny nose. Hepatic necrosis: drugs causing focal to massive necrosis "Very Angry Hepatocytes": Quote: Valproic acid Acetaminophen Halothane Adrenoceptors: vasomotor function of alpha vs.): Quote: Timolol Pindolol Hismolol Naldolol Propranolol .. Pindolol and Carteolol have high and moderate ISA respectively. Beta blockers with intrinsic sympathomimetic activity Quote: Picture diabetic and asthmatic kids riding away on a cart that rolls on pinwheels.
.Phenyltriazines C.... Quote: D.BHAISAB's New PC.. cyclic gaba analogues adverse effects of tetracyclins-KAPIL DEV Quote: K kidney toxicity A antianabolic effect P phototoxicity I inc ICP L liver toxicity D diabetes insipidus E enamel problems V vestibular toxicity .....PREANASTHETIC MEDICATION HOSANA this is a christian word...... Quote: H-H2blockers O-opeoids S-sedatives-antianxiety A-anticholenergic N-neuroleptics A-antiemetics simple and sobar anti epeleptic drugs Dr. aliphatic carb acids I..BZD's N.iminostilbenes S.......hydantoin A....barbiturates H. newer drugs P.deoxy barbiturates B..succinimides B.
irritative effects S..hypersensitivity I.. Drugs causing pulmonary fibrosis: Quote: BAB like in baba (father) Bleomycin Amiodarone Busulfan ADRS OF CHLORAMPHENICOL smart boys in girls hostel B....... for clinical uses of beta blockers.. bone marrow depression H.. 'melbourne cricket authority has high funds though players get minor amount' .GENERAL TOXICITY OF ANTICANCER DRUGS SHaLi's BF Ghoghari Gautam is Chor..superinfections G... Quote: S-skin H-hyperurecemia L-lymphoreticular tissue B-bone marrow F-Foetus G-gonads G-git C-carcinogenecity 6 H s and 8 H s of adverse effects of thaizide diuretics and loop diuretics respectively..........Gray baby syndrome ampicillin uses UR GMCS BeST Quote: UTI Respi ..
Other interesting facts about him: he can pee for 12 hours straight! (The half-life is 12h and it’s excreted unchanged in the kidney . Cephamandole “…Man doll” You have to inflate your man doll and you get an upper respiratory infection. If you “use” this anatomically correct man doll. stage 2.Gonorrhoea Maningitis cholecystitis septicemias bacillary dysentry sabe typhoid misch Acyclovir “I see clover” I see a three-leaf clover (this is a prodrug that gets converted into a triphosphate – it resembles dNTP and inhibits DNA Polymerase). Homan is our new SOM dean. slurred speech. in viral infection). and inability to concentrate (these are some of the adverse effects) Cephachlor “Chlorine” – as in swimming pools You swim and get water up your nose and in your ears (this drug treats sinusitis and OTITIS media). Cephalothin “…Loathing” If your heart is infected. He’s also so real that . Dr. feelings of detachment. ataxia. Imagine putting clovers over herpes sores and genital warts (this is used to treat those).) Dr. insomnia. His new policy: he won’t let us come to school without our white coats (this drug blocks uncoating. Amantadine “Homan to Dean” In case you haven’t heard. Homan can’t take the pressure of being a new dean so he becomes a nervous drunk with depression. only loathe (this is used to treat severe infections such as endocarditis). Cephadroxil “Drop rocks” While you are peeing you drop rocks (This drug treats UTIs). dizziness. he will give you pelvic inflammatory disease (This drug is indicated for URI and PID). you can’t love.
