Making an Antibody

By Katy Version 1

Making an Antibody

CHARACTERS

“B Cells” “T Cells” “Plasma Cells” “Bacteria” “Red Blood Cells” “Antibodies”

We see:

EXT. ARTERY– DAY

(Music Soundtrack)

An external view of the artery is seen. Slowly the camera zooms into the artery and into the flow of the blood.

INT.INSIDE ARTERY – DAY

(Music Soundtrack and rushing fluid sound)

Red blood cells are seen coming round the corner and passing the camera. After a few blood cells are seen rushing past, multiple bacteria appear from around the corner and are seen passing the camera and continuing with the flow of the blood.

We follow one of the bacterium as it rushes on through inside the artery, following many twists and turns of its journey.

EXT.ARTERY AND LYMPH NODE CONNECTION– DAY

(Music Soundtrack)

We zoom out of the artery still following the bacteria’s journey. The camera zooms out to view the whole lymph node and network of arteries and veins, while still following the blood flow going towards the lymph node.

INT.LYMPH NODE – DAY

(Music Soundtrack and eerie cave like ambient sounds)

Inside the lymph node facing the entrance to it. Blood cells are seen entering, followed by the bacteria. The bacteria spread out in search of their prey, cells they can damage. We follow one as it swims slowly throughout the lymph node.

As we follow this bacterium, B cells are seen sitting bellow it and attached to the stringy, elastic like structures around them that go from the floor up to the ceiling.

We see the bacteria swim freely through the B cells, knocking and pushing them out of their way. Back to following our chosen bacterium, we see one in the background get captured by a B cell. Our bacterium continues to swim through the B cells which is then joined by another bacterium and they swim together side by side.

Suddenly our bacterium’s mate gets captured by a B cell, which nearly captures our bacterium who manages to dodge the B cells’ attack, only to run into the grasp of another B cell.

The Bacterium is pulled into the B cells’ body and dissolved. The antigens that were on the body of the bacterium are visible floating around inside the B cell. These antigens are then moved to the B cells’ membrane and exposed on its surface. The B cell is seen waiting for further instructions.

From another part of the lymph node, T cells are seen awaking and moving from their location and heading towards the direction of the B cells. We follow one of them as it nears the B cell we saw earlier. Viewed from a distance above we see them come closer to each other until they stop almost touching one another.

Zoomed up closer and spinning slowly around both our B cell and T cell, we see the T cell start to gently wrap its tentacles around the B cell. Zooming in we can see the T cell then pull itself closer to connect its receptor to the exposed antigen on the B cells’ body.

The T cell communicates to the B cell telling it to start multiplying. When it has finished the camera zooms out to see the T cell let go and swim away.

Viewing this one B cell, it starts to divide into more B cells and plasma cells. Showing one of the plasma cells, it starts to shed its receptors which are now antibodies.

We see multiple swarms of antibodies sticking to the bacteria. We follow one swarm as it exits the lymph node through the main vein exit.

EXT.VEIN – DAY

(Music Soundtrack)

Still following the antibodies, the camera zooms out to view the vein leaving the lymph node.

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