P. 1
Diuretics (2)

Diuretics (2)

|Views: 14|Likes:
Published by vinodmedicoz

More info:

Published by: vinodmedicoz on Apr 23, 2011
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as PPT, PDF, TXT or read online from Scribd
See more
See less

04/23/2011

pdf

text

original

DIURETICS

SONG Hui

OUTLINE    BACKGROUND CLASSIFICATION OF DIURETICS REVIEW AND QUESTIONS .

Look at the diagram . Ald.BACKGROUND       The essential of urine. How urine formation. Which ion play an important role in this procedure. ADH The action sites of diuretics.

CLASSIFICATION      High effect diuretics: Lasix Mediate effect: Thiazide diuretics Mild (Low)effect: K+ sparing diuretics Osmotic diuretics: Mannitol Others .

Cl K-Na-2Cl .High effect diuretics     High ceiling (loop) diuretics Agent furosemide (lasix) Action site thick ascending loop (AL) Mechanism 1.

30 min by p.High effect diuretics         2. Onset in 5 min by i. Cl Na Renal Blood Flow (RBF) P. PGE P.K.v.E.o. t1/2=2hr last for 4-6 hr ADR Ototoxicity (etacrynic acid>lasix>bumetanide) .

Mediate effect diuretics        Thiazides Agent Hydrochlorothiazide (HCT) Action site Distal convoluted tubule (DCT) Mechanism Na-K-2Cl. CA. PDE .

Hyperuricemia--.insulin Hypercalcemia--.compete with uric acid Hyperglycemia--.Ca .Mediate effect diuretics      ADR Hypokalemia ---be careful when use with digitalis.

Triamterene & amiloride Action site DCT & CT (Collecting Tubule) Mechanism 1. Ald-R Na K 2. Na channel .Low effect diuretics         K+ sparing diuretics Agent Antisterone.

outside cell .inside cell ----.Low effect diuretics      ADR Hyperkalemia. sex hormone like effects (antisterone) Others Carbonic anhydrase inhibitors (acetazolamide) H2O + CO2 CA H + HCO3 Na -------.

gastrointestinal tract Mechanism 1. AL. Glucose Action site PCT. Blood volume RBF .Osmotic diuretics        Agents (characters) Mannitol. Vessels. Hyperosmolarity 2.

H2O ADR BV CHF Dehydration Hypernatremia .E.Osmotic diuretics       P.

CLINIC USES of DIURETICS          Edema CHF ARF Hypertension Poisoning Hypercalciuria Hypercalciumia Glaucoma Diabetes insipidus .

electrolyte imbalances .D (antisterone) In common _ _ + + + + _ + _ + _ _ BV _ LDL + Sex H effects Hyponatremia.Ca ototoxicity others H.ADR of Diuretics Pla.D (HCT) L.D (Lasix) M. K Pla.UricA Pla.

E of diuretics The clinic uses of diuretics. The Common ADR of diuretics The common P. Why DM patients have a lot of urine? . The mechanisms of each.Review & questions       The classes of diuretics.

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->