they won’t reproduce (this drug is a stage 3 inhibitor). Foscarnet “Fox cARRR net” If you catch foxes in a net. (This is used to treat oral and esophageal candidiasis in AIDS patients).he bleeds!!! (Adverse effect: It affects Vit-K dependent clotting function) Cephazolin “…Soul in” You want to keep your soul in and not die if you go to surgery (this drug is used prophylactically for surgery). These drugs. a foxy lady is HOT (this drug will cause a fever) and never wear fox urine to hunt (this is excreted in the kidney and causes renal insufficiency).). Cephoperazone “…Opera zone” Going to the opera makes me want to get drunk to the point of illness. Also. inhalational corticosteroids . fragilis infections). when mixed with ethanol interfere with ALDH. ARRR… it inhibits RNA polymerase and Reverse transcriptase to block Reproduction. if you see Phantom of the Opera. expect to see some blood! (This affects Vit-K dependent clotting function. Clindamycin “Clean the mice” You’re cleaning the mice because they are covered with ticks (this drug is used to treat Lyme Disease). Also. affecting alcohol metabolism (you end up with increased acetaldehyde – a DISULFIRAM-LIKE REACTION). You have to use SOS kitchen cleaner to clean the mice (SOS = 50 S ribosomal unit – where this drug acts). Richard Gere likes to put mice in “where the sun don’t shine” and this is a very FRAGILE procedure (Clindamycin may cause Pseudomembranous enterocolitis and it’s also used to treat B.) Cephotaxime “…Tax time” IRS is hard to kill off – they are MULTIPLE DRUG RESISTANT (Use this drug against MDR strains. You’re going to put the foxes into a car that’s made out of bones instead of metal (this drug binds to bones and decreases Ca2+ and Mg2+). Fluconazole “Flu cone” Imagine an emaciated AIDS patient eating an ice cream cone made of the flu and he gets an oral and esophageal fungal infection.
use Quote: Succinylcholine gets Stuck to Ach receptor. You Suck stuff in through a mouth-tube. and drug is used for intubation Cholinergics (eg organophosphates): effects If you know these.Bed Bug Flew To Florida Quote: B-BECLOMETHASONE DIPROPIONATE B-BUDESONIDE F-FLUTICASONE PROPIONATE T-TRIAMCINALONE F-FLUNISOLIDE Succinylcholine: action. you will be "LESS DUMB": Quote: Lacrimation Excitation of nicotinic synapses Salivation Sweating Diarrhea Urination Micturition Bronchoconstriction Steroids: side effects BECLOMETHASONE: Quote: Buffalo hump Easy bruising Cataracts Larger appetite Obesity Moonface Euphoria Thin arms & legs Hypertension/ Hyperglycaemia Avascular necrosis of femoral head Skin thinning Osteoporosis . then Sucks ions in through open pore.
Negative nitrogen balance Emotional liability Methyldopa: side effects METHYLDOPA: Quote: Mental retardation Electrolyte imbalance Tolerance Headache/ Hepatotoxicity psYcological upset Lactation in female Dry mouth Oedema Parkinsonism Anaemia (haemolytic) Sodium valproate: side effects VALPROATE: Quote: Vomiting Alopecia Liver toxicity Pancreatitis/ Pancytopenia Retention of fats (weight gain) Oedema (peripheral oedema) Appetite increase Tremor Enzyme inducer (liver) Captopril (an ACE inhibitor): side effects CAPTOPRIL: Quote: Cough Angioedema/ Agranulocystosis Proteinuria/ Potassium excess Taste changes Orthostatic hypotension Pregnancy contraindication/ Pancreatitis/ Pressure drop (first dose hypertension) Renal failure (and renal artery stenosis contraindication)/ Rash Indomethacin inhibition Leukopenia/ Liver toxicity .
fibrillation Supraventricular tachycardia Hypertension · Alternatively: "CHASM": Quote: Cererbral vasospasm / CHF Hypertension Angina Suprventricular tachyarrhythmia Migranes .Lithium: side effects LITH: Quote: Leukocytosis Insipidus [diabetes insipidus. tied to polyuria] Tremor/ Teratogenesis Hypothyroidism Opioids: effects BAD AMERICANS: Quote: Bradycardia & hypotension Anorexia Diminished pupilary size Analgesics Miosis Euphoria Respiratory depression Increased smooth muscle activity (biliary tract constriction) Constipation Ameliorate cough reflex Nausea and vomiting Sedations Ca++ channel blockers: uses CA++ MASH: Quote: Cerebral vasospasm/ CHF Angina Migranes Atrial flutter.
