DRUG STUDY Medical Diagnosis: hydrocephalus, status post- shunt insertion Category: Student Nurse: BSN III-A (Group

IV) Indication/ Contraindication INDICATIONS: Generic Name: Treatment of infections ceftriaxone of the lower resp tract, acute bacterial otitis Brand Name: media, skin & skin Forgram structure infection, UTI, uncomplicated Classification: gonorrhea, pelvic Cephalosporins inflammatory disease, bacterial septicemia, Dosage: bone & joint infections, 1 gram dissolve in 1 vial intra-abdominal in 1.75ml distilled water infections, meningitis. + 1.75ml 2% Lidocaine CONTRADICTIONS: Frequency: Hypersensitivity to Once a day cephalosporins. Hypersensitivity to Route: lidocaine (IM inj) intramuscular Mechanism of Action Works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of of defective cell walls and cell death. Side Effects/ Adverse Effects • Pain • Induration • Phlebitis • Rash • Diarrhea • Thrombocytosis • Leucopenia • Glossitis • Respiratory superinfections Nursing Considerations • Assess patient’s previous sensitivity reaction to penicillin or other cephalosphorins. • Assess patient for signs and symptoms of infection before and during the treatment • Obtain C&S before beginning drug therapy to identify if correct treatment has been initiated. • Assess for allergic reaction. • Monitor hematologic,electrolytes, renal and hepatic function. • Assess for possible superinfection: itching fever, malaise, redness, diarhhea

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