Side Effect

Nursing Responsibility

Aldomet Antihypertensive

Stimulation of central alpha-adrenergic receptors by a false transmitter that results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature


Sedation, headache, asthenia, orthostatic hypotension, bradycardia, edema, GI upset, rash, nasal congestion, arthralgia, amenorrhea, hyperprolactinemia, gynecomastia, pancreatitis, impotence, decreased libido, CNS effects, eosinophilia, liver dysfunction, jaundice, (+) Coombs test, hemolytic anemia; rarely: fatal hepatic necrosis, blood dyscrasias.


Administer IV slowly; monitor injection site. Monitor hepatic function, especially in the first 6---12 wk of therapy or if unexplained fever appears. Discontinue drug if fever, abnormalities in liver function tests, or jaundice occur. Ensure that methyldopa is not reinstituted in such patients. Monitor blood counts periodically to detect hemolytic anemia; a direct Coombs' test before therapy and 6 and 12 mo later may



be helpful. Discontinue if edema progresses or signs of CHF occur. Discontinue drug if Coombs'. ensure that drug is not reinstituted. If hemolytic anemia is related to methyldopa. drug y y y . Monitor BP carefully when discontinuing methyldopa.positive hemolytic anemia occurs. y Discontinue therapy if involuntary choreoathetotic movements occur. Add a thiazide to drug regimen or increase dosage if methyldopa tolerance occurs (second and third mo of therapy).

. and hypertension usually returns within 48 h.has short duration of action.

Monitor I&O rates and pattern: Especially important in severely ill patients receiving high doses. Inspect IM and IV injection sites frequently for signs of phlebitis. Report any significant changes. bronchitis. urinary tract infections. positive Coombs' test. pharyngitis/tonsillitis. and is used for surgical prophylaxis. decreased creatinine clearance. sinusitis. and history of allergies. penicillins. Urogenital: Increased serum creatinine and BUN. y y y y Determine history of hypersensitivity reactions to cephalosporins. pruritus. otitis media. Skin: Rash. urticaria. Report onset of loose stools or diarrhea. Although pseudomembrano us colitis. skin and soft tissue infections. antibiotic-associated colitis. Effectively treats bone and joint infections. before therapy is initiated. . GI: Diarrhea. superinfections. particularly to drugs. meningitis. nausea. Body as a Whole: Thrombophlebitis (IV site). reducing or eliminating infection. gonorrhea.Classification Action Indication Side Effect Nursing Responsibility Cefuroxime Antibiotic Decreases orcontrol the infection It is effective for the treatment of penicillinaseproducing Neisseria gonorrhoea (PPNG). lower respiratory tract infections.

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