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Albendazole Drug Interactions | Drug - Drug Interactions

Albendazole Drug Interactions

Albendazole + Carbamazepine

Carbamazepine approximately halves the levels of albendazole.

For systemic infections it may be necessary to increase the albendazole dosage. Monitor
the outcome of concurrent use. This interaction is of no importance in the treatment of
intestinal worm infections.

Albendazole + Contraceptives

The manufacturer of albendazole recommends that women should use non-hormonal


methods of contraception during and for one month after stopping albendazole. This
is because there is a theoretical risk of an interaction (albendazole is a liver enzyme
inducer) and because albendazole is potentially teratogenic.

Counsel patients on additional/alternative contraception.

Albendazole + Food

Giving albendazole with a meal (especially fatty meals) markedly increases the levels of
its active metabolite.

Albendazole absorption is poor, and if it is being used for systemic infections, it is


advisable to take it with a meal.

Albendazole + Phenobarbital

Phenobarbital (and therefore probably primidone) approximately halves the levels of


albendazole.

For systemic infections it may be necessary to increase the albendazole dosage. Monitor
the outcome of concurrent use. This interaction is of no importance in the treatment of
intestinal worm infections.

Albendazole + Phenytoin

Phenytoin approximately halves the levels of albendazole. Fosphenytoin, a prodrug of


phenytoin, may interact similarly.

For systemic infections it may be necessary to increase the albendazole dosage. Monitor
the outcome of concurrent use. This interaction is of no importance in the treatment of
intestinal worm infections.
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Albendazole Drug Interactions | Drug - Drug Interactions

Refer: Stockley’s Drug Interactions

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