your pupils dilate so you can see Atropine use: tachycardia or bradycardia "A goes with B": Atropine used clinically to treat Bradycardia Reserpine action Reserpine depletes the Reserves of catecholamines [and serotonin] Sodium channel blockade: Procainamide. irritability. dizziness. amphetamine MorPHINE: Fine. insomnia." Quaker-Quinidine Preachers-Procainamide Discussed-Disopyramide Sobriety-Sodium channel blockade Class IB . Mexiletine. AmPHETamine: Fat "Morphine overdose: pupils constricted (fine) Amphetamine overdose: pupils dilated (fat) Phenobarbitone side effects Children are annoying (hyperkinesia. Phenytoin. tocainide . and it came from nightshade [belladona]In the night or in shade. aggression) Adults are dosy (sedation.Sodium channel blockade: Lidocaine. Quinidine. Disopyramide "Quaker Preachers Discussed Sobriety.Pupils in overdose: morphine vs. drowsiness Atropine: origin tells action or vice versa Atropine causes your pupils to dilate.
" Betting-Beta-adrenergic blockade Professionals-Propranolol Class III ." Philadelphians-Phenytoin Like-Lidocaine Salty-Sodium channel blockade Mexican-Mexiletine Tacos-Tocainide Class IC ." Britain-Bretylium Repossessed-Repolarization is prolonged. American-Amiodarone Soaps-Solatol .Beta-adrenergic blockade: Propranolol "Betting Professionals. Propafenone "Flea Encrusted Prophets."Philadelphians Like Salty Mexican Tacos." Flea-Flecainide Encrusted-Encainide Prophets-Propafenone Class II . Encainide. Bretylium. Solatol "Britain Repossessed American Soaps.Prolong repolarization: Amiodarone.Sodium channel blockade: Flecainide.
" Calligraphist-Calcium channel blockade Verbal-Verapamil Dilemma-Diltiazem Antiarrhythmic agents: "A Dubious Quality Product. Side Effects CAPTOPRIL . Diltiazem "Calligraphist's Verbal Dilemma. Can Fabricate Enough Problems.Class IV .. Bought To Preserve Little Money... ACEI." A-1a B-1b C-1c 1a-A: D-Disopyramide Q-Quinidine P-Procainamide 1b-B: T-Tocainamide P-Phenytoin L-Lidocaine M-Mexiletine 1c-C: F-Flecainamide E-Encainamide P-Propafenone Mnemonics For Side Effects..Calcium channel blockade: Verapamil.
Renal impairment. depression / drowsy / diplopia Cholinergic OD side Effects DUMB BELS Diarrhoea. impotence. cleft lip. behavioural disturbance. taste. leucocytosis Anti-epileptic side Effects ABCDEFGH Ataxia. palpitations. Fits. exfoliation of skin & Stevens Johnson’s. orthostatic ↓BP. Miosis / muscle weakness. dupuytrens / vit D def. Potassium (↑K+). Urination. hepatitis / hairy Barbiturate side Effects ABCD Ataxia. anaphylaxis. . GI upset / gum hypertrophy.Cough. ↓concentration / coma. blood dyscrasia.
lacrimation.low MAOI side Effects 3Hs Hepatocellular jaundice. emesis. salivation / sweating Cyclosporin Side Effects 4HRT 4H . confusion. abdo pain. Neuro. hypertension TCAD side Effects CAN WOO Cvs. gum hypertrophy.Tremor Digoxin S/E GECCKO GIT – n&v.Hyper K+. halo. . ulcers Eyes – blurring.bronchorrea Bradycardia. delirium. hallucinations Cardiac – ANY arrhythmia K . Hyperthermia. xanthopsia CNS – depression. Anticholinergic. Withdrawal. hypertension. hairy R – Renal toxicity T .
Hypertension / hairy. . Path # / Psychosis. Myopathy (prox) / muscle wasting (prox) Cushingoid / Cataract. Thin skin Increased appetite. Myopathy. Glycosuria. Muscle weakness. poor wound healing. stress response reduced AM CUSHINGOID Acne. Others Steroids Side Effects HIGH COMPACT IMPS Hypertension. Infection. Heartburn Cataract. Cushingoid.Overdose. Gastric Ulcer (bleeding). Acne / Altered Glucose. Striae. skin thin (bruising). Osteoporosis. Ulcers. Immunosuppression. Obesity / Osteoporosis / Oedema.
Depression http://imedrx.Immunosuppression / Insomnia.com/2010/02/physiology-and-pharmacology-video.blogspot.html .
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