Sanguis Technologies Matt Christensen

Diabetes affects 250 million people worldwide and it is the fourth leading cause of death in the US. To keep the disease in check a diabetic must regularly check their blood glucose levels. Non-invasive blood glucose monitoring has been called the Holy Grail of the self-testing market, which is about 10 billion a year across the globe. Users break skin to draw blood and use a test strip to monitor their glucose levels. The strips are about $0.50 each, so testing 6-7 times a day costs about $1200 a year. Testing is painful, costly, and the drawing of blood creates a social impediment to testing in public. Research has begun using the impedance of blood as an indication of glucose levels, in particular interstitial blood. Some newer glucometers draw blood to measure changes in impedance, which is invasive and still requires expensive test strips. Some have tried drawing interstitial fluid out of the finger to measure its impedance, but this causes irritation. A European company tried measuring the impedance of the skin at one point as an indication of blood glucose levels, this product got to market but ultimately failed due to lack of efficacy. Our idea is to measure blood glucose using electrical impedance tomography (EIT). Small alternating currents go through a source electrode, and the resulting voltages are measured at receiving electrodes. Through Ohms Law, the resistance is known, and by using Radon math, the spatial distribution can be derived. The benefit to this approach is that the impedance of interstitial fluid can be measured noninvasively. A fixed ring device containing electrodes could be placed around the finger and would get a 2-D or 3-D map of impedances in the finger. The device can automatically segment out bone and skin and the remaining impedance values would be correlated to blood glucose levels. The device would then display to a LED to alert the user. The primary benefit of this approach is the avoidance of drawing blood and using expensive test strips. Because the components are simple and cheap, the device could be built for about the cost of an Ipod, drastically reducing a users cost to maintain blood glucose levels. The device could potentially be used in either an Intensive Care Unit setting where tight monitoring is essential or as a handheld portable device that could be carried around in a purse or pocket.

Sign up to vote on this title
UsefulNot useful