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Peripheral neuropathy*

Red orange body fluids

Itchness without rash


Red-green blindness

C/I to pregnancy
Risk for seizure
Nephrotoxicity

Hyperuricemia
Optic neuritis
Ototoxicity

Arthralgia
Hepatitis

Vertigo
Rash
Isoniazid [H] 2 1
Rifampicin [R] 3
Pyrazinamide [Z] 1 1
Streptomycin [S]
Ethambutol [E] mild

*owing to Vit. B6 (Pyridoxine) deficiency


numbers tell the most common cause (1 most common, and so on)

If the organism is known to be fully sensitive, then treatment is with isoniazid,


rifampicin, and pyrazinamide for two months, followed by isoniazid and rifampicin
for four months. Ethambutol need not be used.

Current regimen (UK and WHO):


2HREZ/4HR or 2SHRZ/4HR